Drug | Time course of opioid withdrawal symptoms following last dose | ||
Onset | Peak | Nearly complete | |
Fentanyl (IV) | 3 to 5 hours | 8 to 12 hours | 4 to 5 days |
Heroin (diamorphine) (IV or inhaled) | 8 to 12 hours | 36 to 72 hours | 7 to 10 days |
Methadone | 24 to 72 hours | 4 to 6 days | 14 to 21 days |
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