Diagnostic approach to the erythrodermic newborn or infant presenting with bullae/pustules and/or areas of denuded skin

CBC: complete blood count; SSSS: staphylococcal scalded skin syndrome; TSS: toxic shock syndrome; HSV: herpes simplex virus; HTLV-1: human T-lymphotropic virus type I; SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis; GVHD: graft-versus-host disease; SCID: severe combined immunodeficiency.
* Refer to UpToDate topics on the diagnosis of epidermolysis bullosa.
¶ Refer to UpToDate topics on cutaneous and systemic mastocytosis in children.