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Spotlight on the July 20 Issue
José G. Merino
doi : 10.1212/WNL.0000000000012280
vol. 97 no. 3 103-104
New Amyotrophic Lateral Sclerosis Gene Identified
Peter Hedera
doi : 10.1212/WNL.0000000000012279
vol. 97 no. 3 105-106
Subthalamic Nucleus Deep Brain Stimulation
Kelvin L. Chou, David Charles
doi : 10.1212/WNL.0000000000012245
vol. 97 no. 3 107-108
Pathogenic Effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis
Kristi L. Russell, Jonathan M. Downie, Summer B. Gibson, Spyridoula Tsetsou, Matthew D. Keefe, Jerry A. Duran, Karla P. Figueroa, Mark B. Bromberg, L. Charles Murtaugh, View ORCID ProfileJoshua L. Bonkowsky, Stefan M. Pulst, Lynn B. Jorde
doi : 10.1212/WNL.0000000000012285
vol. 97 no. 3 e225-e235
To identify novel disease associated loci for amyotrophic lateral sclerosis (ALS), we used sequencing data and performed in vitro and in vivo experiments to demonstrate pathogenicity of mutations identified in TP73.
Rare Missense Functional Variants at COL4A1 and COL4A2 in Sporadic Intracerebral Hemorrhage
Jaeyoon Chung, Graham Hamilton, Minsup Kim, Sandro Marini, Bailey Montgomery, Jonathan Henry, Art E. Cho, Devin L. Brown, Bradford B. Worrall, James F. Meschia, Scott L. Silliman, Magdy Selim, David L. Tirschwell, Chelsea S. Kidwell, Brett Kissela, Steven M. Greenberg, Anand Viswanathan, Joshua N. Goldstein, Carl D. Langefeld, Kristiina Rannikmae, Catherine L.M. Sudlow, Neshika Samarasekera, Mark Rodrigues, Rustam Al-Shahi Salman, James G.D. Prendergast, Sarah E. Harris, Ian Deary, Daniel Woo, Jonathan Rosand, Tom Van Agtmael, Christopher D. Anderson
doi : 10.1212/WNL.0000000000012227
vol. 97 no. 3 e236-e247
To test the genetic contribution of rare missense variants in COL4A1 and COL4A2 in which common variants are genetically associated with sporadic intracerebral hemorrhage (ICH), we performed rare variant analysis in multiple sequencing data for the risk for sporadic ICH.
Reversible Cerebral Vasoconstriction SyndromeSymptoms, Incidence, and Resource Utilization in a Population-Based US Cohort
Jessica Magid-Bernstein, Setareh S. Omran, Neal S. Parikh, Alexander E. Merkler, Babak Navi, Hooman Kamel
doi : 10.1212/WNL.0000000000012223
vol. 97 no. 3 e248-e253
To estimate the incidence of hospitalization for reversible cerebral vasoconstriction syndrome (RCVS), we identified RCVS-related hospital admissions across 11 US states in 2016.
Long-term Outcomes (15 Years) After Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease
Francesco Bove, Delia Mulas, Francesco Cavallieri, Anna Castrioto, Stephan Chabardès, Sara Meoni, Emmanuelle Schmitt, Amélie Bichon, Enrico Di Stasio, Andrea Kistner, Pierre Pélissier, Eric Chevrier, Eric Seigneuret, Paul Krack, Valerie Fraix, Elena Moro
doi : 10.1212/WNL.0000000000012246
vol. 97 no. 3 e254-e262
To evaluate the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) on motor complications in patients with Parkinson disease (PD) beyond 15 years after surgery.
Nomograms to Predict Verbal Memory Decline After Temporal Lobe Resection in Adults With Epilepsy
Robyn M. Busch, Olivia Hogue, Margaret Miller, Lisa Ferguson, Mary Pat McAndrews, Marla Hamberger, Michelle Kim, Carrie R. McDonald, Anny Reyes, Daniel L. Drane, Bruce P. Hermann, William Bingaman, Imad M. Najm, Michael W. Kattan, Lara Jehi
doi : 10.1212/WNL.0000000000012221
vol. 97 no. 3 e263-e274
To develop and externally validate models to predict the probability of postoperative verbal memory decline in adults after temporal lobe resection (TLR) for epilepsy using easily accessible preoperative clinical predictors.
