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JCD – January 2021 Editorial
Michael H. Gold MD
doi : 10.1111/jocd.13889
Volume20, Issue1 January 2021 Pages 5-5
Recommendations for the treatment of tear trough deformity with cross?linked hyaluronic acid filler
Javier Anido MD José Manuel Fern?ndez MD Ignacio Genol MD Natalia Ribé MD Gema Pérez Sevilla MD
doi : 10.1111/jocd.13475
Volume20, Issue1 January 2021 Pages 6-17
Recent years have seen a growing interest in the appearance of the eyes among the concerns expressed by patients in cosmetic clinics. This has led to an increase in the frequency of diagnosis of tear trough deformity, and, as a result, the number of treatments performed by specialized professionals has also risen. Hyaluronic acid filler injection is a rapid, nonsurgical technique that gives good long?lasting, but not permanent, results. However, to achieve optimal results, the attending physician must have good anatomical knowledge of the area and involvement of the structures in the tear trough, carry out proper clinical assessment of the patient, and use an appropriate injection technique with the right product.
Chemical reconstruction of skin scars (CROSS) method for atrophic scars: A comprehensive review
Hye Jin Chung MD, MMSc Sara Al Janahi MD, MSc Sung Bin Cho MD, PhD Yunyoung Claire Chang MD
doi : 10.1111/jocd.13556
Volume20, Issue1 January 2021 Pages 18-27
Chemical reconstruction of skin scars (CROSS) applies a high strength acid focally to treat atrophic scars. Although this method has gained popularity over the past two decades, no standardized treatment guideline exists for CROSS method in the treatment of atrophic scars.
Rheologic properties of soft tissue fillers and implications for clinical use
Kerry Heitmiller MD Christina Ring MD Nazanin Saedi MD
doi : 10.1111/jocd.13487
Volume20, Issue1 January 2021 Pages 28-34
The use of injectable soft?tissue fillers has become an essential tool in esthetic rejuvenation. Rheology, the study of flow of matter, helps to understand the function of these products.
Pityriasis capitis: Causes, pathophysiology, current modalities, and future approach
Umang Sheth B.Pharm Payal Dande M.Pharm, PhD
doi : 10.1111/jocd.13488
Volume20, Issue1 January 2021 Pages 35-47
Pityriasis capitis commonly known as dandruff is one of the most common and widely seen dermatological disease that affects majority of the world population. It is more than superficial flaking, as it leads to significant structural changes in the stratum corneum and inflammatory biomarkers. Various intrinsic and extrinsic factors, such as Malassezia yeast, host epidermal conditions, sebaceous secretion, and abnormal immune responses, are found to contribute to the pathogenesis. Regardless of wide research, detail understanding, and treatment modalities, it still remains to be a cause of concern due to its recurring nature.
The role of artificial intelligence in cosmetic dermatology—Current, upcoming, and future trends
Alexandra Elder BS Christina Ring MD Kerry Heitmiller MD Zena Gabriel MD Nazanin Saedi MD
doi : 10.1111/jocd.13797
Volume20, Issue1 January 2021 Pages 48-52
Within the field of cosmetic dermatology, several promising developments utilize artificial intelligence to better patient care. While many new treatments in cosmetic dermatology feature components of artificial intelligence, there is a knowledge gap within the field regarding the current and developing products featuring AI.
Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate?to?severe acne scars
Araco Antonino MD Araco Francesco MD, PhD
doi : 10.1111/jocd.13472
Volume20, Issue1 January 2021 Pages 53-61
Acne scars are the most common sequelae of the severe inflammatory process of acne, and its managing is a challenge. Objective of this study was to assess safety and effectiveness of calcium hydroxylapatite monotherapy and its association with high?intensity microfocused ultrasound for treating moderate?to?severe atrophic acne scars.
Correction of temporal wasting using calcium hydroxylapatite with integral lidocaine: An underused procedure for enhancing overall facial appearance
Sheila C. Barbarino MD, FACS
doi : 10.1111/jocd.13505
Volume20, Issue1 January 2021 Pages 62-66
Hollowing of the temple area is an early sign of aging that is often overlooked, but when corrected, can lead to significant subject and physician satisfaction.
Newer injection points for facial contouring with hyaluronic acid filler—Case Report
Indu Ballani MD Rashmi Sarkar MD, MNAMS
doi : 10.1111/jocd.13726
Volume20, Issue1 January 2021 Pages 67-70
Hyaluronic fillers have been used for filling in folds and contour the face according to global aesthetic standards to achieve a smooth ogee curve on the face. But sometimes these result in a bulkier look to the face thus preventing more people from opting for these procedures. Although M.D codes have now been given to guide the injecting physicians for various points of injections on the face, they need to be used judiciously and tailored to individuals, using the lateral points of the face first.
