Fentanyl transmucosal preparation | Brand name (United States) | Starting dose in an opioid-tolerant adult* | Serum half-life (hours)¶ | Duration of analgesic effect (hours)¶ |
Buccal tablet | Fentora | 100 mcg | 13.3 | 1 to 2 |
Oral lozenge | Actiq | 200 mcg | 7.6 | 2 |
Sublingual tablet | AbstralΔ | 100 mcg | 11.5 to 25 | 1 |
mcg: microgram.
* Always initiate transmucosal fentanyl preparations at the lowest starting dose for breakthrough pain, even in patients with high baseline opioid requirements. Data do not support specific transmucosal fentanyl dose equivalents to other opioids. For additional detail, including recommendations on frequency of repeat dosing, dose titration, and recommendations on converting between transmucosal forms if necessary, refer to the fentanyl monograph included in UpToDate.
¶ Serum half-life and duration of effect are dose dependent.
Δ Not available in the United States but available in other areas.Courtesy of Kathleen Broglio, DNP, MN, ANP-BC, ACHPN and Russell K Portenoy, MD.
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