Association of Type 1 Diabetes and Hypoglycemic and Hyperglycemic Events and Risk of Dementia
Rachel A. Whitmer, Paola Gilsanz, Charles P. Quesenberry, Andrew J. Karter, Mary E. Lacy
doi : 10.1212/WNL.0000000000012243
vol. 97 no. 3 e275-e283
To determine whether severe hypoglycemic and hyperglycemic events are associated with longitudinal dementia risk in older adults with type 1 diabetes.
Tripartite Relationship Among Synaptic, Amyloid, and Tau ProteinsAn In Vivo and Postmortem Study
Kaitlin B. Casaletto, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, William Honer, Julie A. Schneider, David A. Bennett, Nina Djukic, Michelle You, Sophia Weiner-Light, Corrina Fonseca, Bruce L. Miller, Joel Kramer
doi : 10.1212/WNL.0000000000012145
vol. 97 no. 3 e284-e297
To test the hypothesis that fundamental relationships along the amyloid, tau, and neurodegeneration (A/T/N) cascade depend on synaptic integrity in older adults in vivo and postmortem.
White Matter Disruption in Pediatric Traumatic Brain InjuryResults From ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury
Emily L. Dennis, Karen Caeyenberghs, Kristen R. Hoskinson, Tricia L. Merkley, Stacy J. Suskauer, Robert F. Asarnow, Talin Babikian, Brenda Bartnik-Olson, Kevin Bickart, Erin D. Bigler, Linda Ewing-Cobbs, Anthony Figaji, Christopher C. Giza, Naomi J. Goodrich-Hunsaker, Cooper B. Hodges, Elizabeth S. Hovenden, Andrei Irimia, Marsh K?nigs, Harvey S. Levin, Hannah M. Lindsey, Jeffrey E. Max, Mary R. Newsome, Alexander Olsen, Nicholas P. Ryan, Adam T. Schmidt, Matthew S. Spruiell, Benjamin S.C. Wade, Ashley L. Ware, Christopher G. Watson, Anne L. Wheeler, Keith Owen Yeates, Brandon A. Zielinski, Peter Kochunov, Neda Jahanshad, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
doi : 10.1212/WNL.0000000000012222
vol. 97 no. 3 e298-e309
Our study addressed aims (1) to test the hypothesis that moderate-severe traumatic brain injury (TBI) in pediatric patients is associated with widespread white matter (WM) disruption, (2) to test the hypothesis that age and sex affect WM organization after injury, and (3) to examine associations between WM organization and neurobehavioral outcomes.
Variability in Pediatric Brain Death Determination Protocols in the United States
Conall Francoeur, Matthew J. Weiss, Jennifer M. MacDonald, Craig Press, David M. Greer, Robert A. Berg, Alexis A. Topjian, Wynne Morrison, Matthew P. Kirschen
doi : 10.1212/WNL.0000000000012225
vol. 97 no. 3 e310-e319
To determine the variability in pediatric death by neurologic criteria (DNC) protocols between US pediatric institutions and compared to the 2011 DNC guidelines.
Clinical Presentation and Management of SMART Syndrome
Sebastian F. Winter, Joshua P. Klein, Eugene J. Vaios, Philipp Karschnia, Eudocia Q. Lee, Helen A. Shih, Franziska Loebel, Jorg Dietrich
doi : 10.1212/WNL.0000000000012150
vol. 97 no. 3 118-120
What Is the Potential Role of Poly(ADP-Ribose) Polymerase 1 in Parkinson Disease?
Rodolfo Savica, Eduardo Benarroch
doi : 10.1212/WNL.0000000000012287
vol. 97 no. 3 121-124
Career Development Program for Underrepresented in Medicine Scholars in Academic NeurologyTRANSCENDS
Raelle Tagge, Daniel T. Lackland, Philip B. Gorelick, Irene Litvan, Salvador Cruz-Flores, José G. Merino, Bruce Ovbiagele
doi : 10.1212/WNL.0000000000012058
vol. 97 no. 3 125-133
The Training in Research for Academic Neurologists to Sustain Careers and Enhance the Numbers of Diverse Scholars (TRANSCENDS) program is a career advancement opportunity for individuals underrepresented in biomedical research funded by the National Institute of Neurologic Disorders and Stroke and American Academy of Neurology (AAN).
