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Mechanisms of radiation-induced endothelium damage: Emerging models and technologies
Harshani Wijerathne,Jordan C. Langston,Qingliang Yang,Curtis Miyamoto,Laurie E. Kilpatrick,Mohammad F. Kiani
doi : 10.1016/j.radonc.2021.02.007
REVIEW ARTICLE| VOLUME 158, P21-32, MAY 01, 2021
Radiation-induced endothelial/vascular injury is a major complicating factor in radiotherapy and a leading cause of morbidity and mortality in nuclear or radiological catastrophes. Exposure of tissue to ionizing radiation (IR) leads to the release of oxygen radicals and proteases that result in loss of endothelial barrier function and leukocyte dysfunction leading to tissue injury and organ damage. Microvascular endothelial cells are particularly sensitive to IR and radiation-induced alterations in endothelial cell function are thought to be a critical factor in organ damage through endothelial cell activation, enhanced leukocyte-endothelial cell interactions, increased barrier permeability and initiation of apoptotic pathways. These radiation-induced inflammatory responses are important in early and late radiation pathologies in various organs. A better understanding of mechanisms of radiation-induced endothelium dysfunction is therefore vital, as radiobiological response of endothelium is of major importance for medical management and therapeutic development for radiation injuries. In this review, we summarize the current knowledge of cellular and molecular mechanisms of radiation-induced endothelium damage and their impact on early and late radiation injury. Furthermore, we review established and emerging in vivo and in vitro models that have been developed to study the mechanisms of radiation-induced endothelium damage and to design, develop and rapidly screen therapeutics for treatment of radiation-induced vascular damage. Currently there are no specific therapeutics available to protect against radiation-induced loss of endothelial barrier function, leukocyte dysfunction and resulting organ damage. Developing therapeutics to prevent endothelium dysfunction and normal tissue damage during radiotherapy can serve as the urgently needed medical countermeasures.
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis
Deheng Nie,Xin Wang,Meiting Sun,Wenhui Liu,Zonghan Wang,Fujun Han
doi : 10.1016/j.radonc.2021.02.001
ORIGINAL ARTICLE| VOLUME 158, P13-20, MAY 01, 2021
To assess the survival benefits associated with epidermal growth factor receptor (EGFR) inhibitors in head and neck squamous cell carcinoma (HNSCC) according to the primary site.
Individual patient data meta-analysis of prophylactic cranial irradiation in locally advanced non-small cell lung cancer
Willem J.A. Witlox,Bram L.T. Ramaekers,Benjamin Lacas,Harry J.M. Groen,Manuela A. Joore,Dirk K.M. De Ruysscher
doi : 10.1016/j.radonc.2021.02.002
ORIGINAL ARTICLE| VOLUME 158, P40-47, MAY 01, 2021
Prophylactic cranial irradiation (PCI) was compared to observation in several randomized trials (RCTs), and a reduction greater than 50% was shown regarding the incidence of brain metastases (BM). However, none of these studies showed an improvement of overall survival (OS), possibly related to relatively small sample sizes and short follow-up. The aim of this meta-analysis was therefore to assess the impact of PCI on long term OS for stage III non-small cell lung cancer (NSCLC) compared to observation based on the pooled updated individual patient RCT data.
Local control and postponement of systemic therapy after modest dose radiotherapy in oligometastatic myxoid liposarcomas
Jules Lansu,Winan J. van Houdt,Kirsten van Langevelde,Hester van Boven,Astrid N. Scholten,Rick L. Haas
doi : 10.1016/j.radonc.2021.02.013
ORIGINAL ARTICLE| VOLUME 158, P33-39, MAY 01, 2021
Oligometastatic disease and/or oligoprogression in myxoid liposarcoma(oMLS) triggers discussions on local treatment options and delay of systemic treatments. We hypothesized that satisfactory local control and postponement of systemic therapy could be achieved with a modest radiotherapy(RT) dose in oMLS.
