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Uterus transplantation in a Nordic perspective: A proposition for clinical introduction with centralization
Mats Br?nnstr?m
doi : 10.1111/aogs.14164
Volume 100, Issue 8 p. 1361-1363
Cervical cancer prevention among older women – challenges in screening, diagnostic workup and treatment
Line W. Gustafson,Lone Kjeld Petersen,Pinar Bor,Berit Andersen,Anne Hammer
doi : 10.1111/aogs.14162
Volume 100, Issue 8 p. 1364-1368
Cervical cancer incidence and mortality have declined dramatically after screening for cervical cancer was implemented. Yet, studies have reported high cervical cancer incidence and mortality rates at older age despite low HPV prevalence and incidence of precursor lesions. The underlying reason for these findings remains unclear. However, it is well known that the impact of screening depends not only on the uptake and effectiveness of screening but also on the uptake and effectiveness of diagnostic workup (ie colposcopy), treatment and follow-up. In older women, sensitivity of screening and performance of colposcopy are impaired due to age-dependent changes to the cervix. In this commentary, we aimed to discuss challenges in screening and clinical management of older women, and to identify crucial areas of particular interest for future research.
Frozen section diagnosis of borderline ovarian tumors with suspicious features of invasive cancer is a devil’s dilemma for the surgeon: A systematic review and meta-analysis
Koen De Decker,Karina H. Jaroch,Mireille A. Edens,Joost Bart,Loes F. S. Kooreman,Roy F. P. M. Kruitwagen,Hans W. Nijman,Arnold-Jan Kruse
doi : 10.1111/aogs.14105
Volume 100, Issue 8 p. 1369-1376
Frozen section diagnoses of borderline ovarian tumors are not always straightforward and a borderline frozen section diagnosis with suspicious features of invasive carcinoma (reported as “at least borderline� or synonymous descriptions) presents us with the dilemma of whether or not to perform a full surgical staging procedure. By performing a systematic review and meta-analysis, the prevalence of straightforward borderline and “at least borderline� frozen section diagnoses, as well as proportion of patients with a final diagnosis of invasive carcinoma in these cases, were assessed and compared, as quantification of this dilemma may help us with the issue of this clinical decision.
Objective measures of adenomyosis on MRI and their diagnostic accuracy—a systematic review & meta-analysis
Connie O. Rees,Joost Nederend,Massimo Mischi,Huib A. A. M. van Vliet,Benedictus C. Schoot
doi : 10.1111/aogs.14139
Volume 100, Issue 8 p. 1377-1391
Magnetic resonance imaging (MRI) diagnosis of adenomyosis is considered the most accurate non-invasive technique, but remains subjective, with no consensus on which diagnostic parameters are most accurate. We aimed to systematically review the literature on how adenomyosis can be objectively quantified on MRI in a scoping manner, to review the diagnostic performance of these characteristics compared with histopathological diagnosis, and to summarize correlations between measures of adenomyosis on MRI and clinical outcomes.
Early delivery or expectant management for late preterm preeclampsia: A meta-analysis of randomized controlled trials
Christos Chatzakis,Anastasios Liberis,Apostolos Zavlanos,Stamatis Petousis,Evangelia Tsakmaki,Konstantinos Dinas,Alexandros Sotiriadis
doi : 10.1111/aogs.14149
Volume 100, Issue 8 p. 1392-1400
Currently, there is no consensus regarding the timing of delivery in women with non-severe preeclampsia at the late preterm period. The aim of the present meta-analysis is to compare expectant management with immediate delivery in pregnant women with preeclampsia between 34+0 and 36+6 gestational weeks, in terms of maternal and neonatal outcomes.
