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Removing barriers and disparities in health: lessons from the COVID-19 pandemic
Emily Sirotich & Jonathan S. Hausmann
doi : 10.1038/s41584-020-00524-8
Volume 17, Issue 3, March 2021, Published 07 October 2020
The COVID-19 pandemic has compelled the global community to work together to understand SARS-CoV-2 and mitigate its effects, but it has also highlighted health disparities faced by people from minority racial or ethnic groups and other marginalized populations. International collaboration needs to be leveraged to address these disparities and inequities.
Exercise exerts anti-inflammatory effects on muscle via the JAK–STAT pathway
Joanna Clarke
doi : 10.1038/s41584-021-00581-7
Volume 17, Issue 3, March 2021, Published 08 February 2021
Targeting the EGFR pathway shows promise for OA
Jessica McHugh
doi : 10.1038/s41584-021-00583-5
Volume 17, Issue 3, March 2021, Published 08 February 2021
New insights into RA genetics from GWAS meta-analysis
Sarah Onuora
doi : 10.1038/s41584-021-00580-8
Volume 17, Issue 3, March 2021, Published 08 February 2021
Metabolic defect causes invasive phenotype in RA T cells
Joanna Clarke
doi : 10.1038/s41584-021-00572-8
Volume 17, Issue 3, March 2021, Published 08 January 2021
Gut microbiome could predict drug response in RA
Sarah Onuora
doi : 10.1038/s41584-021-00582-6
Volume 17, Issue 3, March 2021, Published 08 February 2021
Adipose tissue triggers OA
Joanna Clarke
doi : 10.1038/s41584-021-00579-1
Volume 17, Issue 3, March 2021, Published 08 February 2021
Getting to the root of the anti-inflammatory effects of ginger
Jessica McHugh
doi : 10.1038/s41584-021-00577-3
Volume 17, Issue 3, March 2021, Published 27 January 2021
Unravelling the complex genetic regulation of immune cells
Paula S. Ramos
doi : 10.1038/s41584-020-00563-1
Volume 17, Issue 3, March 2021, Published 16 December 2020
Genetic variation contributes to immune cell function. An unprecedented analysis of genetic associations with immune cell traits provides insights into the complex regulation of immune cells, reveals variants that coincidently influence immune traits and autoimmune disease risk, and offers specific therapeutic targets for these diseases.
JAK inhibitors and VTE risk: how concerned should we be?
Stanley B. Cohen
doi : 10.1038/s41584-021-00575-5
Volume 17, Issue 3, March 2021, Published 15 January 2021
Janus kinase (JAK) inhibitors have become standard treatment for patients with rheumatoid arthritis who do not respond well to other DMARDs. Concerns have been raised over an increased risk of venous thromboembolism with JAK inhibitors, tempering enthusiasm for their use in the clinic, but are these concerns justified?
Why remission is not enough: underlying disease mechanisms in RA that prevent cure
Georg Schett, Yoshiya Tanaka & John D. Isaacs
doi : 10.1038/s41584-020-00543-5
Volume 17, Issue 3, March 2021, Published 10 December 2020
For the past two decades, remission has been the focus of treatment strategies for rheumatoid arthritis (RA). This Review addresses the differences between remission and cure in RA and the underlying factors (‘drivers’) that trigger chronic inflammation and prevent cure.
Immune cartography of macrophage activation syndrome in the COVID-19 era
Dennis McGonagle, Athimalaipet V. Ramanan & Charlie Bridgewood
doi : 10.1038/s41584-020-00571-1
Volume 17, Issue 3, March 2021, Published 05 February 2021
In this Review, the authors discuss macrophage activation syndrome (MAS) in relation to other cytokine storm scenarios, and provide a framework for understanding MAS within the spectrum of innate and adaptive immunity in the context of gain or loss of immune function.
Cell-based strategies for IVD repair: clinical progress and translational obstacles
Abbie L. A. Binch, Joan C. Fitzgerald, Emily A. Growney & Frank Barry
doi : 10.1038/s41584-020-00568-w
Volume 17, Issue 3, March 2021, Published 01 February 2021
Intervertebral disc (IVD) degeneration is a common condition associated with low back pain, but approved pharmacological interventions to prevent progression of IVD degeneration are lacking. This Review discusses the clinical progress and challenges of cell-based therapeutics for repairing the IVD.
The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET
Rosaria Talarico, Silvia Aguilera, […]Marta Mosca
doi : 10.1038/s41584-020-00565-z
Volume 17, Issue 3, March 2021, Published 06 January 2021
In this Perspective article, members of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases discuss clinical and organizational challenges in this community caused by the COVID-19 pandemic and what lessons might be learned for the future.
What could a new disease activity score for polymyalgia rheumatica do better?
Burkhard F. Leeb
doi : 10.1038/s41584-020-00550-6
Volume 17, Issue 3, March 2021, Published 30 November 2020
Reply to: What could a new disease activity score for polymyalgia rheumatica do better?
Dario Camellino, Eric L. Matteson, Frank Buttgereit & Christian Dejaco
doi : 10.1038/s41584-020-00551-5
Volume 17, Issue 3, March 2021, Published 30 November 2020
