Diabetes, Obesity and Metabolism




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Front Cover

Johnny T. K. Cheung MBChB, Aimin Yang PhD, Hongjiang Wu PhD, Eric S. H. Lau PhD, Juliana Lui PhD, Alice P. S. Kong MD, Ronald C. W. Ma MBChB, Andrea O. Y. Luk MD, Elaine Chow PhD, Juliana C. N. Chan MD

doi : 10.1111/dom.15818

Volume 26, Issue 8

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Getting the measure of the pressure: Optimal assessment of the effects of glucagon-like peptide-1 receptor agonists on blood pressure

Karen L. Jones PhD, Chinmay S. Marathe PhD, Tongzhi Wu PhD, Christopher K. Rayner PhD, Michael Nauck MD, Michael Horowitz DSc

doi : 10.1111/dom.15631

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Japan initiates market authorization of weight-loss drug semaglutide under universal health coverage, but with stringent prescription restrictions

Hayase Hakariya PhD, Mutsuko Ohnishi MD, Tetsuya Tanimoto MD

doi : 10.1111/dom.15638

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Identification of diagnostic biomarkers used in the diagnosis of cardiovascular diseases and diabetes mellitus: A systematic review of quantitative studies

Megan Wilson BSc, Abdullah Al-Hamid PhD, Ismail Abbas PhD, Jason Birkett PhD, Iftikhar Khan PhD, Matthew Harper PhD, Dhiya Al-Jumeily OBE PhD, Sulaf Assi PhD

doi : 10.1111/dom.15593

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Once-weekly insulin efsitora alfa: Design and rationale for the QWINT phase 3 clinical development programme

Richard M. Bergenstal MD, Athena Philis-Tsimikas MD, Carol Wysham MD, Molly C. Carr MD, Juliana M. Bue-Valleskey MS, Fady T. Botros PhD, Thomas Blevins MD, Julio Rosenstock MD

doi : 10.1111/dom.15604

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Depression and type 2 diabetes: A causal relationship and mechanistic pathway

Wael Y. Khawagi PhD, Hayder M. Al-kuraishy PhD, Nawar R. Hussein PhD, Ali I. Al-Gareeb PhD, Esraa Atef PhD, Omnya Elhussieny PhD, Athanasios Alexiou PhD, Marios Papadakis PhD, Majid S. Jabir PhD, Abdullah A. Alshehri PhD, Hebatallah M. Saad PhD, Gaber El-Saber Batiha PhD … See fewer authors 

doi : 10.1111/dom.15630

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Obesity-induced tissue alterations resist weight loss: A mechanistic review

Lucio Della Guardia MD, Andrew C. Shin PhD

doi : 10.1111/dom.15637

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Real-world effectiveness of sodium-glucose cotransporter-2 inhibitors on the progression of chronic kidney disease in patients without diabetes, with and without albuminuria

Afif Nakhleh MD, Muhammad Abdul-Ghani MD, Sivan Gazit MD, Adi Gross DVM, Idit Livnat PhD, Maya Greenbloom PhD, Adva Yarden MD, Khaled Khazim MD, Naim Shehadeh MD, Cheli Melzer Cohen MSc … See fewer authors 

doi : 10.1111/dom.15623

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A phase 1, randomized, double-blind, placebo-controlled trial investigating the pharmacokinetics, pharmacodynamics, safety and tolerability of oral semaglutide in healthy Chinese subjects

Panpan Xie MPharm, Morten T. Abildlund MSc, Tine A. Bækdal MSc, Xuemei He MD, Yassine K. Lyauk PhD, Usha Rani H. Patted MD, Zu Ning MD, Aixin Shi PhD

doi : 10.1111/dom.15624

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Gastric emptying in newly diagnosed, treatment-naïve Han Chinese with type 2 diabetes and the impact of 4-week insulin pump therapy

