One-year access to more than 500 world journals available in the system
-
http://medilib.ir
- Duration of Time : 365 Day
Price : 300$- Special Price : 100$
Spotlight on the July 27 Issue
Merino, Jose G. MD, MPhil; Editor-in-Chief, Neurology(R)
doi : 10.1212/WNL.0000000000012338
Volume 97(4), 27 July 2021, p 153-154
Is Late-Onset Alzheimer Disease Spelled "ATV(N)"?
Hughes, Timothy M.; Hajjar, Ihab
doi : 10.1212/WNL.0000000000012259
Volume 97(4), 27 July 2021, p 155-156
Magnesium and Intracranial Aneurysms: Not Only Acute Subarachnoid Hemorrhage
Pera, Joanna MD, PhD; Anderson, Christopher D. MD, MMSc
doi : 10.1212/WNL.0000000000012247
Volume 97(4), 27 July 2021, p 157-158
Outside, Inside, Inside, Out: Different Genes Contribute to Cardioembolic Stroke in Indian Populations
Nyquist, Paul MD, MPH; Lefebvre, Austen MD
doi : 10.1212/WNL.0000000000012260
Volume 97(4), 27 July 2021, p 159-160
Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration
Moore, Elizabeth E. PhD; Liu, Dandan PhD; Li, Judy BS; Schimmel, Samantha J.; Cambronero, Francis E. AB; Terry, James G. MS; Nair, Sangeeta DVM, MS; Pechman, Kimberly R. PhD; Moore, Marissa E. MS; Bell, Susan P. MBBS, MSCI; Beckman, Joshua A. MD, MS; Gifford, Katherine A. PsyD; Hohman, Timothy J. PhD; Blennow, Kaj MD, PhD; Zetterberg, Henrik MD, PhD; Carr, John Jeffrey MD, MSc; Jefferson, Angela L. PhD
doi : 10.1212/WNL.0000000000012257
Volume 97(4), 27 July 2021, p e329-e340
To test the hypothesis that increased aortic stiffening is associated with greater CSF evidence of core Alzheimer disease pathology ([beta]-amyloid [A[beta]], phosphorylated tau [p-tau]), neurodegeneration (total tau [t-tau]), synaptic dysfunction (neurogranin), neuroaxonal injury (neurofilament light [NFL]), and neuroinflammation (YKL-40, soluble triggering receptor expressed on myeloid cells 2 [sTREM2]), we analyzed pulse wave velocity (PWV) data and CSF data among older adults.
Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study
Larsson, Susanna C. PhD; Gill, Dipender BMBCh, PhD
doi : 10.1212/WNL.0000000000012244
Volume 97(4), 27 July 2021, p e341-e344
Magnesium has been implicated in regulating blood pressure and vascular endothelial cell function, but its role in the pathophysiology of intracranial aneurysm is not known. Here we performed a Mendelian randomization analysis to investigate the association between serum magnesium concentration and risk of intracranial aneurysm.
Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India
Kumar, Amit PhD*; Chauhan, Ganesh PhD*; Sharma, Shriram DM; Dabla, Surekha DM; Sylaja, P.N. DM; Chaudhary, Neera DM; Gupta, Salil DM; Agrawal, Chandra Sekhar DM; Anand, Kuljeet Singh DM; Srivastava, Achal Kumar DM; Vibha, Deepti DM; Sagar, Ram PhD; Raj, Ritesh MSc; Maheshwari, Ankita MSc; Vivekanandhan, Subbiah PhD; Kaul, Bhavna DM; Raghavan, Samudrala DM; Gorthi, Sankar Prasad DM; Mohania, Dheeraj PhD; Kaushik, Samander PhD; Yadav, Rohtas Kanwar MD; Hazarika, Anjali MBBS; Sharma, Pankaj DM, PhD; Prasad, Kameshwar DM
doi : 10.1212/WNL.0000000000012258
Volume 97(4), 27 July 2021, p e345-e356
To undertake a genome-wide association study (GWAS) to identify genetic variants for stroke in an Indian population.
Impact of the Surgical Approach to Thymectomy Upon Complete Stable Remission Rates in Myasthenia Gravis: A Meta-analysis
Solis-Pazmino, Paola MD*; Baiu, Ioana MD, MPH*; Lincango-Naranjo, Eddy MD; Trope, Winston; Prokop, Larry; Ponce, Oscar J. MD; Shrager, Joseph B. MD
doi : 10.1212/WNL.0000000000012153
Volume 97(4), 27 July 2021, p e357-e368
To determine whether the available operative techniques for thymectomy in myasthenia gravis (MG) confer variable chances for achieving complete stable remission (CSR), we performed a meta-analysis of comparative studies of surgical approaches to thymectomy.
