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Psychiatry and Deaths of Despair
Lilly Shanahan, PhD1,2; William E. Copeland, PhD3
doi : 10.1001/jamapsychiatry.2021.0256
JAMA Psychiatry. 2021;78(7):695-696
Three Important Considerations for Studies Examining Pathophysiological Pathways in Psychiatric Illness
Mary L. Phillips, MD1; Kenneth S. Kendler, MD2,3
doi : 10.1001/jamapsychiatry.2021.0022
JAMA Psychiatry. 2021;78(7):697-698
A New Consensus Framework for Phenotyping and Treatment Selecting in Addiction and Obsessive-Compulsive–Related Disorders
Murat Yücel, PhD1; Rico S. C. Lee, PhD1; Leonardo F. Fontenelle, MD1,2
doi : 10.1001/jamapsychiatry.2021.0243
JAMA Psychiatry. 2021;78(7):699-700
Moving Beyond Medications That Act at the ? Receptor in the Treatment of Opioid Use Disorder
Eric C. Strain, MD1; Kyle M. Kampman, MD2; Roger D. Weiss, MD3
doi : 10.1001/jamapsychiatry.2021.0259
JAMA Psychiatry. 2021;78(7):701-702
Healing Ethno-Racial Trauma in Black CommunitiesCultural Humility as a Driver of Innovation
Opemipo Akerele, BS; Madison McCall, BS; Gowri Aragam, MD
doi : 10.1001/jamapsychiatry.2021.0537
JAMA Psychiatry. 2021;78(7):703-704
Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents With Social Anxiety DisorderA Randomized Clinical Trial
Martina Nordh, PhD1; Tove Wahlund, PhD1; Maral Jolstedt, PhD1; Hanna Sahlin, PhD1; Johan Bjureberg, PhD1; Johan Ahlen, PhD1,2; Maria Lalouni, PhD1,3; Sigrid Salomonsson, PhD1; Sarah Vigerland, PhD1; Malin Lavner, MSc1; Lars-G?ran ?st, PhD4; Fabian Lenhard, PhD1; Hugo Hesser, PhD5,6; David Mataix-Cols, PhD1; Jens H?gstr?m, PhD1; Eva Serlachius, MD, PhD1
doi : 10.1001/jamapsychiatry.2021.0469
JAMA Psychiatry. 2021;78(7):705-713
Social anxiety disorder (SAD) is a prevalent childhood-onset disorder associated with lifelong adversity and high costs for the individual and society at large. Cognitive behavioral therapy (CBT) is an established evidence-based treatment for SAD, but its availability is limited.
Effects of SlowMo, a Blended Digital Therapy Targeting Reasoning, on Paranoia Among People With PsychosisA Randomized Clinical Trial
Philippa Garety, PhD1,2; Thomas Ward, PhD1,2; Richard Emsley, PhD3; Kathryn Greenwood, PhD4,5; Daniel Freeman, PhD6,7; David Fowler, MSc4,5; Elizabeth Kuipers, PhD1,2; Paul Bebbington, PhD8; Mar Rus-Calafell, PhD6,7,9; Alison McGourty, DPsych5; Catarina Sacadura, PsyD5; Nicola Collett, DClinPsy6,7,10; Kirsty James, MSc3; Amy Hardy, PhD1,2
doi : 10.1001/jamapsychiatry.2021.0326
JAMA Psychiatry. 2021;78(7):714-725
Persistent paranoia is common among patients with psychosis. Cognitive-behavioral therapy for psychosis can be effective. However, challenges in engagement and effectiveness remain.
Racial/Ethnic Disparities in the Performance of Prediction Models for Death by Suicide After Mental Health Visits
R. Yates Coley, PhD1,2; Eric Johnson, MS1; Gregory E. Simon, MD, MPH1; Maricela Cruz, PhD1; Susan M. Shortreed, PhD1,2
doi : 10.1001/jamapsychiatry.2021.0493
JAMA Psychiatry. 2021;78(7):726-734
Clinical prediction models estimated with health records data may perpetuate inequities.
Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample
Kenneth S. Kendler, MD1,2; Henrik Ohlsson, PhD3; Jan Sundquist, MD, PhD3,4,5; Kristina Sundquist, MD, PhD3,4,5
doi : 10.1001/jamapsychiatry.2021.0336
JAMA Psychiatry. 2021;78(7):735-743
Family and genetic approaches have traditionally been used to evaluate our diagnostic concepts. Using a novel method, the family genetic risk score (FGRS), can we validate the genetic architecture of major affective and psychotic disorders in a national Swedish sample?
