AAPS PharmSciTech




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The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling

Motasem M. Alsmadi, Alla A. Abudaqqa, Nasir Idkaidek, Nidal A. Qinna & Ahmad Al-Ghazawi

doi : 0.1208/s12249-024-02803-z

Volume 25, Issue 4

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Novel Drug Delivery Approaches for the Localized Treatment of Cervical Cancer

Ivy Saha, Jitu Halder, Tushar Kanti Rajwar, Ritu Mahanty, Deepak Pradhan, Priyanka Dash, Chandan Das, Vineet Kumar Rai, Biswakanth Kar, Goutam Ghosh & Goutam Rath

doi : 10.1208/s12249-024-02801-1

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Multicomponent Amorphous Solid Forms of Telmisartan: Insights into Mechanochemical Activation and Physicochemical Attributes

Jamshed Haneef & Shakir Ali

doi : 10.1208/s12249-024-02799-6

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Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma

Kiran K. Mali, Yogeshkumar N. Gavhane & Rita D. Chakole

doi : 10.1208/s12249-024-02797-8

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On the Feasibility of Rugose Lipid Microparticles in Pressurized Metered Dose Inhalers with Established and New Propellants

Zahra Minootan, Hui Wang, Patrick Connaughton, Kellisa Lachacz, Nicholas Carrigy, Mani Ordoubadi, David Lechuga-Ballesteros, Andrew R. Martin & Reinhard Vehring

doi : 10.1208/s12249-024-02776-z

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Polymer Characteristics for Drug Layering on Particles Using a Novel Melt Granulation Technology, MALCORE®

Ryota Kimata, Naoki Yoshihara, Yuya Tomita, Takayuki Terukina & Hiromu Kondo

doi : 0.1208/s12249-024-02798-7

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Revolutionizing Knee Osteoarthritis Treatment: Innovative Self-Nano-Emulsifying Polyethylene Glycol Organogel of Curcumin for Effective Topical Delivery

Mahtab Baharizade, Seyed Iman Ghetmiri, Mohsen Mohammady, Soliman Mohammadi-Samani & Gholamhossein Yousefi

doi : 10.1208/s12249-024-02789-8

Buy The Package and View The Article Online


Development of Losartan Orally Disintegrating Tablets by Direct Compression: a Cost-Effective Approach to Improve Paediatric Patient’s Compliance

Candela Juan, Loreana Gallo & Noelia Gonzalez Vidal

doi : 10.1208/s12249-024-02796-9

Buy The Package and View The Article Online


Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems

Sanskriti Singh & Sarika Wairkar

doi : 10.1208/s12249-024-02793-y

Buy The Package and View The Article Online


Keratin Formed Bioadhesive Ophthalmic Gel for the Bacterial Conjunctivitis Treatment

Mengjuan Sun, Jialin Niu, Yin Zhang, Mengrong Wang, Yan Shen, Xiaolan Chen, Yujuan Mao & Qian Li

doi : 10.1208/s12249-024-02772-3

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Non-destructive Raman Method Development for Quantifying Active Pharmaceutical Ingredient in an Oral Suspension Through Plastic Dosing Syringes

Jacquelyn North, Raaidah Saari-Nordhaus, Gregory Doddridge, Madeline Seefeldt, Daniel A Young & Yemin Liu

doi : 10.1208/s12249-024-02775-0

Buy The Package and View The Article Online


Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth

Rania Hamed & Hebah F. I. Alhadidi

doi : 10.1208/s12249-024-02771-4

Buy The Package and View The Article Online


Transmucosal Delivery of Peptides and Proteins Through Nanofibers: Current Status and Emerging Developments

Priyanka Gavali, Jagruti Desai, Pranav Shah & Sujata Sawarkar

doi : 10.1208/s12249-024-02794-x

Buy The Package and View The Article Online


Formulation of Metoclopramide Hydrochloride-Loaded Lipid Carriers by QbD Approach for Combating Nausea: Safety and Bioavailability Evaluation in New Zealand Rabbit

Juste Baranauskaite, Meryem Aydin, Burcu Uner & Cetin Tas

doi : 10.1208/s12249-024-02791-0

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Eugenol-Loaded Transethosomal Gel for Improved Skin Delivery and Treatment of Atopic Dermatitis

Bhawna Kashyap, Azhar Khan & Deepak N. Kapoor

doi : 10.1208/s12249-024-02785-y

Buy The Package and View The Article Online


Film-Forming, Moisturizing, and Sensory Properties of a Cosmetic Formulation Containing Tara Gum and Brazilian Berry Extracts

Patrícia M. B. G. Maia Campos, Leticia Kakuda & Cláudia R. F. Souza

doi : 10.1208/s12249-024-02790-1

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Development of pH-Sensitive Nanoparticle Incorporated into Dissolving Microarray Patch for Selective Delivery of Methotrexate