Yixuan Sun MD, Yong Luo PhD, Chunjie Xiang PhD, Cong Xie PhD, Weikun Huang PhD, Zilin Sun PhD, Karen L. Jones PhD, Michael Horowitz PhD, Christopher K. Rayner PhD, Jianhua Ma PhD, Tongzhi Wu PhD … See fewer authors 

doi : 10.1111/dom.15626

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Fluoroquinolones and the risk of severe hypoglycaemia among sulphonylurea users: Population-based cohort study

Jenny Dimakos MD, Ying Cui MSc, Robert W. Platt PhD, Christel Renoux MD, Kristian B. Filion PhD, Antonios Douros MD

doi : 10.1111/dom.15627

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Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors in improvement of fatty liver index in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease: A retrospective nationwide claims database study in Japan

Mitsuhiro Shikamura MPharm, Atsushi Takayama PhD, Masato Takeuchi PhD, Koji Kawakami PhD

doi : 10.1111/dom.15632

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Earlier detection of gestational diabetes impacts on medication requirements, neonatal and maternal outcomes

Omar Alberto Tirado-Aguilar MD, Nayeli Martinez-Cruz MD, Lidia Arce-Sanchez MD, Hector Borboa-Olivares PhD, Enrique Reyes-Muñoz PhD, Salvador Espino-y-Sosa MSc, Jose Rafael Villafan-Bernal PhD, Raigam Jafet Martinez-Portilla PhD, Guadalupe Estrada-Gutierrez PhD, Regina Uribe-Torres MD, Ricardo Daniel Tirado Aguilar MD, Maria Fernanda Lopez-Torres MD, Cecilia Ramos-Mendoza MD, Zaira Alexi Camacho-Martinez MD, Nelson Yesid Aguilar-Jaimes MD, Johnatan Torres-Torres MPH

doi : 10.1111/dom.15633

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Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia

Chunjie Xiang MD, Yixuan Sun MD, Yong Luo PhD, Cong Xie PhD, Weikun Huang PhD, Karen L. Jones PhD, Michael Horowitz PhD, Zilin Sun PhD, Christopher K. Rayner PhD, Jianhua Ma PhD, Tongzhi Wu PhD

doi : 10.1111/dom.15635

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Risks of peri- and postoperative complications with glucagon-like peptide-1 receptor agonists

David C. Klonoff MD, Sun H. Kim MD, Rodolfo J. Galindo MD, Jeffery I. Joseph DO, Valerie Garrett MD, Saurabh Gombar MD, Rachel E. Aaron BA, Tiffany Tian BA, David Kerr MBChB

doi : 10.1111/dom.15636

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Pioglitazone reduces serum ketone bodies in sodium-glucose cotransporter-2 inhibitor-treated non-obese type 2 diabetes: A single-centre, randomized, crossover trial

Min Yang MD, Han Yue MD, Qinqin Xu MD, Shiying Shao MD, Yong Chen MD

doi : 10.1111/dom.15641

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Total and H-specific growth/differentiation factor 15 levels are unaffected by liraglutide or naltrexone/bupropion administration

Sofia K. Konstantinidou MSc, Georgia Argyrakopoulou PhD, Stamatia Simati MD, Konstantinos Stefanakis MD, Alexander Kokkinos PhD, Antonis Analitis, Christos S. Mantzoros PhD

doi : 10.1111/dom.15642

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Once-daily oral small-molecule glucagon-like peptide-1 receptor agonist lotiglipron (PF-07081532) for type 2 diabetes and obesity: Two randomized, placebo-controlled, multiple-ascending-dose Phase 1 studies

Clare Buckeridge PhD, Nikolaos Tsamandouras PhD, Santos Carvajal-Gonzalez PhD, Lisa S. Brown BS, Martha Hernandez-Illas MD, Aditi R. Saxena MD

doi : 10.1111/dom.15643

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A randomized, double-blind trial assessing the efficacy and safety of two doses of dulaglutide in Japanese participants with type 2 diabetes (AWARD-JPN)

