- Peripheral blood leukocytosis due to increased numbers of neutrophils and their precursors (promyelocytes, myelocytes, metamyelocytes) comprising ≥10% of leukocytes
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- Dysgranulopoiesis, which may include abnormal chromatin clumping
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- No or minimal absolute basophilia; basophils usually <2% of leukocytes
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- No or minimal absolute monocytosis; monocytes <10% of leukocytes
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- Hypercellular bone marrow with granulocytic proliferation and granulocytic dysplasia, with or without dysplasia in the erythroid and megakaryocytic lineages
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- <20% blasts in the blood and bone marrow
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- No evidence of PDGFRA, PDGFRB, or FGFR1 rearrangement, or PCM1-JAK2
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- Not meeting WHO criteria for BCR-ABL1+ CML, PMF, PV, or ET*
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