Factors favoring initiation of an aggressive approach | Factors against initiation of an aggressive approach |
Young age | Older age |
Previously healthy | Medical comorbidities/immune compromise |
One or more doses of rabies vaccine administered prior to the onset of clinical symptoms | No previous history of administration of rabies vaccine |
Early clinical rabies (eg, local sensory symptoms) | Late clinical rabies (eg, quadriparesis or coma) |
Presence of neutralizing anti-rabies virus antibodies in serum and/or cerebrospinal fluid | Absence of neutralizing anti-rabies virus antibodies in serum and/or cerebrospinal fluid |
Diagnostic tests negative for rabies virus antigen and rabies virus RNA | Diagnostic tests positive for rabies virus antigen and rabies virus RNA |
Access to critical care facilities | Lack of access to critical care facilities |
Acceptance that the outcome could result in severe neurological deficits | Lack of acceptance that the outcome could result in severe neurological deficits |
Do you want to add Medilib to your home screen?