Tomoaki Morioka MD, Masakazu Takeuchi PhD, Akichika Ozeki PhD, Masanori Emoto MD

doi : 10.1111/dom.15644

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Cost-utility analysis and drug pricing for tirzepatide for type 2 diabetes in the Chinese market compared with semaglutide

Shanshan Hu MPharm, Chenyang Shi PharmD, Yuhang Ma MD, Shuowen Wang MPharm, Shengying Gu PharmD, Chendong Qi MPharm, Guorong Fan PharmD

doi : 10.1111/dom.15645

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Frequency of prediabetes in individuals with increased adiposity and metabolically healthy or unhealthy phenotypes

Chiara M. A. Cefalo MD, Alessia Riccio MD, Elena Succurro MD, Maria Adelaide Marini MD, Teresa Vanessa Fiorentino MD, Mariangela Rubino MD, Maria Perticone MD, Angela Sciacqua MD, Francesco Andreozzi MD, Giorgio Sesti MD

doi : 10.1111/dom.15646

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Validation of the Individualized Metabolic Surgery score in predicting long-term remission of diabetes after duodenal switch-type procedures

Sultan Almuallem MD, Abdulaziz Karam Ali MD, Phil Vourtzoumis MD, Sebastian Demyttenaere MD, Olivier Court MD, Amin Andalib MD

doi : 10.1111/dom.15647

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Modelling and assessment of glucose-lactate kinetics in youth with overweight, obesity and metabolic dysfunction-associated steatotic liver disease: A pilot study

Jacopo Bonet PhD, Delaney Fox BS, Rafaela Nelson RD, Michael B. Nelson MD, Loretta Nelson MD, Cristina Fernandez MD, Emiliano Barbieri MD, Chiara Dalla Man PhD, Nicola Santoro MD

doi : 10.1111/dom.15648

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Association between recent exposure to continuous glucose monitoring-recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes

Cecilie H. Svensson MD, Therese W. Fabricius MD, Clementine E. M. Verhulst MD, Peter L. Kristensen MD, Cees J. Tack MD, Simon R. Heller MD, Stephanie A. Amiel MD, Rory J. McCrimmon MD, Mark Evans MD, Jens J. Holst MD, Bastiaan E. de Galan MD, Ulrik Pedersen-Bjergaard MD, on behalf of the Hypo-RESOLVE consortium … See fewer authors 

doi : 10.1111/dom.15649

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Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the ORION-9, ORION-10 and ORION-11 Phase 3 randomized trials

Lawrence A. Leiter MD, Frederick J. Raal PhD, Gregory G. Schwartz MD, Wolfgang Koenig MD, Kausik K. Ray FMedSci, Ulf Landmesser MD, Jackie Han MS, Lorena Garcia Conde MD, R. Scott Wright MD

doi : 10.1111/dom.15650

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Association between two novel anthropometric measures and type 2 diabetes in a Chinese population

Di Wang MPH, Ziting Chen MPH, Yinru Wu MSc, Jiaojiao Ren PhD, Dong Shen PhD, Guifang Hu PhD, Chen Mao PhD

doi : 10.1111/dom.15651

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Effect of preceding drug therapy on the renal and cardiovascular outcomes of combined sodium-glucose cotransporter-2 inhibitor and glucagon-like peptide-1 receptor agonist treatment in patients with type 2 diabetes and chronic kidney disease

RECAP study group, Shunichiro Tsukamoto MD, Kazuo Kobayashi MD, Masao Toyoda MD, Atsuhito Tone MD, Daiji Kawanami MD, Daisuke Suzuki MD, Daisuke Tsuriya MD, Hideo Machimura MD, Hidetoshi Shimura MD, Hiromichi Wakui MD, Hiroshi Takeda MD, Hisashi Yokomizo MD, Kei Takeshita MD, Keiichi Chin MD, Keizo Kanasaki MD, Masaaki Miyauchi MD, Masuo Saburi MD, Miwa Morita MD, Miwako Yomota MD, Moritsugu Kimura MD, Nobuo Hatori MD, Shinichi Nakajima MD, Shun Ito MD, Takashi Murata MD, Takaya Matsushita MD, Takayuki Furuki MD, Takuya Hashimoto MD, Tomoya Umezono MD, Yoshimi Muta MD, Yuichi Takashi MD, Kouichi Tamura MD … See fewer authors 

doi : 10.1111/dom.15652

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Cardiometabolic factors and population risks of cardiovascular disease in community-dwelling adults with varied blood pressure statuses

