- Onset 2 to 4 weeks after GAS infection
- Fever is common
- Acute joint symptoms and signs
- Carditis
- Skin manifestations and subcutaneous nodules (both are rare)
- Raised inflammatory markers
- Evidence of preceding GAS infection (elevated ASO and anti-DNase B titers)
- Dramatic symptomatic response to aspirin and NSAIDS
- Duration usually <6 weeks
- Followed by RHD in approximately 75%
| - Later onset
- Two to 6 months after GAS infection
- No fever
- Joint manifestations are not a feature
- Behavioral disorder and distinctive chorea
- Carditis >30%
- Often normal inflammatory markers
- ASO often unhelpful, anti-DNase B may be raised
- Followed by RHD in approximately 50%
|