Accuracy of a Deep Learning System for Classification of Papilledema Severity on Ocular Fundus Photographs
Vasseneix, Caroline MD; Najjar, Raymond P. PhD; Xu, Xinxing PhD; Tang, Zhiqun PhD; Loo, Jing Liang MBBS, MMed, FRCS(Ed); Singhal, Shweta MBBS; Tow, Sharon MBBS; Milea, Leonard; Ting, Daniel Shu Wei MD, PhD; Liu, Yong PhD; Wong, Tien Y. MD, PhD; Newman, Nancy J. MD; Biousse, Valerie MD; Milea, Dan MD, PhD; on behalf of the BONSAI Group; on behalf of the BONSAI Group; Gohier, Philippe MD; Miller, Neil MD; Padungkiatsagul, Tanyatuth MD; Poonyathalang, Anuchit MD; Suwan, Yanin MD; Vanikieti, Kavin MD; Amore, Giulia MD; Barboni, Piero MD; Carbonelli, Michele MD; Carelli, Valerio MD, PhD; La Morgia, Chiara MD, PhD; Romagnoli, Martina PhD; Rougier, Marie-Benedicte MD, PhD; Ambika, Selvakumar DO, DNB; Swetha, Komma DO, DNB; Fonseca, Pedro MD; Raimundo, Miguel MD; Hamann, Steffen MD, PhD, FEBO; Karlesand, Isabelle MD; Fuhrmann, Lars MD; Kuchlin, Sebastian MD; Lagreze, Wolf Alexander MD; Sanda, Nicolae MD, PhD; Thumann, Gabriele MD, PD; Aptel, Florent MD, PhD; Chiquet, Christophe MD, PhD; Liu, Kaiqun MD; Yang, Hui MD, PhD; Chan, Carmen KM MRCP, FRCSEd(Ophth); Chan, Noel CY FRCSEd(Ophth); Cheung, Carol Y PhD; Ha Chau, Tran Thi MD; Acheson, James BM, MRCP (UK) , FRCOphth; Habib, Maged S MD, MSc Ophth, FRCS, FRCOphth ; Jurkute, Neringa MD, FEBO ; Yu-Wai-Man, Patrick PhD, MB, BS, FRCPath, FRCOphth ; Kho, Richard MD; Jonas, Jost B MD; Chen, John J. MD, PhD; Sabbagh, Nouran MD; VignalClermont, Catherine MD; Hage, Rabih MD; Khanna, Raoul Kanav MD; Hwang, Jeong-Min MD; Kim, Dong Hyun MD; Yang, Hee Kyung MD; Aung, Tin MD, PhD; Cheng, Ching-Yu MD, PhD; Lamoureux, Ecosse MSc, PhD; Schmetterer, Leopold PhD; Jiang, Zhubo MSc; Fraser, Clare L MBBS, MMed, FRANZCO ; Mejico, Luis J. MD; Fard, Masoud Aghsaei MD
doi : 10.1212/WNL.0000000000012226
Volume 97(4), 27 July 2021, p e369-e377
To evaluate the performance of a deep learning system (DLS) in classifying the severity of papilledema associated with increased intracranial pressure on standard retinal fundus photographs.
Parkinson Disease-Related Brain Metabolic Patterns and Neurodegeneration in Isolated REM Sleep Behavior Disorder
Shin, Jung Hwan MD, PhD; Lee, Jee-Young MD, PhD; Kim, Yu-Kyeong MD, PhD; Yoon, Eun Jin PhD; Kim, Heejung PhD; Nam, Hyunwoo MD, PhD; Jeon, Beomseok MD, PhD
doi : 10.1212/WNL.0000000000012228
Volume 97(4), 27 July 2021, p e378-e388
To elucidate the role of Parkinson disease (PD)-related brain metabolic patterns as a biomarker in isolated REM sleep behavior disorder (iRBD) for future disease conversion.
Contralateral Sensory and Pain Perception Changes in Patients With Unilateral Neuropathy
Enax-Krumova, Elena MD; Attal, Nadine MD, PhD; Bouhassira, Didier MD, PhD; Freynhagen, Rainer MD; Gierthmuhlen, Janne MD; Hansson, Per MD, DMSci, DDS; Kuehler, Bianca M. MD; Maier, Christoph MD; Sachau, Juliane MD; Segerdahl, Marta MD, PhD; Tolle, Thomas MD; Treede, Rolf-Detlef MD; Ventzel, Lise MD, PhD; Baron, Ralf MD; Vollert, Jan PhD
doi : 10.1212/WNL.0000000000012229
Volume 97(4), 27 July 2021, p e389-e402
To test whether contralateral sensory abnormalities in the clinically unaffected area of patients with unilateral neuropathic pain are due to the neuropathy or pain mechanisms.
