Name | Biologically active peptide(s) | Incidence (new cases/106 population/year) | Tumor location | Most common symptoms/signs |
Most common syndromes | ||||
Insulinoma | Insulin | 1 to 3 |
| Hypoglycemic syndromes (Whipple's triad) |
Zollinger-Ellison syndrome | Gastrin | 0.5 to 2 |
| Abdominal pain, gastroesophageal reflux, diarrhea, duodenal ulcers, PUD/GERD |
Less common syndromes (additional, rarer syndromes also exist) | ||||
VIPoma (Verner-Morrison syndrome, pancreatic cholera, WDHA syndrome) | Vasoactive intestinal peptide | 0.05 to 0.2 |
| Diarrhea, hypokalemia, dehydration |
Glucagonoma | Glucagon | 0.01 to 0.1 |
| Rash, glucose intolerance, necrolytic migratory erythema, weight loss |
Somatostatinoma | Somatostatin | Rare |
| Diabetes mellitus, cholelithiasis, diarrhea |
ACTHoma/Cushing's syndrome | ACTH | Rare |
| Cushing's syndrome |
Pancreatic NET causing carcinoid syndrome | Serotonin | Rare |
| Flushing, diarrhea |
PTHrp-oma (hypercalcemia) | PTHrp, others unknown | Rare |
| Symptoms due to hypercalcemia (mimics primary hyperparathyroidism) |
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