Diabetes, Obesity and Metabolism




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Front Cover

Lixin Guo MD, Fengsheng Tian MM, Li Liu MM, Mingwei Chen MD, Chengxia Jiang BS, Shuangqing Li MM, Cong Liu MD, Yawei Zhang BS, Jie Qin MD, Dongni Yu MM, Yicen Zong MM, Wei Dai PhD

doi : 10.1111/dom.15720

Volume 26, Issue 7

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The need for registry-based studies in diabetes and stroke: A unique opportunity to understand whether diabetic treatments improve post-stroke outcome

Vladimer Darsalia PhD, Ellen Vercalsteren PhD, Dimitra Karampatsi MSc, Mihaela Oana Romanitan MD, Michael V. Mazya MD, Thomas Nyström MD, Cesare Patrone PhD

doi : 10.1111/dom.15577

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An update review of post-transplant diabetes mellitus: Concept, risk factors, clinical implications and management

Mehmet Kanbay MD, Sidar Copur MD, A. Umur Topçu MD, Mustafa Guldan MD, Lasin Ozbek MD, Abduzhappar Gaipov MD, Charles Ferro MD, Mario Cozzolino MD, David Z. I. Cherney MD, Katherine R. Tuttle MD

doi : 10.1111/dom.15575

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A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications

Mahmoud Abuawwad BM, Ameya Tibude MBBS, Devinder Bansi BM, Iskandar Idris BMBS, Brijesh Madhok MBBS

doi : 10.1111/dom.15613

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The sclerotic component of metabolic syndrome: Fibroblast activities may be the central common denominator driving organ function loss and death

Alexander Lynge Reese-Petersen PhD, Signe Holm Nielsen PhD, Jannie Marie Bülow Sand PhD, Jörn M. Schattenberg MD, Elisabetta Bugianesi MD, Morten A. Karsdal PhD

doi : 10.1111/dom.15615

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Cardiorenal outcomes and mortality after sodium-glucose cotransporter-2 inhibitor initiation in type 2 diabetes patients with percutaneous coronary intervention history

Jin Hwa Kim MD, Young Sang Lyu MD, BongSeong Kim PhD, Mee Kyung Kim MD, Sang Yong Kim MD, Ki-Hyun Baek MD, Ki-Ho Song MD, Kyungdo Han PhD, Hyuk-Sang Kwon MD

doi : 10.1111/dom.15565

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Impact of empagliflozin on insulin needs in patients with heart failure and diabetes: An EMPEROR-Pooled analysis

Khawaja M. Talha MBBS, Jennifer Green MD, Gerasimos Filippatos MD, Stuart Pocock PhD, Faiez Zannad MD, Martina Brueckmann MD, Elke Schueler, Anne Pernille Ofstad MD, João Pedro Ferreira MD, Stefan D. Anker MD, Javed Butler MD, Julio Rosenstock MD, Milton Packer MD

doi : 10.1111/dom.15572

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The effect of renal function on the pharmacokinetics and pharmacodynamics of enavogliflozin, a potent and selective sodium-glucose cotransporter-2 inhibitor, in type 2 diabetes

Sae Im Jeong MD, Mu Seong Ban MD, Jun-Gi Hwang MD, Min-Kyu Park MD, Soo Lim MD, Sejoong Kim MD, Soon Kil Kwon MD, Yoonjin Kim MD, Jae Min Cho PhD, Jae Jin Na BS, Wan Huh MS, Jae-Yong Chung MD

doi : 10.1111/dom.15573

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Healthy Outcomes through Peer Educators: Feasibility of a peer support diabetes prevention programme for African-American grandmother caregivers

Eva M. Vivian PharmD, Betty A. Chewning PhD, Corrine I. Voils PhD, Roger L. Brown PhD

doi : 10.1111/dom.15574

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Effect of combination pioglitazone with sodium-glucose cotransporter-2 inhibitors or glucagon-like peptide-1 receptor agonists on outcomes in type 2 diabetes: A systematic review, meta-analysis, and real-world study from an international federated database

Matthew Anson MBBS, Alex E. Henney MBChB, Sizheng S. Zhao PhD, Gema H. Ibarburu PhD, Gregory Y. H. Lip PhD, Daniel J. Cuthbertson PhD, Katarzyna Nabrdalik PhD, Uazman Alam PhD

doi : 10.1111/dom.15576

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Artificial intelligence-enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes

