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Spotlight on the August 17 Issue
Merino, Jose G. MD, MPhil; Editor-in-Chief
doi : 10.1212/WNL.0000000000012420
Volume 97(7), 17 August 2021, p 301-302
Measuring the Quality of Neurologic Care in the United States: There Is Room for Improvement
Sato, Koryu MPH; Tsugawa, Yusuke MD, PhD
doi : 10.1212/WNL.0000000000012379
Volume 97(7), 17 August 2021, p 303-304
Nigerian Study Validates Wide Variations in Epilepsy Prevalence and Elucidates Potential Targets for Disease Prevention
Patel, Archana A. MD, MPH; Birbeck, Gretchen L. MD, MPH, DTMH
doi : 10.1212/WNL.0000000000012418
Volume 97(7), 17 August 2021, p 305-306
Quality of Neurologic Care in the United States: Initial Report From the Axon Registry
Wilson, Andrew M. MD, MS, MBA; Benish, Sarah M. MD, FAAN; McCarthy, Lucas MD; Romano, Jose G. MD, FAAN; Lundgren, Karen B. MBA; Byrne, Margaret MPH; Schierman, Becky MPH; Jones, Lyell K. Jr MD, FAAN
doi : 10.1212/WNL.0000000000012378
Volume 97(7), 17 August 2021, p e651-e659
To provide the initial description of the quality of outpatient US neurologic care as collected and reported in the Axon Registry.
Prospective Evaluation of Health Care Provider and Patient Assessments in Chemotherapy-Induced Peripheral Neurotoxicity
Alberti, Paola MD, PhD*; Bernasconi, Davide P. PhD*; Cornblath, David R. MD; Merkies, Ingemar S.J. MD, PhD; Park, Susanna B. PhD; Velasco, Roser MD, PhD; Bruna, Jordi MD, PhD; Psimaras, Dimitri MD; Koeppen, Susanne MD; Pace, Andrea MD; Dorsey, Susan G. PhD; Argyriou, Andreas A. MD; Kalofonos, Haralabos P. MD; Briani, Chiara MD; Schenone, Angelo MD; Faber, Catharina G. MD, PhD; Mazzeo, Anna MD; Grisold, Wolfgang MD; Valsecchi, MariaGrazia PhD; Cavaletti, Guido MD; on behalf of the CI-PeriNomS group; on behalf of the CI-PeriNomS group; Cazzaniga, Marina Elena MD; Longarini, Raffaella MD; Guidi, Alessandro MD; Postma, Tjeerd J MD; Goldstein, David MBBS, FRACP; Ricard, Damien MD; Tafani, Camille MD; Brooks, DuBose BS; Renn, Cynthia L PhD; Galie, Edvina MD; Campagnolo, Marta MD, PhD; Castellani, Francesca MD; Grandis, Marina MD, PhD; Lalisang, Roy I MD; Gentile, Luca MD; Russo, Massimo MD; Toscano, Antonio MD
doi : 10.1212/WNL.0000000000012300
Volume 97(7), 17 August 2021, p e660-e672
There is no agreement on the gold standard for detection and grading of chemotherapy-induced peripheral neurotoxicity (CIPN) in clinical trials. The objective is to perform an observational prospective study to assess and compare patient-based and physician-based methods for detection and grading of CIPN.
Sustained Tumor Control With MAPK Inhibition in BRAF V600-Mutant Adult Glial and Glioneuronal Tumors
Berzero, Giulia MD, PhD; Bellu, Luisa MD; Baldini, Capucine MD; Ducray, Francois MD, PhD; Guyon, David MD; Eoli, Marica MD, PhD; Silvani, Antonio MD; Dehais, Caroline MD; Idbaih, Ahmed MD, PhD; Younan, Nadia MD; Nguyen-Them, Ludovic MD; Gaillard, Stephan MD; Pasqualetti, Francesco MD, PhD; Lepage-Seydoux, Coralie PharmD; Sekkate, Sakina MD; Tresca, Patricia MD; Kas, Aurelie MD, PhD; Gratieux, Julie MD; Ammari, Samy MD, MSc; Saragoussi, Edouard MD; Savatovsky, Julien MD; Delattre, Jean-Yves MD, PhD; Hoang-Xuan, Khe MD, PhD; Meyronet, David MD, PhD; Villa, Chiara MD, PhD; Bielle, Franck MD, PhD; Sanson, Marc MD, PhD; Touat, Mehdi MD; Di Stefano, Anna Luisa MD, PhD
doi : 10.1212/WNL.0000000000012330
Volume 97(7), 17 August 2021, p e673-e683
To assess whether RAF and MEK inhibitors (RAFi/MEKi) can provide long-term clinical benefit in adult patients with BRAF V600-mutant glial and glioneuronal tumors (GGNTs), we analyzed tumor response and long-term outcome in a retrospective cohort.
