Primary tumor (T) | ||
T category | Thickness | Ulceration status |
TX: Primary tumor thickness cannot be assessed (eg, diagnosis by curettage) | Not applicable | Not applicable |
T0: No evidence of primary tumor (eg, unknown primary or completely regressed melanoma) | Not applicable | Not applicable |
Tis (melanoma in situ) | Not applicable | Not applicable |
T1 | ≤1.0 mm | Unknown or unspecified |
T1a | <0.8 mm | Without ulceration |
T1b | <0.8 mm | With ulceration |
0.8 to 1 mm | With or without ulceration | |
T2 | >1 to 2 mm | Unknown or unspecified |
T2a | >1 to 2 mm | Without ulceration |
T2b | >1 to 2 mm | With ulceration |
T3 | >2 to 4 mm | Unknown or unspecified |
T3a | >2 to 4 mm | Without ulceration |
T3b | >2 to 4 mm | With ulceration |
T4 | >4 mm | Unknown or unspecified |
T4a | >4 mm | Without ulceration |
T4b | >4 mm | With ulceration |
Regional lymph nodes (N) | ||
N category | Extent of regional lymph node and/or lymphatic metastasis | |
Number of tumor-involved regional lymph nodes | Presence of in-transit, satellite, and/or microsatellite metastases | |
NX | Regional nodes not assessed (eg, SLN biopsy not performed, regional nodes previously removed for another reason). Exception: Pathological N category is not required for T1 melanomas, use cN. | No |
N0 | No regional metastases detected | No |
N1 | One tumor-involved node or in-transit, satellite, and/or microsatellite metastases with no tumor-involved nodes | |
N1a | One clinically occult (ie, detected by SLN biopsy) | No |
N1b | One clinically detected | No |
N1c | No regional lymph node disease | Yes |
N2 | Two or three tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with one tumor-involved node | |
N2a | Two or three clinically occult (ie, detected by SLN biopsy) | No |
N2b | Two or three, at least one of which was clinically detected | No |
N2c | One clinically occult or clinically detected | Yes |
N3 | Four or more tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with two or more tumor-involved nodes, or any number of matted nodes without or with in-transit, satellite, and/or microsatellite metastases | |
N3a | Four or more clinically occult (ie, detected by SLN biopsy) | No |
N3b | Four or more, at least one of which was clinically detected, or presence of any number of matted nodes | No |
N3c | Two or more clinically occult or clinically detected and/or presence of any number of matted nodes | Yes |
Distant metastasis (M) | ||
M category | M criteria | |
Anatomic site | LDH level | |
M0 | No evidence of distant metastasis | Not applicable |
M1 | Evidence of distant metastasis | See below |
M1a | Distant metastasis to skin, soft tissue including muscle, and/or nonregional lymph node | Not recorded or unspecified |
M1a(0) | Not elevated | |
M1a(1) | Elevated | |
M1b | Distant metastasis to lung with or without M1a sites of disease | Not recorded or unspecified |
M1b(0) | Not elevated | |
M1b(1) | Elevated | |
M1c | Distant metastasis to non-CNS visceral sites with or without M1a or M1b sites of disease | Not recorded or unspecified |
M1c(0) | Not elevated | |
M1c(1) | Elevated | |
M1d | Distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease | Not recorded or unspecified |
M1d(0) | Normal | |
M1d(1) | Elevated |
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