Krzysztof Irlik, Hanadi Aldosari MSc, Mirela Hendel, Hanna Kwiendacz PhD, Julia Piaśnik, Justyna Kulpa, Paweł Ignacy MBBS, Sylwia Boczek, Mikołaj Herba, Kamil Kegler, Frans Coenen PhD, Janusz Gumprecht PhD, Yalin Zheng PhD, Gregory Y. H. Lip MD, Uazman Alam PhD, Katarzyna Nabrdalik PhD … See fewer authors 

doi : 10.1111/dom.15578

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Dual glucagon-like peptide-1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesity

Rajna Golubic MD, Jane Kennet RN, Victoria Parker MBBS, Darren Robertson PhD, Dan Luo PhD, Lars Hansen MD, Lutz Jermutus MD, Phil Ambery MBChB, Maria Ryaboshapkina MS, Manasa Surakala MTech, Rhianna C. Laker PhD, Michelle Venables PhD, Albert Koulman PhD, Adrian Park MBBS, Mark Evans MD … See fewer authors 

doi : 10.1111/dom.15579

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Combined intake of caffeine and low-dose glucose to reduce exercise-related hypoglycaemia in individuals with type 1 diabetes on ultra-long-acting insulin degludec: A randomized, controlled, double-blind, cross-over trial

Tobias Kühne MD, Esmè Wallace MS, David Herzig PhD, Simon Helleputte PhD, Sam Scott PhD, Jordan Pickles PhD, Andreas Melmer MD, Christoph Stettler MD

doi : 10.1111/dom.15580

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Safety and efficacy of teplizumab in the treatment of type 1 diabetes mellitus: An updated systematic review and meta-analysis of randomized controlled trials

Gabriel Grando Alves, Luisa Cunha MD, Rafael Henkes Machado, Vanessa Lins de Menezes MD

doi : 10.1111/dom.15581

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Sleep duration and association with cardiometabolic health in adolescents and adults with type 1 diabetes: Results from the BCQR-T1D study

Stacey L. Simon PhD, Janet K. Snell-Bergeon PhD, Michal Schäfer PhD, Alex J. Barker PhD, Lorna P. Browne MD, Uyen Truong MD, Shoshana S. Tell MD, Timothy Vigers MS, Amy D. Baumgartner MS, Ellen Lyon PhD, Sarit Polsky MD, Irene E. Schauer MD, Kristen J. Nadeau MS … See fewer authors 

doi : 10.1111/dom.15582

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Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study

Ze-Gui Huang PhD, Jing-Wei Gao PhD, Hai-Feng Zhang PhD, Si You MD, Zhuo-Chao Xiong PhD, Yu-Biao Wu MD, Da-Chuan Guo MD, Jing-Feng Wang PhD, Yang-Xin Chen PhD, Shao-Ling Zhang PhD, Pin-Ming Liu PhD … See fewer authors 

doi : 10.1111/dom.15583

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Patterns of initial and first-intensifying antidiabetic drug utilization among patients with type 2 diabetes mellitus in Scotland, 2010–2020: A retrospective population-based cohort study

Fatema Mahmoud PhD, Tanja Mueller PhD, Alexander Mullen PhD, Christopher Sainsbury MD, Gordon F. Rushworth PhD, Amanj Kurdi PhD

doi : 10.1111/dom.15584

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Gamma-aminobutyric acid supplementation improves olanzapine-induced insulin resistance by inhibiting macrophage infiltration in mice subcutaneous adipose tissue

Lulu Ren MD, Lingling Xuan MD, Anning Li MD, Yaqi Yang MS, Wen Zhang MD, Jie Zhang MD, Yi Zhang MD, Zhuoling An MD

doi : 10.1111/dom.15585

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The effect of sodium-glucose cotransporter-2 inhibitors on inflammatory biomarkers: A meta-analysis of randomized controlled trials

Leonardo Buttice BSc, Maryam Ghani BSc, Janahan Suthakar BSc, Sathyan Gnanalingham BSc, Elliott Carande BM BCh, Brett W. C. Kennedy BM BCh, Alex Pitcher BM BCh, James H. P. Gamble MD, Mahmood Ahmad MBBS, Andrew Lewis DPhil, Peter Jüni MD, Oliver J. Rider DPhil, Jeffrey W. Stephens PhD, Jonathan J. H. Bray MBChB … See fewer authors 

doi : 10.1111/dom.15586

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Prediction of cardiovascular risk factors from retinal fundus photographs: Validation of a deep learning algorithm in a prospective non-interventional study in Kenya

