AA amyloidosis: amyloid A amyloidosis; AL amyloidosis: amyloid light-chain amyloidosis; ANA: antinuclear antibody; ANCA: antineutrophil cytoplasmic antibody; anti-dsDNA: anti-double-stranded DNA; anti-PLA2R: anti-phospholipase-A2-receptor; APOL1: apolipoprotein L1; C3: complement component 3; C4: complement component 4; eGFR: estimated glomerular filtration rate; ELISA: enzyme-linked immunoassay; FSGS: focal segmental glomerulosclerosis; GBM: glomerular basement membrane; HbA1c: hemoglobin A1C; HBV: hepatitis B virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; IgA: immunoglobulin A; immunotactoid GN: immunotactoid glomerulopathy; MPO: myeloperoxidase; NSAIDs: nonsteroidal antiinflammatory drugs; PR3: proteinase 3; RBC: red blood cell.
* Glomerular hematuria and proteinuria are defined as follows:¶ A systemic disorder that also involves the kidney should be suspected if there is evidence for inflammation of other organ systems, such as the skin (eg, purpura, rash), joints (eg, arthritis), eye (eg, retinitis, uveitis), nose (eg, epistaxis), mouth (eg, ulcers), lungs (eg, hemoptysis, infiltrates), nervous system (eg, seizures, neuropathy), extremities (eg, digital ischemia or infarction), or abdomen (eg, enteritis, colitis), or if there is an infection (particularly with Staphylococcus, Streptococcus, hepatitis virus, or HIV).
Δ Orthostatic proteinuria is characterized by increased protein excretion while in the upright posture but normal protein excretion when recumbent; it is typically found in adolescents and young adults but not in older adults. The diagnosis is made by establishing that urine protein excretion is normal when the patient is supine, either with an overnight urine collection or a first-morning voided urine specimen.
◊ Some patients with FSGS will have a genetic mutation that results in a defect of podocyte or slit diaphragm function; the most commonly involved genes include nephrin, podocin, alpha-actinin-4, TRPC6, INF2, and MYO1E.Do you want to add Medilib to your home screen?