Quality Improvement in NeurologyMultiple Sclerosis Quality Measurement Set 2020 Update
Alexander Rae-Grant, Lilyana Amezcua, Jeffrey English, Neeta Garg, Barbara Giesser, Adam G. Kelly, Iris Vanessa Marin Collazo, Amanda Montague, Michael Olek, Elizabeth Page, Amy Bennett, Tracie Caller
doi : 10.1212/WNL.0000000000012124
vol. 97 no. 3 134-141
Bilateral Posterior Temporal Lobe Contusions as a Rare Pattern of Traumatic Brain Injury
Annelies Geebels, Patrick Vermylen, Lode Janssen, Maarten Dewil
doi : 10.1212/WNL.0000000000012146
vol. 97 no. 3 142-143
Journal Club: Trends in Incidence and Epidemiologic Characteristics of Cerebral Venous Thrombosis in the United States
Nikolaos Raptis, Susanna M. Zuurbier, Mirjam R. Heldner
doi : 10.1212/WNL.0000000000011760
vol. 97 no. 3 144-147
Pearls & Oy-sters: Paradoxical Head Tilt in a Congenital Fourth Nerve Palsy
Amit Kumar Sharma, David Dongkyung Kim, John Alexander Fraser
doi : 10.1212/WNL.0000000000012082
vol. 97 no. 3 e320-e323
Teaching NeuroImages: MRI Abnormalities of Spinal Dural Arteriovenous Fistula in the Absence of Flow Voids
Andre Miguel Miranda, Marta Gomes Rodrigues, Andre Araujo, Manuel Queiros Ribeiro, Henrique Costa, Sergio Castro
doi : 10.1212/WNL.0000000000012053
vol. 97 no. 3 e324-e325
Teaching Video NeuroImages: Optic Ataxia as the Presenting Sign of the Heidenhain Variant of Creutzfeldt-Jakob Disease
Shi-Lin Yang, Xiang Han, Qiang Dong
doi : 10.1212/WNL.0000000000012057
vol. 97 no. 3 e326-e328
Editors' Note: Cause of Death in Spontaneous Intracerebral Hemorrhage Survivors: Multistate Longitudinal Study
James E. Siegler, Steven Galetta
doi : 10.1212/WNL.0000000000012281
vol. 97 no. 3 148
Reader Response: Cause of Death in Spontaneous Intracerebral Hemorrhage Survivors: Multistate Longitudinal Study
Andrés E. Llamas-Nieves, Ivan D. Lozada-Martinez, Daniela M. Torres-Llin?s, Luis R. Moscote-Salazar
doi : 10.1212/WNL.0000000000012282
vol. 97 no. 3 148-149
Author Response: Cause of Death in Spontaneous Intracerebral Hemorrhage Survivors: Multistate Longitudinal Study
Lindsey Kuohn, Kevin Sheth
doi : 10.1212/WNL.0000000000012283
vol. 97 no. 3 149
Editors' Note: Sex, Race, and Risk of Dementia Diagnosis After Traumatic Brain Injury Among Older Veterans
James E. Siegler, Steven Galetta
doi : 10.1212/WNL.0000000000012284
vol. 97 no. 3 149-150
Reader Response: Sex, Race, and Risk of Dementia Diagnosis After Traumatic Brain Injury Among Older Veterans
Jomar S. Roberts I
doi : 10.1212/WNL.0000000000012288
vol. 97 no. 3 150
Author Response: Sex, Race, and Risk of Dementia Diagnosis After Traumatic Brain Injury Among Older Veterans
Erica S. Kornblith
doi : 10.1212/WNL.0000000000012286
vol. 97 no. 3 151
Thrombolysis in Acute Ischemic Stroke in Patients With DementiaA Swedish Registry Study
doi : 10.1212/WNL.0000000000010325
vol. 97 no. 3 151
ALS is a Multistep Process in South Korean, Japanese, and Australian Patients
doi : 10.1212/WNL.0000000000010323
vol. 97 no. 3 151