Effects of Age and Disease Duration on Excess Mortality in Patients With Multiple Sclerosis From a French Nationwide Cohort
Rollot, Fabien MSc; Fauvernier, Mathieu PhD; Uhry, Zoe MSc; Vukusic, Sandra PhD; Bossard, Nadine PhD; Remontet, Laurent MSc; Leray, Emmanuelle PhD; on behalf of the OFSEP Investigators; on behalf of the OFSEP Investigators; Brochet, Bruno MD, PhD; Casey, Romain PhD; Cotton, Francois MD, PhD; De Seze, Jerome MD, PhD; Mansuy, Lucilla; Douek, Pascal MD; Guillemin, Francis MD, PhD; Laplaud, David MD, PhD; LebrunFrenay, Christine MD, PhD; Moreau, Thibault MD, PhD; Olaiz, Javier PhD; Pelletier, Jean MD, PhD; Bully, Claire Rigaud; Stankoff, Bruno MD, PhD; Vukusic, Sandra MD, PhD; Marignier, Romain MD, PhD; Debouverie, Marc MD, PhD; Edan, Gilles MD, PhD; Ciron, Jonathan MD; Ruet, Aurelie MD, PhD; Collongues, Nicolas MD, PhD; Vermersch, Patrick MD, PhD; Cohen, Mikael MD; Fromont, Agnes MD, PhD; Defer, Gilles MD; Wiertlewski, Sandrine MD; Clavelou, Pierre MD, PhD; Labauge, Pierre MD, PhD; Berger, Eric MD; Audoin, Bertrand MD, PhD; Heinzlef, Olivier MD; Thouvenot, Eric MD, PhD; Camdessanche, Jean Philippe MD, PhD
doi : 10.1212/WNL.0000000000012224
Volume 97(4), 27 July 2021, p e403-e413
To determine the effects of current age and disease duration on excess mortality in multiple sclerosis (MS), we describe the dynamics of excess death rates over these 2 time scales and study the effect of age at MS clinical onset on these dynamics, separately in each initial phenotype.
Clinical and Radiologic Features, Pathology, and Treatment of Balo Concentric Sclerosis
Jolliffe, Evan A. MBChB; Guo, Yong MD, PhD; Hardy, Todd A. MBBS; Morris, P. Pearse MBBCh; Flanagan, Eoin P. MBBCh; Lucchinetti, Claudia F. MD; Tobin, W. Oliver MBBCh, BAO, PhD
doi : 10.1212/WNL.0000000000012230
Volume 97(4), 27 July 2021, p e414-e422
To describe clinical, radiologic, and pathologic features of Balo concentric sclerosis (BCS) and assess overlap between BCS and other CNS inflammatory demyelinating diseases.
Can Transcranial Direct Current Stimulation Enhance Poststroke Motor Recovery?: Development of a Theoretical Patient-Tailored Model
Hordacre, Brenton PhD; McCambridge, Alana B. PhD; Ridding, Michael C. PhD; Bradnam, Lynley V. PhD
doi : 10.1212/WNL.0000000000012187
Volume 97(4), 27 July 2021, p 170-180
New treatments that can facilitate neural repair and reduce persistent impairments have significant value in promoting recovery following stroke. One technique that has gained interest is transcranial direct current stimulation (tDCS) as early research suggested it could enhance plasticity and enable greater behavioral recovery. However, several studies have now identified substantial intersubject variability in response to tDCS and clinical trials revealed insufficient evidence of treatment effectiveness. A possible explanation for the varied and negative findings is that the physiologic model of stroke recovery that researchers have used to guide the application of tDCS-based treatments in stroke is overly simplistic and does not account for stroke heterogeneity or known determinants that affect the tDCS response. Here, we propose that tDCS could have a more clearly beneficial role in enhancing stroke recovery if greater consideration is given to individualizing treatment. By critically reviewing the proposed mechanisms of tDCS, stroke physiology across the recovery continuum, and known determinants of tDCS response, we propose a new, theoretical, patient-tailored approach to delivering tDCS after stroke. The proposed model includes a step-by-step principled selection strategy for identifying optimal neuromodulation targets and outlines key areas for further investigation. Tailoring tDCS treatment to individual neuroanatomy and physiology is likely our best chance at producing robust and meaningful clinical benefit for people with stroke and would therefore accelerate opportunities for clinical translation.
