One-year access to more than 500 world journals available in the system
-
http://medilib.ir
- Duration of Time : 365 Day
Price : 300$- Special Price : 100$
Spotlight on the August 10 Issue
Merino, Jose G. MD, MPhil; Editor-in-Chief, Neurology(R)
doi : 10.1212/WNL.0000000000012384
Volume 97(6), 10 August 2021, p 255-256
Ongoing Axonal Injury in Chronic Active Lesions in Multiple Sclerosis: In Vivo Quantification Using Serum Neurofilament
Preziosa, Paolo MD, PhD; Schoonheim, Menno M. MSc, PhD
doi : 10.1212/WNL.0000000000012331
Volume 97(6), 10 August 2021, p 257-258
Chronic White Matter Inflammation and Serum Neurofilament Levels in Multiple Sclerosis
Maggi, Pietro MD, PhD*; Kuhle, Jens MD, PhD*; Schadelin, Sabine MSc; van der Meer, Franziska PhD; Weigel, Matthias PhD; Galbusera, Riccardo MD; Mathias, Amandine PhD; Lu, Po-Jui MSc; Rahmanzadeh, Reza MD; Benkert, Pascal PhD; La Rosa, Francesco MSc; Bach Cuadra, Meritxell PhD; Sati, Pascal PhD; Theaudin, Marie MD; Pot, Caroline MD, PhD; van Pesch, Vincent MD, PhD; Leppert, David MD; Stadelmann, Christine MD; Kappos, Ludwig MD; Du Pasquier, Renaud MD; Reich, Daniel S. MD, PhD; Absinta, Martina MD, PhD*; Granziera, Cristina MD, PhD*
doi : 10.1212/WNL.0000000000012326
Volume 97(6), 10 August 2021, p e543-e553
To assess whether chronic white matter inflammation in patients with multiple sclerosis (MS) as detected in vivo by paramagnetic rim MRI lesions (PRLs) is associated with higher serum neurofilament light chain (sNfL) levels, a marker of neuroaxonal damage.
Association of Epilepsy Surgery With Changes in Imaging-Defined Brain Age
de Bezenac, Christophe E. PhD; Adan, Guleed MBBS; Weber, Bernd MD, PhD; Keller, Simon S. PhD
doi : 10.1212/WNL.0000000000012289
Volume 97(6), 10 August 2021, p e554-e563
To determine whether surgery in patients with mesial temporal lobe epilepsy (mTLE) is associated with reduced brain-predicted age as a neural marker overall brain health, we compared brain-predicted and chronologic age difference (brain age gap estimation [BrainAGE]) in patients before and after surgery with healthy controls.
Safety and Efficacy of Coma Induction Following First-Line Treatment in Status Epilepticus: A 2-Center Study
De Stefano, Pia MD; Baumann, Sira Maria; Semmlack, Saskia MD; Ruegg, Stephan MD; Marsch, Stephan MD; Seeck, Margitta MD PhD*; Sutter, Raoul MD*
doi : 10.1212/WNL.0000000000012292
Volume 97(6), 10 August 2021, p e564-e576
To explore the safety and efficacy of artificial coma induction to treat status epilepticus (SE) immediately after first-line antiseizure treatment instead of following the recommended approach of first using second-line drugs.
Clinical and Genetic Features in Patients With Reflex Bathing Epilepsy
Accogli, Andrea MD*; Wiegand, Gert MD*; Scala, Marcello MD; Cerminara, Caterina MD; Iacomino, Michele PhD; Riva, Antonella MD; Carlini, Barbara MSc; Camerota, Letizia MD; Belcastro, Vincenzo MD; Prontera, Paolo MD, PhD; Fernandez-Jaen, Alberto MD, PhD; Bebek, Nerses MD, PhD; Scudieri, Paolo PhD; Baldassari, Simona PhD; Salpietro, Vincenzo MD; Novelli, Giuseppe PhD; De Luca, Chiara MD; von Stulpnagel, Celina MD; Kluger, Felicitas MD; Kluger, Gerhard Josef MD; Wohlrab, Gabriele Christine MD; Ramantani, Georgia MD; Lewis-Smith, David MClinRes, MRCP; Thomas, Rhys H. PhD, FRCP; Lai, Ming MBBS; Verrotti, Alberto MD, PhD; Striano, Salvatore MD; Depienne, Christel PhD; Minetti, Carlo MD, PhD; Benfenati, Fabio MD, PhD; Brancati, Francesco MD, PhD; Zara, Federico PhD; Striano, Pasquale MD, PhD
doi : 10.1212/WNL.0000000000012298
Volume 97(6), 10 August 2021, p e577-e586
To describe the clinical and genetic findings in a cohort of individuals with bathing epilepsy, a rare form of reflex epilepsy.