Two-year toxicity of simultaneous integrated boost in hypofractionated prone breast cancer irradiation: Comparison with sequential boost in a randomized trial
Hans Van Hulle,Eline Desaunois,Vincent Vakaet,Chris Monten,Pieter Deseyne,Liv Veldeman
doi : 10.1016/j.radonc.2021.02.010
ORIGINAL ARTICLE| VOLUME 158, P62-66, MAY 01, 2021
A simultaneous integrated boost (SIB) leads to less acute toxicity. Less is known for late toxicity due to SIB. In this first and only randomized trial, two-years toxicity is analysed.
Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients (DERMISHEAD trial)
Jolien Robijns,Joy Lodewijckx,Stefan Claes,Mieke Govers,Annelies Maes,Jeroen Mebis
doi : 10.1016/j.radonc.2021.03.002
ORIGINAL ARTICLE| VOLUME 158, P268-275, MAY 01, 2021
The purpose of this study was to investigate the effectiveness of photobiomodulation therapy (PBMT) for the prevention of acute radiation dermatitis (ARD) in head and neck cancer (HNC) patients.
Alexithymia and professional quality of life in radiation oncology: The moderator effect of the professional profile
Pierfrancesco Franco,Marialaura Di Tella,Valentina Tesio,Martin-Immanuel Bittner,Jenny Bertholet,Lorys Castelli
doi : 10.1016/j.radonc.2021.01.033
ORIGINAL ARTICLE| VOLUME 158, P48-54, MAY 01, 2021
Cancer care can be taxing. Alexithymia, a personality construct characterized by difficulties in identifying and describing feeling and emotions, an externally-oriented thinking style and scarcity of imagination and fantasy, is significantly correlated with higher levels of both secondary traumatic stress (STS) and burnout and lower levels of compassion satisfaction in medical professionals in radiation oncology. In this study, we aimed to assess the difference in professional quality of life (QoL) and the association with alexithymia in this multidisciplinary field depending on the specific profession (radiation/clinical oncologist, RO; medical physicist, MP; radiation therapist, RTT).
Survival after palliative radiation therapy for cancer: The METSSS model
Nicholas G. Zaorsky,Menglu Liang,Rutu Patel,Kristina B. Newport,Edward J. Fox,Ming Wang
doi : 10.1016/j.radonc.2021.02.011
ORIGINAL ARTICLE| VOLUME 158, P104-111, MAY 01, 2021
We propose a predictive model that identifies patients at greatest risk of death after palliative radiotherapy, and subsequently, can help medical professionals choose treatments that better align with patient choice and prognosis.
Longitudinal impact of postmastectomy radiotherapy on arm lymphedema in patients with breast cancer: An analysis of serial changes in arm volume measured by infrared optoelectronic volumetry
Nalee Kim,Haeyoung Kim,Ji Hye Hwang,Seung Mi Yeo,Hyebin Lee,Sei Kyung Lee
doi : 10.1016/j.radonc.2021.02.033
ORIGINAL ARTICLE| VOLUME 158, P167-174, MAY 01, 2021
This study was conducted to evaluate the longitudinal impact of postmastectomy radiation therapy (PMRT) on persistent severe lymphedema (PSL) using arm volume measurements by an infrared optoelectronic volumetry.
Intrafraction motion monitoring to determine PTV margins in early stage breast cancer patients receiving neoadjuvant partial breast SABR
Matthew Mouawad,Owen Lailey,Per Poulsen,Frank S. Prato,R. Terry Thompson,Stewart Gaede
doi : 10.1016/j.radonc.2021.02.021
GUIDELINES| VOLUME 158, P276-284, MAY 01, 2021
To quantify intra-fraction tumor motion using imageguidance and implanted fiducial markers to determine if a 5 mm planning-target-volume (PTV) margin is sufficient for early stage breast cancer patients receiving neoadjuvant stereotactic ablative radiotherapy (SABR).
Relapse pattern and quality of life in patients with localized basal ganglia germinoma receiving focal radiotherapy, whole-brain radiotherapy, or craniospinal irradiation
Bo Li,Jin Feng,Li Chen,Shuai Liu,Shiqi Luo,Xiaoguang Qiu
doi : 10.1016/j.radonc.2021.02.009
ORIGINAL ARTICLE| VOLUME 158, P90-96, MAY 01, 2021
The optimal target volume in localized basal ganglia (BG) germinoma is still undetermined. Thus, based on the relapse pattern and health-related quality of life (HRQOL), we evaluated three target volumes.