Tom White PhD, Viknesh Selvarajah PhD, Fredrik Wolfhagen-Sand PhD, Nils Svangård MSc, Gayathri Mohankumar MS, Peter Fenici MD, Kathryn Rough ScD, Nelson Onyango PhD, Kendall Lyons MPH, Christina Mack PhD, Videlis Nduba PhD, Mansoor Noorali Saleh MD, Innocent Abayo BSc, Afrah Siddiqui MBBS, Malgorzata Majdanska-Strzalka MPharm, Katarzyna Kaszubska PhD, Tove Hegelund-Myrback PhD, Russell Esterline PhD, Antonio Manzur BS, Victoria E. R. Parker PhD

doi : 10.1111/dom.15587

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Improved glycaemic control induced by evening activity breaks does not persist overnight amongst healthy adults: A randomized crossover trial

Jennifer T. Gale MDiet, Jillian J. Haszard PhD, Meredith C. Peddie PhD

doi : 10.1111/dom.15589

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Prediction of new-onset heart failure in patients with type 2 diabetes derived from ALTITUDE and CANVAS

Fatema Said MD, Clare Arnott MD, Adriaan A. Voors MD, Hiddo J. L. Heerspink MD, Jozine M. ter Maaten MD

doi : 10.1111/dom.15592

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Time trends and regional variation in utilization of antidiabetic medicines in China, 2015–2022

Jieqiong Zhang, Sen Xu PhD, Xingyu Liu, Jinwei Zhang, Shuchen Hu, Xiaoyong Liu, Caijun Yang PhD, Yu Fang PhD

doi : 10.1111/dom.15594

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C-peptide index at 2 h post-meal is a useful predictor of endogenous insulin secretory capacity and withdrawal from insulin therapy in subjects with type 2 diabetes

Yuichiro Iwamoto MD, Tomohiko Kimura MD, Masashi Shimoda MD, Yuichi Morimoto MD, Yuki Watanabe MD, Takashi Itoh MD, Taku Sasaki MD, Shigehito Mori MD, Masato Kubo MD, Haruka Takenouchi MD, Kazunori Dan MD, Hideyuki Iwamoto MD, Junpei Sanada MD, Yoshiro Fushimi MD, Yukino Katakura MD, Shuhei Nakanishi MD, Tomoatsu Mune MD, Kohei Kaku MD, Hideaki Kaneto MD

doi : 10.1111/dom.15595

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Combination of retagliptin and henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, active-controlled, phase 3 trial

Yao Wang MM, Chengxia Jiang MB, Xiaolin Dong MD, Mingwei Chen MD, Qin Gu MM, Lihui Zhang MM, Yanqin Fu MM, Tianrong Pan MM, Yan Bi MD, Weihong Song MB, Jing Xu MA, WeiPing Lu MD, Xiaodong Sun MD, Zi Ye MD, Danli Zhang MM, Liang Peng MD, Xiang Lin MA, Wei Dai PhD, Quanren Wang PhD, Wenying Yang MD

doi : 10.1111/dom.15596

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Geographic variation in sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide-1 receptor agonist use in people with type 2 diabetes in New South Wales, Australia

Juliana de Oliveira Costa PhD, Jialing Lin PhD, Tamara Y. Milder FRACP, Jerry R. Greenfield FRACP, Richard O. Day FRACP, Sophie L. Stocker PhD, Brendon L. Neuen PhD, Alys Havard PhD, Sallie-Anne Pearson PhD, Michael O. Falster PhD

doi : 10.1111/dom.15597

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Investigating the causal association of generalized and abdominal obesity with microvascular complications in patients with type 2 diabetes: A community-based prospective study

Jiaheng Chen MM, Yu Ting Li MPH, Zimin Niu MM, Zhanpeng He MD, Yao Jie Xie PhD, Jose Hernandez DPhil, Wenyong Huang MD, Harry H X Wang PhD, The Guangzhou Diabetic Eye Study Group

doi : 10.1111/dom.15598

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Real-world effectiveness and safety of insulin glargine 100 U/mL plus lixisenatide in adults with type 2 diabetes: An international, multicentre, 12-month, prospective observational study