Sex and Race Differences in the Risk of Ischemic Stroke Associated With Fasting Blood Glucose in REGARDS
Madsen, Tracy E. MD, PhD; Long, D. Leann PhD; Carson, April P. PhD, MSPH; Howard, George DrPH; Kleindorfer, Dawn O. MD; Furie, Karen L. MD, MPH; Manson, JoAnn E. MD, DrPH; Liu, Simin MD, ScD; Howard, Virginia J. PhD
doi : 10.1212/WNL.0000000000012296
Volume 97(7), 17 August 2021, p e684-e694
To investigate sex and race differences in the association between fasting blood glucose (FBG) and risk of ischemic stroke (IS).
Association of Metabolic Syndrome and Its Components With Risk of Stroke Recurrence and Mortality: A Meta-analysis
Zhang, Fangfang MD; Liu, Lili MD; Zhang, Chundong MD; Ji, Shiliang MD, PhD; Mei, Zubing MD, PhD; Li, Tian MD
doi : 10.1212/WNL.0000000000012415
Volume 97(7), 17 August 2021, p e695-e705
Because metabolic syndrome is a significant risk factor for cardio-cerebrovascular diseases and the relationship between metabolic syndrome (including its components) and the prognosis of stroke is controversial, this study was conducted to evaluate whether metabolic syndrome is associated with a high recurrence and mortality of stroke.
Recovery and Prediction of Bimanual Hand Use After Stroke
Plantin, Jeanette PT, MSc; Verneau, Marion PhD; Godbolt, Alison K. MD, MRCP; Pennati, Gaia Valentina MD; Laurencikas, Evaldas MD, PhD; Johansson, Birgitta OT; Krumlinde-Sundholm, Lena OT, PhD; Baron, Jean-Claude MD, ScD; Borg, Jorgen MD, PhD; Lindberg, Pavel G. PT, PhD
doi : 10.1212/WNL.0000000000012366
Volume 97(7), 17 August 2021, p e706-e719
To determine similarities and differences in key predictors of recovery of bimanual hand use and unimanual motor impairment after stroke.
Efficacy of Home Anticonvulsant Administration for Second-Line Status Epilepticus Treatment
Wabl, Rafael MD*; Terman, Samuel W. MD, MS*; Kwok, Maria MD, MPH; Elm, Jordan PhD; Chamberlain, James MD; Silbergleit, Robert MD; Hill, Chloe E. MD, MS
doi : 10.1212/WNL.0000000000012414
Volume 97(7), 17 August 2021, p e720-e727
To investigate whether receiving a second-line anticonvulsant medication that is part of a patient's home regimen influences outcomes in benzodiazepine-refractory convulsive status epilepticus.
Epidemiology of Epilepsy in Nigeria: A Community-Based Study From 3 Sites
Watila, Musa M. MBBS, FMCP, PhD; Balarabe, Salisu A. MBBS, MSc, FWACP; Komolafe, Morenikeji A. MBBS, FWACP; Igwe, Stanley C. MD, MSc, FWCPsych; Fawale, Michael B. MBBS, MSc, FMCP; Otte, Willem M. PhD; van Diessen, Eric MD, PhD; Okunoye, Olaitan MBBS, FWACP, MSc; Mshelia, Anthony A. MBBS, FWCPsych; Abdullahi, Ibrahim MBBS, FWACP; Musa, Joseph MBBS; Hedima, Erick W. BPharm; Nyandaiti, Yakub W. MBBS, FMCP, FWACP; Singh, Gagandeep MBBS, PhD, FRCP; Winkler, Andrea S. MD, PhD; Sander, Josemir W. MD, PhD, FRCP, FEAN
doi : 10.1212/WNL.0000000000012416
Volume 97(7), 17 August 2021, p e728-e738
We determined the prevalence, incidence, and risk factors for epilepsy in Nigeria.
Duration of Poverty and Subsequent Cognitive Function and Decline Among Older Adults in China, 2005-2018
Yu, Xuexin MSc; Zhang, Wei MD; Kobayashi, Lindsay C. PhD
doi : 10.1212/WNL.0000000000012343
Volume 97(7), 17 August 2021, p e739-e746
To investigate the relationship between late-life duration of poverty exposure and cognitive function and decline among older adults in China.
Acute Hypertensive Response in Patients With Acute Intracerebral Hemorrhage: A Narrative Review
Hawkes, Maximiliano A. MD; Rabinstein, Alejandro A. MD
doi : 10.1212/WNL.0000000000012276
Volume 97(7), 17 August 2021, p 316-329
To review the role of the acute hypertensive response in patients with intracerebral hemorrhage, current treatment options, and areas for further research.
What Is the Role of Stathmin-2 in Axonal Biology and Degeneration?
