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I. Indices of Pain Intensity Derived From Ecological Momentary Assessments: Rationale and Stakeholder Preferences
Arthur A.Stone*†Joan E.Broderick*Roberta E.Goldman‡Doerte U.Junghaenel*AliciaBolton*MarcellaMay*StefanSchneider
doi : 10.1016/j.jpain.2020.08.003
Volume 22, Issue 4, April 2021, Pages 359-370
Pain assessment that fully represents patients’ pain experiences is essential for chronic pain research and management.
II. Indices of Pain Intensity Derived From Ecological Momentary Assessments and Their Relationships With Patient Functioning: An Individual Patient Data Meta-analysis
StefanSchneider*Doerte U.Junghaenel*Joan E.Broderick*MasakatsuOno*MarcellaMay*Arthur A.Stone*
doi : 10.1016/j.jpain.2020.10.002
Volume 22, Issue 4, April 2021, Pages 371-385
Pain intensity is a complex and dynamic experience. A focus on assessing patients’ average pain levels may miss important aspects of pain that impact functioning in daily life.
III. Detecting Treatment Effects in Clinical Trials With Different Indices of Pain Intensity Derived From Ecological Momentary Assessment
StefanSchneider*Doerte U.Junghaenel*MasakatsuOno*Joan E.Broderick*Arthur A.Stone*
doi : 10.1016/j.jpain.2020.10.003
Volume 22, Issue 4, April 2021, Pages 386-399
Pain intensity represents the primary outcome in most pain clinical trials.
Investigating the True Effect of Psychological Variables Measured Prior to Arthroplastic Surgery on Postsurgical Outcomes: A P-Curve Analysis
Nils GeorgNiederstrasser*StephanieCook
doi : 10.1016/j.jpain.2020.07.005
Volume 22, Issue 4, April 2021, Pages 400-414
Patients’ presurgical psychological profiles have been posited to predict pain and function following arthroplastic surgery of the hip and knee.
Prior Pain Exposure and Mere Possession of a Placebo Analgesic Predict Placebo Analgesia: Findings From a Randomized, Double-Blinded, Controlled Trial
Victoria Wai-lanYeung*Andrew LGeers
doi : 10.1016/j.jpain.2020.10.004
Volume 22, Issue 4, April 2021, Pages 415-431
A recent study found that merely possessing a placebo analgesic reduces pain.
Assessment of Chronic Pain Management in the Treatment of Opioid Use Disorder: Gaps in Care and Implications for Treatment Outcomes
Matthew S.EllisZacharyKasperTheodoreCicero
doi : 10.1016/j.jpain.2020.10.005
Volume 22, Issue 4, April 2021, Pages 432-439
Chronic pain is a significant comorbid condition among individuals with opioid use disorder (OUD).
Analgesic Effects of Topical Amitriptyline in Patients With Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights From Studies in Mice
Anne-LaureGenevois*#JérômeRuel†#VirginiePenalba†SéverineHatton*CamillePetitfils‡MyriamDucrocq†PaolaPrincipe§GillesDietrich‡CélineGreco*¶##PatrickDelmas†
doi : 10.1016/j.jpain.2020.11.002
Volume 22, Issue 4, April 2021, Pages 440-453
Oral amitriptyline hydrochloride (amitriptyline) is ineffective against some forms of chronic pain and is often associated with dose-limiting adverse events.
Central Endothelin-1 Confers Analgesia by Triggering Spinal Neuronal Histone Deacetylase 5 (HDAC5) Nuclear Exclusion in Peripheral Neuropathic Pain in Mice
PanGu*†§TingtingFan*†Stanley Sau ChingWong*†ZhiqiangPan¶Wai LydiaTai*†?Sookja KimChung??††Chi WaiCheung
doi : 10.1016/j.jpain.2020.12.004
Volume 22, Issue 4, April 2021, Pages 454-471
The rationale of spinal administration of endothelin-1(ET-1) mediated anti-nociceptive effect has not been elucidated.
