Neurology




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Cinpanemab in Early Parkinson Disease: Evaluation of Biomarker Results From the Phase 2 SPARK Clinical Trial.

Hutchison, R. Matthew PhD *; Fraser, Kyle PhD *; Yang, Minhua MS; Fox, Tara MS; Hirschhorn, Elizabeth MS; Njingti, Edwin MS; Scott, David PhD; Bedell, Barry J. MD, PhD; Kistner, Kristi M. BS; Cedarbaum, Jesse M. MD; Evans, Karleyton C. MD; Graham, Danielle PhD; Martarello, Laurent PhD; Mollenhauer, Brit PhD; Lang, Anthony E. MD; Dam, Tien MD; Beaver, John PhD

doi : 10.1212/WNL.0000000000209137

Volume 102(5) pgs. e209137-e209211,1-10 March 12, 2024

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Fluid Biomarkers for Trial Enrichment and Effect Monitoring in Disease-Modifying Treatments for Parkinson Disease.

Parnetti, Lucilla MD, PhD; Paoletti, Federico Paolini

doi : 10.1212/WNL.0000000000209194

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Negative Regulator of Reactive Oxygen Species-Related Microgliopathy: A Tale of Epileptic Spasms With Intracranial Calcifications.

Mahesan, Aakash MD; Kamila, Gautam MD, DM; Jauhari, Prashant MD, DM; Chakrabarty, Biswaroop DM; Kumar, Atin MD, DNB; Gulati, Sheffali MD

doi : 10.1212/WNL.0000000000209182

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Teaching Video NeuroImage: Torsional Saccadic Palsy in Bilateral Thalamic Infarctions.

Kwon, Hyesoo MD; Kim, Hyo-Jung; Kim, Ji-Soo MD, PhD

doi : 10.1212/WNL.0000000000209184

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Teaching Video NeuroImage: Calf Hypertrophy and Myoedema Unravel a Diagnosis of Severe Hypothyroidism.

Camargos, Sarah MD, PhD; Ribeiro, Petala Silva; Barbosa, Luiz Sergio M. MD

doi : 10.1212/WNL.0000000000209139

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Teaching Video NeuroImage: TWNK Mutation Causes Chronic Progressive External Ophthalmoplegia and Cerebellar Ataxia: A POLG-Like Phenotype.

Fraiman, Pedro H.A. MD; Silva, Thiago Y.T. MD; Pedroso, Jose Luiz MD, PhD; Barsottini, Orlando G.P. MD, PhD

doi : 10.1212/WNL.0000000000209186

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Clinical Reasoning: A 30-Year-Old Woman Presenting With Rapidly Progressive Dementia and Extreme Hypoglycorrhachia.

Bai, Xiaolin MD; Xiang, Jingyan PhD; Deng, Jiangshan PhD; Ding, Wan Hai PhD; Luan, Xinghua PhD *; Geng, Zhi MD *

doi : 10.1212/WNL.0000000000209188

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Role of Deployment History on the Association Between Epilepsy and Traumatic Brain Injury in Post-9/11 Era US Veterans.

doi : 10.1212/WNL.0000000000209193

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Emerging Subspecialties in Neurology: Women's Neurology.

doi : 10.1212/WNL.0000000000209208

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Access to Pediatric Neurology Training and Services Worldwide: A Survey by the International Child Neurology Association.

doi : 10.1212/WNL.0000000000208125

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Author Response: Effects of Season and Daylight Saving Time Shifts on Sleep Symptoms: Canadian Longitudinal Study on Aging.

Zolfaghari, Sheida; Postuma, Ronald B.

doi : 10.1212/WNL.0000000000209233

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Reader Response: Effects of Season and Daylight Saving Time Shifts on Sleep Symptoms: Canadian Longitudinal Study on Aging.

Kunz, Dieter

doi : 10.1212/WNL.0000000000209232

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Editors' Note: Effects of Season and Daylight Saving Time Shifts on Sleep Symptoms: Canadian Longitudinal Study on Aging.

Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD

doi : 10.1212/WNL.0000000000209231

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Author Response: IV Thrombolysis vs Early Dual Antiplatelet Therapy in Patients With Mild Noncardioembolic Ischemic Stroke.

Sykora, Marek; Ferrari, Julia

doi : 10.1212/WNL.0000000000209235

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Reader Response: IV Thrombolysis vs Early Dual Antiplatelet Therapy in Patients With Mild Noncardioembolic Ischemic Stroke.