What is the role of the subventricular zone in radiotherapy of glioblastoma patients?
Katja Bender,Malte Tr?ger,Helena Wahner,Felix Ehret,Volker Budach,David Kaul
doi : 10.1016/j.radonc.2021.02.017
FULL LENGTH ARTICLE| VOLUME 158, P138-145, MAY 01, 2021
Current glioblastoma (GBM) therapies prolong survival, but overall prognosis is still poor. Irradiation of the subventricular zone (SVZ) has recently been discussed as a promising concept as this tissue harbors stem cells which seem to play a role in the initiation and recurrence of GBM. In this study, we retrospectively examined the relationship of SVZ irradiation dose and survival in a large, homogeneous GBM patient cohort.
Impact of prophylactic cranial irradiation and hippocampal sparing on 18F-FDG brain metabolism in small cell lung cancer patients
Shaïma El Chammah,Gilles Allenbach,Raphaël Jumeau,Marie Nicod Lalonde,Niklaus Schaefer,Marie Meyer
doi : 10.1016/j.radonc.2021.02.016
ORIGINAL ARTICLE| VOLUME 158, P200-206, MAY 01, 2021
Prophylactic cranial irradiation (PCI) in small-cell lung cancer (SCLC) patients improves survival. However, it is also associated with cognitive impairment, although the underlying mechanisms remain poorly understood. Our study aims to evaluate the impact of PCI and potential benefit of hippocampal sparing (HS) on brain metabolism assessed by 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT).
Evaluation of interim MRI changes during limited-field radiation therapy for glioblastoma and implications for treatment planning
Comron Hassanzadeh,Soumon Rudra,Sirui Ma,Jian Campian,Christina Tsien,Jiayi Huang
doi : 10.1016/j.radonc.2021.01.040
ORIGINAL ARTICLE| VOLUME 158, P237-243, MAY 01, 2021
Consensus for defining gross tumor volume (GTV) and clinical target volume (CTV) for limited-field radiation therapy (LFRT) of GBM are not well established. We leveraged a department MRI simulator to image patients before and during LFRT to address these questions.
Prognostic factors of colorectal cancer patients with brain metastases
Pauline Roussille,Marie Auvray,Damien Vansteene,Sheik Emambux,Violaine Randrian,David Tougeron
doi : 10.1016/j.radonc.2021.02.006
ORIGINAL ARTICLE| VOLUME 158, P67-73, MAY 01, 2021
Brain metastases (BMs) from colorectal cancer (CRC) are rare (?2%) but are increasing with the improvement of CRC prognosis. The main objective of this study was to evaluate the prognostic factors of BM from CRC.
High expression of krüppel-like factor 10 or Smad4 predicts clinical benefit of adjuvant chemoradiotherapy in curatively resected pancreatic adenocarcinoma: From a randomized phase III trial
Shu-Ling Pen,Yan-Shen Shan,Chin-Fu Hsiao,Ruey-Kuen Hsieh,Li-Tzong Chen,Hui-Ju Ch'ang
doi : 10.1016/j.radonc.2021.02.037
ORIGINAL ARTICLE| VOLUME 158, P146-154, MAY 01, 2021
Our previous studies have demonstrated that Krüppel-like factor 10 (Klf10) modulated tumor radiation resistance and helps to predict clinical outcomes of pancreatic adenocarcinoma (PDAC). This study aimed to evaluate whether the expression levels of Klf10, Smad4 and Runx3 can help predict the benefits of adjuvant chemoradiotherapy (CRT) in resected PDAC.
High incidence of esophageal fistula on patients with clinical T4b esophageal squamous cell carcinoma who received chemoradiotherapy: A retrospective analysis
Baoqing Chen,Meiling Deng,Chen Yang,Yonghong Hu,Yujia Zhu,Qiaoqiao Li
doi : 10.1016/j.radonc.2021.02.031
ORIGINAL ARTICLE| VOLUME 158, P191-199, MAY 01, 2021
Despite definitive chemoradiotherapy (CRT) being a recommended therapeutic method for patients with T4b esophageal squamous cell carcinoma (ESCC), treatment response and complications remain unclear. Esophageal fistula is a severe CRT-related complication when treating locally advanced ESCC, but data on risk factors that lead to esophageal fistula formation are limited. The aim of this analysis is to characterize the outcomes of T4b ESCC treated by CRT and investigate the risk factors of esophageal fistula.
