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Associate Editorial Board
doi : 10.1016/S0007-0912(21)00120-3
Volume 126, Issue 4, April 2021, Page iii
Enhanced recovery: joining the dots
William J. Fawcett, Michael G. Mythen, Michael J. Scott
doi : 10.1016/j.bja.2020.12.027
Volume 126, Issue 4, April 2021, Pages 751-755
Developmental exposure to general anaesthesia: missed connections?
Mark G. Baxter, Tristan Fehr
doi : 10.1016/j.bja.2021.01.013
Volume 126, Issue 4, April 2021, Pages 756-758
Normalising good communication in hospital teams
Jennifer M. Weller, Craig S. Webster
doi : 10.1016/j.bja.2020.12.036
Volume 126, Issue 4, April 2021, Pages 758-760
Rebound pain: distinct pain phenomenon or nonentity?
Duncan L. Hamilton
doi : 10.1016/j.bja.2020.12.034
Volume 126, Issue 4, April 2021, Pages 761-763
Measuring frailty in the older surgical patient: the case for evidence synthesis
Simon J. Howell, Sherena Nair
doi : 10.1016/j.bja.2021.01.002
Volume 126, Issue 4, April 2021, Pages 763-767
THRIVE: five years on and into the COVID-19 era
Anika Sud, Anil Pate
doi : 10.1016/j.bja.2020.12.030
Volume 126, Issue 4, April 2021, Pages 768-773
Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: a systematic review and expert consensus statement
Laura C. Price, Guillermo Martinez, Aimee Brame, Thomas Pickworth, ... Stephen John Wort
doi : 10.1016/j.bja.2021.01.005
Volume 126, Issue 4, April 2021, Pages 774-790
The risk of complications, including death, is substantially increased in patients with pulmonary hypertension (PH) undergoing anaesthesia for surgical procedures, especially in those with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH). Sedation also poses a risk to patients with PH. Physiological changes including tachycardia, hypotension, fluid shifts, and an increase in pulmonary vascular resistance (PH crisis) can precipitate acute right ventricular decompensation and death.
Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study
Robert D. Sanders, Lenka Craigova, Benjamin Schessler, Cameron Casey, ... Richard Lennertz
doi : 10.1016/j.bja.2020.10.012
Volume 126, Issue 4, April 2021, Pages 791-798
Myocardial and neuronal injury occur commonly after noncardiac surgery. We examined whether patients who had perioperative myocardial injury (PMI) also incurred neuronal injury, and whether myocardial and neuronal injury were associated with similar changes in inflammatory markers or overlapping clinical predictors.
Assessment of prognostic value of intraoperative oliguria for postoperative acute kidney injury: a retrospective cohort study
Bing-Cheng Zhao, Shao-Hui Lei, Xiao Yang, Ya Zhang, ... Ke-Xuan Liu
doi : 10.1016/j.bja.2020.11.018
Volume 126, Issue 4, April 2021, Pages 799-807
Oliguria is often viewed as a sign of renal hypoperfusion and an indicator for volume expansion during surgery. However, the prognostic association and the predictive utility of intraoperative oliguria for postoperative acute kidney injury (AKI) are unclear.
Deep learning models for the prediction of intraoperative hypotension
Solam Lee, Hyung-Chul Lee, Yu Seong Chu, Seung Woo Song, ... Sang Baek Koh
doi : 10.1016/j.bja.2020.12.035
Volume 126, Issue 4, April 2021, Pages 808-817
Intraoperative hypotension is associated with a risk of postoperative organ dysfunction. In this study, we aimed to present deep learning algorithms for real-time predictions 5, 10, and 15 min before a hypotensive event.
Effect of fluid strategy on stroke volume, cardiac output, and fluid responsiveness in adult patients undergoing major abdominal surgery: a sub-study of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) trial
Tuong D. Phan, Yoshiaki Uda, Philip J. Peyton, Roman Kluger, Paul S. Myles
doi : 10.1016/j.bja.2021.01.011
Volume 126, Issue 4, April 2021, Pages 818-825
We designed a prospective sub-study of the larger Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) trial to measure differences in stroke volume and other haemodynamic parameters at the end of the intraoperative fluid protocols. The haemodynamic effects of the two fluid regimens may increase our understanding of the observed perioperative outcomes.
Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: an observational study
Benoît Bataille, Jade de Selle, Pierre-Etienne Moussot, Philippe Marty, ... Pierre Cocquet
doi : 10.1016/j.bja.2020.11.039
Volume 126, Issue 4, April 2021, Pages 826-834
Passive leg raising (PLR) predicts fluid responsiveness in critical illness, although restrictions in mobilising patients often preclude this haemodynamic challenge being used. We investigated whether machine learning applied on transthoracic echocardiography (TTE) data might be used as a tool for predicting fluid responsiveness in critically ill patients.
