New England Journal of Medicine




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Vaccinating Children against Covid-19 — The Lessons of Measles

Perri Klass, M.D., and Adam J. Ratner, M.D., M.P.H.

doi : 10.1056/NEJMp2034765

N Engl J Med 2021; 384:589-591

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The FDA’s Experience with Covid-19 Antibody Tests

Jeffrey Shuren, M.D., J.D., and Timothy Stenzel, M.D., Ph.D.

doi : 10.1056/NEJMp2033687

N Engl J Med 2021; 384:592-594

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Breathe

C. Alessandra Colaianni, M.D., illustrated by Kim Knoper, M.A., and Natalie Koscal, M.A.

doi : 10.1056/NEJMp2035380

N Engl J Med 2021; 384:595-597

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Avacopan for the Treatment of ANCA-Associated Vasculitis

David R.W. Jayne, M.D., Peter A. Merkel, M.D., M.P.H., Thomas J. Schall, Ph.D., and Pirow Bekker, M.D, Ph.D. for the ADVOCATE Study Group*

doi : 10.1056/NEJMoa2023386

N Engl J Med 2021; 384:599-609

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Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Romina Libster, M.D., Gonzalo Pérez Marc, M.D., Diego Wappner, M.D., Silvina Coviello, M.S., Alejandra Bianchi, Virginia Braem, Ignacio Esteban, M.D., Mauricio T. Caballero, M.D., Cristian Wood, M.D., Mabel Berrueta, M.D., An?bal Rondan, M.D., Gabriela Lescano, M.D., Pablo Cruz, M.D., Yvonne Ritou, M.D., Valeria Fern?ndez Vi?a, M.D., Dami?n ?lvarez Paggi, Ph.D., Sebasti?n Esperante, Ph.D., Adri?n Ferreti, Gast?n Ofman, M.D., ?lvaro Ciganda, B.I.T., Roc?o Rodriguez, Jorge Lantos, M.D., Ricardo Valentini, M.D., Nicol?s Itcovici, M.D., Alejandra Hintze, M.D., M. Laura Oyarvide, M.D., Candela Etchegaray, M.D., Alejandra Neira, M.D., Ivonne Name, M.D., Julieta Alfonso, M.D., Roc?o L?pez Castelo, M.D., Gisela Caruso, M.D., Sof?a Rapelius, M.S., Fernando Alvez, M.D., Federico Etchenique, M.D., Federico Dimase, M.D., Dar?o Alvarez, M.S., Sof?a S. Aranda, M.D., Clara S?nchez Yanotti, Juli?n De Luca, Sof?a Jares Baglivo, Sof?a Laudanno, Florencia Nowogrodzki, Ramiro Larrea, M.D., Mar?a Silveyra, M.D., Gabriel Leberzstein, M.D., Alejandra Debonis, M.D., Juan Molinos, M.D., Miguel Gonz?lez, M.D., Eduardo Perez, M.D., Nicol?s Kreplak, M.D., Susana Pastor Argüello, M.D., Luz Gibbons, Ph.D., Fernando Althabe, M.D., Eduardo Bergel, Ph.D., and Fernando P. Polack, M.D. for the Fundaci?n INFANT–COVID-19 Group*

doi : 10.1056/NEJMoa2033700

N Engl J Med 2021; 384:610-618

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A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

Ventura A. Simonovich, M.D., Leandro D. Burgos Pratx, M.D., Paula Scibona, M.D., Mar?a V. Beruto, M.D., Marcelo G. Vallone, M.D., Carolina V?zquez, M.D., Nadia Savoy, M.D., Diego H. Giunta, M.D., M.P.H., Ph.D., Luc?a G. Pérez, M.D., Marisa del L. S?nchez, M.D., Andrea Vanesa Gamarnik, Ph.D., Diego S. Ojeda, Ph.D., Diego M. Santoro, M.D., Pablo J. Camino, M.D., Sebastian Antelo, M.D., Karina Rainero, M.D., Gabriela P. Vidiella, M.D., Erica A. Miyazaki, M.D., Wanda Cornistein, M.D., Omar A. Trabadelo, M.D., Fernando M. Ross, M.D., Mariano Spotti, M.D., Gabriel Funtowicz, M.D., Walter E. Scordo, M.D., Marcelo H. Losso, M.D., Inés Ferniot, M.D., Pablo E. Pardo, M.D., Eulalia Rodriguez, M.D., Pablo Rucci, M.D., Julieta Pasquali, M.D., Nora A. Fuentes, M.D., Mariano Esperatti, M.D., Ph.D., Gerardo A. Speroni, M.D., Esteban C. Nannini, M.D., Alejandra Matteaccio, M.D., Hern?n G. Michelangelo, M.D., Dean Follmann, Ph.D., H. Clifford Lane, M.D., and Waldo H. Belloso, M.D. for the PlasmAr Study Group*

doi : 10.1056/NEJMoa2031304

N Engl J Med 2021; 384:619-629

Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered randomized, controlled trials.