Clarence J. Gibbs Effect and the "Creutzfeldt-Jakob Disease" Eponym
Lanska, Douglas J. MD, MS, MSPH
doi : 10.1212/WNL.0000000000012199
Volume 97(4), 27 July 2021, p 181-187
In 2014, American neurologist and Nobel laureate Stanley Prusiner reported that microbiologist Clarence Joseph Gibbs at the US NIH had intentionally, systematically, and mischievously used the eponym Creutzfeldt-Jakob disease, rather than Jakob-Creutzfeldt disease, because of the correspondence with Gibbs' own initials, to imply "Clarence Joseph disease." The present study examines temporal trends in the use of "Creutzfeldt-Jakob" and "Jakob-Creutzfeldt" in scientific articles and monographs from 1946 to 2019 to assess whether there was a "Clarence J. Gibbs effect" that influenced the general use of a specific eponym by the scientific community. During Gibbs' period of publication on Creutzfeldt-Jakob disease (CJD), there was an abrupt, dramatic, and steady increase in use of the CJD eponym while use of the Jakob-Creutzfeldt disease (JCD) eponym remained at a low level. In the period after Gibbs ceased to publish, there was a corresponding marked fall-off in use of the CJD eponym. Surviving collaborators thought Gibbs may have been joking, but in 1991 Gibbs had admitted what Prusiner reported. Regardless of motive, Gibbs strongly influenced the preferred eponym for this human prion disease by (1) publishing a seminal and highly referenced initial article in a high-profile journal; (2) sustained output of further important studies published in high-quality journals over more than 30 years; (3) professional affiliation with an esteemed national laboratory where he worked with a large number of high-profile colleagues; and (4) extensive collaborations with a large number of colleagues, who published multiple further articles using the eponym Gibbs preferred.
The Last Shot
Gutmann, Ludwig MD
doi : 10.1212/WNL.0000000000011923
Volume 97(4), 27 July 2021, p 188-190
Neuro-Behcet Disease Manifesting as Multiple Cerebral Aneurysms
Guimaraes, Filipa MD; Duque, Cristina MD
doi : 10.1212/WNL.0000000000012184
Volume 97(4), 27 July 2021, p 191-192
Resident & Fellow Rounds
Strowd, Roy E. III MD, MEd, MS, FAAN; Editor; Aamodt, Whitley MD, MPH; Deputy Editor
doi : 10.1212/WNL.0000000000012332
Volume 97(4), 27 July 2021, p 193-195
Pearls & Oy-sters: Idiopathic Normal Pressure Hydrocephalus With Synucleinopathy: Diagnosis and Treatment
Han, Sang-Won MD; Park, Young Ho MD, PhD; Ryoo, Nayoung MD; Kim, Kitae MD; Pyun, Jung-Min MD; Kim, SangYun MD, PhD
doi : 10.1212/WNL.0000000000012099
Volume 97(4), 27 July 2021, p 196-199
Clinical Reasoning: A 68-Year-Old Man With Proximal Weakness and Seizures
Chen, Tychicus MD, FRCPC
doi : 10.1212/WNL.0000000000012137
Volume 97(4), 27 July 2021, p e423-e428
Teaching Video NeuroImage: Clenched Fists as an Unusual Presentation of Focal Neuromyotonia
Dhanapalaratnam, Roshan MMed, MBBS; Schwartz, Raymond PhD, MBBS; Huynh, William PhD, MBBS, BSc
doi : 10.1212/WNL.0000000000012055
Volume 97(4), 27 July 2021, p e429-e430
Teaching Video NeuroImage: ECG-Gated 4-D CT Angiography Can Detect Aortic Plaque Mobility in Cryptogenic Stroke
Saito, Mikito MD; Kawano, Hiroyuki MD, PhD; Koyanagi, Masamichi MSc; Gomyo, Miho MD, PhD; Yokoyama, Kenichi MD, PhD; Hirano, Teruyuki MD, PhD
doi : 10.1212/WNL.0000000000012054
Volume 97(4), 27 July 2021, p e431-e432
Myasthenia Gravis: Which Type of Surgery Is Best?
Karceski, Steven MD
doi : 10.1212/WNL.0000000000012339
Volume 97(4), 27 July 2021, p e433-e435
Editors' Note: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology
Lewis, Ariane MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012337
Volume 97(4), 27 July 2021, p 200
Reader Response: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology
Langer-Gould, Annette
doi : 10.1212/WNL.0000000000012333
Volume 97(4), 27 July 2021, p 200-201
Author Response: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology
Keran, Chris; Gross, Robert A.; Yuan, Yan; Miyasaki, Janis M.
doi : 10.1212/WNL.0000000000012334
Volume 97(4), 27 July 2021, p 201
Reader Response: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology
Silver, Julie K.; Bank, Anna M.; Poorman, Julie A.; Goldstein, Richard
doi : 10.1212/WNL.0000000000012335
Volume 97(4), 27 July 2021, p 201-202
Author Response: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology
Gross, Robert A.; Yuan, Yan; Keran, Chris; Miyasaki, Janis M.
doi : 10.1212/WNL.0000000000012336
Volume 97(4), 27 July 2021, p 203
Long-term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis
doi : 10.1212/WNL.0000000000011825
Volume 97(4), 27 July 2021, p 203
Hospital Admission and Readmission Among Homeless Patients With Neurologic Disease
doi : 10.1212/WNL.0000000000009565
Volume 97(4), 27 July 2021, p 203
