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Cutaneous sarcoidosis post platelet-rich plasma injections: A case report during the COVID pandemic
Serena Saade MD, Nohra Ghaoui MD, Micheline Maamari MD
doi : 10.1111/jocd.15901
Reply to the letter “skin manifestations following anti-COVID-19 vaccination: A multicentric study from Turkey: Correspondence�
Ilteris Oguz Topal MD, AyÅŸe Serap KaradaÄŸ MD
doi : 10.1111/jocd.15884
Review of hair prosthetic options for patients with alopecia
Adaora Ewulu MD, Randy Amibang MS, Min Deng MD
doi : 10.1111/jocd.15907
Advanced cases of alopecia can be very difficult to treat pharmacologically. Hair loss can be emotionally taxing for many, leading to depression, anxiety, or suicide. Currently, there is limited medical literature on prosthetic hair devices available for patients with alopecia.
Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review
Rana Abu-Huwaij PhD, Abdullah N. Zidan BSc
doi : 10.1111/jocd.15895
In a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.
Potential role of inflammaging mediated by the complement system in enlarged facial pores
Wei Qiu MD, Feng Chen MS, Xiaoyue Feng MM, Jianli Shang MS, Xingyi Luo BS, Yong Chen MD
doi : 10.1111/jocd.15956
Enlarged facial pores are a common cosmetic concern of the skin, rather than a disease, and have not received much attention from dermatologists in recent years. Consequently, progress in understanding their pathogenesis has been limited, and current cosmetic solutions have limitations. Given that the complement system has regained interest as a key player in chronic inflammatory skin conditions, various mechanisms involving this system are being investigated.
The efficacy and safety of microneedling with topical tranexamic acid for melasma treatment: A systematic review and meta-analysis
Xiaowei Feng MD, Hong Su MD, Jinwei Xie MD, PhD
doi : 10.1111/jocd.15965
Treating rosacea with botulism toxin: Protocol for a systematic review and meta-analysis
Guanjin He MD, Qifeng Yang MM, Jin Wu MM, Yuanen Huang MM, Huilan Zheng MD, Hongbin Cheng MD
doi : 10.1111/jocd.15962
Rosacea is a chronic inflammatory disease usually associated with persistent erythema and periodic flushing. This disease is difficult to treat, and the outcomes are often unsatisfactory and prone to recurrence. In recent years, botulinum toxin has been used as a new treatment for rosacea; however, its efficacy and safety remain under discussion. Although a systematic review of the effectiveness and safety of botulinum toxin has been previously conducted by other researchers, our systematic review and meta-analysis evaluate the efficacy of botulinum toxin from a more comprehensive and detailed perspective to provide evidence for clinicians.
Rosehip extract and wound healing: A review
Malachy Belkhelladi, Amina Bougrine MD
doi : 10.1111/jocd.15971
Each year, over 100 million patients are afflicted with new scars from medical procedures worldwide. Natural compounds have shown promise in the treatment of scars and skin disorders. Rosehip oil (RO), produced from the pressed fruit of the rosehip (Rosa canina L.) plant, is used in the pharmaceutical, cosmetic, and food industries. The use of this plant in the treatment of scars has yet to be reviewed.
Adenosine deaminase 2 deficiency in a Chinese patient: Report of one novel mutation and literature review
Bai Yuxuan MM, Duan Yan MD
doi : 10.1111/jocd.15920
Through a case of deficiency of adenosine deaminase 2 (DADA2) to improve domestic clinicians' understanding of the disease, and to review the literature, promote dermatologists for clinical secondary primary lesion diagnosis.
Dermal hinge flap with adjuvant corticosteroid injection for ear keloid
Joon Suk Bae MD, Eun Soo Park MD, PhD, Seung Min Nam MD, PhD, Han Gyu Cha MD, PhD, Chang Yong Choi MD, PhD
doi : 10.1111/jocd.15949
Treating the double chin with hyaluronic acid injection
Jui-Hui Peng MD, Hsien-Li Peter Peng MD
doi : 10.1111/jocd.16100
Submental fullness (SMF), or the double chin, is a condition regarded as undesirable. Many treatment modalities are available for SMF reduction, such as energy-based devices, injection lipolysis, or surgery. However, of minimal invasive modalities, hyaluronic acid (HA) injection has not been explored for possible SMF treatment.
