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Tearing up the traditional biotech playbook
doi : 10.1038/s41587-023-02119-6
Volume 42 Issue 1, January 2024
The world’s first CRISPR therapy is approved: who will receive it?
By Cormac Sheridan
Reducing the costs of blockbuster gene and cell therapies in the Global South
Ben JohnsonÂÂ
Cell and gene therapy approvals in Japan and the need for international harmonization
Teruyo Arato & Kaori NomuraÂ
Growth of biotech clusters over several decades through pioneering, variety and entrepreneurial science
Bart Van Looy, Grabowska Marcelina, Vesna Vlaisavljevic, Catherine Lecocq & Koenraad DebackereÂ
Discovering value: women’s participation in university and commercial AI invention
Alexander V. Giczy, Nicholas A. Pairolero & Andrew A. TooleÂ
Designer enhancers for cell-type-specific gene regulation
Alexandra DespangÂÂ
N1-methylpseudouridylation affects the fidelity of mRNA translation
Rong LiÂÂ
Live cell imaging of signaling networks using a conventional microscope
Anahita BishopÂÂ
A genome-wide view of disordered proteins
Benjamin J. Leslie, Benjamin Lang & M. Madan BabuÂ
Exploring tRNAs and their modifications and crosstalk using Nano-tRNAseq
Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Chenqu Suo, Krzysztof Polanski, Emma Dann, Rik G. H. Lindeboom, Roser Vilarrasa-Blasi, Roser Vento-Tormo, Muzlifah Haniffa, Kerstin B. Meyer, Lisa M. Dratva, Zewen Kelvin Tuong, Menna R. Clatworthy & Sarah A. TeichmannÂ
DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins
Yu-Hang Xing, Rui Dong, Lukuo Lee, Shruthi Rengarajan, Nicolò Riggi, Gaylor Boulay & Miguel N. RiveraÂ
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope
Fabian F. Voigt, Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L. Hotz, Lachlan Whitehead, Armin Bahl, Stephan C. F. Neuhauss, Alard Roebroeck, Esther T. Stoeckli, Soeren S. Lienkamp, Adriano Aguzzi & Fritjof HelmchenÂ
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Morghan C. Lucas, Leszek P. Pryszcz, Rebeca Medina, Ivan Milenkovic, Noelia Camacho, Virginie Marchand, Yuri Motorin, LluÃÂs Ribas de Pouplana & Eva Maria NovoaÂ
Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases
George D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy, Sanne E. Klompe, Marcus I. Hogan, Phuc Leo H. Vo, Stephen Tang, Alejandro Chavez & Samuel H. SternbergÂ
A relay velocity model infers cell-dependent RNA velocity
Shengyu Li, Pengzhi Zhang, Weiqing Chen, Lingqun Ye, Kristopher W. Brannan, Nhat-Tu Le, Jun-ichi Abe, John P. Cooke & Guangyu WangÂ
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray & Andreas KellerÂ
RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators
Bin Li, Shurong Liu, Wujian Zheng, Anrui Liu, Peng Yu, Di Wu, Jie Zhou, Ping Zhang, Chang Liu, Qiao Lin, Jiayi Ye, Simeng He, Qiaojuan Huang, Hui Zhou, Jianjun Chen, Lianghu Qu & Jianhua YangÂ
Sequencing by avidity enables high accuracy with low reagent consumption
Sinan Arslan, Francisco J. Garcia, Minghao Guo, Matthew W. Kellinger, Semyon Kruglyak, Jake A. LeVieux, Adeline H. Mah, Haosen Wang, Junhua Zhao, Chunhong Zhou, Andrew Altomare, John Bailey, Matthew B. Byrne, Chiting Chang, Steve X. Chen, Byungrae Cho, Claudia N. Dennler, Vivian T. Dien, Derek Fuller, Ryan Kelley, Omid Khandan, Michael G. Klein, Michael Kim, Bryan R. Lajoie, …Michael PreviteÂ
Inference of phylogenetic trees directly from raw sequencing reads using Read2Tree
David Dylus, Adrian Altenhoff, Sina Majidian, Fritz J. Sedlazeck & Christophe DessimozÂ
The impact of a graduate training and career outlook program on diversity in the biotechnology sector
Angelita P. Howard, Liane S. Slaughter, Joan Adebowale, Keisha Bentley & Rebecca McPhersonÂ
