Flow cytometry for CD11b in leukocyte adhesion deficiency I (LAD-I).
Flow cytometry for CD11b in leukocyte adhesion deficiency I (LAD-I).
Flow cytometry on stimulated neutrophils from an individual with normal neutrophil function, an LAD-I carrier (heterozygote), and moderate and severe LAD-I, showing CD11b fluorescence (solid line) versus a nonspecific control (dashed line). Percentages refer to the amount of fluorescence intensity relative to the normal control.
Adapted from: Dinauer MC, Coates TD. Disorders of phagocyte function. In: Hematology: Basic Principles and Practice, 6th ed, Hoffman R, Benz EJ Jr, Silberstein LE (Eds), Elsevier, Philadelphia 2012. p.655. Illustration used with the permission of Elsevier Inc. All rights reserved.