Does injecting small amounts of fillers prevent the development of secondary blindness?
Kyu-Ho Yi MD, PhD, Hyung-Jin Lee PhD, Woo-Ram Kim MD, Min Ho An MD, Hyun-Jin Park PhD, Hyewon Hu MFA, Hee-Jin Kim DDS, PhD
doi : 10.1111/jocd.15898
Inadvertent entry of filler products into the supratrochlear, supraorbital, or dorsal nasal arteries, among other branches of the ophthalmic artery, might result in an immediate and devastating loss of vision. We wanted to examine how much filler could block the ophthalmic artery.
Classification of gastrocnemius muscle hypertrophy for personalized botulinum toxin type A treatment
Dandan Liu MD, PhD, Xiangwen Xu MD, Mengfan Wu MD, PhD, Lin Luo MD, PhD, Jun Feng MD, PhD, Yanting Ou MD, Adriana C. Panayi MD, Yun Long MBBS, Yongyan Cui MD
doi : 10.1111/jocd.15943
Owing to its safety and convenience, botulinum toxin type A (BoNtA) has become a first-choice treatment for contouring calf muscle asymmetries or deformities. Different injection methods and dosages have been discussed in the literature, but a standardized BoNtA treatment remains unclear.
Biostimulating fillers and induction of inflammatory pathways: A preclinical investigation of macrophage response to calcium hydroxylapatite and poly-L lactic acid
Bartosch Nowag PhD, Daniela Schäfer, Thomas Hengl PhD, Niamh Corduff MBBS, FRACS, Kate Goldie MD
doi : 10.1111/jocd.15928
Initial macrophage response to biostimulatory substances is key in determining the subsequent behavior of fibroblasts and the organization of newly synthesized collagen. Though histological studies suggest that calcium hydroxylapatite (CaHA) filler initiates a regenerative healing response with collagen and elastin deposition similar to natural, healthy tissue rather than an inflammatory response with fibrosis, the relative activity of macrophages stimulated by CaHA, as well as how this activity compares to that induced by other biostimulatory fillers, has not been explored. The aim of the study is to characterize the in vitro macrophage response to two biostimulory fillers, CaHA and PLLA (poly-L lactic acid), and to evaluate their inflammatory potential.
Self-perception of natural outcome, appearance, and emotional well-being after OnabotulinumtoxinA treatment for upper facial lines: Post hoc analysis across age and gender
Steven Dayan MD, Patricia Ogilvie MD, Charles Boyd MD, Koenraad De Boulle MD, Maurizio Cavallini MD, Julia K. Garcia PhD, MS, Maria Musumeci PhD
doi : 10.1111/jocd.15947
OnabotulinumtoxinA (onabotA) is indicated for upper facial lines (UFL). Fear of unnatural-looking outcomes is a frequently reported treatment barrier.
Efficacy and safety of high-intensity, high-frequency, non-focused ultrasound parallel beams for facial skin laxity
Michael H. Gold MD, Julie Biron BSc
doi : 10.1111/jocd.16098
Ultrasound energy has been used for dermal rejuvenation to treat fine lines, wrinkles and to lift lax skin. High intensity ultrasound waves induce thermal injury in the dermis, stimulating neocollagenesis and neoelastinogenesis.
Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation
Hui-Hui Wu MMS, Mei-Qing Chen MMS, Juan-Hua Liu MMS, Lu-Li Song BMS, Di-Qing Luo MMS, Jing-Fa Lu MMS, Yu-Kun Zhao MMS
doi : 10.1111/jocd.15942
The most visible sign of facial aging is often seen in the periocular area. However, periocular rejuvenation remains challenging due to the particularity of periocular anatomic locations.