Seizure Control in Neonates Undergoing Screening vs Confirmatory EEG Monitoring
Wusthoff, Courtney J. MD, MS; Sundaram, Vandana MPH; Abend, Nicholas S. MD, MSCE; Massey, Shavonne L. MD, MSCE; Lemmon, Monica E. MD; Thomas, Cameron MD, MS; McCulloch, Charles E. PhD; Chang, Taeun MD; Soul, Janet S. MDCM; Chu, Catherine J. MD, MA, MMSc; Rogers, Elizabeth E. MD; Bonifacio, Sonia Lomeli MD; Cilio, Maria Roberta MD, PhD; Glass, Hannah C. MDCM*; Shellhaas, Renee A. MD, MS*; on behalf of the Neonatal Seizure Registry Group
doi : 10.1212/WNL.0000000000012293
Volume 97(6), 10 August 2021, p e587-e596
To determine whether screening continuous EEG monitoring (cEEG) is associated with greater odds of treatment success for neonatal seizures.
Health Care Resource Utilization Associated With Parkinson Disease Among Medicare Beneficiaries
Gandhi, Aakash Bipin BPharm; Onukwugha, Eberechukwu PhD; Albarmawi, Husam MS*; Johnson, Abree MS; Myers, Daniela E. MPH; Gray, David PhD*; Alvir, Jose DrPH; Hynicka, Lauren PharmD; Shulman, Lisa M. MD
doi : 10.1212/WNL.0000000000012290
Volume 97(6), 10 August 2021, p e597-e607
To compare differences in health care resource utilization (HcRU) over time between Medicare beneficiaries with and without Parkinson disease (PD).
Short- and Long-term Health Care Resource Utilization and Costs Following Intracerebral Hemorrhage
Fernando, Shannon M. MD, MSc; Qureshi, Danial MSc; Talarico, Robert MSc; Dowlatshahi, Dar MD, PhD; Sood, Manish M. MD, MSc; Smith, Eric E. MD, MPH; Hill, Michael D. MD, MSc; McCredie, Victoria A. MBChB, PhD; Scales, Damon C. MD, PhD; English, Shane W. MD, MSc; Rochwerg, Bram MD, MSc; Tanuseputro, Peter MD, MHSc*; Kyeremanteng, Kwadwo MD, MHA*
doi : 10.1212/WNL.0000000000012355
Volume 97(6), 10 August 2021, p e608-e618
We sought to evaluate the short- and long-term resource use and costs associated with intracerebral hemorrhage (ICH) taken from an entire population. We in addition sought to evaluate the association of oral anticoagulation (OAC) and health care costs.
Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population
Lu, Xiangfeng PhD*; Niu, Xiaoge PhD*; Shen, Chong PhD; Liu, Fangchao PhD; Liu, Zhongying PhD; Huang, Keyong PhD; Wang, Laiyuan PhD; Li, Jianxin MD; Hu, Dongsheng PhD; Zhao, Yingxin MD; Yang, Xueli PhD; Lu, Fanghong MD; Liu, Xiaoqing MD; Cao, Jie MD; Chen, Shufeng PhD; Li, Hongfan MD; Tang, Wuzhuang MD; Ren, Zhanyun MD; Yu, Ling MD; Wu, Xianping MD; Wu, Xigui MD; Li, Ying MD; Zhang, Huan PhD; Huang, Jianfeng MD; Hu, Zhibin PhD; Shen, Hongbing PhD; Willer, Cristen J. PhD; Gu, Dongfeng PhD
doi : 10.1212/WNL.0000000000012263
Volume 97(6), 10 August 2021, p e619-e628
To construct a polygenic risk score (PRS) for stroke and evaluate its utility in risk stratification and primary prevention for stroke.
