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Evolving concepts in systemic lupus erythematosus damage assessment
Megan R. W. BarberSindhu R. Johnson and Ian N. Bruce
doi : 10.1038/s41584-021-00611-4
Nature Reviews Rheumatology volume 17, pages307–308 (2021)
Complement primes joints for inflammation
Joanna Clarke
doi : 10.1038/s41584-021-00619-w
Nature Reviews Rheumatology volume 17, page309 (2021)
IFNs disrupt T cell metabolism in SLE
Jessica McHugh
doi : 10.1038/s41584-021-00622-1
Nature Reviews Rheumatology volume 17, page310 (2021)
Upadacitinib improves PsA in phase III trial
Sarah Onuora
doi : 10.1038/s41584-021-00617-y
Nature Reviews Rheumatology volume 17, page310 (2021)
Glycosylation influences IgG effects in LN
Joanna Clarke
doi : 10.1038/s41584-021-00626-x
Nature Reviews Rheumatology volume 17, page310 (2021)
Repurposed drugs could target PIM kinases in early RA
Sarah Onuora
doi : 10.1038/s41584-021-00618-x
Nature Reviews Rheumatology volume 17, page311 (2021)
Inducing apoptosis in joint cells improves advanced arthritis
Sarah Onuora
doi : 10.1038/s41584-021-00623-0
Nature Reviews Rheumatology volume 17, page311 (2021)
Polygenic risk scores outperform other tests in AS
Jessica McHugh
doi : 10.1038/s41584-021-00630-1
Nature Reviews Rheumatology volume 17, page312 (2021)
Osteoarthritis risk factors differ between sexes
Jessica McHugh
doi : 10.1038/s41584-021-00631-0
Nature Reviews Rheumatology volume 17, page312 (2021)
Ultrasound scoring system shows promise in pSS
Jessica McHugh
doi : 10.1038/s41584-021-00632-z
Nature Reviews Rheumatology volume 17, page312 (2021)
MIS-C is a risk factor for thrombotic events
Jessica McHugh
doi : 10.1038/s41584-021-00633-y
Nature Reviews Rheumatology volume 17, page312 (2021)
Pathogenic UBA1 variants define a subset of relapsing polychondritis
Jessica McHugh
doi : 10.1038/s41584-021-00624-z
Nature Reviews Rheumatology volume 17, page312 (2021)
Streamlining cell fate decisions during chondrogenesis
Yeri Alice Rim and Ji Hyeon Ju
doi : 10.1038/s41584-021-00604-3
Nature Reviews Rheumatology volume 17, pages313–314 (2021)
Systemic and organ-specific immune-related manifestations of COVID-19
Manuel Ramos-Casals.Pilar Brito-Zer?nXavier Mariette
doi : 10.1038/s41584-021-00608-z
Nature Reviews Rheumatology volume 17, pages315–332 (2021)
Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS-CoV-2 infection is predominantly centred on the respiratory system, some patients can develop an abnormal inflammatory reaction involving extrapulmonary tissues.
Epithelial–immune cell interplay in primary Sj?gren syndrome salivary gland pathogenesis
Gwenny M. Verstappen.Sarah PringleFrans G. M. Kroese
doi : 10.1038/s41584-021-00605-2
Nature Reviews Rheumatology volume 17, pages333–348 (2021)
In primary Sj?gren syndrome (pSS), the function of the salivary glands is often considerably reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland epithelium in pSS, including the nuclear factor-?B pathway, the inflammasome and interferon signalling.
Interferon lambda in inflammation and autoimmune rheumatic diseases
Rishi R. GoelSergei V. Kotenko.Mariana J. Kaplan
doi : 10.1038/s41584-021-00606-1
Nature Reviews Rheumatology volume 17, pages349–362 (2021)
Interferons are potent antiviral cytokines that modulate immunity in response to infection or other danger signals.
Rheumatic diseases in Africa
Olufemi AdelowoGirish M. Mody.Samy Slimani
doi : 10.1038/s41584-021-00603-4
Nature Reviews Rheumatology volume 17, pages363–374 (2021)
Historically, rheumatic diseases have not received much attention in Africa, particularly in sub-Saharan Africa, possibly owing to a focus on the overwhelming incidence of infectious diseases and the decreased life span of the general population in this region. Global attention and support, together with better health policies and planning, have improved outcomes for many infectious diseases; thus, increasing attention is being turned to chronic non-communicable diseases. Rheumatic diseases were previously considered to be rare among Africans but there is now a growing interest in these conditions, particularly as the number of rheumatologists on the continent increases.
Author Correction: Evolving concepts in systemic lupus erythematosus damage assessment
Megan R. W. BarberSindhu R. Johnson.Ian N. Bruce
doi : 10.1038/s41584-021-00620-3
Nature Reviews Rheumatology volume 17, page375 (2021)