The application of microwaves in axillary hyperhidrosis: Curative effect observation of a pathological examination over 1 year
Yaxin Tan MM, Wanxiao Huang MM, Jianmeng Liu MM, Zhiyi Duan MM, Xiaolin He MM, Qiongyan Li MB, Zhi Yang PhD
doi : 10.1111/jocd.15909
In Asia, axillary hyperhidrosis is a frequent problem for many people, and the consequent excessive sweating can seriously affect many aspects of daily life and even lead to mental disorders. Microwave therapy is a new, non-invasive treatment method for axillary hyperhidrosis, whose energy and long-term effectiveness still needs to be clinically validated.
Using 3% retinol peeling and cosmeceuticals for the aesthetic wellness of the oncological patient after precautionary endocrine treatment: A case series
M. Belmontesi MD, C. Noberasco MD
doi : 10.1111/jocd.15908
Roughness, sagging, and skin rash are common in patients with breast cancer treated with LH-RH analog plus tamoxifen or aromatase inhibitors as adjuvant postsurgical endocrine therapy. The use of topical retinol (vitamin A) has shown to be an efficacious cosmetic treatment.
Multicenter evaluation of a topical antioxidant serum
Amir Moradi MD, MBA, Faiza Shafiq MBBS, CCRP, Tiffany Robison MS, CCRC, Lora Colvan BA, Jeannette Poehler BA, CCRC, Alan D. Widgerow MBBCh, MMed, FCS, FACS
doi : 10.1111/jocd.16067
A new antioxidant serum has been formulated with sodium ascorbate, a sodium salt of Vit C, which aims to address facial photodamage while maintaining a low irritation profile and preserving elastin. Detailed background science has been submitted in a previous publication. This open-label study was conducted to validate the science by demonstrating product efficacy and tolerability in patients with moderate to severe facial photodamage.
The relative effect of monotherapy with 5-alpha reductase inhibitors and minoxidil for female pattern hair loss: A network meta-analysis study
Aditya K. Gupta MD, PhD, Tong Wang MSc, Mary A. Bamimore PhD, Mesbah Talukder BPharm, MPharm, PhD
doi : 10.1111/jocd.15910
Minoxidil and the 5-alpha reductase inhibitors (5-ARIs), specifically, dutasteride and finasteride, are usually used to treat pattern hair loss (PHL), but evidence on the relative effectiveness of these drugs is far less for women than men.
An absence of imperfections: A proposed framework for defining, assessing, and achieving skin glow
Greg J. Goodman MBBS, FACD, MD, GradDipClinEpi, Katherine Armour MBCHB (OTAGO), FACD, David Ong MBBS, DipSurgAnat, FAACS, Tanongkiet Tienthavorn MD, Yan Wu MD, PhD, Pei-Chun Chen MD, Elias Tam MD, Amanda Ong MBBS, Gina Messiha MBBS, FRACGP, Tara Telfer BA (Hons), Luiz E. T. Avelar MD
doi : 10.1111/jocd.16063
Skin glow is a subcomponent of skin quality. It has become entrenched in the cosmeceuticals and aesthetics lexicons as a synonym for health and youth, but is not well-defined as a scientific metric.
A retrospective study on the clinical features of skin lesions in Chinese acquired digital fibrokeratoma patients
Acquired digital fibrokeratoma (ADFK) is an uncommon benign fibro-epithelioma, which is rarely reported in China.
doi : 10.1111/jocd.15889
Yang Liu MD, Yueqian Zhu MD, PhD, Guodong Chen MD, Hui Xu MD, PhD, Yamin Rao MD, Ke Liu MD, PhD
Evaluation of pathogen distribution and antimicrobial resistance in breast plastic surgery infection
Xueshang Su MM, Jintian Hu MD, Fengli Jiang MM, Yuanyuan Wu MM, Jingjing He MM, Ximeng Jia MM, Sien Zhan MD
doi : 10.1111/jocd.15919
The demand for mammaplasty has increased in recent years, and infection remains one of the common and serious post-operative complications. In this study, we analyzed the pathogen distribution and antibiotic susceptibility of breast plastic surgery infections, and compared the differences in pathogenic species between surgical procedures.
