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Exacerbating factors for restless legs syndrome

Exacerbating factors for restless legs syndrome
Known
Iron deficiency
Prolonged immobility (airplane, car, etc)
Serotonergic antidepressants
Renal failure
Obstructive sleep apnea
Suspected
Sedating antihistamines
Dopamine antagonists (antiemetics, antipsychotics)
Sleep deprivation
Hypoxia
Caffeine
Tobacco
Alcohol
Pain
Peripheral neuropathy
Radiculopathy
Venous insufficiency
Inflammatory/immunological conditions
Reproduced from: Picchietti DL, Hensley JG, Bainbridge JL, et al. Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev 2015; 22:64. Table used with the permission of Elsevier Inc. All rights reserved.
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