Increasing neutrophil-to-lymphocyte ratio following radiation is a poor prognostic factor and directly correlates with splenic radiation dose in pancreatic cancer
Adam R. Wolfe,Michael Siedow,Ansel Nalin,Aslam Ejaz,Allan Tsung,Terence M. Williams
doi : 10.1016/j.radonc.2021.02.035
ORIGINAL ARTICLE| VOLUME 158, P207-214, MAY 01, 2021
Neutrophil-to-lymphocyte ratio has been correlated with clinical outcomes in many cancers. We investigated whether the delta-NLR (?NLR) following radiation therapy (RT) could predict achieving surgical resection and the overall survival (OS) of patients with borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC), and whether the splenic radiation dose impacted ?NLR.
Liver SBRT with active motion-compensation results in excellent local control for liver oligometastases: An outcome analysis of a pooled multi-platform patient cohort
Susanne Stera,Georgia Miebach,Daniel Buergy,Jens Fleckenstein,Oliver Blanck,Judit Boda-Heggemann
doi : 10.1016/j.radonc.2021.02.036
ORIGINAL ARTICLE| VOLUME 158, P230-236, MAY 01, 2021
Local treatment of metastases in combination with systemic therapy can prolong survival of oligo-metastasized patients. To fully exploit this potential, safe and effective treatments are needed to ensure long-term metastases control. Stereotactic body radiotherapy (SBRT) is one means, however, for moving liver tumors correct delivery of high doses is challenging. After validating equal in-vivo treatment accuracy, we analyzed a pooled multi-platform liver-SBRT-database for clinical outcome.
End to end intussusception anastomosis decreases the risk of anastomotic leakage after neoadjvant chemoradiation and McKeown oesophagectomy
Yutian Lai,Xiaoxiao Zeng,Kun Zhou,Xiaojuan Zhou,Yongmei Liu,Yang Hu
doi : 10.1016/j.radonc.2021.02.030
ORIGINAL ARTICLE| VOLUME 158, P285-292, MAY 01, 2021
To investigate the relationship between the radiation dose to the anastomotic region and postoperative anastomotic leakage rates after McKeown oesophagectomy with cervical anastomosis.
Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study
Jie Lee,Shih-Hua Liu,John Chun-Hao Chen,Yi-Shing Leu,Chung-Ji Liu,Yu-Jen Chen
doi : 10.1016/j.radonc.2021.02.014
ORIGINAL ARTICLE| VOLUME 158, P83-89, MAY 01, 2021
To investigate the association between progressive muscle loss and survival outcomes of patients with advanced-stage oral squamous cell carcinoma (OSCC) undergoing surgery and adjuvant (chemo)radiotherapy.
Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma
Alexandra N. De Leo,Adam L. Holtzman,Meng Wei Ho,Dinesh Rao,Mohammad ASA Hasan,William M. Mendenhall
doi : 10.1016/j.radonc.2021.02.012
ORIGINAL ARTICLE| VOLUME 158, P125-130, MAY 01, 2021
Dose escalation for skull-based chordoma and chondrosarcoma can put critical adjacent structures at risk, specifically the anterior optic pathway. We report the incidence of vision loss following high-dose conformal proton-based radiotherapy.
The impact of delivery daytime and seasonality of radiotherapy for head and neck cancer on toxicity burden
Eliane Koller Brolese,Nikola Cihoric,Beat Bojaxhiu,Daniel M. Aebersold,Roland Giger,Olgun Elicin
doi : 10.1016/j.radonc.2021.02.039
ORIGINAL ARTICLE| VOLUME 158, P162-166, MAY 01, 2021
The potential impact of the daytime and season of radiotherapy application on acute and late toxicity burden was analyzed on a cohort of curatively treated head and neck squamous cell carcinoma patients.
