Chemotherapy agents | Incidence of heart failure (%) | Incidence of decline in LVEF (%) |
Anthracyclines (cumulative dose) | ||
Doxorubicin (Adriamycin) | ||
100 | 0 | 0.5 |
150 mg/m2 | 0.2 | 7 |
300 mg/m2 | 0.6 | 16 |
400 mg/m2 | 3 to 5 | 32 |
550 mg/m2 | 7 to 26 | 65 |
700 mg/m2 | 18 to 48 | 86 |
Idarubicin (>90 mg/m2) | 5 to 18 | |
Epirubicin (>900 mg/m2) | 0.9 to 11.4 | |
Mitoxantrone (>120 mg/m2) | 2.6 | |
Liposomal anthracyclines (>900 mg/m2) | 2 |
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