Propofol sedation-induced alterations in brain connectivity reflect parvalbumin interneurone distribution in human cerebral cortex
Michael M. Craig, Bratislav Misic, Ioannis Pappas, Ram M. Adapa, ... Emmanuel A. Stamatakis
doi : 10.1016/j.bja.2020.11.035
Volume 126, Issue 4, April 2021, Pages 835-844
Propofol, a commonly used intravenous anaesthetic, binds to type A gamma aminobutyric acid (GABA) receptors in mammalian brain. Previous work on its anaesthetic action has characterised either the biochemistry underlying propofol binding or the associated changes in brain network dynamics during sedation. Despite these advances, no study has focused on understanding how propofol action at the cellular level results in changes in brain network connectivity.
General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys
Jeffrey T. Young, Roza M. Vlasova, Brittany R. Howell, Rebecca C. Knickmeyer, ... Martin Styner
doi : 10.1016/j.bja.2020.12.029
Volume 126, Issue 4, April 2021, Pages 845-853
Non-human primates are commonly used in neuroimaging research for which general anaesthesia or sedation is typically required for data acquisition. In this analysis, the cumulative effects of exposure to ketamine, Telazol® (tiletamine and zolazepam), and the inhaled anaesthetic isoflurane on early brain development were evaluated in two independent cohorts of typically developing rhesus macaques.
Positive communication behaviour during handover and team-based clinical performance in critical situations: a simulation randomised controlled trial
Barthélémy Bertrand, Jean-Noël Evain, Juliette Piot, Rémi Wolf, ... Julien Picard
doi : 10.1016/j.bja.2020.12.011
Volume 126, Issue 4, April 2021, Pages 854-861
Positive communication behaviour within anaesthesia teams may decrease stress response and improve clinical performance. We aimed to evaluate the effect of positive communication during medical handover on the subsequent team-based clinical performance in a simulated critical situation. We also assessed the effect of positive communication behaviour on stress response.
Factors associated with rebound pain after peripheral nerve block for ambulatory surgery
Garrett S. Barry, Jonathan G. Bailey, Joel Sardinha, Paul Brousseau, Vishal Uppal
doi : 10.1016/j.bja.2020.10.035
Volume 126, Issue 4, April 2021, Pages 862-871
Rebound pain is a common, yet under-recognised acute increase in pain severity after a peripheral nerve block (PNB) has receded, typically manifesting within 24 h after the block was performed. This retrospective cohort study investigated the incidence and factors associated with rebound pain in patients who received a PNB for ambulatory surgery.
Population pharmacokinetics of ropivacaine used for local infiltration anaesthesia during primary total unilateral and simultaneous bilateral knee arthroplasty
Kirill Gromov, Stanislas Grassin-Delyle, Nicolai B. Foss, Lars M?ller Pedersen, ... Henrik Husted
doi : 10.1016/j.bja.2020.11.038
Volume 126, Issue 4, April 2021, Pages 872-880
Ropivacaine is commonly used in local infiltration anaesthesia (LIA) as pain management after total knee arthroplasty (TKA). Although considered safe, no studies evaluated the pharmacokinetics of high-dose ropivacaine infiltration in simultaneous bilateral TKA.
Peripheral nerve block anaesthesia and postoperative pain in acute ankle fracture surgery: the AnAnkle randomised trial
Rune Sort, Stig Brorson, Ismail G?genur, Lasse L. Hald, ... Ann M. M?ller
doi : 10.1016/j.bja.2020.12.037
Volume 126, Issue 4, April 2021, Pages 881-888
Peripheral nerve blocks (PNBs) are increasingly popular in acute ankle fracture surgery but rebound pain may outweigh the benefits. The AnAnkle Trial was designed to assess the postoperative pain profile of PNB anaesthesia compared with spinal anaesthesia (SA).
Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation
Daniel Stolady, Marianna Laviola, Arani Pillai, Jonathan G. Hardman
doi : 10.1016/j.bja.2020.12.031
Volume 126, Issue 4, April 2021, Pages 889-895
Studies of pulmonary denitrogenation (pre-oxygenation) in obstetric populations have shown high flow nasal oxygen therapy (HFNO) is inferior to facemask techniques. HFNO achieves median end-tidal oxygen fraction (FE?O2) of 0.87 after 3 min. As HFNO prolongs safe apnoea times through apnoeic oxygenation, we postulated that HFNO would still extend safe apnoeic times despite the lower FE?O2 after pre-oxygenation.
Rabbit training model for establishing an emergency front of neck airway in children
Christian P. Both, Birgit Diem, Elena Alonso, Michael Kemper, ... J?rg Thomas
doi : 10.1016/j.bja.2020.12.032
Volume 126, Issue 4, April 2021, Pages 896-902
A ‘cannot intubate, cannot oxygenate’ (CICO) situation is rare in paediatric anaesthesia, but can always occur in children under certain emergency situations. There is a paucity of literature on specific procedures for securing an emergency invasive airway in children younger than 6 yr. A modified emergency front of neck access (eFONA) technique using a rabbit cadaver model was developed to teach invasive airway protection in a CICO situation in children.
