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Segmented neutrophils plus band forms ≥80% of WBCs |
Neutrophil precursors (promyelocytes, myelocytes, and metamyelocytes) <10% of WBC |
Myeloblasts rarely observed |
Monocyte count <1 × 109/L |
No dysgranulopoiesis |
|
Neutrophil granulocytes increased in percentage and number |
Neutrophil maturation appears normal |
Myeloblasts <5% of nucleated cells |
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|
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or |
In the absence of a CSFR3R mutation, persistent neutrophilia (at least 3 months), splenomegaly and no identifiable cause of reactive neutrophilia including absence of a plasma cell neoplasm or, if present, demonstration of clonality of myeloid cells by cytogenetic or molecular studies |
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