Benarroch, Eduardo MD
doi : 10.1212/WNL.0000000000012419
Volume 97(7), 17 August 2021, p 330-333
American Academy of Neurology Telehealth Position Statement
Hatcher-Martin, Jaime M. MD, PhD; Busis, Neil A. MD; Cohen, Bruce H. MD; Wolf, Rebecca A. MBA; Jones, Elaine C. MD; Anderson, Eric R. MD, PhD; Fritz, Joseph V. PhD; Shook, Steven J. MD, MBA; Bove, Riley M. MD, MMSc
doi : 10.1212/WNL.0000000000012185
Volume 97(7), 17 August 2021, p 334-339
Telehealth services complement in-person neurologic care. The American Academy of Neurology supports patient access to telehealth services regardless of location, coverage for telehealth services by all subscriber benefits and insurance, equitable provider reimbursement, simplified state licensing requirements easing access to virtual care, and expanding telehealth research and quality initiatives. The roles and responsibilities of providers should be clearly delineated in telehealth service models.
A 73-Year-Old Woman With Hyperammonemic Encephalopathy Caused by Noncirrhotic Congenital Portosystemic Shunts
Yang, Tingting MD; Cheng, Yuanyuan MD; Deng, Zhikuan PhD; Lai, Yujie PhD
doi : 10.1212/WNL.0000000000012274
Volume 97(7), 17 August 2021, p 340-341
Clinical Reasoning: A 49-Year-Old Woman With Progressive Numbness and Gait Instability
Zahid, Anza MD; Shah, Shailee MD; Martinez-Thompson, Jennifer M. MD; Arment, Courtney A. MD; Huang, Yajue MD; Sturgis, Charles D. MD; Dubey, Divyanshu MD
doi : 10.1212/WNL.0000000000012135
Volume 97(7), 17 August 2021, p 342-347
Teaching NeuroImage: Human Polymerase Gamma Gene (POLG) Disorder Presenting as Refractory Status Epilepticus
Lemus, Hernan Nicolas MD; Pyburn, Dewitt MD; Youn, Clover DO; Liang, John MD; Yousefi, Arash MD; Saunders-Pullman, Rachel MD, MPH; Tantillo, Gabriela MD; Marcuse, Lara MD; Fields, Madeline MD
doi : 10.1212/WNL.0000000000012105
Volume 97(7), 17 August 2021, p e747-e748
Teaching Video NeuroImage: Shedding Light on Sunflower Syndrome
Nascimento, Fabio A. MD; Thiele, Elizabeth A. MD, PhD
doi : 10.1212/WNL.0000000000011776
Volume 97(7), 17 August 2021, p e749
Training in Neurology: Implementation and Evaluation of an Objective Structured Clinical-Examination Tool for Neurology Postgraduate Trainees in Lusaka, Zambia
DiBiase, Rebecca Marie MD, MPH; Salas, Rachel Marie E. MD, MEd; Gamaldo, Charlene E. MD; Nutakki, Aparna BA; Elicer, Isabel MD; Attarian, Hrayr P. MD; Kapembwa, Kenneth C. MD; Strowd, Roy E. MD, MEd; Tackett, Sean MD, MPH; Saylor, Deanna R. MD, MHS
doi : 10.1212/WNL.0000000000012134
Volume 97(7), 17 August 2021, p e750-e754
We established Zambia's first neurology residency program at the University of Zambia School of Medicine and the University Teaching Hospital in Lusaka.
Editors' Note: Systolic Blood Pressure Postural Changes Variability is Associated With Greater Dementia Risk
Lewis, Ariane MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012417
Volume 97(7), 17 August 2021, p 348
Reader Response: Systolic Blood Pressure Postural Changes Variability is Associated With Greater Dementia Risk
Soysal, Pinar
doi : 10.1212/WNL.0000000000012431
Volume 97(7), 17 August 2021, p 348-349
Author Response: Systolic Blood Pressure Postural Changes Variability is Associated With Greater Dementia Risk
Rouch, Laure; Vidal, Jean-Sebastien; Hoang, Tina; Cestac, Philippe; Hanon, Olivier; Yaffe, Kristine
doi : 10.1212/WNL.0000000000012432
Volume 97(7), 17 August 2021, p 349
Editors' Note: Temporal Trends and Autopsy Findings of SUDEP Based on Medicolegal Investigations in the United States
Lewis, Ariane MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012434
Volume 97(7), 17 August 2021, p 349-350
Reader Response: Temporal Trends and Autopsy Findings of SUDEP Based on Medicolegal Investigations in the United States
Bleasel, Andrew
doi : 10.1212/WNL.0000000000012433
Volume 97(7), 17 August 2021, p 350-351
Author Response: Temporal Trends and Autopsy Findings of SUDEP Based on Medicolegal Investigations in the United States
Friedman, Daniel; Cihan, Esma; Devinsky, Orrin
doi : 10.1212/WNL.0000000000012435
Volume 97(7), 17 August 2021, p 351