Discriminating Heterogeneous Trajectories of Resilience and Depression After Major Life Stressors Using Polygenic Scores
Katharina Schultebraucks, PhD1,2,3; Karmel W. Choi, PhD4; Isaac R. Galatzer-Levy, PhD5; George A. Bonanno, PhD6
doi : 10.1001/jamapsychiatry.2021.0228
JAMA Psychiatry. 2021;78(7):744-752
Major life stressors, such as loss and trauma, increase the risk of depression. It is known that individuals show heterogeneous trajectories of depressive symptoms following major life stressors, including chronic depression, recovery, and resilience. Although common genetic variation has been associated with depression risk, genomic factors that could help discriminate trajectories of risk vs resilience following adversity have not been identified.
Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing PsychosisAn ENIGMA Working Group Mega-analysis
ENIGMA Clinical High Risk for Psychosis Working Group
doi : 10.1001/jamapsychiatry.2021.0638
JAMA Psychiatry. 2021;78(7):753-766
The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk.
Cost-effectiveness of Treatments for Opioid Use Disorder
Michael Fairley, PhD1; Keith Humphreys, PhD2,3; Vilija R. Joyce, MS4; Mark Bounthavong, PharmD, PhD4; Jodie Trafton, PhD3,5; Ann Combs, MHA5; Elizabeth M. Oliva, PhD2; Jeremy D. Goldhaber-Fiebert, PhD6; Steven M. Asch, MD, MPH2,7; Margaret L. Brandeau, PhD1; Douglas K. Owens, MS, MD2,6,7
doi : 10.1001/jamapsychiatry.2021.0247
JAMA Psychiatry. 2021;78(7):767-777
Opioid use disorder (OUD) is a significant cause of morbidity and mortality in the US, yet many individuals with OUD do not receive treatment.
Association of Multigenerational Family History of Depression With Lifetime Depressive and Other Psychiatric Disorders in ChildrenResults from the Adolescent Brain Cognitive Development (ABCD) Study
Milenna T. van Dijk, PhD1,2; Eleanor Murphy, PhD1,2; Jonathan E. Posner, MD1,3; Ardesheer Talati, PhD1,2; Myrna M. Weissman, PhD1,2,4
doi : 10.1001/jamapsychiatry.2021.0350
JAMA Psychiatry. 2021;78(7):778-787
Three-generation family studies of depression have established added risk of psychopathology for offspring with 2 previous generations affected with depression compared with 1 or none. Because of their rigorous methodology, there are few of these studies, and existing studies are limited by sample sizes. Consequently, the 3-generation family risk paradigm established in family studies can be a critical neuropsychiatric tool if similar transmission patterns are reliably demonstrated with the family history method.
Neuromelanin-Sensitive Magnetic Resonance Imaging as a Proxy Marker for Catecholamine Function in Psychiatry
Guillermo Horga, MD, PhD1,2; Kenneth Wengler, PhD1,2; Clifford M. Cassidy, PhD3
doi : 10.1001/jamapsychiatry.2021.0927
JAMA Psychiatry. 2021;78(7):788-789
Neural Correlates of Affective Benefit From Real-life Social Contact and Implications for Psychiatric Resilience
Gabriela Gan, PhD1; Ren Ma, MSc1; Markus Reichert, PhD1,2,3; Marco Giurgiu, PhD1,2; Ulrich W. Ebner-Priemer, PhD1,2; Andreas Meyer-Lindenberg, MD1; Heike Tost, MD, PhD1
doi : 10.1001/jamapsychiatry.2021.0560
JAMA Psychiatry. 2021;78(7):790-792
Polygenic Liability and Recurrence of Depression in Patients With First-Onset Depression Treated in Hospital-Based Settings
Katherine L. Musliner, MPH, PhD1,2; Esben Agerbo, PhD1,2,3; Bjarni J. Vilhj?lmsson, PhD1; Clara Albi?ana, MSc1; Thomas D. Als, PhD2,4; S?ren D. ?stergaard, MD, PhD5,6; Preben B. Mortensen, MD1,2,3
doi : 10.1001/jamapsychiatry.2021.0701
JAMA Psychiatry. 2021;78(7):792-795
Improving the Assessment of COVID-19–Associated Posttraumatic Stress Disorder
Brian P. Marx, PhD1,2; Paula P. Schnurr, PhD3,4; Matthew J. Friedman, MD, PhD4
doi : 10.1001/jamapsychiatry.2021.1123
JAMA Psychiatry. 2021;78(7):795
Improving the Assessment of COVID-19–Associated Posttraumatic Stress Disorder—Reply
Delfina Janiri, MD1; Georgios D. Kotzalidis, MD, PhD1; Gabriele Sani, MD1,2
doi : 10.1001/jamapsychiatry.2021.1126
JAMA Psychiatry. 2021;78(7):795-796