The use of botulinum toxin A in upper lip augmentation
Yunzhu Li MD Yuming Chong MD Nanze Yu MD Ruijia Dong MD Xiao Long MD
doi : 10.1111/jocd.13731
Volume20, Issue1 January 2021 Pages 71-74
Full lips are beauty standards. Botulinum toxin A (BTA) paralyzes the orbicularis oris muscle to achieve the eversion of the lip, and thus makes the lip look plump.
Topographic computer analysis for acne scar treatment on face accompanying biopsy study after dermal injection of hydrotoxin mixture
JongSeo Kim MD
doi : 10.1111/jocd.13462
Volume20, Issue1 January 2021 Pages 75-83
Acne during youth can leave permanent facial scarring. The depressed acne scars can be treated by injection of stabilized hyaluronic acid (S?HA) into the dermis. Due to the large number of acne scars, manual injection methods are technically difficult and bear high risk of lump formation in the dermis. Therefore, the author designed a specific injection method to solve the two abovementioned problems.
Laser therapy in the treatment of cicatricial ectropion
Hua?Wei Ouyang MD Michael H. Gold MD Ying Lei MD Jun Tan MD
doi : 10.1111/jocd.13821
Volume20, Issue1 January 2021 Pages 84-92
The objective of this study was to investigate the clinical effects of laser therapy in treating cicatricial ectropion.
The use of radiofrequency?assisted lipolysis with radiofrequency microneedling in premature jowl and neck laxity following facialplasty
Daniel Demesh MD Robert T. Cristel MD Nimit D. Gandhi MD Eljona Kola MS Steven H. Dayan MD, FACS
doi : 10.1111/jocd.13824
Volume20, Issue1 January 2021 Pages 93-98
A subset of facelift patients have premature redevelopment of skin laxity in the lower face and neck. Many patients seek alternatives to revision facelifts to avoid high risks and costs. Radiofrequency?assisted lipolysis (RFAL) with Radiofrequency (RF) microneedling may be alternative minimally invasive options.
Nonablative laser skin resurfacing for periorbital wrinkling—A case series of 16 patients
Tamir Horovitz MD Matteo Tretti Clementoni MD Ofir Artzi MD
doi : 10.1111/jocd.13851
Volume20, Issue1 January 2021 Pages 99-104
Many modalities have been described for the treatment of periorbital wrinkling.
Laser?assisted delivery of tranexamic acid for melasma: Pilot study using a novel 1927 nm fractional thulium fiber laser
Jordan V. Wang MD, MBE, MBA Mitalee P. Christman MD Hao Feng MD, MHS Georgina Ferzli MD Hana Jeon MD Roy G. Geronemus MD
doi : 10.1111/jocd.13817
Volume20, Issue1 January 2021 Pages 105-109
Melasma can be associated with immense psychosocial stress, which can impact quality of life. One theory suggests that ultraviolet light can increase plasmin activity in keratinocytes, which has led to the investigation of tranexamic acid for treating melasma, since it possesses anti?plasmin properties. The use of laser?assisted drug delivery can also increase the uptake of topical medications.
Full?face skin resurfacing using a combination of fractional and full spot ablative 2940 nm erbium laser
Nasrin Mani MD Franja Pajk PhD Zdenko Vizintin BSEE, MSc
doi : 10.1111/jocd.13450
Volume20, Issue1 January 2021 Pages 110-115
Full?field deep ablative laser resurfacing is a popular method for skin rejuvenation due to maximum improvement in a single treatment. However, it is associated with disadvantages such as pain, prolonged erythema, swelling, crusting, infections, pigmentary changes, and scarring. Patients are increasingly seeking less invasive options with comparable effect.
A comparative clinical and histopathological pilot study of different fractional CO2 laser parameters in treatment of atrophic linear scars
Ahmad I. Rasheed MD Sylvia R. Shawki MBBCH Rabab G. Mostafa MD Manal A. Sharara MD
doi : 10.1111/jocd.13489
Volume20, Issue1 January 2021 Pages 116-123
Atrophic scars cause significant patient morbidity. Fractional photothermolysis is one of the most effective treatment options used to resurface scars of different etiologies.
Combined microwaves and fractional microablative CO2 laser treatment for postpartum abdominal laxity
Paolo Bonan MD Alice Verdelli MD
doi : 10.1111/jocd.13510
Volume20, Issue1 January 2021 Pages 124-131
Postpartum abdominal changes represent a major esthetic concern affecting women. As the abdomen stretches during pregnancy and some of the muscles lose tone, there is an increased skin laxity and a loss of abdominal elasticity. As a result, the abdomen becomes saggy.
Accuracy of a high?intensity focused ultrasound device with and without real?time visualization system in face and neck treatment of skin laxity
Vasanop Vachiramon MD, MSc Rattiya Techakajornkeart MD, MSc Kanchana Leerunyakul MD, MSc Pamela Chayavichitsilp MD
doi : 10.1111/jocd.13512
Volume20, Issue1 January 2021 Pages 132-137
Microfocused ultrasound (MFU) is a nonsurgical treatment for the improvement of skin laxity. Multiple MFU devices with and without a visualization system are commercially available.
