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Physical activity and living well with kidney disease
Thomas J. Wilkinson & Alice C. Smith
doi : 10.1038/s41581-021-00398-3
Volume 17, Issue 3, March 2021, Published 20 January 2021
Regular physical activity can help people to live well with kidney disease, yet the promotion, funding, level of interest, and general support of physical activity remains poor. Novel high-quality approaches to increase physical activity must be considered, and practical means of scaling up effective interventions at the population level are required.
The challenge of insomnia for patients on haemodialysis
Daniel Cukor, Mark Unruh, Susan M. McCurry & Rajnish Mehrotra
doi : 10.1038/s41581-021-00396-5
Volume 17, Issue 3, March 2021, Published 21 January 2021
Insomnia is common among patients on maintenance haemodialysis and may be exacerbated by the challenges of the COVID pandemic. However, data on the efficacy of insomnia interventions in this population are limited. Efforts are needed to address this important problem and increase access to insomnia interventions for patients on haemodialysis.
Prioritizing the quality of life of older adults with kidney disease
Rasheeda K. Hall
doi : 10.1038/s41581-021-00397-4
Volume 17, Issue 3, March 2021, Published 20 January 2021
Older adults receiving dialysis commonly experience poor quality of life. A cyclical process of quality of life assessment, needs assessment and individualized care plans should be implemented to integrate quality of life into care planning. Improvements in health-care delivery and interpersonal communication are needed to prioritize quality of life.
Tracing the origins and differentiation of human kidney myofibroblasts
Ellen F. Carney
doi : 10.1038/s41581-020-00382-3
Volume 17, Issue 3, March 2021, Published 02 December 2020
Targeting Kv1.3 channels on T cells
Ellen F. Carney
doi : 10.1038/s41581-020-00387-y
Volume 17, Issue 3, March 2021, Published 03 December 2020
Meta-analysis identifies rare variants associated with blood pressure regulation
Susan J. Allison
doi : 10.1038/s41581-020-00386-z
Volume 17, Issue 3, March 2021, Published 07 December 2020
Gak loss promotes calpain-induced injury
Monica Wang
doi : 10.1038/s41581-020-00385-0
Volume 17, Issue 3, March 2021, Published 04 December 2020
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
Denise Mafra, Natalia A. Borges, Bengt Lindholm, Paul G. Shiels, Pieter Evenepoel & Peter Stenvinkel
doi : 10.1038/s41581-020-00345-8
Volume 17, Issue 3, March 2021, Published 22 September 2020
Here, the authors discuss the mechanisms by which food and specific nutrients could affect the uraemic phenotype in chronic kidney disease (CKD). They suggest that a food-as-medicine approach could potentially be used to prevent and treat CKD and its complications.
WNT–?-catenin signalling — a versatile player in kidney injury and repair
Stefan J. Schunk, Jürgen Floege, Danilo Fliser & Thimoteus Speer
doi : 10.1038/s41581-020-00343-w
Volume 17, Issue 3, March 2021, Published 28 September 2020
This Review discusses advances in the understanding of WNT–?-catenin signalling and its regulation during kidney injury, along with its potential diagnostic and therapeutic implications.
Nuclear receptors in podocyte biology and glomerular disease
Shipra Agrawal, John C. He & Pierre-Louis Tharaux
doi : 10.1038/s41581-020-00339-6
Volume 17, Issue 3, March 2021, Published 17 September 2020
Nuclear receptors have important roles in normal physiological functions and in the pathophysiology of various diseases. Here, the authors focus on the roles of nuclear receptors in podocyte biology and non-diabetic glomerular disease as well as their potential as therapeutic targets.
The tissue proteome in the multi-omic landscape of kidney disease
Markus M. Rinschen & Julio Saez-Rodriguez
doi : 10.1038/s41581-020-00348-5
Volume 17, Issue 3, March 2021, Published 07 October 2020
Technological advances continue to expand the use of proteomics in medicine. In this Review, the authors discuss proteomics research findings in nephrology and the potential, as well as the limitations, of using proteomics techniques to uncover disease mechanisms and develop new therapeutic strategies.
