Primary tumor (T), squamous cell carcinoma and adenocarcinoma | |||||
T category | T criteria | ||||
TX | Tumor cannot be assessed | ||||
T0 | No evidence of primary tumor | ||||
Tis | High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane | ||||
T1 | Tumor invades the lamina propria, muscularis mucosae, or submucosa | ||||
T1a | Tumor invades the lamina propria or muscularis mucosae | ||||
T1b | Tumor invades the submucosa | ||||
T2 | Tumor invades the muscularis propria | ||||
T3 | Tumor invades adventitia | ||||
T4 | Tumor invades adjacent structures | ||||
T4a | Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum | ||||
T4b | Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway | ||||
Regional lymph nodes (N), squamous cell carcinoma and adenocarcinoma | |||||
N category | N criteria | ||||
NX | Regional lymph nodes cannot be assessed | ||||
N0 | No regional lymph node metastasis | ||||
N1 | Metastases in 1 or 2 regional lymph nodes | ||||
N2 | Metastases in 3 to 6 regional lymph nodes | ||||
N3 | Metastases in 7 or more regional lymph nodes | ||||
Distant metastasis (M), squamous cell carcinoma and adenocarcinoma | |||||
M category | M criteria | ||||
M0 | No distant metastasis | ||||
M1 | Distant metastasis | ||||
Histologic grade (G), squamous cell carcinoma and adenocarcinoma | |||||
G | G definition | ||||
GX | Grade cannot be assessed | ||||
G1 | Well differentiated | ||||
G2 | Moderately differentiated | ||||
G3 | Poorly differentiated, undifferentiated | ||||
Location, squamous cell carcinoma | |||||
Location plays a role in the stage grouping of esophageal squamous cancers. | |||||
Location category | Location criteria | ||||
X | Location unknown | ||||
Upper | Cervical esophagus to lower border of azygos vein | ||||
Middle | Lower border of azygos vein to lower border of inferior pulmonary vein | ||||
Lower | Lower border of inferior pulmonary vein to stomach, including gastroesophageal junction | ||||
NOTE: Location is defined by the position of the epicenter of the tumor in the esophagus. | |||||
Prognostic stage groups, squamous cell carcinoma | |||||
Clinical (cTNM) | |||||
When cT is... | And cN is... | And M is... | Then the stage group is... | ||
Tis | N0 | M0 | 0 | ||
T1 | N0-1 | M0 | I | ||
T2 | N0-1 | M0 | II | ||
T3 | N0 | M0 | II | ||
T3 | N1 | M0 | III | ||
T1-3 | N2 | M0 | III | ||
T4 | N0-2 | M0 | IVA | ||
Any T | N3 | M0 | IVA | ||
Any T | Any N | M1 | IVB | ||
Pathological (pTNM) | |||||
When pT is... | And pN is... | And M is... | And G is... | And location is... | Then the stage group is... |
Tis | N0 | M0 | N/A | Any | 0 |
T1a | N0 | M0 | G1 | Any | IA |
T1a | N0 | M0 | G2-3 | Any | IB |
T1a | N0 | M0 | GX | Any | IA |
T1b | N0 | M0 | G1-3 | Any | IB |
T1b | N0 | M0 | GX | Any | IB |
T2 | N0 | M0 | G1 | Any | IB |
T2 | N0 | M0 | G2-3 | Any | IIA |
T2 | N0 | M0 | GX | Any | IIA |
T3 | N0 | M0 | Any | Lower | IIA |
T3 | N0 | M0 | G1 | Upper/middle | IIA |
T3 | N0 | M0 | G2-3 | Upper/middle | IIB |
T3 | N0 | M0 | GX | Any | IIB |
T3 | N0 | M0 | Any | Location X | IIB |
T1 | N1 | M0 | Any | Any | IIB |
T1 | N2 | M0 | Any | Any | IIIA |
T2 | N1 | M0 | Any | Any | IIIA |
T2 | N2 | M0 | Any | Any | IIIB |
T3 | N1-2 | M0 | Any | Any | IIIB |
T4a | N0-1 | M0 | Any | Any | IIIB |
T4a | N2 | M0 | Any | Any | IVA |
T4b | N0-2 | M0 | Any | Any | IVA |
Any T | N3 | M0 | Any | Any | IVA |
Any T | Any N | M1 | Any | Any | IVB |
Post-neoadjuvant therapy (ypTNM) | |||||
When ypT is... | And ypN is... | And M is... | Then the stage group is... | ||
T0-2 | N0 | M0 | I | ||
T3 | N0 | M0 | II | ||
T0-2 | N1 | M0 | IIIA | ||
T3 | N1 | M0 | IIIB | ||
T0-3 | N2 | M0 | IIIB | ||
T4a | N0 | M0 | IIIB | ||
T4a | N1-2 | M0 | IVA | ||
T4a | NX | M0 | IVA | ||
T4b | N0-2 | M0 | IVA | ||
Any T | N3 | M0 | IVA | ||
Any T | Any N | M1 | IVB | ||
Prognostic stage groups, adenocarcinoma | |||||
Clinical (cTNM) | |||||
When cT is... | And cN is... | And M is... | Then the stage group is... | ||
Tis | N0 | M0 | 0 | ||
T1 | N0 | M0 | I | ||
T1 | N1 | M0 | IIA | ||
T2 | N0 | M0 | IIB | ||
T2 | N1 | M0 | III | ||
T3 | N0-1 | M0 | III | ||
T4a | N0-1 | M0 | III | ||
T1-4a | N2 | M0 | IVA | ||
T4b | N0-2 | M0 | IVA | ||
Any T | N3 | M0 | IVA | ||
Any T | Any N | M1 | IVB | ||
Pathological (pTNM) | |||||
When pT is... | And pN is... | And M is... | And G is... | Then the stage group is... | |
Tis | N0 | M0 | N/A | 0 | |
T1a | N0 | M0 | G1 | IA | |
T1a | N0 | M0 | GX | IA | |
T1a | N0 | M0 | G2 | IB | |
T1b | N0 | M0 | G1-2 | IB | |
T1b | N0 | M0 | GX | IB | |
T1 | N0 | M0 | G3 | IC | |
T2 | N0 | M0 | G1-2 | IC | |
T2 | N0 | M0 | G3 | IIA | |
T2 | N0 | M0 | GX | IIA | |
T1 | N1 | M0 | Any | IIB | |
T3 | N0 | M0 | Any | IIB | |
T1 | N2 | M0 | Any | IIIA | |
T2 | N1 | M0 | Any | IIIA | |
T2 | N2 | M0 | Any | IIIB | |
T3 | N1-2 | M0 | Any | IIIB | |
T4a | N0-1 | M0 | Any | IIIB | |
T4a | N2 | M0 | Any | IVA | |
T4b | N0-2 | M0 | Any | IVA | |
Any T | N3 | M0 | Any | IVA | |
Any T | Any N | M1 | Any | IVB | |
Post-neoadjuvant therapy (ypTNM) | |||||
When ypT is... | And ypN is... | And M is... | Then the stage group is... | ||
T0-2 | N0 | M0 | I | ||
T3 | N0 | M0 | II | ||
T0-2 | N1 | M0 | IIIA | ||
T3 | N1 | M0 | IIIB | ||
T0-3 | N2 | M0 | IIIB | ||
T4a | N0 | M0 | IIIB | ||
T4a | N1-2 | M0 | IVA | ||
T4a | NX | M0 | IVA | ||
T4b | N0-2 | M0 | IVA | ||
Any T | N3 | M0 | IVA | ||
Any T | Any N | M1 | IVB |
Do you want to add Medilib to your home screen?