Nur Qadri Febrianti, Anugerah Yaumil Ramadhani Aziz, Muhamad Gilang Ramadhan Tunggeng, Indianty Dwi Ramadhany, Nur Syafika, Sumayya Binti Abd Azis, Yulia Yusrini Djabir, Rangga Meidianto Asri & Andi Dian Permana

doi : 10.1208/s12249-024-02777-y

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Development and Characterization of Transdermal Patches Using Novel Thymoquinone-L-Arginine-Based Polyamide Nanocapsules for Potential Use in the Management of Psoriasis

Eman Zmaily Dahmash, Lama Murad Attiany, Dalia Ali, Shereen M. Assaf, Jamal Alkrad & Hamad Alyami

doi : 10.1208/s12249-024-02781-2

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Sustainable Alternatives to Petroleum-Derived Excipients in Pharmaceutical Oil-in-Water Creams

Dana Gates, Abu Zayed Md Badruddoza, Md Ikhtiar Zahid, Thean Yeoh, Jaymin Shah, Taylor Walsh & Md Nurunnabi

doi : 10.1208/s12249-024-02784-z

Buy The Package and View The Article Online


Co-Processed Crystalline Solids of Ivermectin with Span® 60 as Solubility Enhancers of Ivermectin in Natural Oils

Luandri de Vos, Minja Gerber, Wilna Liebenberg, Johanna C. Wessels & Hendrik J. R. Lemmer

doi : 10.1208/s12249-024-02783-0

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Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis

Chetan Hasmukh Mehta, Varalakshmi Velagacherla, Suman Manandhar, Yogendra Nayak, Sreedhara Ranganath K Pai, Shruthi Acharya & Usha Yogendra Nayak

doi : 10.1208/s12249-024-02787-w

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Correction: Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons

Shiji Liao, Guirong Qiu, Yanping Hu, Bohong Guo & Yuqin Qiu

doi : 10.1208/s12249-024-02779-w

Buy The Package and View The Article Online


A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications

Huma Hameed, Saleha Faheem, Ana Cláudia Paiva-Santos, Hafiz Shoaib Sarwar & Muhammad Jamshaid

doi : 10.1208/s12249-024-02786-x

Buy The Package and View The Article Online


Retraction Note: Natural Polymer–Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery

Sadia Rehman, Asadullah Madni, Qazi Adnan Jameel, Faisal Usman, M. Rafi Raza, Faiz Ahmad, Hina Shoukat, Hamdan Aali & Afifa Shafiq

doi : 10.1208/s12249-024-02788-9

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The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling

Motasem M. Alsmadi, Alla A. Abudaqqa, Nasir Idkaidek, Nidal A. Qinna & Ahmad Al-Ghazawi

doi : 0.1208/s12249-024-02803-z

Volume 25, Issue 4

Buy The Package and View The Article Online


Novel Drug Delivery Approaches for the Localized Treatment of Cervical Cancer

Ivy Saha, Jitu Halder, Tushar Kanti Rajwar, Ritu Mahanty, Deepak Pradhan, Priyanka Dash, Chandan Das, Vineet Kumar Rai, Biswakanth Kar, Goutam Ghosh & Goutam Rath

doi : 10.1208/s12249-024-02801-1

Buy The Package and View The Article Online


Multicomponent Amorphous Solid Forms of Telmisartan: Insights into Mechanochemical Activation and Physicochemical Attributes

Jamshed Haneef & Shakir Ali

doi : 10.1208/s12249-024-02799-6

Buy The Package and View The Article Online


Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma

Kiran K. Mali, Yogeshkumar N. Gavhane & Rita D. Chakole

doi : 10.1208/s12249-024-02797-8

Buy The Package and View The Article Online


On the Feasibility of Rugose Lipid Microparticles in Pressurized Metered Dose Inhalers with Established and New Propellants

Zahra Minootan, Hui Wang, Patrick Connaughton, Kellisa Lachacz, Nicholas Carrigy, Mani Ordoubadi, David Lechuga-Ballesteros, Andrew R. Martin & Reinhard Vehring

doi : 10.1208/s12249-024-02776-z

Buy The Package and View The Article Online


Polymer Characteristics for Drug Layering on Particles Using a Novel Melt Granulation Technology, MALCORE®

Ryota Kimata, Naoki Yoshihara, Yuya Tomita, Takayuki Terukina & Hiromu Kondo

doi : 0.1208/s12249-024-02798-7

Buy The Package and View The Article Online


Revolutionizing Knee Osteoarthritis Treatment: Innovative Self-Nano-Emulsifying Polyethylene Glycol Organogel of Curcumin for Effective Topical Delivery

Mahtab Baharizade, Seyed Iman Ghetmiri, Mohsen Mohammady, Soliman Mohammadi-Samani & Gholamhossein Yousefi

doi : 10.1208/s12249-024-02789-8

Buy The Package and View The Article Online


Development of Losartan Orally Disintegrating Tablets by Direct Compression: a Cost-Effective Approach to Improve Paediatric Patient’s Compliance

Candela Juan, Loreana Gallo & Noelia Gonzalez Vidal

doi : 10.1208/s12249-024-02796-9

Buy The Package and View The Article Online


Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems

Sanskriti Singh & Sarika Wairkar

doi : 10.1208/s12249-024-02793-y

Buy The Package and View The Article Online


Keratin Formed Bioadhesive Ophthalmic Gel for the Bacterial Conjunctivitis Treatment

