Risk category* | Genetic abnormality |
Favorable | t(8;21)(q22;q22.1); RUNX1-RUNX1T1 |
inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBFB-MYH11 | |
Mutated NPM1 without FLT3-ITD or with FLT3-ITDlow¶ | |
Biallelic mutated CEBPA | |
Intermediate | Mutated NPM1 and FLT3-ITDhigh¶ |
Wild type NPM1 without FLT3-ITD or with FLT3-ITDlow¶ (without adverse-risk genetic lesions) | |
t(9;11)(p21.3;q23.3); MLLT3-KMT2AΔ | |
Cytogenetic abnormalities not classified as favorable or adverse | |
Adverse | t(6;9)(p23;q34.1); DEK-NUP214 |
t(v;11q23.3); KMT2A rearranged | |
t(9;22)(q34.1;q11.2); BCR-ABL1 | |
inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2,MECOM(EVI1) –5 or del(5q); –7; –17/abn(17p) | |
Complex karyotype,◊ monosomal karyotype§ | |
Wild type NPM1 and FLT3-ITDhigh¶ | |
Mutated RUNX1¥ | |
Mutated ASXL1¥ | |
Mutated TP53‡ |
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