The prognostic impact of daytime and seasonality of radiotherapy on head and neck cancer
Olgun Elicin,Eliane Koller Brolese,Beat Bojaxhiu,Daniel Matthias Aebersold,Roland Giger,Nikola Cihoric
doi : 10.1016/j.radonc.2021.04.004
ORIGINAL ARTICLE| VOLUME 158, P293-299, MAY 01, 2021
The potential impact of daytime and season of radiotherapy application on prognosis is unclear. This was analyzed in a retrospective cohort of patients who were diagnosed with non-metastatic head and neck squamous cell carcinoma (HNSCC) and treated with definitive radiotherapy with or without chemotherapy.
68Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
Liang Zhao,Shanyu Chen,Sijia Chen,Hua Wu,Haojun Chen,Qin Lin
doi : 10.1016/j.radonc.2021.02.015
ORIGINAL ARTICLE| VOLUME 158, P55-61, MAY 01, 2021
To compare 68Ga-fibroblast activation protein inhibitor (FAPI) and 18F-FDG PET/CT in imaging locally advanced oesophageal cancer, and evaluate the potential usefulness of 68Ga-FAPI PET/CT on gross target volume (GTV) delineation aimed at radiotherapy planning for oesophageal cancer as compared with contrast-enhanced CT (CE-CT) and 18F-FDG PET/CT.
Adaptive intensity-modulated radiotherapy with simultaneous integrated boost for stage III non-small cell lung cancer: Is a routine adaptation beneficial?
Yinnan Meng,Wei Luo,Hailing Xu,Zihong Li,Chao Zhou,Haihua Yang
doi : 10.1016/j.radonc.2021.02.019
GUIDELINES| VOLUME 158, P118-124, MAY 01, 2021
Tumor and anatomical changes during radiotherapy have been observed in stage III non-small cell lung cancer (NSCLC) from many previous studies. We hypothesized that a routinely scheduled adaptive radiotherapy would have clinical important dose benefits to lower the risk of toxicities, without increasing the tumor recurrences.
Ablative radiotherapy for ultracentral lung cancers: Dosimetric, geometric, and volumetric predictors of outcomes and toxicity
William G. Breen,Elizabeth B. Jeans,Kimberly R. Gergelis,Kenneth R. Olivier,J. John Lucido III,Dawn Owen
doi : 10.1016/j.radonc.2021.03.001
ORIGINAL ARTICLE| VOLUME 158, P246-252, MAY 01, 2021
Ultracentral lung cancers arise near the proximal bronchial tree (PBT), trachea, or esophagus, and have been associated with worse outcomes and increased toxicity after radiotherapy. We sought to associate dosimetric and anatomic factors with oncologic outcomes and toxicities.
Acute patient-reported intestinal toxicity in whole pelvis IMRT for prostate cancer: Bowel dose-volume effect quantification in a multicentric cohort study
Andrea Bresolin,Adriana Faiella,Elisabetta Garibaldi,Nadia Di Muzio,Claudio Fiorino,Cesare Cozzarini
doi : 10.1016/j.radonc.2021.02.026
GUIDELINES| VOLUME 158, P74-82, MAY 01, 2021
To assess bowel dose-volume relationships for acute patient-reported intestinal symptoms of patients treated with whole-pelvis intensity-modulated radiotherapy (WPRT) for prostate cancer.
Ultra-hypofractionated radiotherapy for low- and intermediate risk prostate cancer: High-dose-rate brachytherapy vs stereotactic ablative radiotherapy
Yat Man Tsang,Hannah Tharmalingam,Katherine Belessiotis-Richards,Robert Hughes,Roberto Alonzi,Peter J Hoskin
doi : 10.1016/j.radonc.2021.02.028
GUIDELINES| VOLUME 158, P184-190, MAY 01, 2021
To compare the biochemical control rates (BCRs), late gastrointestinal (GI) and genitourinary (GU) toxicities in patients with low- and intermediate risk prostate cancer (PCa) treated with high-dose-rate brachytherapy (HDR BT) of 19 Gy/1 fraction, 26 Gy/2 fractions, or stereotactic ablative radiotherapy (SABR) of 36.25 Gy/5 fractions.