Plasma long-chain omega-3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study
Laura Goodfellow,Angharad Care,Jane Harrold,Andrew Sharp,Jelena Ivandic,Borna Poljak,Devender Roberts,Ana Alfirevic,Bertram M?¼ller-Myhsok,Robert Gibson,Maria Makrides,Zarko Alfirevic
doi : 10.1111/aogs.14147
Volume 100, Issue 8 p. 1401-1411
A 2018 Cochrane review found that omega-3 supplementation in pregnancy was associated with a risk reduction of early preterm birth of 0.58; prompting calls for universal supplementation. Recent analysis suggests the benefit may be confined to women with a low baseline omega-3 fatty acid status. However, the contemporary omega-3 fatty acid status of pregnant women in the UK is largely unknown. This is particularly pertinent for women with a previous preterm birth, in whom a small relative risk reduction would have a larger reduction of absolute risk. This study aimed to assess the omega-3 fatty acid status of a UK pregnant population and determine the association between the long-chain omega-3 fatty acids and recurrent spontaneous early preterm birth.
Placental volume in gestational week 27 measured by three-dimensional ultrasound and magnetic resonance imaging
Karianne Sagberg,Anne Eskild,Silje Sommerfelt,Kjell I. Gjesdal,Lucy E. Higgins,Arne Borthne,Vigdis Hillestad
doi : 10.1111/aogs.14115
Volume 100, Issue 8 p. 1412-1418
Ultrasound is the diagnostic tool of choice in pregnancy. We lack valid ultrasound methods for placental size measurements. Our aim was therefore to compare three-dimensional (3D) ultrasound with magnetic resonance imaging (MRI) for measurements of placental volume.
Thyroid-stimulating hormone and free thyroxine fail to predict the severity and clinical course of hyperemesis gravidarum: A prospective cohort study
Kelly Nijsten,Marjette H. Koot,Joris A. M. van der Post,Joke M. J. Bais,Carrie Ris-Stalpers,Christiana Naaktgeboren,Henk A. Bremer,David P. van der Ham,Wieteke M. Heidema,Anjoke Huisjes,Gunilla Kleiverda,Simone M. Kuppens,Judith O. E. H. van Laar,Josje Langenveld,Flip van der Made,Dimitri Papatsonis,Marie-Jos?© Pelinck,Paula J. Pernet,Leonie van Rheenen-Flach,Robbert J. Rijnders,Hubertina C. J. Scheepers,Sarah E. Siegelaar,Tatjana Vogelvang,Ben W. Mol,Tessa J. Roseboom,Iris J. Grooten,Rebecca C. Painter
doi : 10.1111/aogs.14131
Volume 100, Issue 8 p. 1419-1429
Little is known about the pathophysiology of hyperemesis gravidarum (HG). Proposed underlying causes are multifactorial and thyroid function is hypothesized to be causally involved. In this study, we aimed to assess the utility of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) as a marker and predictor for the severity and clinical course of HG.
Outcome of early-onset fetal growth restriction with or without abnormal umbilical artery Doppler flow
Diana Gairabekova,Joost van Rosmalen,Johannes J. Duvekot
doi : 10.1111/aogs.14142
Volume 100, Issue 8 p. 1430-1438
Early-onset fetal growth restriction is a pregnancy complication often coinciding with abnormal Doppler flow in the umbilical artery. Absent or reversed end-diastolic flow in the umbilical artery is associated with adverse perinatal outcome. As the optimal management of this condition is unclear, the objective of this study was to analyze the time interval from admission to delivery of pregnancies with early-onset fetal growth restriction, while pursuing a policy of postponing delivery unless active management of labor would be required because of fetal distress or maternal condition. We also assessed short- and long-term perinatal outcome.
Perinatal outcomes in women with cystic fibrosis: Data from the Italian Cystic Fibrosis Registry
Rita F. Padoan,Serena Quattrucci,Annalisa Amato,Marco Salvatore,Donatello Salvatore,Giuseppe Campagna
doi : 10.1111/aogs.14190
Volume 100, Issue 8 p. 1439-1444
Data from the Italian Cystic Fibrosis Registry concerning pregnancies in the period 2010–2015 were used to investigate the association between the preconception clinical status and perinatal outcomes of women with cystic fibrosis (CF).