Weida Qiu MD, Anping Cai MD, Zhiqiang Nie MD, Jiabin Wang MD, Yanqiu Ou MD, Yingqing Feng MD

doi : 10.1111/dom.15653

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Determinants of serious health outcome-free status in middle-aged and older people with dysglycaemia: Exploratory analysis of the ORIGIN trial

Kamel Mohammedi MD, Sibylle Hess PhD, Matthew McQueen MD, Marie Pigeyre MD, Shun Fu Lee PhD, Guillaume Pare MD, Hertzel C. Gerstein MD

doi : 10.1111/dom.15654

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Metformin use associated with lower rate of hospitalization for influenza in individuals with diabetes

Elizabeth Greene MD, Cynthia L. Green PhD, Jillian Hurst PhD, Nancie J. MacIver MD

doi : 10.1111/dom.15655

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A prospective observational study to evaluate a possible relationship between vitamin K antagonist therapy and risk of peripheral arterial disease in patients with type 2 diabetes

Olivier Bourron MD, Kamel Mohammedi MD, Joe De Keizer MSc, Fabrice Schneider MD, Samy Hadjadj MD, Pierre-Jean Saulnier MD

doi : 10.1111/dom.15656

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Development and first-stage validation of a digital version of the Digit Symbol Substitution test for use in assessing cognitive function in older people with diabetes

Omri Segev BMedSc, Itamar Raz MD, Hertzel C. Gerstein MD, Hillel Aviezer PhD, Yael Sela PhD, Dani Cukierman MBA, Rahul Shankar BSc, Rachel Natovich PhD, Tali Cukierman-Yaffe MD

doi : 10.1111/dom.15657

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Effects of gut microbiome on type 1 diabetes susceptibility and complications: A large-scale bidirectional Mendelian randomization and external validation study

Keyu Guo MD, Jianan Ye MD, Jiaqi Li MD, Juan Huang MD, Zhiguang Zhou MD

doi : 10.1111/dom.15658

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Cross-sectional association of continuous glucose monitoring-derived metrics with cerebral small vessel disease in older adults with type 2 diabetes

Taiki Sugimoto PhD, Naoki Saji MD, Takuya Omura MD, Haruhiko Tokuda MD, Hisayuki Miura MD, Shuji Kawashima MD, Takafumi Ando PhD, Akinori Nakamura MD, Kazuaki Uchida PhD, Nanae Matsumoto PhD, Kosuke Fujita PhD, Yujiro Kuroda PhD, Paul K. Crane MD, Takashi Sakurai MD … See fewer authors 

doi : 10.1111/dom.15659

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The prognostic value of metabolic dysfunction-associated steatotic liver disease in acute myocardial infarction: A propensity score-matched analysis

Gwyneth Kong MBBS, Grace Cao MBBS, Jaycie Koh MBBS, Siew Pang Chan PhD, Audrey Zhang MBBS, Esther Wong MBBS, Bryan Chong MBBS, Silingga Metta Jauhari PhD, Jiong-Wei Wang PhD, Anurag Mehta MD, Gemma A. Figtree MBBS, Mamas A. Mamas MBChB, Gavin Ng MBBS, Koo Hui Chan MBBS, Ping Chai MBBS, Adrian F. Low MBBS, Chi Hang Lee MBBS, Tiong Cheng Yeo MBBS, James Yip MBBS, Roger Foo MBBS, Huay Cheem Tan MBBS, Daniel Q. Huang MBBS, Mark Muthiah MBBS, Mark Yan-Yee Chan PhD, Poay-Huan Loh MBChB, Nicholas W. S. Chew MBChB

doi : 10.1111/dom.15660

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Association of dipeptidyl peptidase-4 inhibitor initiation at glycated haemoglobin <7.5% with reduced major clinical events mediated by low glycated haemoglobin variability