Automated Quantitative Pupillometry in the Critically Ill: A Systematic Review of the Literature
Opic, Petra MD, PhD; Ruegg, Stephan MD; Marsch, Stephan MD, DPhil; Gut, Stephan Sebastian MSc; Sutter, Raoul MD
doi : 10.1212/WNL.0000000000012295
Volume 97(6), 10 August 2021, p e629-e642
A systematic literature search has been performed to identify potential confounders for outcome prediction using pupillary light reflex in adult critically ill patients, as measured by handheld automated pupillometry devices.
Robert Wartenberg and the American Academy of Neurology
Burkholder, David B. MD; Boes, Christopher J. MD
doi : 10.1212/WNL.0000000000012104
Volume 97(6), 10 August 2021, p 268-272
Robert Wartenberg (1887-1956) was born in Grodno (in present-day Belarus) and received his medical degree in Germany in 1919. He enjoyed a productive career at the University of Freiburg until 1935, when he fled Nazi Germany for the United States. Bernard Sachs, with whom he had worked during a Rockefeller fellowship in 1926, helped him secure a position at the University of California Medical Center in San Francisco in 1936. He was popular with students there as his sizeable personality translated into an engaging classroom style, but that same personality could create friction with colleagues. Following World War II, neurology as a specialty was growing and establishing its place in the medical landscape. With this goal in mind, A.B. Baker and other young neurologic leaders formed the American Academy of Neurology (AAN) in 1948 as an inclusive professional society. Baker recruited Wartenberg to join, he agreed, and immediately provided his own critiques on the organization. Wartenberg's standing in the academic community combined with his strong personality would serve Baker well as Wartenberg shielded the young AAN leadership from potential retribution. He was especially invested in ensuring the Academy had a journal as a means of development, and the journal Neurology(R) was born. Wartenberg died on November 16, 1956, and was honored for his service to the Academy with the Robert Wartenberg Memorial Lecture, which stands today as one of the principal events at the Annual Meeting.
Brain Health-Curbing Stroke, Heart Disease, and Dementia: The 2020 Wartenberg Lecture
Hachinski, Vladimir MD, DSc
doi : 10.1212/WNL.0000000000012103
Volume 97(6), 10 August 2021, p 273-279
There is no health without brain health, which is threatened by rising curves of stroke, ischemic heart disease, and dementia (the triple threat). The fastest growing and intractable threat has been dementia. Focusing on finding a drug to stop Alzheimer disease has yielded growing knowledge but no treatments, partly because in the elderly, cognitive impairment results from multiple interactive pathologies aggravated by fragility and tempered by resilience on the advancing background of aging. The concept of vascular cognitive impairment (VCI) cuts pragmatically through this complexity. VCI is any cognitive impairment caused by or associated with vascular factors. It spans the spectrum of undetected cognitive impairment to full-blown dementia. The vascular component represents the only major current, treatable, and preventable contributor to dementia and offers the possibility of delaying, mitigating, or preventing more dementias in the near future. The triple threat conditions share the same protective and treatable risk factors and can be prevented together. The approach needs to be comprehensive, identifying all relevant environmental, socioeconomic, health care, and individual factors; targeted, as risks and protective factors differ among populations and individuals; and and investment valued, yielding worthwhile returns in terms of money, effort, or time. The World Stroke Organization's proclamation calling for the joint prevention of stroke and potentially preventable dementias has been endorsed by 23 international, regional, and national brain and heart organizations, including the American Academy of Neurology. We need to develop joint prevention programs to curb the triple threat. Millions of brains depend on it.
Factors Associated With, and Mitigation Strategies for, Health Care Disparities Faced by Patients With Headache Disorders
Kiarashi, Jessica MD; VanderPluym, Juliana MD; Szperka, Christina L. MD, MSCE; Turner, Scott DNP; Minen, Mia T. MD, MPH; Broner, Susan MD; Ross, Alexandra C. PhD; Wagstaff, Amanda E. PhD; Anto, Marissa MD; Marzouk, Maya MA; Monteith, Teshamae S. MD; Rosen, Noah MD; Manrriquez, Salvador L. DDS; Seng, Elizabeth PhD; Finkel, Alan MD; Charleston, Larry IV MD, MSc
doi : 10.1212/WNL.0000000000012261
Volume 97(6), 10 August 2021, p 280-289
To review contemporary issues of health care disparities in headache medicine with regard to race/ethnicity, socioeconomic status (SES), and geography and propose solutions for addressing these disparities.
