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Methadone in Pain Management: A Systematic Review
VerinaHanna*HelenSenderovich
doi : 10.1016/j.jpain.2020.04.004
Volume 22, Issue 3, March 2021, Pages 233-245
Adequate analgesia can be challenging, as pharmacological options are not necessarily effective for all types of pain and are associated with adverse effects. Methadone is increasingly being considered in the management of both cancer-related and noncancer-related pain.
Chronic Opioid Therapy: A Scoping Literature Review on Evolving Clinical and Scientific Definitions
YunShen*†HemitaBhagwandass*TychellBranchcomb*Sophia A.Galvez*IvannaGrande*JuliaLessing*MikelaMollanazar*NatalieOurhaan*RazanneOueini*MichaelSasser*Ivelisse L.Valdes*AshmitaJadubans*JosefHollmann*MichaelMaguire*SilkenUsmani*Scott MVouri*†Juan MHincapie-Castillo*†‡Lauren E.Adkins§Amie JGoodin*†
doi : 10.1016/j.jpain.2020.09.002
Volume 22, Issue 3, March 2021, Pages 246-262
The management of chronic noncancer pain (CNCP) with chronic opioid therapy (COT) is controversial.
Transcranial Direct Current Stimulation Accelerates The Onset of Exercise-Induced Hypoalgesia: A Randomized Controlled Study
JanaBorovskis*†RoccoCavaleri*†FelicityBlackstock*Simon JSummers
doi : 10.1016/j.jpain.2020.08.004
Volume 22, Issue 3, March 2021, Pages 263-274
Exercise-induced hypoalgesia (EIH) describes acute reductions in pain that occur following exercise.
Molecular Pathways Linking Oxylipins to Nociception in Rats
Anthony F.Domenichiello*Matthew R.Sapio†Amelia J.Loydpierson†DraganMaric‡TaichiGoto§Mark S.Horowitz*Gregory S.Keyes*Zhi-XinYuan*Sharon. F.Majchrzak-Hong¶Andrew J.Mannes†Michael J.Iadarola†Christopher E.Ramsden
doi : 10.1016/j.jpain.2020.09.001
Volume 22, Issue 3, March 2021, Pages 275-299
Oxylipins are lipid peroxidation products that participate in nociceptive, inflammatory, and vascular responses to injury.
Median Nerve Stimulation as a Nonpharmacological Approach to Bypass Analgesic Tolerance to Morphine: A Proof-of-Concept Study in Mice
Ming TattLee*†‡Yi-HungChen§¶KenMackie???Lih-ChuChiou
doi : 10.1016/j.jpain.2020.09.003
Volume 22, Issue 3, March 2021, Pages 300-312
Analgesic tolerance to opioids contributes to the opioid crisis by increasing the quantity of opioids prescribed and consumed.
Pain Intensity as a Lagging Indicator of Patient Improvement: Longitudinal Relationships With Sleep, Psychiatric Distress, and Function in Multidisciplinary Care
John A.Sturgeon*DaleLangford*DavidTauben*‡MarkSullivan
doi : 10.1016/j.jpain.2020.10.001
Volume 22, Issue 3, March 2021, Pages 313-321
Despite a common assumption that reductions in chronic pain intensity must precede improvements in other pain-relevant domains, there has been limited empirical inquiry into the temporal ordering of improvements in chronic pain treatment.
Longitudinal Transcriptomic Profiling in Carrageenan-Induced Rat Hind Paw Peripheral Inflammation and Hyperalgesia Reveals Progressive Recruitment of Innate Immune System Components
TaichiGoto*Matthew R.Sapio†DraganMaric‡Jeffrey M.Robinson§Leorey N.Saligan*Andrew J.Mannes†Michael J.Iadarola
doi : 10.1016/j.jpain.2020.11.001
Volume 22, Issue 3, March 2021, Pages 322-343
Pain is a common but potentially debilitating symptom, often requiring complex management strategies.
A Cost-effectiveness Analysis of an Internet-delivered Pain Management Program Delivered With Different Levels of Clinician Support: Results From a Randomised Controlled Trial
Blake F.Dear*EyalKarin*RhiannonFogliati*JoanneDudeney*OlavNielssen*Amelia J.Scott*MilenaGandy*Madelyne A.Bisby*Andreea I.Heriseanu*TaylorHathway*LaurenStaples*NickolaiTitov*LizSchroeder
doi : 10.1016/j.jpain.2020.11.003
Volume 22, Issue 3, March 2021, Pages 344-358
There is growing interest in the potential of internet-delivered pain management programs (PMPs) to increase access to care for people with chronic pain. However, very few economic evaluations of these interventions have been reported.
