Adults | Children | Duration | |
Ciprofloxacin | Oral: 500 mg twice daily | Oral: 30 mg/kg per day in two divided doses (maximum 1000 mg per day)* | 7 to 10 days |
IV: 400 mg twice daily | IV: 20 mg/kg per day in two divided doses (maximum 800 mg per day)* | ||
Ofloxacin¶ | 400 mg orally or IV twice daily | 15 to 30 mg/kg per day orally in two divided doses (maximum 800 mg per day)*¶ based upon limited experience; optimal pediatric dose is not known | 7 to 10 days |
Ceftriaxone | 2 g IV once or twice daily | 50 to 100 mg/kg IV in one or two divided doses (maximum 4 g per day) | 10 to 14 days |
Cefotaxime | 1 to 2 g IV every six or eight hours | 150 to 200 mg/kg IV per day in three to four divided doses (maximum 8 g per day) | 10 to 14 days |
Cefixime | 200 mg orally twice daily | 20 mg/kg orally in two divided doses (maximum 400 mg per day) | 10 to 14 days |
Azithromycin | 1 g orally once then 500 mg orally daily OR 1 g orally once daily | 10 to 20 mg/kg orally once per day (maximum 1000 mg per day) | 5 to 7 days |
MeropenemΔ | 1 to 2 g IV every eight hours | 20 to 40 mg/kg every eight hours (maximum 6000 mg per day) | 10 to 14 days |
Agents of limited usefulness due to the high prevalence of multidrug resistance | |||
Chloramphenicol◊ | Oral: 500 to 750 mg four times per day | 50 to 100 mg/kg per day orally or IV in four divided doses (maximum 3 g per day) | 14 to 21 days |
IV: 50 to 100 mg/kg per day in four divided doses (maximum 3 g per day) | |||
Amoxicillin | 1 g orally three times daily | 100 mg/kg per day orally in three divided doses (maximum 3 g per day) | 10 to 14 days |
TMP-SMX | 1 double-strength tablet (160/800 mg) orally twice daily | 8 mg/kg TMP and 40 mg/kg SMX orally in two or four divided doses (maximum 320 mg TMP/1600 mg SMX per day) | 10 to 14 days |
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