Protein C and S function in the termination of coagulation
Protein C and S function in the termination of coagulation
Protein C is activated on the endothelial cell membrane, where it is anchored by the endothelial protein C receptor. Activated protein C and protein S assemble on the platelet membrane. Protein S acts as a cofactor for protein C in proteolytically cleaving activated factors V and VIII (factors Va and VIIIa).
TM: thrombomodulin; T: thrombin; EPCR: endothelial protein C receptor; PC: protein C; PS: protein S; APC: activated protein C; Va: activated factor V; VIIIa: activated factor VIII.