Pensato, Umberto; Forlivesi, Stefano; Zini, Andrea

doi : 10.1212/WNL.0000000000209234

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Editors' Note: IV Thrombolysis vs Early Dual Antiplatelet Therapy in Patients With Mild Noncardioembolic Ischemic Stroke.

Siegler, James E. MD; Galetta, Steven MD

doi : 10.1212/WNL.0000000000209236

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Sex Differences in the Role of Multimorbidity on Poststroke Disability: The Taiwan Stroke Registry.

Egle, Marco PhD; Wang, Wei-Chun MD; Fann, Yang C. PhD *; Johansen, Michelle C. MD, PhD; Lee, Jiunn-Tay MD; Yeh, Chung-Hsin MD, PhD; Jason Lin, Chih-Hao MD; Jeng, Jiann-Shing MD, PhD; Sun, Yu MD, PhD; Lien, Li-Ming MD, PhD; the Taiwan Stroke Registry Investigators,; Gottesman, Rebecca F. MD, PhD *

doi : 10.1212/WNL.0000000000209140

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Safety and Efficacy of Apitegromab in Patients With Spinal Muscular Atrophy Types 2 and 3: The Phase 2 TOPAZ Study.

Crawford, Thomas O. MD; Darras, Basil T. MD; Day, John W. MD, PhD; Dunaway Young, Sally PT, DPT; Duong, Tina MPT, PhD; Nelson, Leslie L. MPT, PhD; Barrett, Doreen MS; Song, Guochen MS, DRPH; Bilic, Sanela PharmD, MBA; Cote, Shaun PhD; Sadanowicz, Mara MSW; Iarrobino, Ryan BA; Xu, Tiina J. BA; O'Neil, Janet MBA; Rossello, Jose MD, PhD, MHCM; Place, Amy PhD; Kertesz, Nathalie PhD; Nomikos, George MD, PhD; Chyung, Yung MD

doi : 10.1212/WNL.0000000000209151

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What Is the Role of Nuclear Envelope Proteins in Neurologic Disorders?.

Benarroch, Eduardo MD

doi : 10.1212/WNL.0000000000209202

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Clinical Reasoning: A 54-Year-Old Woman With Progressive Headache and Neurologic Decline.

Cheng, Yao MD; Zachariah, Joseph DO

doi : 10.1212/WNL.0000000000209190

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Teaching NeuroImage: Tension Pneumocephalus After Meningioma Resection.

Yang, Ailing E. MD; Shutran, Max S. MD; Fehnel, Corey R. MD; Yoon, Jason MD; Das, Alvin S. MD

doi : 10.1212/WNL.0000000000209185

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Effect of Evobrutinib on Slowly Expanding Lesion Volume in Relapsing Multiple Sclerosis: A Post Hoc Analysis of a Phase 2 Trial.

Arnold, Douglas L. MD; Elliott, Colm PhD; Martin, Emily C. PhD; Hyvert, Yann PhD; Tomic, Davorka MD; Montalban, Xavier MD, PhD

doi : 10.1212/WNL.0000000000208058

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Chronically Active Lesions as a Trial Outcome in Multiple Sclerosis: A New Perspective on an Old Foe.

Chard, Declan T. PhD

doi : 10.1212/WNL.0000000000209246

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Efficacy and Safety of Vamorolone Over 48 Weeks in Boys With Duchenne Muscular Dystrophy: A Randomized Controlled Trial.

Dang, Utkarsh J. PhD; Damsker, Jesse M. PhD; Guglieri, Michela MD; Clemens, Paula R. MD; Perlman, Seth J. MD; Smith, Edward C. MD; Horrocks, Iain MD; Finkel, Richard S. MD; Mah, Jean K. MD; Deconinck, Nicolas MD; Goemans, Nathalie M. MD, PhD; Haberlova, Jana MD; Straub, Volker MD, PhD; Mengle-Gaw, Laurel PhD; Schwartz, Benjamin D. MD, PhD; Harper, Amy MD; Shieh, Perry B. MD, PhD; De Waele, Liesbeth MD; Castro, Diana MD; Yang, Michele L. MD; Ryan, Monique M. MBBS, MMed, FRACP; McDonald, Craig M. MD; Tulinius, Mar MD, PhD; Webster, Richard I. MBBS, MSc, FRACP; Mcmillan, Hugh J. MD, MSc; Kuntz, Nancy MD; Rao, Vamshi K. MD; Baranello, Giovanni MD, PhD; Spinty, Stefan MD; Childs, Anne-Marie MB ChB, FRCPCH; Sbrocchi, Annie M. MD; Selby, Kathryn A. MD; Monduy, Migvis MD; Nevo, Yoram MD; Vilchez, Juan J. MD; Nascimento-Osorio, Andres MD; Niks, Erik H. MD, PhD; De Groot, Imelda J.M. MD; Katsalouli, Marina MD; Van Den Anker, John N. MD, PhD; Ward, Leanne M. MD; Leinonen, Mika MS; D'Alessandro, Andrea L. MSGC; Hoffman, Eric P. PhD