The third generation barbed lifting threads: Added value of hyaluronic acid
Georges Ziade MD, FACS, Dayane Daou MD, MSc, Desiree Karam MD, Murat Tsintsadze MD
doi : 10.1111/jocd.15885
Facial thread lifting is a highly demanded procedure in esthetic clinics worldwide. The aim of this retrospective study is to evaluate the clinical effectiveness and overall patients’ satisfaction of a new generation of barbed threads, in which a hyaluronic acid (HA) coat was added to the PLLA/PCL threads and compare the results with PLLA/PCL threads without HA.
Ultrasound-based histological differences of pretarsal fat fascia before and after double eyelid blepharoplasty with the orbital septum method
Qian Chen MSc, Xiren Long MSc, Youqi Luo MSc, Xi Li, Gaofeng Li MD
doi : 10.1111/jocd.15948
To observe the changes of pretarsal fat fascia histological structure after double eyelid blepharoplasty with the orbital septum method.
Non-surgical rhinoplasty using polydioxanone threads
Omotara Sulyman MD, Robert Cristel MD, Nimit Gandhi MD, Eljona Kola MS, Selika Gutierrez Borst MS, RN, Benjamin Caughlin MD, Steven Dayan MD
doi : 10.1111/jocd.15894
To demonstrate the effects of PDO threads non-surgical rhinoplasty on patients' quality of life (using FACE-Q Scale) and first impression assessments.
AGA practitioner challenges: A mixed-methods pilot survey
Glen S. Jankowski PhD, Dirk Kranz PhD
doi : 10.1111/jocd.15940
Androgenetic alopecia (AGA) practitioner care may be hampered by commercial biases and hair loss' omission from most medical curricula.
Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin
Hyun-A Park BS, Hoonhee Seo PhD, Sukyung Kim PhD, Asad Ul Haq PhD, Sung Hae Bae MS, Hyun-Ji Lee MS, Se Hee Ju MS, Hanieh Tajdozian MS, Md Abdur Rahim MS, Fatemeh Ghorbanian MS, Indrajeet Barman BS, Youjin Yoon MS, Sujin Jo BS, Youngkyoung Lee MS, Gyutae Cho MS, Hyein Jo MS, Mijung Kim PhD, Saebim Lee PhD, Ho-Yeon Song MD, PhD … See fewer authors
doi : 10.1111/jocd.15891
The excessive production and accumulation of melanin in the epidermal skin layer can result in skin hyperpigmentation and darkening. Current technologies for regulating melanin are based on inhibiting melanin biosynthesis. They have low effectiveness and safety issues.
Curcumin alleviates hypertrophic scarring by inhibiting fibroblast activation and regulating tissue inflammation
Huanhuan Fei MD, Yao Qian MD, Tianyun Pan MD, Ying Wei MD, Yun Hu MD
doi : 10.1111/jocd.15905
Hypertrophic scar (HS) that can lead to defects in appearance and function is often characterized by uncontrolled fibroblast proliferation and excessive inflammation. Curcumin has been shown to have anti-inflammatory and anti-oxidative effects and to play an anti-fibrotic role by interfering transforming growth factor-β1 (TGF-β1)/Smads signaling pathways.
Liposome-assisted penetration and antiaging effects of collagen in a 3D skin model
Mi So Lee MS, Hoai-Thuong Duc Bui MS, Su Ji Kim MS, Jun Bae Lee PhD, Hyuk Sang Yoo PhD
doi : 10.1111/jocd.15912
Collagen is a major component of the extracellular matrix that supports the epidermal layers of the skin; thus, many strategies have been made to enhance the topical delivery of collagen for antiaging purposes. In addition, our previous study indicated that liposome can help the penetration of active ingredients into the skin.
Potent pigmentation inhibitory activity of incensole-enriched frankincense volatile oil-identification, efficacy and mechanism
Xiufang Yan MS, Xiaoyu Ma PhD, Daoxin Dai PhD, Xiaojuan Yan PhD, Xingyan Han BS, Xijun Bao MS, Qiufang Xie BS
doi : 10.1111/jocd.15887
Frankincense volatile oil (FVO) has long been considered a side product in pharmaceutical industry since frankincense of large molecular weight is the prime target. However, the volatile oil recycled in the extract process might contain a series of functional actives, serving as promising ingredients in the cosmetic field.
