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Dementia therapy: time for an energy boost

doi : 10.1093/brain/awae120

Volume 147, Issue 5, May 2024

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Lucretius and the neural consequences of traumatic amputation: the role of descending inhibition?

doi : 10.1093/brain/awae087

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Blood GFAP reflects astrocyte reactivity to Alzheimer’s pathology in post-mortem brain tissue

doi : 10.1093/brain/awae104

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More than 185 CAG repeats: a point of no return in Huntington’s disease biology

doi : 10.1093/brain/awae105

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Vaccination with structurally modified fungal protein fibrils: a new treatment for synucleinopathies?

doi : 10.1093/brain/awae115

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Potassium seeks a role in the drama of neurodegeneration

doi : 10.1093/brain/awae108

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How do we get from hyperexcitability to excitotoxicity in amyotrophic lateral sclerosis?

doi : 10.1093/brain/awae039

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Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development

doi : 10.1093/brain/awae028

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Engineered Wnt7a ligands rescue blood–brain barrier and cognitive deficits in a COVID-19 mouse model

doi : 10.1093/brain/awae031

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Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson’s disease

doi : 10.1093/brain/awae061

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L-serine treatment in patients with GRIN-related encephalopathy: a phase 2A, non-randomized study

doi : 10.1093/brain/awae041

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Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles

doi : 10.1093/brain/awae035

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Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains

doi : 10.1093/brain/awad398

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Longitudinal flortaucipir, metabolism and volume differ between phonetic and prosodic speech apraxia

doi : 10.1093/brain/awae016

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New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer’s disease

doi : 10.1093/brain/awad432

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Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration

doi : 10.1093/brain/awae075

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Skin innervation across amyotrophic lateral sclerosis clinical stages: new prognostic biomarkers

doi : 10.1093/brain/awad426

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Biallelic BORCS8 variants cause an infantile-onset neurodegenerative disorder with altered lysosome dynamics

doi : 10.1093/brain/awad427

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The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis

doi : 10.1093/brain/awad410

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A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease

doi : 10.1093/brain/awae063

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Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson’s disease

doi : 10.1093/brain/awad420

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PAK2 is necessary for myelination in the peripheral nervous system

doi : 10.1093/brain/awad413

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Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome

doi : 10.1093/brain/awae010

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Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes

doi : 10.1093/brain/awad403

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Increased expression of chondroitin sulfate proteoglycans in dentate gyrus and amygdala causes postinfectious seizures

doi : 10.1093/brain/awad430

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p38γ MAPK delays myelination and remyelination and is abundant in multiple sclerosis lesions

doi : 10.1093/brain/awad421

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Role of the repeat expansion size in predicting age of onset and severity in RFC1 disease

doi : 10.1093/brain/awad436

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Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation

doi : 10.1093/brain/awae018

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Autologous bone marrow mononuclear cells to treat severe traumatic brain injury in children

doi : 10.1093/brain/awae005

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Increased core-periphery connectivity in ticker-tape synesthetes

doi : 10.1093/brain/awae001

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Follow the allosteric transitions to predict variant pathogenicity: a channel-specific approach

doi : 10.1093/brain/awae008

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Reply: Follow the allosteric transitions to predict variant pathogenicity: a channel-specific approach

doi : 10.1093/brain/awae009

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Higher than expected incident cases of spinal bulbar muscular atrophy in western Canada

doi : 10.1093/brain/awae052

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