Lack of experience is a main cause of maternal death in placenta accreta spectrum patients
Albaro J. Nieto-Calvache,Jose M. Palacios-Jaraquemada,Gabriel Osanan,Rafael Cortes-Charry,Rozi A. Aryananda,Vidyadhar B. Bangal,Aziz Slaoui,Ahmed M. Abbas,Godwin O. Akaba,Zaman N. Joshua,Lina M. Vergara Galliadi,Alejandro S. Nieto-Calvache,José E. San?n-Blair,Juan M Burgos-Luna,the Latin American group for the study of placenta accreta spectrum
doi : 10.1111/aogs.14163
Volume 100, Issue 8 p. 1445-1453
Placenta accreta spectrum (PAS) is a serious condition with a mortality as high as 7%. However, the factors associated with this type of death have not been adequately described, with an almost complete lack of publications analyzing the determining factors of death in this disease. The aim of our work is to describe the causes of death related to PAS and to analyze the associated diagnosis and treatment problems.
Pelvic capacity in pregnant women, identified using magnetic resonance imaging
Louise L. Kjeldsen,Anne Dorte Blankholm,Anne Grethe Jurik,Jannie D. Salvig,Rikke D. Maimburg
doi : 10.1111/aogs.14168
Volume 100, Issue 8 p. 1454-1462
Maternal pelvic capacity plays a major role during childbirth because the passage of the fetus through the bony birth canal enables vaginal birth. Maternal birthing position may influence pelvic capacity because upright positions optimize capacity, possibly due to free movement of the pelvic joints. Herein, pelvic capacity was assessed by comparing changes in pelvic dimensions across pregnancy and in three birthing positions.
Efficacy and safety of oral misoprostol vs transvaginal balloon catheter for labor induction: An observational study within the SWEdish Postterm Induction Study (SWEPIS)
M?rten Alkmark,Ylva Carlsson,Sophia Brismar Wendel,Helen Elden,Helena Fadl,Maria Jonsson,Lars Ladfors,Sissel Saltvedt,Verena Sengpiel,Anna Wessberg,Anna-Karin Wikstr?m,Henrik Hagberg,Ulla-Britt Wennerholm
doi : 10.1111/aogs.14155
Volume 100, Issue 8 p. 1463-1477
Induction of labor is increasing. A common indication for induction of labor is late term and postterm pregnancy at 41 weeks or more. We aimed to evaluate if there are any differences regarding efficacy, safety, and women's childbirth experience between oral misoprostol and transvaginal balloon catheter for cervical ripening in women with a low-risk singleton pregnancy and induction of labor at 41+0 to 42+0 to 1 weeks of gestation.
Association between travel time to delivery unit and unplanned out-of-hospital birth, infant morbidity and mortality: A population-based cohort study
Anne K. ?–rtqvist,Jan Haas,Mia Ahlberg,Mikael Norman,Olof Stephansson
doi : 10.1111/aogs.14156
Volume 100, Issue 8 p. 1478-1489
Over the last decade, a number of delivery units have been closed in Sweden, justified by both economic incentives and patient safety issues. However, concentrating births to larger delivery units naturally increases travel time for some parturient women, which may lead to unintended negative consequences. We aimed to investigate the association between travel time to delivery unit and unplanned out-of-hospital birth, and subsequent infant morbidity and mortality.
Association of complicated appendicitis on the risk of later in vitro fertilization treatment requirement and ectopic pregnancy: a nationwide cohort study
Jaana M?nnist?,Henna Sammalkorpi,Maarit Niinim?ki,Maarit Mentula,Panu Mentula
doi : 10.1111/aogs.14165
Volume 100, Issue 8 p. 1490-1496
A population-based register study utilizing three Finnish National Registers was carried out to determine whether uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis are associated with a subsequent risk of requiring in vitro fertilization (IVF) treatment or a risk of ectopic pregnancy among reproductive-age women.
Evaluation of repeat testing of a non-sequencing based NIPT test on a Finnish general-risk population
Filip Karlsson,Tarja Ahola,Jenny Dahlberg,Lawrence Prensky,Helena Moilanen,Heli Spalding
doi : 10.1111/aogs.14125
Volume 100, Issue 8 p. 1497-1500
To evaluate the effect of repeating test failures using an automated, non-sequencing based non-invasive prenatal testing test on a general-risk population in Finland.