Seawater pearl hydrolysate inhibits photoaging via decreasing oxidative stress, autophagy and apoptosis of Ultraviolet B-induced human skin keratinocytes
Siyin Han PhD, Peng Liu PhD, Qiangqiang Yan MD, Yanhui Cen PhD, Guanyi Wu PhD, Zhenxing Chen PhD, Mingxing Li PhD, Yasheng Deng MD, Fei Luo MD, Jiang Lin PhD
doi : 10.1111/jocd.15916
Ultraviolet (UV) is the main reason to cause photoaging skin which not only hinders beauty, brings the patients with psychological burden, but also pathologically leads to the occurrence of tumors in skin.
Experimental study on the effect and mechanism of adipose stem cell-derived exosomes combined with botulinum toxin AÂ on skin trauma in rats
Hui-Hui Zheng MD, Xin-Yu Ben MD, Ya-Ru Wang MASc, Meng-Si Tian MASc, Qing-wen Meng MD, De-Xian Li MASc, Shi-Lei Wen MASc, Pan-Li Ni MASc, Jing-Wen Hao MD, Quan-Peng Zhang MD, Juan Yang MD, Qi-Bing Liu PhD, Qi-Fu Li MD, Xi-Nan Yi MD
doi : 10.1111/jocd.15922
Adipose stem cell-derived exosomes (ADSC-EXO) and botulinum toxin type A (BTX-A) individually showed a therapeutic effect on skin wound repair.
Evaluation of systemic oxidative stress in patients with melasma
Hoda Rahimi MD, Mina Mirnezami MD, Anousha Yazdabadi MD, Aazam Hajihashemi MSc
doi : 10.1111/jocd.15924
The significance of oxidative stress has been assessed and proven in the etiopathogenesis of many cutaneous disorders, but there are few studies that evaluated the role of only some factors involved in oxidative stress in patients with melasma.
Design and evaluation of adapalene microemulsion for transfollicular drug delivery through guinea pig skin
Anayatollah Salimi PhD, Behzad Sharifmakhmalzadeh PhD, Fatemeh safari amirabadi PharmD
doi : 10.1111/jocd.15933
Acne vulgaris can be treated topically with adapalene, a synthetic derivative of naphthoic acid with retinoid activity. Adapalene has a very low rate of percutaneous absorption and is almost completely insoluble in water. To obviate this problem, microemulsion (ME) carrier is used. The study's goals were to create and characterize adapalene-loaded ME and assess the drug's transfollicular route of penetration to see if hair follicles can serve as a conduit for the drug to enter the skin.
Stratum corneum compliance enhances tactile sensitivity through increasing skin deformation: A study protocol for a randomized controlled trial
Saito Sakaguchi MS, Kaoru Saito MS, Naomi Arakawa MS, Masashi Konyo PhD
doi : 10.1111/jocd.15934
Tactile sensation plays a crucial role in object manipulation, communication, and even emotional well-being. It has been reported that the deformability of skin (also described as skin compliance) that shows a large mechanical response to stimuli is associated with high tactile sensitivity. However, although the compliance of the stratum corneum, the outermost layer of skin, can change daily due to skin care and environmental factors, few studies have quantified the effect of the stratum corneum on tactile sensation.
Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters
Arnaud Fontbonne, Baba Teme, Elise Abric, Guillaume Lecerf, Sylvie Callejon, Alain Moga, Benoît Cadars, Félix Giraud, Marlène Chavagnac-Bonneville PhD, Nathalie Ardiet, Aurélie Guyoux, Sandra Trompezinski PhD
doi : 10.1111/jocd.15893
Chronic exposure to ultraviolet (UV) irradiation causes immunosuppression, photoaging, and carcinogenesis by induction of a cascade of skin damages. Sunscreens currently on the market are not absorbing UV rays uniformly throughout the full UV range, high sun protection factor (SPF) sunscreens absorb most of UVB rays but are less effective in absorbing the UVA part of the spectrum.