Johnny T. K. Cheung MBChB, Aimin Yang PhD, Hongjiang Wu PhD, Eric S. H. Lau PhD, Juliana Lui PhD, Alice P. S. Kong MD, Ronald C. W. Ma MBChB, Andrea O. Y. Luk MD, Elaine Chow PhD, Juliana C. N. Chan MD

doi : 10.1111/dom.15662

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Long-term changes in frailty and incident type 2 diabetes: A prospective cohort study based on the UK Biobank

Ying Sun MD, Weihao Li MD, Yinuo Zhou MD, Bin Wang PhD, Xiao Tan PhD, Yingli Lu MD, Jingjing Zhu MD, Wentao Shi PhD, Ningjian Wang MD

doi : 10.1111/dom.15676

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Differential associations of risk factors with severe and non-severe hypoglycaemia: the Hypoglycaemia Assessment Tool prospective observational study in people with insulin-treated type 1 diabetes and type 2 diabetes

Ying He PhD, Setor K. Kunutsor PhD, Andrew P. Kingsnorth PhD, Clare Gillies PhD, Pratik Choudhary MBBS, Kamlesh Khunti PhD, Francesco Zaccardi PhD

doi : 10.1111/dom.15677

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Machine learning for prediction of chronic kidney disease progression: Validation of the Klinrisk model in the CANVAS Program and CREDENCE trial

Navdeep Tangri MD, Thomas W. Ferguson MSc, Ryan J. Bamforth MSc, Silvia J. Leon MSc, Clare Arnott MD, Kenneth W. Mahaffey MD, Sradha Kotwal MD, Hiddo J. L. Heerspink MD, Vlado Perkovic MD, Robert A. Fletcher MSc, Brendon L. Neuen MD

doi : 10.1111/dom.15678

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Real world use of tirzepatide in the treatment of type 2 diabetes in an Arab population

Adam Buckley PhD, Sara Suliman PhD, Matthew Allum MD, Nagi Mohammed MD, Nader Lessan MD, Carel W. le Roux PhD, Mohamed Suliman MD

doi : 10.1111/dom.15680

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Cumulative effect of metabolic risk factors on left ventricular geometry in those with versus without early-onset type 2 diabetes or prediabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) study

Yilin Yoshida PhD, Yuanhao Zu MS, Bingbing Fan PhD, Shengxu Li MD, Tadashi Yoshida PhD, Emily Harville PhD, Tao Zhang PhD, Sejong Bae PhD, James Shikany DrPH, Vivian A. Fonseca MD

doi : 10.1111/dom.15681

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Comparative safety and cardiovascular effectiveness of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in nursing homes

Melissa R. Riester PharmD, Andrew R. Zullo PharmD, Richa Joshi MS, Lori A. Daiello PharmD, Kaleen N. Hayes PharmD, Darae Ko MD, Dae Hyun Kim MD, Medha Munshi MD, Sarah D. Berry MD

doi : 10.1111/dom.15682

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Moderate resistance training reduces intermuscular adipose tissue and risk factors of atherosclerotic cardiovascular disease for elderly patients with type 2 diabetes

Fangli Tang MS, Wenjun Wang PhD, Ying Wang MS, Yaujiunn Lee PhD, Qingqing Lou MD

doi : 10.1111/dom.15684

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Plasma fatty acid esters of hydroxy fatty acids and surrogate fatty acid esters of hydroxy fatty acids hydrolysis activity in children with or without obesity and in adults with or without coronary artery disease

Sze Min Ong BSc, Daniel Zhi Wei Ng BSc, Thaddeus En Zhe Chee, Andrew Anjian Sng MBBS, Chew Kiat Heng PhD, Yung Seng Lee MBBS, Eric Chun Yong Chan PhD, Delicia Shu Qin Ooi PhD

doi : 10.1111/dom.15686

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Integrated biomarker profiling for predicting the response of type 2 diabetes to metformin

