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Vaccine Innovations — Past and Future
Julie L. Gerberding, M.D., M.P.H., and Barton F. Haynes, M.D.
doi : 10.1056/NEJMp2029466
N Engl J Med 2021; 384:393-396
In Search of a Better Equation — Performance and Equity in Estimates of Kidney Function
James A. Diao, B.S., Lesley A. Inker, M.D., Andrew S. Levey, M.D., Hocine Tighiouart, M.S., Neil R. Powe, M.D., M.P.H., M.B.A., and Arjun K. Manrai, Ph.D.
doi : 10.1056/NEJMp2028243
N Engl J Med 2021; 384:396-399
Learning about End-of-Life Care from Grandpa
Scott D. Halpern, M.D., Ph.D.
doi : 10.1056/NEJMp2026629
N Engl J Med 2021; 384:400-401
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Lindsey R. Baden, M.D., Hana M. El Sahly, M.D., Brandon Essink, M.D., Karen Kotloff, M.D., Sharon Frey, M.D., Rick Novak, M.D., David Diemert, M.D., Stephen A. Spector, M.D., Nadine Rouphael, M.D., C. Buddy Creech, M.D., John McGettigan, M.D., Shishir Khetan, M.D., Nathan Segall, M.D., Joel Solis, M.D., Adam Brosz, M.D., Carlos Fierro, M.D., Howard Schwartz, M.D., Kathleen Neuzil, M.D., Lawrence Corey, M.D., Peter Gilbert, Ph.D., Holly Janes, Ph.D., Dean Follmann, Ph.D., Mary Marovich, M.D., John Mascola, M.D., Laura Polakowski, M.D., Julie Ledgerwood, D.O., Barney S. Graham, M.D., Hamilton Bennett, M.S., Rolando Pajon, Ph.D., Conor Knightly, M.P.H., Brett Leav, M.D., Weiping Deng, Ph.D., Honghong Zhou, Ph.D., Shu Han, Ph.D., Melanie Ivarsson, Ph.D., Jacqueline Miller, M.D., and Tal Zaks, M.D. for the COVE Study Group*
doi : 10.1056/NEJMoa2035389
N Engl J Med 2021; 384:403-416
Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19
Oriol Mitjà, Ph.D., Marc Corbacho-Monné, B.M., Maria Ubals, B.M., Andrea Alemany, B.M., Clara Su?er, Ph.D., Cristian Tebé, Ph.D., Aurelio Tobias, Ph.D., Judith Pe?afiel, M.Sc., Ester Ballana, Ph.D., Carla A. Pérez, B.M., Pol Admella, B.M., N?ria Riera-Mart?, B.M., Pep Laporte, B.M., Jordi Mitjà, M.B.A., Mireia Clua, M.B.A., Laia Bertran, M.A., Maria Sarquella, M.A., Sergi Gavil?n, B.A., Jordi Ara, Ph.D., Josep M. Argimon, Ph.D., Gabriel Cuatrecasas, B.M., Paz Ca?adas, Ph.D., Aleix Elizalde-Torrent, Ph.D., Robert Fabregat, Ph.D., Mag? Farré, Ph.D., Anna Forcada, B.M., Gemma Flores-Mateo, Ph.D., Cristina L?pez, B.Sc., Esteve Muntada, M.Sc., N?ria Nadal, M.B., Silvia Narejos, B.M., Aroa Nieto, B.N., Nuria Prat, B.M., Jordi Puig, B.N., Carles Qui?ones, M.Pharm., Ferran Ram?rez-Viaplana, M.Sc., Juliana Reyes-Urue?a, Ph.D., Eva Riveira-Mu?oz, Ph.D., Lidia Ruiz, Ph.D., Sergi Sanz, Ph.D., Alexis Sent?s, M.P.H., Alba Sierra, B.N., César Velasco, Ph.D., Rosa M. Vivanco-Hidalgo, Ph.D., Juani Zamora, B.Sc., Jordi Casabona, Ph.D., Mart? Vall-Mayans, Ph.D., Camila Gonz?lez-Beiras, Ph.D., and Bonaventura Clotet, Ph.D. for the BCN-PEP-CoV2 Research Group*
doi : 10.1056/NEJMoa2021801
N Engl J Med 2021; 384:417-427
Current strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited to nonpharmacologic interventions. Hydroxychloroquine has been proposed as a postexposure therapy to prevent coronavirus disease 2019 (Covid-19), but definitive evidence is lacking.
Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women
Breast Cancer Association Consortium*
doi : 10.1056/NEJMoa1913948
N Engl J Med 2021; 384:428-439
Genetic testing for breast cancer susceptibility is widely used, but for many genes, evidence of an association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risk estimates are lacking.