Sesamin attenuates UVA-induced keratinocyte injury via inhibiting ASK-1-JNK/p38 MAPK pathways
Hailong Li BSc, Lijian Zhu BSc, Zhiwei Weng MSc, Hangjie Fu MSc, Jinyuan Liu BSc, Qingqing Mao BSc, Wenxia Li MM, Bin Ding PhD, Yi Cao MD
doi : 10.1111/jocd.15951
Ultraviolet (UV) exposure-stimulated reactive oxygen species (ROS) formation in keratinocytes is a crucial factor in skin aging. Phytochemicals have become widely popular for protecting the skin from UV-induced cell injury. Sesamin (SSM) has been shown to play a role in extensive pharmacological activity and exhibit photoprotective effects.
IL-17A is involved in the hyperplasia of blood vessels in local lesions of psoriasis by inhibiting autophagy
Juanjuan Wang MSc, Ling Zhou MSc, Hui Hou MSc, Jiao Li MSc, Xincheng Zhao MSc, Jiajie Li MSc, Junqin Li MD, Xuping Niu MD, Ruixia Hou MD, Kaiming Zhang MD
doi : 10.1111/jocd.15975
Increased angiogenesis is a pathological feature of psoriasis, but the pathomechanisms of angiogenesis in psoriasis are not clear. Interleukin-17A (IL-17A) is the major effect factor in the pathogenesis of psoriasis. Our results showed that IL-17A can promote angiogenesis and cause endothelial cell inflammation.
Minoxidil sulfotransferase enzymatical activity in plants: A novel paradigm in increasing minoxidil response in androgenetic alopecia
Nina Mehta BS, Sam Huang MD, Rachita Dhura MD, Carlos Wambier MD, PhD, Daniel do Nascimento Fonesca MD, Sabrina Little BA, Andy Goren MD
doi : 10.1111/jocd.15980
Minoxidil is the only US FDA approved topical drug for the treatment of androgenetic alopecia (AGA). Minoxidil is effective in hair re-growth in 30%–40% of patients and 50% of males.
Retrospective analysis of aesthetic medical malpractice in mediation proceeding: A single-court experience
Yi-Teng Hung MD, Jinn-Min Lin JD, Yen-Wen Chen MD, Yau-Li Huang MD
doi : 10.1111/jocd.15892
Effective treatment of refractory alopecia areata in pediatric patients with oral abrocitinib
Jiangxia Huang MM, Ougen Liu MM
doi : 10.1111/jocd.15896
Efficacy and safety of topical ruxolitinib cream for the treatment of vitiligo: A systematic review and meta-analysis of randomized controlled trials
Muhammad Ehsan MBBS, Aqeeb Ur Rehman MBBS, Muhammad Ayyan MBBS, Huzaifa Ahmad Cheema MBBS, Talha Zartash Ahmad MBBS, Biah Mustafa MBBS, Abia Shahid MBBS, Tarek Khedro MD, Heba Ismail MD, Abdulqadir J. Nashwan RN, MSc … See fewer authors
doi : 10.1111/jocd.15921
Improvement of skin firmness and reduction of striae distensae with an energy-based device using quantum molecular resonance
Eujin Cho MD, PhD, Min-Hee Kim MD, PhD
doi : 10.1111/jocd.15915
Comparative in vivo degradation of hyaluronic acid-based fillers following injection of hyaluronidase
Maurizio Cavallini MD, Alex Pierce BS, Lauren Nakab PharmD, MSc
doi : 10.1111/jocd.15932
Reply to comment to “Chemical peel recipe��Caution. Phenol is not safe for use for chemo-exfoliation
Siddhi Chikhalkar MD, Tejas Vishwanath MD, Aditi Shende MD
doi : 10.1111/jocd.15939
Answer to the letter Post hoc analysis of “clinical and histological comparative outcomes after injections of poly-l-lactic acid and calcium hydroxyapatite in arms: A split side study�
Rosemarie Mazzuco MD
doi : 10.1111/jocd.15931
Selenium in the supplement as the probable cause of hair loss and nail dystrophy
Ekrem Civas MD, Ümit Akpınar MD
doi : 10.1111/jocd.15902