doi : 10.1212/WNL.0000000000208112

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Prognostic Role of Ventricular Size and Its Dynamics in Patients With Leptomeningeal Metastasis From Solid Tumors.

Le Rhun, Emilie MD, PhD; Devos, Patrick; Seystahl, Katharina MD; Jongen, Joost L. M. MD, PhD; Gramatzki, Dorothee MD; Roth, Patrick MD; Van Den Bent, Martin J. MD; Regli, Luca MD; Brandsma, Dieta MD, PhD; Weller, Michael MD

doi : 10.1212/WNL.0000000000207959

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Association of EEG Background With Diffusion-Weighted Magnetic Resonance Neuroimaging and Short-Term Outcomes After Pediatric Cardiac Arrest.

Bach, Ashley M. MD, MPH; Kirschen, Matthew P. MD, PhD; Fung, France W. MD; Abend, Nicholas S. MD, MSCE; Ampah, Steve PhD; Mondal, Antara MS; Huh, Jimmy W. MD; Chen, Shih-Shan L. MD; Yuan, Ian MD; Graham, Kathryn MLAS; Berman, Jeffrey I. PhD; Vossough, Arastoo MD, PhD; Topjian, Alexis MD, MSCE

doi : 10.1212/WNL.0000000000209134

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Combining Electrophysiology and Neuroimaging to Enhance Accuracy of Neuroprognostication in Children After Cardiac Arrest.

Ganesan, Saptharishi L. MBBS, MD, DM, FACNS

doi : 10.1212/WNL.0000000000209254

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Variation in Resting Metabolic Rate Affects Identification of Metabolic Change in Geographically Distinct Cohorts of Patients With ALS.

Holdom, Cory J. BBiomSc (Hons); Janse van Mantgem, Mark R. MD; He, Ji MD, PhD; Howe, Stephanie L. BSc (Hons); McCombe, Pamela A. FRACP, PhD; Fan, Dongsheng MD, PhD; van den Berg, Leonard H. MD, PhD; Henderson, Robert D. MBBS, PhD, FRACP; van Eijk, Ruben MD, PhD; Steyn, Frederik J. MSc, PhD *; Ngo, Shyuan T. PhD *

doi : 10.1212/WNL.0000000000208117

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Hypermetabolism in Amyotrophic Lateral Sclerosis: Step Ahead Toward Global Consensus.

Urushitani, Makoto MD, PhD; Nakamura, Ryutaro

doi : 10.1212/WNL.0000000000209179

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Sleep Characteristics and Risk of Stroke and Dementia: An Observational and Mendelian Randomization Study.

Guo, Chutian BSc; Harshfield, Eric L. PhD *; Markus, Hugh S. DM *

doi : 10.1212/WNL.0000000000209141

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Investigating the Prevalence of Comorbidity in Multiple Sclerosis Clinical Trial Populations.

Salter, Amber PhD; Lancia, Samantha MS; Kowalec, Kaarina PhD; Fitzgerald, Kathryn C. ScD; Marrie, Ruth Ann MD, PhD

doi : 10.1212/WNL.0000000000209135

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Incidence of Stroke in Indigenous Populations of Countries With a Very High Human Development Index: A Systematic Review.

