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Clinical complications of pertussis among infants, adolescents, and adults

Clinical complications of pertussis among infants, adolescents, and adults
Complication Frequency in: (%)
Infants Adolescents and adults
Apnea[1-4] 50 to 67 27 to 86
Pneumonia[1-5] 20 to 23 0.6 to 8
Convulsions[2-4] 1 0 to 0.6
Death[1,2,6,7] 1 to 1.6 0.01
Insomnia[3] NA 77
Sinusitis[5] NA 13
Otitis media[5,8] 6 4
Weight loss[2,3,5,8] 12 3 to 33
Urinary incontinence[1,3,5] NA 3 to 28
Syncope[1,2,5,9] NA 2 to 6
Rib fracture[1-5] NA 1 to 4
Loss of consciousness[3] NA 1
Hospitalization[1,3,4] Approximately 50 0 to 12
NA: data not available.
References:
  1. Centers for Disease Control and Prevention. Pregnancy and whooping cough: vaccinating pregnant patients. CDC, Atlanta, GA 2014. http: //www.cdc.gov/pertussis/pregnant/hcp/pregnant-patients.html.
  2. Cortese MM, Bisgard KM. Pertussis. Maxcy-Rosenau-Last Public Health and Preventive Medicine, 15th ed, Wallace RB (Ed). McGraw-Hill Medical, New York, NY 2008. p 111.
  3. Broder KR, Cortese MM, Iskander JK, et al. Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006; 55:1.
  4. Kretsinger K, Broder KR, Cortese MM, et al. Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel. MMWR Recomm Rep 2006; 55:1.
  5. De Serres G, Shadmani R, Duval B, et al. Morbidity of pertussis in adolescents and adults. J Infect Dis 2000; 182:174.
  6. Farizo KM, Cochi SL, Zell ER, et al. Epidemiological features of pertussis in the United States, 1980-1989. Clin Infect Dis 1992; 14:708.
  7. Thampi N, Gurol-Urganci I, Crowcroft NS, Sander B. Pertussis post-exposure prophylaxis among household contacts: a cost-utility analysis. PLoS One 2015; 10:e0119271.
  8. Stojanov S, Liese J, Belohradsky BH. Hospitalization and complications in children under 2 years of age with Bordetella pertussis infection. Infection 2000; 28:106.
  9. Jenkins P, Clarke SW. Cough syncope: a complication of adult whooping cough. Br J Dis Chest 1981; 75:311.

From: Kilgore PE, Salim AM, Zervos MJ, Schmitt H-J. Pertussis: microbiology, disease, treatment, and prevention. Clin Microbiol Rev 2016; 29:449–486. DOI: 10.1128/CMR.00083-15. Reproduced with permission from American Society for Microbiology. Copyright © 2016 American Society for Microbiology.

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