JAMA Ophthalmology

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Genetic Analysis in a Swiss Cohort of Bilateral Congenital Cataract

Delia Rechsteiner, MD1,2; Lydia Issler, MD1,2; Samuel Koller, PhD2; Elena Lang, MD1,2; Luzy B?hr2; Silke Feil2; Christoph M. Rüegger, MD3; Raimund Kottke, MD4; Sandra P. Toelle, MD5; Noëmi Zweifel, MD6; Katharina Steindl, MD7; Pascal Joset, PhD7; Markus Zweier, PhD7; Aude-Annick Suter, MD7; Laura Gogoll, MD7; Cordula Haas, PhD8; Wolfgang Berger, PhD2,9,10; Christina Gerth-Kahlert, MD1

doi : 10.1001/jamaophthalmol.2021.0385

JAMA Ophthalmol. 2021;139(7):691-700

Importance Identification of geographic population-based differences in genotype and phenotype heterogeneity are important for targeted and patient-specific diagnosis and treatment, counseling, and screening strategies.

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Effect of Intravitreous Anti–Vascular Endothelial Growth Factor vs Sham Treatment for Prevention of Vision-Threatening Complications of Diabetic Retinopathy

Raj K. Maturi, MD1; Adam R. Glassman, MS2; Kristin Josic, PhD2; Andrew N. Antoszyk, MD3; Barbara A. Blodi, MD4; Lee M. Jampol, MD5; Dennis M. Marcus, MD6; Daniel F. Martin, MD7; Michele Melia, ScM2; Hani Salehi-Had, MD8; Cynthia R. Stockdale, MSPH2; Omar S. Punjabi, MD3; Jennifer K. Sun, MD, MPH9; for the DRCR Retina Network

doi : 10.1001/jamaophthalmol.2021.0606

JAMA Ophthalmol. 2021;139(7):701-712

Importance The role of anti–vascular endothelial growth factor injections for the management of nonproliferative diabetic retinopathy (NPDR) without center-involved diabetic macular edema (CI-DME) has not been clearly established.

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Prevalence of Visual Acuity Loss or Blindness in the US

Abraham D. Flaxman, PhD1; John S. Wittenborn, BS2; Toshana Robalik, BS1; Rohit Gulia, MS1; Robert B. Gerzoff, MS3; Elizabeth A. Lundeen, PhD, MPH4; Jinan Saaddine, MD, MPH4; David B. Rein, PhD, MPA2; for the Vision and Eye Health Surveillance System study group

doi : 10.1001/jamaophthalmol.2021.0527

JAMA Ophthalmol. 2021;139(7):713-724

Importance Globally, more than 250 million people live with visual acuity loss or blindness, and people in the US fear losing vision more than memory, hearing, or speech. But it appears there are no recent empirical estimates of visual acuity loss or blindness for the US.

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Visual Acuity, Vitreous Hemorrhage, and Other Ocular Outcomes After Vitrectomy vs Aflibercept for Vitreous Hemorrhage Due to Diabetic Retinopathy

Adam R. Glassman, MS1; Wesley T. Beaulieu, PhD1; Maureen G. Maguire, PhD2; Andrew N. Antoszyk, MD3; Clement C. Chow, MD4; Michael J. Elman, MD5; Lee M. Jampol, MD6; Hani Salehi-Had, MD7; Jennifer K. Sun, MD, MPH8; for the DRCR Retina Network

doi : 10.1001/jamaophthalmol.2021.1110

JAMA Ophthalmol. 2021;139(7):725-733

Importance Although there were no differences in mean visual acuity (VA) over 24 weeks after vitrectomy with panretinal photocoagulation (PRP) vs aflibercept in a randomized clinical trial among eyes with vitreous hemorrhage due to proliferative diabetic retinopathy (PDR), post hoc analyses may influence treatment choices.

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Comparison of Central Macular Fluid Volume With Central Subfield Thickness in Patients With Diabetic Macular Edema Using Optical Coherence Tomography Angiography

Qi Sheng You, MD, PhD1; Kotaro Tsuboi, MD1; Yukun Guo, MS1; Jie Wang, MS1,2; Christina J. Flaxel, MD1; Steven T. Bailey, MD1; David Huang, MD, PhD1; Yali Jia, PhD1,2; Thomas S. Hwang, MD1

doi : 10.1001/jamaophthalmol.2021.1275

JAMA Ophthalmol. 2021;139(7):734-741

Importance Diabetic macular edema (DME) is the predominant cause of visual impairment in patients with type 1 or 2 diabetes. Automated fluid volume measurements using optical coherence tomography (OCT) may improve the diagnostic accuracy of DME screening.

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Enlargement of Geographic Atrophy From First Diagnosis to End of Life

Johanna M. Colijn, MD, MSc1,2; Bart Liefers, MSc3; Nichole Joachim, BSc(Hons), PhD4; Timo Verzijden, MSc1,2; Magda A. Meester-Smoor, PhD1,2; Marc Biarnés, MSc5,6; Jordi Monés, MD, PhD5,6; Paulus T. V. M. de Jong, MD, PhD7; Johannes R. Vingerling, MD, PhD1; Paul Mitchell, MD, PhD8; Clara I. S?nchez, PhD9,10; Jie J. Wang, MMed, PhD8,11; Caroline C. W. Klaver, MD, PhD1,2,12,13; for the EyeNED Reading Center and EYE-RISK Consortium

doi : 10.1001/jamaophthalmol.2021.1407

JAMA Ophthalmol. 2021;139(7):743-750

Importance Treatments for geographic atrophy (GA), a late stage of age-related macular degeneration (AMD), are currently under development. Understanding the natural course is needed for optimal trial design. Although enlargement rates of GA and visual acuity (VA) in the short term are known from clinical studies, knowledge of enlargement in the long term, life expectancy, and visual course is lacking.