Balabanski, Anna H. MBBS, FRACP, PhD; Dos Santos, Angela MBBS, FRACP; Woods, John A. PhD; Mutimer, Chloe A. MD; Thrift, Amanda G. PhD, PGDipBiostat; Kleinig, Timothy J. PhD; Suchy-Dicey, Astrid M. PhD; Siri, Susanna Ragnhild A. PhD; Boden-Albala, Bernadette MPH, DrPH; Krishnamurthi, Rita V. BSc, MApplSc, PhD; Feigin, Valery L. MD, PhD, FAAN; Buchwald, Dedra MD; Ranta, Annemarei PhD; Mienna, Christina S. PhD; Zavaleta-Cortijo, Carol PhD; Churilov, Leonid PhD; Burchill, Luke PhD; Zion, Deborah PhD; Longstreth, W.T. Jr MD; Tirschwell, David L. MD; Anand, Sonia S. MD, PhD; Parsons, Mark W. MBBS, FRACP, PhD; Brown, Alex PhD; Warne, Donald K. MD; Harwood, Matire PhD; Barber, P. Alan PhD; Katzenellenbogen, Judith M. PhD

doi : 10.1212/WNL.0000000000209138

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Brody Disease, an Early-Onset Myopathy With Delayed Relaxation and Abnormal Gait: A Case Series of 9 Children.

Verhoeven, Jamie I. MD *; Kramer, Jasper MD *; Seeger, Juergen; Molenaar, Joery P. MD; Braakman, Hilde MD, PhD; Kamsteeg, Erik-Jan PhD; Rodenburg, Richard J. PhD; Kusters, Benno PhD; Koudijs, Suzanne MD, PhD; Van Engelen, Baziel G. MD, PhD; Erasmus, Corrie E. MD, PhD +; Voermans, Nicol C. MD, PhD +

doi : 10.1212/WNL.0000000000209164

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Neurobehavioral Phenotype of Children With Congenital Myotonic Dystrophy.

Patel, Namita MD *; Berggren, Kiera N. MA, MS *; Hung, Man PhD; Bates, Kameron MS; Dixon, Melissa M. PhD; Bax, Karen PhD, CPsych; Adams, Heather PhD; Butterfield, Russell J. MD, PhD; Campbell, Craig MD; Johnson, Nicholas E. MD, MSci

doi : 10.1212/WNL.0000000000208115

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Disseminating Necrotizing Leukoencephalopathy Associated With Intra-CSF Methotrexate Chemotherapy: A Retrospective Observational Study.

Kim, Ki Hoon MD *; Park, Moowan MD *; Park, Eun Young MS; Gwak, Ho-Shin MD, PhD; Kim, Su-Hyun MD, PhD; Seo, Ji Won MD; Hyun, Jae-Won MD, PhD; Kim, Ho Jin MD, PhD; Dho, Yun-Sik MD, PhD; Shin, Sang-Hoon MD; Yoo, Heon MD, PhD; Chang Wang, Kyu MD, PhD

doi : 10.1212/WNL.0000000000209167

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Association of PM2.5 Exposure and Alzheimer Disease Pathology in Brain Bank Donors-Effect Modification by APOE Genotype.

Christensen, Grace M. PhD *; Li, Zhenjiang PhD *; Liang, Donghai PhD; Ebelt, Stefanie ScD; Gearing, Marla PhD; Levey, Allan I. MD, PhD; Lah, James J. MD, PhD; Wingo, Aliza MD; Wingo, Thomas MD; Huls, Anke PhD

doi : 10.1212/WNL.0000000000209162

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Long-Term Longitudinal Course of Cognitive and Motor Symptoms in Patients With Cerebral Small Vessel Disease.

Bergkamp, Mayra I. MD; Jacob, Mina A. MD; Cai, Mengfei MD, PhD; Claassen, Jurgen A. MD, PhD; Kessels, Roy P.C. PhD; Esselink, Rianne MD, PhD; Tuladhar, Anil Man MD, PhD; De Leeuw, Frank-Erik MD, PhD

doi : 10.1212/WNL.0000000000209148

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SARS-CoV-2 Infection and Risk of Postacute Psychiatric and Neurologic Diagnoses: A Nationwide Danish Cohort Study.

Nielsen, Nete M. MD, MSc, PhD; Spiliopoulos, Lampros MSc; Hansen, Jorgen V. MSc, PhD; Videbech, Poul MD, DrMedSci; Hviid, Anders MSc, DrMedSci

doi : 10.1212/WNL.0000000000208113

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Untangling the Landscape of Neurologic and Psychiatric Post-COVID-19 Conditions.

Chow, Eric J. MD, MS, MPH; Chopra, Anita MD

doi : 10.1212/WNL.0000000000209211

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