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Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy

Ayman Al-Hendy, M.D., Ph.D., Andrea S. Lukes, M.D., Alfred N. Poindexter, III, M.D., Roberta Venturella, M.D., Ph.D., Claudio Villarroel, M.D., Hilary O.D. Critchley, M.D., Yulan Li, Ph.D., Laura McKain, M.D., Juan C. Arjona Ferreira, M.D., Andria G.M. Langenberg, M.D., Rachel B. Wagman, M.D., and Elizabeth A. Stewart, M.D.

doi : 10.1056/NEJMoa2008283

N Engl J Med 2021; 384:630-642

Uterine fibroids are a common cause of heavy menstrual bleeding and pain. Treatment with the combination of relugolix (an oral gonadotropin-releasing hormone-receptor antagonist), estradiol, and norethindrone acetate, administered once daily, may have efficacy in women with uterine fibroids and heavy bleeding while avoiding hypoestrogenic effects.

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Maintaining Safety with SARS-CoV-2 Vaccines

Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D.

doi : 10.1056/NEJMra2035343

N Engl J Med 2021; 384:643-649

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Emergency Intubation in Covid-19

Gentle Sunder Shrestha, M.D., Ninadini Shrestha, M.D., Ritesh Lamsal, M.D., D.M., Saurabh Pradhan, M.D., D.M., Anil Shrestha, M.D., Robert Canelli, M.D., and Rafael Ortega, M.D.

doi : 10.1056/NEJMvcm2007198

N Engl J Med 2021; 384:e20

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Bone Marrow Necrosis in Acute Monoblastic Leukemia

Toshiki Terao, M.D., and Kosei Matsue, M.D., Ph.D.

doi : 10.1056/NEJMicm2026508

N Engl J Med 2021; 384:650

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Omental Endometriosis

Tomoko Arakawa, M.D., and Soichiro Ishihara, M.D., Ph.D.

doi : 10.1056/NEJMicm2027936

N Engl J Med 2021; 384:e21

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Case 5-2021: A 68-Year-Old Man with Delirium and Renal Insufficiency

David B. Hellmann, M.D., Jo-Anne O. Shepard, M.D., Pamela W. Schaefer, M.D., Jacob H. Johnson, M.D., and Rory K. Crotty, M.B., B.Ch.

doi : 10.1056/NEJMcpc1913474

N Engl J Med 2021; 384:651-662

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Avacopan — Time to Replace Glucocorticoids?

Kenneth J. Warrington, M.D.

doi : 10.1056/NEJMe2033621

N Engl J Med 2021; 384:664-665

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(A Little) Clarity on Convalescent Plasma for Covid-19

Louis M. Katz, M.D.

doi : 10.1056/NEJMe2035678

N Engl J Med 2021; 384:666-668

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Audio Interview: Viral Variants and Covid-19

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Jeremy J. Farrar, M.D., Ph.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2102882

N Engl J Med 2021; 384:e38

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Beyond Politics — Promoting Covid-19 Vaccination in the United States

Stacy Wood, Ph.D., and Kevin Schulman, M.D.

doi : 10.1056/NEJMms2033790

N Engl J Med 2021; 384:e23

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Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden

doi : 10.1056/NEJMc2026670

N Engl J Med 2021; 384:669-671

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Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19

doi : 10.1056/NEJMc2027040

N Engl J Med 2021; 384:671-673

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Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy

doi : 10.1056/NEJMc2030164

N Engl J Med 2021; 384:673-674

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Osimertinib in EGFR-Mutated Lung Cancer

doi : 10.1056/NEJMc2033951

N Engl J Med 2021; 384:675-676

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Subcutaneous or Transvenous Defibrillator Therapy

doi : 10.1056/NEJMc2034917

N Engl J Med 2021; 384:676-679

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Women Physicians and Promotion in Academic Medicine

doi : 10.1056/NEJMc2035793

N Engl J Med 2021; 384:679-681

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The Covid-19 Vaccine-Development Multiverse

doi : 10.1056/NEJMc2034838

N Engl J Med 2021; 384:681-682

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