Vaginal streptococcus B colonization is not associated with increased infectious morbidity in labor induction
Katariina Place,Leena Rahkonen,Irmeli Nupponen,Heidi Kruit
doi : 10.1111/aogs.14154
Volume 100, Issue 8 p. 1501-1510
Labor induction rates are increasing and, in Finland today, one of three labors is induced. Group B streptococcus (GBS) is a bacterium found in 10%–30% of pregnant women and it can be transmitted to the neonate during vaginal delivery. Although GBS is rarely harmful in the general population, it is the leading cause of severe neonatal infections such as sepsis, pneumonia, and meningitis. In addition, GBS can cause maternal morbidity. Labor induction in GBS-positive women has not yet been investigated but concerns of infectious morbidity associated with balloon catheters have been raised.
A prognostic system for epithelial ovarian carcinomas using machine learning
Philip M. Grimley,Zhenqiu Liu,Kathleen M. Darcy,Matthew T. Hueman,Huan Wang,Li Sheng,Donald E. Henson,Dechang Chen
doi : 10.1111/aogs.14137
Volume 100, Issue 8 p. 1511-1519
Integrating additional factors into the International Federation of Gynecology and Obstetrics (FIGO) staging system is needed for accurate patient classification and survival prediction. In this study, we tested machine learning as a novel tool for incorporating additional prognostic parameters into the conventional FIGO staging system for stratifying patients with epithelial ovarian carcinomas and evaluating their survival.
Contralateral lymph node metastases in patients with vulvar cancer and unilateral sentinel lymph node metastases
Tanja Ignatov,Johannes Ga?ner,Mihaela Bozukova,Stylianos Ivros,J?zsef Mész?ros,Olaf Ortmann,Holm Eggemann,Atanas Ignatov
doi : 10.1111/aogs.14157
Volume 100, Issue 8 p. 1520-1525
The risk of contralateral lymph node metastases following unilateral sentinel lymph node (SLN) metastases in patients with vulvar cancer(s) remains to be systematically assessed.
Preoperative and intraoperative assessment of myometrial invasion in endometrial cancer—A Swedish Gynecologic Cancer Group (SweGCG) study
Bj?¶rg J?³nsd?³ttir,Janusz Marcickiewicz,Christer Borgfeldt,Maria Bjurberg,Pernilla Dahm-K?¤hler,Angelique Fl?¶ter-R?¥destad,Kristina Hellman,Erik Holmberg,Preben Kj?¸lhede,Per Rosenberg,Bengt Tholander,Elisabeth ?…vall-Lundqvist,Karin St?¥lberg,Thomas H?¶gberg
doi : 10.1111/aogs.14146
Volume 100, Issue 8 p. 1526-1533
Deep myometrial invasion (≥50%) is a prognostic factor for lymph node metastases and decreased survival in endometrial cancer. There is no consensus regarding which pre/intraoperative diagnostic method should be preferred. Our aim was to explore the pattern of diagnostic methods for myometrial invasion assessment in Sweden and to evaluate differences among magnetic resonance imaging (MRI), transvaginal sonography, frozen section, and gross examination in clinical practice.
Maternal death in placenta accreta spectrum: Three possible factors preventing patients’ transfer
Shigeki Matsubara,Daisuke Matsubara,Teppei Matsubara
doi : 10.1111/aogs.14171
Volume 100, Issue 8 p. 1534-1535
How to avoid maternal deaths in PAS?
Albaro J. Nieto-Calvache,Jose M. Palacios-Jaraquemada,Rozi A. Aryananda
doi : 10.1111/aogs.14202
Volume 100, Issue 8 p. 1536-1536
Mental health among postpartum women during the COVID-19 pandemic
Siew Lim,Melissa Savaglio,Helen Skouteris,Lisa Moran
doi : 10.1111/aogs.14144
Volume 100, Issue 8 p. 1537-1538
Position therapy in pregnancy: Can trending maternal cardiac output put it on a more objective foundation?
Thomas L. Archer
doi : 10.1111/aogs.14167
Volume 100, Issue 8 p. 1539-1540
Lars Hamberger: in memory of a Nordic pioneer in IVF
Mats Br?nnstr?m,Ganesh Acharya,Christina Bergh
doi : 10.1111/aogs.14220
Volume 100, Issue 8 p. 1541-1542