Impact of a fiducial marker based ART strategy on margins in postoperative IMRT of gynecological tumors
Monica Buijs,Monique C.W.M. Bloemers,Peter Remeijer
doi : 10.1016/j.radonc.2021.01.039
ORIGINAL ARTICLE| VOLUME 158, P1-6, MAY 01, 2021
To investigate the potential of an offline Adaptive Radiotherapy (ART) strategy, based on the interfractional vagina motion (IVM) measured using fiducial markers (FM) during an initial number of fractions, on the CTV to PTV margins in post-operative gynecological patients.
Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis
Sofia Spampinato,Lars U. Fokdal,Richard P?tter,Kathrin Kirchheiner,Kari Tanderupon behalf of the EMBRACE Collaborative Group
doi : 10.1016/j.radonc.2020.10.003
ORIGINAL ARTICLE| VOLUME 158, P300-308, MAY 01, 2021
To identify patient- and treatment-related risk factors and dose-effects for urinary frequency and incontinence in locally advanced cervical cancer (LACC) treated with radio(chemo)therapy and image-guided adaptive brachytherapy (IGABT).
Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis
Sofia Spampinato,Lars U. Fokdal,Richard P?tter,Kathrin Kirchheiner,Kari Tanderupon behalf of the EMBRACE Collaborative Group
doi : 10.1016/j.radonc.2021.01.019
ORIGINAL ARTICLE| VOLUME 158, P312-320, MAY 01, 2021
To identify patient- and treatment-related risk factors for fistula, bleeding, cystitis, pain and difficulty in voiding in locally advanced cervical cancer patients treated with radio(chemo)therapy and image-guided adaptive brachytherapy (IGABT).
An evaluation of MR based deep learning auto-contouring for planning head and neck radiotherapy
C. Hague,A. McPartlin,L.W. Lee,M. van Herk,C. West,R. Chuter
doi : 10.1016/j.radonc.2021.02.018
GUIDELINES| VOLUME 158, P112-117, MAY 01, 2021
Auto contouring models help consistently define volumes and reduce clinical workload. This study aimed to evaluate the cross acquisition of a Magnetic Resonance (MR) deep learning auto contouring model for organ at risk (OAR) delineation in head and neck radiotherapy.
On the use of low-dimensional temporal subspace constraints to reduce reconstruction time and improve image quality of accelerated 4D-MRI
Nikolai J. Mickevicius,Eric S. Paulson
doi : 10.1016/j.radonc.2020.12.032
ORIGINAL ARTICLE| VOLUME 158, P215-223, MAY 01, 2021
The purpose of this work is to investigate the use of low-dimensional temporal subspace constraints for 4D-MRI reconstruction from accelerated data in the context of MR-guided online adaptive radiation therapy (MRgOART).
Model based patient pre-selection for intensity-modulated proton therapy (IMPT) using automated treatment planning and machine learning
Jasper Kouwenberg,Joan Penninkhof,Steven Habraken,Jaap Zindler,Mischa Hoogeman,Ben Heijmen
doi : 10.1016/j.radonc.2021.02.034
ORIGINAL ARTICLE| VOLUME 158, P224-229, MAY 01, 2021
Patient selection for intensity modulated proton therapy (IMPT), using comparative photon therapy planning, is workload-intensive and time-consuming. Pre-selection aims at avoidance of manual IMPT planning for patients that are in the end ineligible. We investigated the use of machine learning together with automated IMPT treatment planning for pre-selection of head and neck cancer patients, and validated the methodology for the Dutch model based selection (MBS) approach.
Pre-clinical validation of a novel system for fully-automated treatment planning
Rik Bijman,Abdul Wahab Sharfo,Linda Rossi,Sebastiaan Breedveld,Ben Heijmen
doi : 10.1016/j.radonc.2021.03.003
ORIGINAL ARTICLE| VOLUME 158, P253-261, MAY 01, 2021
Many approaches for automated treatment planning (autoplanning) have been proposed and investigated. Autoplanning can enhance plan quality compared to ‘manual’ trial-and-error planning, and decrease routine planning workload. A few approaches have been implemented in commercial treatment planning systems (TPSs). We performed a pre-clinical validation of a new system (‘NovelATP’) that is based on fully-automated multi-criterial optimization (MCO). The aim of NovelATP is to automatically generate for each patient a single high-quality, Pareto-optimal plan without manual Pareto navigation.
Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage
J?rg Pawelke,Michael Brand,Stefan Hans,Michael Schürer,Em?lia Rita Szab?,Elke Beyreuther
doi : 10.1016/j.radonc.2021.02.003
ORIGINAL ARTICLE| VOLUME 158, P7-12, MAY 01, 2021
In consequence of a previous study, where no protecting proton Flash effect was found for zebrafish embryos, potential reasons and requirements for inducing a Flash effect should be investigated with higher pulse dose rate and partial oxygen pressure (pO2) as relevant parameters.
Effectiveness of fractionated carbon ion treatments in three rat prostate tumors differing in growth rate, differentiation and hypoxia
Christin Glowa,Peter Peschke,Stephan Brons,Jürgen Debus,Christian P. Karger
doi : 10.1016/j.radonc.2021.01.038
ORIGINAL ARTICLE| VOLUME 158, P131-137, MAY 01, 2021
To quantify the fractionation dependence of carbon (12C) ions and photons in three rat prostate carcinomas differing in growth rate, differentiation and hypoxia.
Value of functional in-vivo endpoints in preclinical radiation research
Berit Kummer,Steffen L?ck,Kristin Gurtner,Michael Baumann,Mechthild Krause,Christina Jentsch
doi : 10.1016/j.radonc.2021.02.024
GUIDELINES| VOLUME 158, P155-161, MAY 01, 2021
Cancer research faces the problem of high rates of clinical failure of new treatment approaches after positive preclinical data. We hypothesize that a major confounding factor to this problem in radiooncology is the choice of the preclinical endpoint.
Sample-size calculation for preclinical dose–response experiments using heterogeneous tumour models
Willy Ciecior,Nadja Ebert,Nathalie Borgeaud,Michael Baumann,Mechthild Krause,Steffen L?ck
doi : 10.1016/j.radonc.2021.02.032
ORIGINAL ARTICLE| VOLUME 158, P262-267, MAY 01, 2021
In preclinical radio-oncological research, local tumour control is considered the most relevant endpoint as it reflects the inactivation of cancer stem cells. Preclinical tumour-control assays may compare dose–response curves between different radiotherapy strategies, e.g., assessing additional targeted drugs and immunotherapeutic interventions, or between different radiation modalities. To mimic the biological heterogeneity of human tumour populations and to accommodate for approaches of personalized oncology, preclinical studies are increasingly performed combining larger panels of tumour models. For designing the study protocols and to obtain reliable results, prospective sample-size planning has to be developed that accounts for such heterogeneous cohorts.
Determining the incidence of interstitial pneumonitis and chronic kidney disease following full intensity haemopoetic stem cell transplant conditioned using a forward-planned intensity modulated total body irradiation technique
Emily Durie,Emma Nicholson,Chloe Anthias,Westley Ingram,Frank Saran,Henry C. Mandeville
doi : 10.1016/j.radonc.2021.02.020
GUIDELINES| VOLUME 158, P97-103, MAY 01, 2021
Total body irradiation (TBI) remains a key component of conditioning for allogeneic haemopoietic stem cell transplant (HSCT), with interstitial pneumonitis (IP) and chronic kidney disease (CKD) important late sequelae. We undertook a retrospective service evaluation of TBI patients treated with a forward-planned intensity modulated radiotherapy technique (FP IMRT).
Hematological toxicity in patients with solid malignant tumors treated with radiation – Temporal analysis, dose response and impact on survival
Cynthia Terrones-Campos,Bruno Ledergerber,Ivan Richter Vogelius,Marie Helleberg,Lena Specht,Jens Lundgren
doi : 10.1016/j.radonc.2021.02.029
ORIGINAL ARTICLE| VOLUME 158, P175-183, MAY 01, 2021
To describe the kinetics of the peripheral blood components after radiotherapy, to examine radiation exposure vs. End-of-Radiation-Therapy (EoRT) counts and to associate the EoRT lymphocyte count with death and cancer treatment failure.