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Association Between Visual Impairment and Depression in Patients Attending Eye Clinics

Mariacristina Parravano, MD1; Davide Petri, MSc2; Erica Maurutto, MD3; Ersilia Lucenteforte, PhD2; Francesca Menchini, MD3; Paolo Lanzetta, MD3; Monica Varano, MD1; Ruth M. A. van Nispen, PhD4; Gianni Virgili, MD5,6

doi : 10.1001/jamaophthalmol.2021.1557

JAMA Ophthalmol. 2021;139(7):753-761

Importance Given that depression is treatable and some ocular diseases that cause visual loss are reversible, early identification and treatment of patients with visual impairment who are most at risk of depression may have an important influence on the well-being of these patients.

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Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population

Perttu J. Liuska, MD1; Susanna Lemmel?, PhD2,3; Aki S. Havulinna, DSc2,3; Kai Kaarniranta, MD, PhD4; Hannu Uusitalo, MD, PhD5; Hannele Laivuori, MD, PhD2,6; Tuomo Kiiskinen, MD2; Mark J. Daly, PhD2; Aarno Palotie, MD, PhD2; Joni A. Turunen, MD, PhD1,7; for the FinnGen Consortium

doi : 10.1001/jamaophthalmol.2021.1610

JAMA Ophthalmol. 2021;139(7):762-768

Importance The c.1102C>T, p.(Gln368Ter) variant in the myocilin (MYOC) gene is a known risk allele for glaucoma. It is the most common MYOC risk variant for glaucoma among individuals of European ancestry, and its prevalence is highest in Finland. Furthermore, exfoliation syndrome has high prevalence in Scandinavia, making the Finnish population ideal to study the association of the variant with different types of glaucoma.

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Defining Nonadherence and Nonpersistence to Anti–Vascular Endothelial Growth Factor Therapies in Neovascular Age-Related Macular Degeneration

Mali Okada, MMed1; Tien Yin Wong, MD, PhD2,3; Paul Mitchell, MD, PhD4; Bora Eldem, MD5; S. James Talks, MB Bchir6; Tariq Aslam, PhD7; Vincent Daien, MD, PhD8; Francisco J. Rodriguez, MD9; Richard Gale, MD10; Jane Barratt, MSc, PhD11; Robert P. Finger, MD, PhD12; Anat Loewenstein, MD13

doi : 10.1001/jamaophthalmol.2021.1660

JAMA Ophthalmol. 2021;139(7):769-776

Importance Poor adherence or persistence to treatment can be a barrier to optimizing clinical practice (real-world) outcomes to intravitreal injection therapy in patients with neovascular age-related macular degeneration (nAMD). Currently, there is a lack of consensus on the definition and classification of adherence specific to this context.

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Ocular Assessments of a Series of Newborns Gestationally Exposed to Maternal COVID-19 Infection

Ol?via Pereira Kiappe, MD, MSc1; Natasha Ferreira Santos da Cruz, MD1; Paulo Alberto Cervi Rosa, MD1; Luciana Arrais, MD1; Nilva Simeren Bueno de Moraes, MD, PhD1

doi : 10.1001/jamaophthalmol.2021.1088

JAMA Ophthalmol. 2021;139(7):777-780

Importance Congenital viral infections leading to ocular abnormalities are frequent and devastating. As ophthalmological manifestations of COVID-19 in newborns are still unknown, it is important to clarify if SARS-CoV-2 could be associated with ocular abnormalities.

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Association of Structural Changes in the Brain and Retina After Long-Duration Spaceflight

Karina Marshall-Goebel, PhD1; Brandon R. Macias, PhD2; Larry A. Kramer, MD3; Khader M. Hasan, PhD3; Connor Ferguson, MS4; Nimesh Patel, PhD5; Robert J. Ploutz-Snyder, PhD6; Stuart M. C. Lee, PhD1; Doug Ebert, PhD1; Ashot Sargsyan, MD1; Scott Dulchavsky, MD7; Alan R. Hargens, PhD8; Michael B. Stenger, PhD2; Steven Laurie, PhD1

doi : 10.1001/jamaophthalmol.2021.1400

JAMA Ophthalmol. 2021;139(7):781-784

Importance Long-duration spaceflight induces structural changes in the brain and eye. Identification of an association between cerebral and ocular changes could help determine if there are common or independent causes and inform targeted prevention strategies or treatments.

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Detection and Referral of Orbital and Ocular Injuries Associated With Intimate Partner Violence Following an Educational and Screening Initiative in an Emergency Department

Salma A. Dawoud, MD1; Ali R. Cohen, MD2; Lynette M. Renner, PhD, MSW3; Thomas J. Clark, MD4; M. Bridget Zimmerman, PhD5; Erin M. Shriver, MD1

doi : 10.1001/jamaophthalmol.2021.1546

JAMA Ophthalmol. 2021;139(7):785-789

Importance Intimate partner violence (IPV) is a substantial cause of morbidity and mortality in the US. Previous studies indicate gaps in identifying and referring female patients with IPV-associated orbital and ocular injuries to ancillary services.

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Racial/Ethnic Disparities and Barriers to Diabetic Retinopathy Screening in Youths

Chrystal G. Thomas, MMS1; Roomasa Channa, MD2; Laura Prichett, PhD, MHS3; T. Y. Alvin Liu, MD4; Michael D. Abramoff, MD, PhD5,6,7; Risa M. Wolf, MD1

doi : 10.1001/jamaophthalmol.2021.1551

JAMA Ophthalmol. 2021;139(7):791-795

Importance Diabetic retinopathy is a major complication of diabetes for which regular screening improves visual health outcomes, yet adherence to screening is suboptimal.

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