Variable | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
Recurrent TCH* | 74 (67-81) | 98 (89-100) | 99 (95-100) | 53 (43-64) |
Single TCH* | 15 (10-22) | 96 (85-99) | 92 (75-99) | 25 (19-32) |
Plus normal brain MRI | 2 (0-5) | 100 (92-100) | 100 (30-100) | 23 (18-30) |
Plus FLAIR dot sign | 10 (6-16) | 100 (92-100) | 100 (79-100) | 25 (19-32) |
Plus border zone-only infarcts | 3 (1-6) | 100 (92-100) | 100 (40-100) | 23 (18-30) |
Plus vasogenic edema (PRES) | 4 (1-8) | 100 (92-100) | 100 (54-100) | 24 (18-30) |
Plus ICH or cSAH | 9 (5-15) | 96 (85-99) | 88 (64-98) | 24 (18-31) |
No TCH; positive angiogram* | 11 (6-17) | 49 (34-64) | 42 (23-58) | 14 (9-20) |
Plus normal brain MRI | 1 (0-3) | 100 (92-100) | 100 (17-100) | 23 (17-29) |
Plus border zone-only infarcts | 5 (2-9) | 98 (89-100) | 88 (47-98) | 23 (18-30) |
Plus ICH or cSAH | 3 (1-6) | 98 (89-100) | 80 (29-97) | 23 (17-29) |
Plus vasogenic edema (PRES) | 3 (1-7) | 100 (92-100) | 100 (48-100) | 23 (18-30) |
Plus FLAIR dot sign | 6 (3-11) | 94 (83-99) | 75 (43-94) | 23 (18-30) |
No TCH; positive angiogram; for the diagnosis of PACNS: | ||||
Plus deep/brainstem infarcts | 38 (35-54) | 100 (98-100) | 100 (81-100) | 85 (79-89) |
Plus CSF abnormal¶ | 28 (16-43) | 99 (95-100) | 87 (60-98) | 82 (76-88) |
Plus both of the above | 28 (16-43) | 100 (98-100) | 100 (75-100) | 83 (77-87) |
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