Rayaz A. Malik PhD, Chii-Min Hwu MD, Anwar A. Jammah MD, Juan M. Arteaga-Díaz MD, Khier Djaballah MD, Valerie Pilorget MD, Agustina Alvarez MD, Carine Vera PhD, Olga Vikulova PhD

doi : 10.1111/dom.15599

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Association of single-point insulin sensitivity estimator index (SPISE) with future cardiovascular outcomes in patients with type 2 diabetes

Simin Deng MD, Xinqun Hu MD, Xiangyu Zhang MD

doi : 10.1111/dom.15600

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Retagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, placebo-controlled, phase 3 trial

Lixin Guo MD, Fengsheng Tian MM, Li Liu MM, Mingwei Chen MD, Chengxia Jiang BS, Shuangqing Li MM, Cong Liu MD, Yawei Zhang BS, Jie Qin MD, Dongni Yu MM, Yicen Zong MM, Wei Dai PhD

doi : 10.1111/dom.15601

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A meta-analysis of the association between RBP4 rs3758539 genotype and metabolic syndrome factors

Wen-Chieh Wu PhD, Pei-Yu Wu PhD, Ming-Fen Lee PhD, Chin-Ming Chang MS, Chien-Yi Chan PhD, Chun-Yin Huang PhD

doi : 10.1111/dom.15602

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Smoking timing, genetic susceptibility and the risk of incident type 2 diabetes: A cohort study from the UK Biobank

Ying Hu MD, Xiang Li MD, Xuan Wang MD, Hao Ma MD, Jian Zhou MD, Rui Tang MS, Minghao Kou MHS, Yoriko Heianza PhD, Zhaoxia Liang MD, Lu Qi MD

doi : 10.1111/dom.15603

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Biotransformation and disposition characteristics of HSK7653, a novel long-acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

Yi-cong Bian MS, Jian Meng PhD, Tao Hu MS, Sheng Ma MS, Chen-rong Huang PhD, Feng-yi Zhang MD, Qing-he Wu MD, Hua Zhang MS, Xiao-yan Chen PhD, Li-yan Miao MD

doi : 10.1111/dom.15605

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Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China

Jian Su MM, Xikang Fan PhD, Mengyao Li MB, Hao Yu PhD, Houyue Geng MB, Yu Qin PhD, Yan Lu MM, Pei Pei MB, Dianjianyi Sun PhD, Canqing Yu PhD, Jun Lv PhD, Ran Tao PhD, Jinyi Zhou MM, Hongxia Ma PhD, Ming Wu PhD

doi : 10.1111/dom.15606

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Continuous glucose monitoring for glycaemic control and cardiovascular risk reduction in patients with type 2 diabetes not on insulin therapy: A clinical trial

Joseph Reed MD, Tony Dong MD, Elke Eaton RN, Janice Friswold RDN, Jodie Porges MS, Sadeer G. Al-Kindi MD, Sanjay Rajagopalan MD, Ian J. Neeland MD

doi : 10.1111/dom.15608

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Adiposity indicators exhibit depot- and sex-specific associations with multimorbidity onset: A cohort study of the UK Biobank

Lu Ma PhD, Ying Li MD, Gaixia Li MD, Jiajun Sun MD, Xueli Zhang PhD, Zumin Shi PhD, Yating Yan MD, Yutian Duan BA, Jing Wang PhD, Zengbin Li MD, Lei Zhang PhD

doi : 10.1111/dom.15610

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Factors affecting the sodium-glucose cotransporter 2 inhibitors-related initial decline in glomerular filtration rate and its possible effect on kidney outcome in chronic kidney disease with type 2 diabetes: The Japan Chronic Kidney Disease Database

Tomohiko Kanaoka MD, Hiromichi Wakui MD, Yuichiro Yano MD, Hajime Nagasu MD, Hiroshi Kanegae BSc, Masaomi Nangaku MD, Yosuke Hirakawa MD, Naoki Nakagawa MD, Jun Wada MD, Kazuhiko Tsuruya MD, Toshiaki Nakano MD, Shoichi Maruyama MD, Takashi Wada MD, Masaaki Konishi MD, Takanori Nagahiro MD, Kunihiro Yamagata MD, Ichiei Narita MD, Motoko Yanagita MD, Yoshio Terada MD, Shinichi Araki MD, Masanori Emoto MD, Hirokazu Okada MD, Yoshitaka Isaka MD, Yusuke Suzuki MD, Takashi Yokoo MD, Hiromi Kataoka PhD, Eiichiro Kanda MD, Naoki Kashihara MD, Kouichi Tamura MD, for the J-CKD-DB investigators … See fewer authors 

doi : 10.1111/dom.15611

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Association of gestational diabetes with long-term risk of premature mortality, and cardiovascular outcomes and risk factors: A retrospective cohort analysis in the UK Biobank