A Population-Based Study of Genes Previously Implicated in Breast Cancer
Chunling Hu, M.D., Ph.D., Steven N. Hart, Ph.D., Rohan Gnanaolivu, M.S., Hongyan Huang, Ph.D., Kun Y. Lee, Ph.D., Jie Na, M.S., Chi Gao, M.Sc., Jenna Lilyquist, Ph.D., Siddhartha Yadav, M.D., Nicholas J. Boddicker, Ph.D., Raed Samara, Ph.D., Josh Klebba, B.S., Christine B. Ambrosone, Ph.D., Hoda Anton-Culver, Ph.D., Paul Auer, Ph.D., Elisa V. Bandera, Ph.D., Leslie Bernstein, Ph.D., Kimberly A. Bertrand, Sc.D., Elizabeth S. Burnside, M.D., M.P.H., Brian D. Carter, M.P.H., Heather Eliassen, Sc.D., Susan M. Gapstur, Ph.D., Mia Gaudet, Ph.D., Christopher Haiman, Sc.D., James M. Hodge, M.P.H., J.D., David J. Hunter, Sc.D., Eric J. Jacobs, Ph.D., Esther M. John, Ph.D., Charles Kooperberg, Ph.D., Allison W. Kurian, M.D., Loic Le Marchand, M.D., Ph.D., Sara Lindstroem, Ph.D., Tricia Lindstrom, B.S., Huiyan Ma, Ph.D., Susan Neuhausen, Ph.D., Polly A. Newcomb, Ph.D., M.P.H., Katie M. O’Brien, Ph.D., Janet E. Olson, Ph.D., Irene M. Ong, Ph.D., Tuya Pal, M.D., Julie R. Palmer, Sc.D., Alpa V. Patel, Ph.D., Sonya Reid, M.D., Lynn Rosenberg, Sc.D., Dale P. Sandler, Ph.D., Christopher Scott, M.S., Rulla Tamimi, Sc.D., Jack A. Taylor, M.D., Ph.D., Amy Trentham-Dietz, Ph.D., Celine M. Vachon, Ph.D., Clarice Weinberg, Ph.D., Song Yao, Ph.D., Argyrios Ziogas, Ph.D., Jeffrey N. Weitzel, M.D., David E. Goldgar, Ph.D., Susan M. Domchek, M.D., Katherine L. Nathanson, M.D., Peter Kraft, Sc.D., Eric C. Polley, Ph.D., and Fergus J. Couch, Ph.D.
doi : 10.1056/NEJMoa2005936
N Engl J Med 2021; 384:440-451
Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants.
Management of Antithrombotic Therapy after Acute Coronary Syndromes
Fatima Rodriguez, M.D., M.P.H., and Robert A. Harrington, M.D.
doi : 10.1056/NEJMra1607714
N Engl J Med 2021; 384:452-460
Ochronosis
Berardo Di Matteo, M.D., and Maurilio Marcacci, M.D.
doi : 10.1056/NEJMicm2025932
N Engl J Med 2021; 384:461
Central Retinal Artery and Vein Occlusion
Chan Wu, M.D., and Rongping Dai, M.D.
doi : 10.1056/NEJMicm2026957
N Engl J Med 2021; 384:e9
Hunting for a Diagnosis
Nathan Houchens, M.D., Sarah Hartley, M.D., Scott P. Commins, M.D., Ph.D., Dru Claar, M.D., and Sanjay Saint, M.D., M.P.H.
doi : 10.1056/NEJMcps2017588
N Engl J Med 2021; 384:462-467
Reviewers for the Journal, July–December 2020
Eric J. Rubin, M.D., Ph.D.
doi : 10.1056/NEJMe2100358
N Engl J Med 2021; 384:469
A New Vaccine to Battle Covid-19
Barton F. Haynes, M.D.
doi : 10.1056/NEJMe2035557
N Engl J Med 2021; 384:470-471
Which Genes for Hereditary Breast Cancer?
Steven A. Narod, M.D.
doi : 10.1056/NEJMe2035083
N Engl J Med 2021; 384:471-473
Audio Interview: Covid-19 and the States — A Conversation with Ralph Northam
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Ralph S. Northam, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2102043
N Engl J Med 2021; 384:e25
Race and Genetic Ancestry in Medicine — A Time for Reckoning with Racism
Luisa N. Borrell, D.D.S., Ph.D., Jennifer R. Elhawary, M.S., Elena Fuentes-Afflick, M.D., M.P.H., Jonathan Witonsky, M.D., Nirav Bhakta, M.D., Ph.D., Alan H.B. Wu, Ph.D., Kirsten Bibbins-Domingo, Ph.D., M.D., José R. Rodr?guez-Santana, M.D., Michael A. Lenoir, M.D., James R. Gavin, III, M.D., Ph.D., Rick A. Kittles, Ph.D., Noah A. Zaitlen, Ph.D., David S. Wilkes, M.D., Neil R. Powe, M.D., M.P.H., M.B.A., Elad Ziv, M.D., and Esteban G. Burchard, M.D., M.P.H.
doi : 10.1056/NEJMms2029562
N Engl J Med 2021; 384:474-480
Microvascular Injury in the Brains of Patients with Covid-19
doi : 10.1056/NEJMc2033369
N Engl J Med 2021; 384:481-483
Early Rhythm Control in Atrial Fibrillation
doi : 10.1056/NEJMc2032433
N Engl J Med 2021; 384:483-485
Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration
doi : 10.1056/NEJMc2034836
N Engl J Med 2021; 384:485-486
Beyond Tuskegee — Vaccine Distrust and Everyday Racism
Simar Singh Bajaj, and Fatima Cody Stanford, M.D., M.P.H., M.P.A.
doi : 10.1056/NEJMpv2035827
N Engl J Med 2021; 384:e12
Who Goes First? Government Leaders and Prioritization of SARS-CoV-2 Vaccines
Mark T. Hughes, M.D., Jeffrey Kahn, Ph.D., M.P.H., and Allen Kachalia, M.D., J.D.
doi : 10.1056/NEJMpv2036128
N Engl J Med 2021; 384:e15