Transcortical Sensory Aphasia Sonnet: What Happens When Your Words Are Not Your Own?
Acosta, Lealani Y. Mae MD, MPH
doi : 10.1212/WNL.0000000000012299
Volume 97(6), 10 August 2021, p 290
Autoimmune Septin-5 Disease Presenting as Spinocerebellar Ataxia and Nystagmus
Herrero San Martin, Alejandro MD; Amarante Cuadrado, Carla MD; Gonzalez Arbizu, Maialen MD; Rabano-Suarez, Pablo MD; Ostos-Moliz, Fernando MD; Naranjo, Laura PhD; Sabater, Lidia PhD; Martinez Hernandez, Eugenia MD, PhD; Ruiz Garcia, Raquel PhD; Toledo Alfocea, Daniel MD
doi : 10.1212/WNL.0000000000012240
Volume 97(6), 10 August 2021, p 291-292
Global & Community Health: Implementation of and Patient Satisfaction With the First Neurologic Telemedicine Program in Mexico During COVID-19
Dominguez-Moreno, Rogelio MD*; Garcia-Grimshaw, Miguel MD*; Chavez-Martinez, Oswaldo Alan MD; Rebolledo-Garcia, Daniel MD; Diestel-Bautista, Jarumi Crystal MD; Michel-Chavez, Anaclara MD; Calderon-Martinez, Juan Andres MD; Tristan-Samaniego, Dioselina Panama MD; Vigueras-Hernandez, Alma MD; Estrada-Rodriguez, Humberto MD; Vega-Boada, Felipe Arturo MD; Davila-Maldonado, Luis MD; Tanimoto, Miguel Angel MD; Cantu-Brito, Carlos MD, PhD; Gonzalez-Duarte, Alejandra MD*
doi : 10.1212/WNL.0000000000012291
Volume 97(6), 10 August 2021, p 293-296
Pearls & Oy-sters: Rapidly Reversible Dementia: Vitamin B12 Deficiency in a 29-Year-Old Woman
Huddar, Akshata DM; Seshagiri, Doniparthi Venkata DM; Ramakrishnan, Subasree DM; Kenchaiah, Raghavendra DM
doi : 10.1212/WNL.0000000000012102
Volume 97(6), 10 August 2021, p e643-e646
Teaching NeuroImage: Increasing SPECTations for Ictal SPECT in Epilepsy Surgical Evaluation
Nascimento, Fabio A. MD; Cochran, Rory L. MD, PhD; Chow, David Z. MD; Scott, James A. MD; Chu, Catherine J. MD
doi : 10.1212/WNL.0000000000012097
Volume 97(6), 10 August 2021, p e647-e648
Teaching Video NeuroImage: Resolution of Ptosis After Forceful Eye Closure: Bedside Diagnosis of Myasthenia Gravis
Zouvelou, Vasiliki MD, PhD; Daponte, Ariadne MD
doi : 10.1212/WNL.0000000000012100
Volume 97(6), 10 August 2021, p e649-e650
Editors' Note: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players
Siegler, James E. MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012380
Volume 97(6), 10 August 2021, p 297
Reader Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players
Mez, Jesse; Alosco, Michael L.; Nowinski, Christopher J.; McKee, Ann C.; Tripodis, Yorghos
doi : 10.1212/WNL.0000000000012381
Volume 97(6), 10 August 2021, p 297-298
Author Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players
Wennberg, Richard; Schwab, Nicole; Hazrati, Lili-Naz
doi : 10.1212/WNL.0000000000012382
Volume 97(6), 10 August 2021, p 298-299
Reader Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players
Dams-O'Connor, Kristen
doi : 10.1212/WNL.0000000000012383
Volume 97(6), 10 August 2021, p 299
Author Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players
Wennberg, Richard; Schwab, Nicole; Hazrati, Lili-Naz
doi : 10.1212/WNL.0000000000012385
Volume 97(6), 10 August 2021, p 299-300
Convexity Subarachnoid Hemorrhage in Lobar Intracerebral Hemorrhage: A Prognostic Marker
doi : 10.1212/WNL.0000000000011857
Volume 97(6), 10 August 2021, p 300
Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis
doi : 10.1212/WNL.0000000000012021
Volume 97(6), 10 August 2021, p 300