Jianglan Long MD, Qiushi Fang MS, Zhe Shi MS, Zenghui Miao MS, Dan Yan MD

doi : 10.1111/dom.15689

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Utilizing synchronous care to improve cardiovascular and renal health among patients with type 2 diabetes: Proof-of-concept results from the DECIDE-CV clinical programme

Pedro Marques MD, Thomas A. Mavrakanas MD, Julian Guida BSc, Tara Gédéon MD, Anahita Emami MD, Abdulkhaliq Alaamiri MD, Daniel Ho MD, Elite Possik PhD, Guang Zhang MSc, Michael A. Tsoukas MD, Abhinav Sharma MD … See fewer authors 

doi : 10.1111/dom.15691

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Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B-type natriuretic peptide hormone: Results from a randomized controlled crossover study

Katherine N. Bachmann MD, Ryan P. Ceddia PhD, Deepak K. Gupta MD, Sheila Collins PhD, Thomas J. Wang MD

doi : 10.1111/dom.15628

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Real-world data from first UK Omnipod 5 users: A single-centre observational study

Aisha Aslam MRCP(UK), Alyson Chapman RN, Andrea Urwin RN, Sheetal Ohol RN, Sonia Thomas RN, Rebecca Gough RN, Lynne-Ann Findlow RN, Jonathan Lim PhD, Jonathan Schofield PhD, Lalantha Leelarathna PhD, Hood Thabit PhD … See fewer authors 

doi : 10.1111/dom.15629

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Empagliflozin mitigates metabolic dysfunction-associated steatotic liver disease by reducing de novo lipogenesis in a mouse model of lipoatrophic diabetes

Sarra Smati MD, Thibaud Sotin MSc, Perrine Deniel MSc, Simon Ducheix PhD, Michael Joubert MD, Lucie Arnaud BA, Samy Hadjadj MD, Bertrand Cariou MD, Cédric Le May PhD, Xavier Prieur PhD

doi : 10.1111/dom.15634

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A comparative study of the effects of imeglimin add-on or metformin dose escalation on glycaemic variability in subjects with type 2 diabetes treated with low-dose metformin (MEGMI-CGM study)

Akihiro Takahashi MD, Hiroshi Nomoto MD, Kinnosuke Onishi MD, Satoru Manda MD, Aika Miya MD, Hiraku Kameda MD, Akinobu Nakamura MD, Tatsuya Atsumi MD

doi : 10.1111/dom.15639

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Real-world evidence for computerized insulin dose-adjustment algorithms in the effective use of continuous glucose monitoring by primary care clinicians

Mayer B. Davidson MD, S. Joshua Davidson BA

doi : 10.1111/dom.15679

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Hypoglycaemia and kidney events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: Observations from the VERTIS CV trial

Ayodele Odutayo MD, Francesco Cosentino MD, Richard E. Pratley MD, Samuel Dagogo-Jack MD, Darren K. McGuire MD, Robert Frederich MD, Wei Fu ScM, Christopher P. Cannon MD, David Z. I. Cherney MD, VERTIS CV Investigators … See fewer authors 

doi : 10.1111/dom.15687

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Impact of the basal/bolus ratio on continuous glucose monitoring parameters in patients with type 1 diabetes

Tomás González-Vidal MD, Diego Rivas-Otero MD, Guillermo Ramos-Ruiz MD, Pablo Agüeria-Cabal MD, Carmen Lambert PhD, Jessica Ares PhD, Elías Delgado PhD, Edelmiro Menéndez-Torre PhD

doi : 10.1111/dom.15690

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The daunting task of recruiting insulin-treated patients living with type 2 diabetes mellitus for intensive lifestyle interventions

Cathy J. Sun, Élisabeth Nguyen, Marc Prentki PhD, Rémi Rabasa-Lhoret

doi : 10.1111/dom.15688

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