Methodologies for systematic reviews with meta-analysis of randomised clinical trials in pain, anaesthesia, and perioperative medicine
Brett Doleman, Ole Mathiesen, Janus C. Jakobsen, Alex J. Sutton, ... John P. Williams
doi : 10.1016/j.bja.2021.01.004
Volume 126, Issue 4, April 2021, Pages 903-911
Systematic reviews and meta-analyses (SRMAs) are increasing in popularity, but should they be used to inform clinical decision-making in anaesthesia? We present evidence that the certainty of evidence from SRMAs in anaesthesia (and in general) may be unacceptably low because of risks of bias exaggerating treatment effects, unexplained heterogeneity reducing certainty in estimates, random errors, and widespread prevalence of publication bias.
Predicting severity of adverse cardiorespiratory effects of morphine in premature infants: a post hoc analysis of Procedural Pain in Premature Infants trial data
Caroline Hartley, Luke Baxter, Fiona Moultrie, Ryan Purdy, ... Rebeccah Slater
doi : 10.1016/j.bja.2020.10.034
Volume 126, Issue 4, April 2021, Pages e133-e135
Pharmacological treatment of neonatal pain: are we ready for a paradigm shift? Comment on Br J Anaesth 2021; 126: e133–5
John N. van den Anker
doi : 10.1016/j.bja.2021.01.012
Volume 126, Issue 4, April 2021, Pages e135-e136
Opioid-free anaesthesia for anterior total hip replacement under general anaesthesia: the Observational Prospective Study of Opiate-free Anesthesia for Anterior Total Hip Replacement trial
Brendan Urvoy, Christophe Aveline, Nicolas Belot, Charles Catier, Hélène Beloeil
doi : 10.1016/j.bja.2021.01.001
Volume 126, Issue 4, April 2021, Pages e136-e139
Role of dexamethasone in reducing postoperative pain. Comment on Br J Anaesth 2021; 126: 862–71
Daniel J. Stubbs, Nicholas Levy
doi : 10.1016/j.bja.2021.01.010
Volume 126, Issue 4, April 2021, Pages e139-e140
Ultrasound-guided dynamic needle tip positioning versus conventional palpation approach for catheterisation of posterior tibial or dorsalis pedis artery in infants and small children
Jun Takeshita, Kazuya Tachibana, Yoshinobu Nakayama, Yasufumi Nakajima, ... Nobuaki Shime
doi : 10.1016/j.bja.2020.11.033
Volume 126, Issue 4, April 2021, Pages e140-e142
Fresh gas flow during total intravenous anaesthesia and marginal gains in sustainable healthcare. Comment on Br J Anaesth 2020; 125: 773-8
Morgan Back, Adam Al-Attar, Rebecca Sutton, Clifford Shelton
doi : 10.1016/j.bja.2020.12.006
Volume 126, Issue 4, April 2021, Pages e143-e144
Radial artery catheterisation pressure monitoring with a closed intravascular catheter system and ultrasound-guided dynamic needle tip positioning technique
Penghui Wei, Jianjun Li, Jiapeng Huang, Ting Zhang, Wenxi Tang
doi : 10.1016/j.bja.2020.12.033
Volume 126, Issue 4, April 2021, Pages e144-e146
Anaesthesia workspace layout and intervertebral disc prolapse
Rex R.D. Marks
doi : 10.1016/j.bja.2021.01.003
Volume 126, Issue 4, April 2021, Pages e146-e147
Lost in transition: use of SpO2 in the Australian and New Zealand College of Anaesthetists transition tool. Reply to Br J Anaesth 2020; 125: e465–6
Adam Rehak, Nicholas Chrimes, Andy Higgs
doi : 10.1016/j.bja.2020.12.038
Volume 126, Issue 4, April 2021, Pages e148-e149
Utilising mass cytometry with CD45 barcoding and standardised leucocyte phenotyping for immune trajectory assessment in critically ill patients
Matthew Fish, Richard Ellis, Cynthia Bishop, Katrina Todd, ... Manu Shankar-Hari
doi : 10.1016/j.bja.2021.01.006
Volume 126, Issue 4, April 2021, Pages e149-e152
Authorship patterns in contemporary anaesthesia literature: a cross-sectional study
Lisa Q. Rong, Mohammed Rahouma, Alexandra J. Lopes, Mary E. Charlson, Mario Gaudino
doi : 10.1016/j.bja.2021.01.014
Volume 126, Issue 4, April 2021, Pages e152-e154
Retracted papers on SARS-CoV-2 and COVID-19
Andrea Cortegiani, Giulia Catalisano, Mariachiara Ippolito, Antonino Giarratano, ... Sharon Einav
doi : 10.1016/j.bja.2021.01.008
Volume 126, Issue 4, April 2021, Pages e155-e156
Anesthesia Equipment: Principles and Applications, 3rd edn, J. Ehrenwerth, J.B. Eisenkraft, J.M. Berry (Eds.), Elsevier, St Louis, MO, USA (2021), Pp. 613. Price £138.99. ISBN: 978-0-323-67279-5
Abiodun Noah
doi : 10.1016/j.bja.2020.12.013
Volume 126, Issue 4, April 2021, Page 912