Letter to the editor regarding the article “Online adaptive MR-guided radiotherapy for rectal cancer; feasibility of the workflow on a 1.5T MR-linac: Clinical implementation and initial experience” by Intven et al
Benedikt Engels,Thierry Gevaert,Mark De Ridder
doi : 10.1016/j.radonc.2021.02.041
LETTER TO THE EDITOR| VOLUME 158, P244-245, MAY 01, 2021
Application of the RATING score: In regards to Hansen et al
Pietro Mancosu,Victor Hernandez,Marco Esposito,Christos Moustakis,Serenella Russo,Oliver Blanck
doi : 10.1016/j.radonc.2020.12.040
LETTER TO THE EDITOR| VOLUME 158, P309-310, MAY 01, 2021
Response to the Letter to the Editor “Application of the RATING score: In regards to Hansen et al.”
Christian R?nn Hansen,Wouter Crijns,Mohammad Hussein,Jan Unkelbach,David Thwaites,Ben Heijmen
doi : 10.1016/j.radonc.2021.01.012
LETTER TO THE EDITOR| VOLUME 158, P311, MAY 01, 2021
In regard to Spampinato et al
Sezin Yuce Sari,Ecem Yigit,Melis Gultekin,Ferah Yildiz
doi : 10.1016/j.radonc.2021.02.027
LETTER TO THE EDITOR| VOLUME 158, P321-322, MAY 01, 2021
Response to Yuce Sari et al.
Sofia Spampinato,Lars U. Fokdal,Richard P?tter,Kathrin Kirchheiner,Kari Tanderupon behalf of the EMBRACE Collaborative Group
doi : 10.1016/j.radonc.2021.02.022
LETTER TO THE EDITOR| VOLUME 158, P323-324, MAY 01, 2021
Letter to the editor regarding Shao et al., exercise therapy for cancer treatment-induced trismus in patients with head and neck cancer: A systematic review and meta-analysis of randomized controlled trials
Yi-Hsiang Chiu,Tyng-Guey Wang
doi : 10.1016/j.radonc.2021.02.025
LETTER TO THE EDITOR| VOLUME 158, P325, MAY 01, 2021
Response to the letter to the editor “Exercise therapy for cancer treatment-induced trismus in patients with head and neck cancer: A systematic review and meta-analysis of randomized controlled trials regards to Chiu et al.”
Tsai-Wei Huang,Chia-Hui Shao,Chia-Chun Chiang
doi : 10.1016/j.radonc.2021.02.023
LETTER TO THE EDITOR| VOLUME 158, P326, MAY 01, 2021
Comments on “Temporal lobe sparing radiotherapy with photons or protons for cognitive function preservation in paediatric craniopharyngioma” by Toussaint, et al.: Prior Similar Field Arrangement Work and a Need for Variable RBE Use
Jeffrey C. Buchsbaum
doi : 10.1016/j.radonc.2020.11.035
LETTER TO THE EDITOR| VOLUME 158, P327-329, MAY 01, 2021
Response to: ‘Comments on “Temporal lobe sparing radiotherapy with photons or protons for cognitive function preservation in paediatric craniopharyngioma” by Toussaint, et al.: Prior similar field arrangement work and a need for variable RBE Use’
Laura Toussaint,Daniel J. Indelicato,Ludvig P. Muren,Zuofeng Li,Yasmin Lassen-Ramshad,Kevin Kirby,Catia Pedro,Ronni Mikkelsen,Marcos Di Pinto,Morten H?yer,Camilla H. Stokkev?g
doi : 10.1016/j.radonc.2021.01.025
LETTER TO THE EDITOR| VOLUME 158, P330-331, MAY 01, 2021
Corrigendum to “Interaction between lymphopenia, radiotherapy technique, dosimetry, and survival outcomes in lung cancer patients receiving combined immunotherapy and radiotherapy” [Radiother Oncol 150 (2020) 114–120]
Dawei Chen,Roshal R. Patel,Vivek Verma,Hampartsoum B. Barsoumian,Maria Angelica Cortez,James W. Welsh
doi : 10.1016/j.radonc.2021.01.017
ERRATUM| VOLUME 158, P332-334, MAY 01, 2021