Moscho Michalopoulou DPhil (Oxon), Carmen Piernas PhD, Susan A. Jebb PhD, Min Gao PhD, Nerys M. Astbury PhD

doi : 10.1111/dom.15612

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Cross-sectional, case-control and longitudinal associations between exposure to glucagon-like peptide-1 receptor agonists and the dispensing of antidepressants

Osvaldo P. Almeida PhD, Zheng Fong MBBS, Lydia M. Hill Almeida MD, Frank M. Sanfilippo PhD, Amy Page PhD, Christopher Etherton-Beer PhD

doi : 10.1111/dom.15616

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Prescription medication use among patients with type 2 diabetes in the United States: 1999–2020

Shanshan Li MS, Shaoxi Pan BS, Shaoxiang Jiang PhD, Jung-Im Shin MD, Gordon G. Liu PhD, Beini Lyu MD

doi : 10.1111/dom.15619

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Effect of semaglutide 2.4 mg on physical functioning and weight- and health-related quality of life in adults with overweight or obesity: Patient-reported outcomes from the STEP 1–4 trials

Domenica Rubino MD, Jakob B. Bjorner MD, Naveen Rathor MD, Arya M. Sharma MD, Lisa von Huth Smith PhD, Sean Wharton MD, Thomas Wadden PhD, Niels Zeuthen MSc, Ronette L. Kolotkin PhD

doi : 10.1111/dom.15620

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Adenosine kinase inhibits β-cell proliferation by upregulating DNA methyltransferase 3A expression

Ting Chen MD, Jiayu Yu MD, Xin Guo PhD, Siqi Wang MD, Zhihua Wang MD, Yang Chen MD, Xiang Hu MD, Huiqing Li MD, Lulu Chen MD, Juan Zheng MD

doi : 10.1111/dom.15621

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Factors associated with treatment responses to pioglitazone in patients with steatotic liver disease: A 3-year prospective cohort study

Ming-Ling Chang MD, Jennifer Tai MD, Jur-Shan Cheng PhD, Wei-Ting Chen MD, Sien-Sing Yang MD, Cheng-Hsun Chiu MD, Rong-Nan Chien MD

doi : 10.1111/dom.15622

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Real-world treatment satisfaction with dulaglutide, and its influencing factors, in a Chinese population with type 2 diabetes mellitus

Lixin Guo MD, Yue Xi MD, Li Li MD, Kunquan Guo MD, Jun Wu MD, Jiawei Xu MD, Yihua Wang MD, Guangyu Wu MD, Si Si MD

doi : 10.1111/dom.15590

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Effectiveness and care continuity in an app-based, glucagon-like peptide-1 receptor agonist-supported weight-loss service for women with overweight and obesity in the UK: A real-world retrospective cohort analysis

Louis Talay PhD, Matt Vickers MD

doi : 10.1111/dom.15607

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Real-life effectiveness of iGlarLixi (insulin glargine 100 U/mL and lixisenatide) in people with type 2 diabetes according to prior insulin use

Jochen Seufert MD, Nick Freemantle PhD, Cristian Guja MD, Martin Haluzík MD, Mathilde Tournay MS, Carine Vera PhD, Mireille Bonnemaire MD, Janos T. Kis MD

doi : 10.1111/dom.15609

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Body mass index and remote ischaemic conditioning efficacy in acute ischaemic stroke patients: A post hoc analysis of the Remote Ischaemic Conditioning for Acute Moderate Ischaemic Stroke (RICAMIS) trial

Xiao-Yu Sun MD, Hui-Ling Qu MD, Hui-Sheng Chen MD

doi : 10.1111/dom.15614

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A comment on ‘Glucagon-like peptide-1 receptor agonists and risk of thyroid cancer: A systematic review and meta-analysis of randomized controlled trials’

Ronald M. Goldenberg MD

doi : 10.1111/dom.15588

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Correction to “Defining diabetes status using medication groups in Medicare data: Trends in prescribing diabetes medications to patients without a diabetes diagnosis over time�

doi : 10.1111/dom.15618

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