Mengjuan Sun, Jialin Niu, Yin Zhang, Mengrong Wang, Yan Shen, Xiaolan Chen, Yujuan Mao & Qian Li

doi : 10.1208/s12249-024-02772-3

Buy The Package and View The Article Online


Non-destructive Raman Method Development for Quantifying Active Pharmaceutical Ingredient in an Oral Suspension Through Plastic Dosing Syringes

Jacquelyn North, Raaidah Saari-Nordhaus, Gregory Doddridge, Madeline Seefeldt, Daniel A Young & Yemin Liu

doi : 10.1208/s12249-024-02775-0

Buy The Package and View The Article Online


Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth

Rania Hamed & Hebah F. I. Alhadidi

doi : 10.1208/s12249-024-02771-4

Buy The Package and View The Article Online


Transmucosal Delivery of Peptides and Proteins Through Nanofibers: Current Status and Emerging Developments

Priyanka Gavali, Jagruti Desai, Pranav Shah & Sujata Sawarkar

doi : 10.1208/s12249-024-02794-x

Buy The Package and View The Article Online


Formulation of Metoclopramide Hydrochloride-Loaded Lipid Carriers by QbD Approach for Combating Nausea: Safety and Bioavailability Evaluation in New Zealand Rabbit

Juste Baranauskaite, Meryem Aydin, Burcu Uner & Cetin Tas

doi : 10.1208/s12249-024-02791-0

Buy The Package and View The Article Online


Eugenol-Loaded Transethosomal Gel for Improved Skin Delivery and Treatment of Atopic Dermatitis

Bhawna Kashyap, Azhar Khan & Deepak N. Kapoor

doi : 10.1208/s12249-024-02785-y

Buy The Package and View The Article Online


Film-Forming, Moisturizing, and Sensory Properties of a Cosmetic Formulation Containing Tara Gum and Brazilian Berry Extracts

Patrícia M. B. G. Maia Campos, Leticia Kakuda & Cláudia R. F. Souza

doi : 10.1208/s12249-024-02790-1

Buy The Package and View The Article Online


Development of pH-Sensitive Nanoparticle Incorporated into Dissolving Microarray Patch for Selective Delivery of Methotrexate

Nur Qadri Febrianti, Anugerah Yaumil Ramadhani Aziz, Muhamad Gilang Ramadhan Tunggeng, Indianty Dwi Ramadhany, Nur Syafika, Sumayya Binti Abd Azis, Yulia Yusrini Djabir, Rangga Meidianto Asri & Andi Dian Permana

doi : 10.1208/s12249-024-02777-y

Buy The Package and View The Article Online


Development and Characterization of Transdermal Patches Using Novel Thymoquinone-L-Arginine-Based Polyamide Nanocapsules for Potential Use in the Management of Psoriasis

Eman Zmaily Dahmash, Lama Murad Attiany, Dalia Ali, Shereen M. Assaf, Jamal Alkrad & Hamad Alyami

doi : 10.1208/s12249-024-02781-2

Buy The Package and View The Article Online


Sustainable Alternatives to Petroleum-Derived Excipients in Pharmaceutical Oil-in-Water Creams

Dana Gates, Abu Zayed Md Badruddoza, Md Ikhtiar Zahid, Thean Yeoh, Jaymin Shah, Taylor Walsh & Md Nurunnabi

doi : 10.1208/s12249-024-02784-z

Buy The Package and View The Article Online


Co-Processed Crystalline Solids of Ivermectin with Span® 60 as Solubility Enhancers of Ivermectin in Natural Oils

Luandri de Vos, Minja Gerber, Wilna Liebenberg, Johanna C. Wessels & Hendrik J. R. Lemmer

doi : 10.1208/s12249-024-02783-0

Buy The Package and View The Article Online


Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis

Chetan Hasmukh Mehta, Varalakshmi Velagacherla, Suman Manandhar, Yogendra Nayak, Sreedhara Ranganath K Pai, Shruthi Acharya & Usha Yogendra Nayak

doi : 10.1208/s12249-024-02787-w

Buy The Package and View The Article Online


Correction: Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons

Shiji Liao, Guirong Qiu, Yanping Hu, Bohong Guo & Yuqin Qiu

doi : 10.1208/s12249-024-02779-w

Buy The Package and View The Article Online


A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications

Huma Hameed, Saleha Faheem, Ana Cláudia Paiva-Santos, Hafiz Shoaib Sarwar & Muhammad Jamshaid

doi : 10.1208/s12249-024-02786-x

Buy The Package and View The Article Online


Retraction Note: Natural Polymer–Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery

Sadia Rehman, Asadullah Madni, Qazi Adnan Jameel, Faisal Usman, M. Rafi Raza, Faiz Ahmad, Hina Shoukat, Hamdan Aali & Afifa Shafiq

doi : 10.1208/s12249-024-02788-9

Buy The Package and View The Article Online


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