Algorithm for low density lipoprotein cholesterol (LDL-C) lowering in patients with untreated heterozygous familial hypercholesterolemia

* LDL-C ≤70 to 100 mg or LDL-C ≤50% baseline.
¶ Atorvastatin titrated to 80 mg daily or rosuvastatin 40 mg daily.
Δ Patients who cannot tolerate statin will likely need early specialist referral.
◊ Discuss high burden of therapy with patient (ie, cost, subcutaneous injections).