Version August 2025
| Drug | Effects |
| Bupropion | Agitation, tremor, seizures, tachydysrhythmia, hypertension |
| Venlafaxine | Sedation, seizures, serotonergic symptoms *, tachydysrhythmia |
| Desvenlafaxine | Tachycardia, mild CNS depression |
| Duloxetine | Tachycardia, hypertension, serotonergic symptoms*, gastrointestinal symptoms |
| Mirtazapine | Sedation, tachycardia |
| Milnacipran | Serotonergic symptoms*, cardiac dysfunction (rare), rash (rare) |
| Trazodone | Sedation, QTc prolongation, vomiting, hypotension, tachycardia, priapism |
| Vilazodone | Sedation, agitation, tachycardia, vomiting, seizures, serotonergic symptoms* |
| Nefazodone | Sedation, gastrointestinal symptoms, hypotension, bradycardia, dizziness |
| Vortioxetine | Sedation, gastrointestinal symptoms, pruritus, flushing |
CNS: central nervous system.
* Serotonergic symptoms and signs include tremor, clonus, hyperreflexia, anxiety, restlessness, agitated delirium, diaphoresis, hyperthermia, vomiting, and diarrhea.