Laser?assisted topical steroid application versus steroid injection for treating keloids: A split side study
Dina H. Abd El?Dayem MD Hesham A. Nada MD Noha S. Hanafy MD Mohamed L. Elsaie MD
doi : 10.1111/jocd.13521
Volume20, Issue1 January 2021 Pages 138-142
Approaches to improve keloid scars include intralesional corticosteroid injections and fractional lasers exclusively. The combinative use of ablative fractional laser therapy and occluded topical corticosteroid as a drug delivery method enhances therapeutic outcome of two efficient scar therapy modules into one simple synergistic module.
Clinical and trichoscopic evaluation of trichloroacetic acid 35% vs phenol 88% peels in treatment of alopecia areata
Doaa Mahgoub MD Riham Mohye Eldeen MSc Dina Saadi MD Solwan El?Samanoudy MD Sarah Ibrahim MD
doi : 10.1111/jocd.13465
Volume20, Issue1 January 2021 Pages 143-149
Among alopecia areata (AA) treatments, contact irritants (anthralin) and topical immunotherapies (diphenylcyclopropenone) have been successfully used. Chemoexfoliation can potentially be utilized, acting as irritants and consecutively immunomodulators. Peels via therapeutic wounding provoke growth factors and cytokines that may induce hair regrowth.
Quality attributes of partially hydrolyzed collagen in a liquid formulation used for skin care
Ignacio Mej?a?Calvo BS Leonardo E. L?pez?Ju?rez BS Said V?zquez?Leyva BS Carlos A. L?pez?Morales PhD Daniel Montoya?Escutia BS Pamela G. Merlos Rivera MD José Enrique Herbert?Pucheta PhD Luis Gerardo Zepeda?Vallejo PhD Marco Velasco?Vel?zquez PhD Lenin Pav?n PhD Sonia M. Pérez?Tapia PhD Emilio Medina?Rivero PhD
doi : 10.1111/jocd.13439
Volume20, Issue1 January 2021 Pages 150-158
The deterioration of the skin accentuates over time, affecting its aesthetic appearance. This is characterized by the weakening of the mechanisms involved in the regeneration and repair of the dermal matrix. Consequently, the skin losses elasticity and smoothness resulting in the formation of wrinkles. The alternatives for facial rejuvenation include surgery, injection of botulinum toxin, and the application of masks. Topic products are less invasive, can be self?applied, and have an increased benefit/risk relationship.
Cosmetic camouflage as an adjuvant to vitiligo therapies: Effect on quality of life
Dalia Bassiouny MD Rehab Hegazy MD Samia Esmat MD Heba I. Gawdat MD Marwa Ahmed Ezzat MD Hebat?Allah Tawfik MBBCH Amira Aly Hegazy MD Sarah Ibrahim MD
doi : 10.1111/jocd.13459
Volume20, Issue1 January 2021 Pages 159-165
Vitiligo is a pigmentary disorder associated with considerable psychological imbalance. Partial response to therapy and long duration for repigmentation are common. Meanwhile, camouflage may help through concealing vitiligo lesions and improving patient confidence and self?esteem.
Randomized double?blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging
Simran Dhaliwal BS Iryna Rybak BS Aunna Pourang MD Waqas Burney MBBS Kelly Haas PhD Simran Sandhu BS Robert Crawford PhD Raja K Sivamani MD, MS, AP
doi : 10.1111/jocd.13464
Volume20, Issue1 January 2021 Pages 166-173
Acetyl zingerone (AZ), a derivative of the phytochemical zingerone from Zingiber officinale (ginger), is a novel compound that is purported to have antiaging properties. The objective of this clinical study was to assess the role of acetyl zingerone in its ability to improve the appearance of facial skin wrinkles, redness, pigmentation, and photoaging was assessed.
Comparative physicochemical stability and clinical anti?wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Shima Mohammadi Pharm?D Javad Shokri Pharm?D, PhD Mohammadreza Ranjkesh MD Shahabaddin Akbari Hamed Msc Farnaz Monajjemzadeh Pharm?D, PhD
doi : 10.1111/jocd.13471
Volume20, Issue1 January 2021 Pages 174-180
Antioxidant containing cosmeceuticals are commonly prescribed products in treating wrinkles and revitalizing the skin. The aim of this study was the comparative evaluation of physicochemical stability and clinical anti?wrinkle efficacy of transdermal emulgel preparations of sodium ascorbyl phosphate (SAP) and ascorbic acid (AA) on human volunteers.
Preparation and evaluation of a free surfactant herbal shampoo with Acanthophyllum Squarrosum Saponins
Eskandar Moghimipour PhD Malek Jasemnezhad PharmD Saeed Mohammad Soleymani PharmD Anayatollah Salimi PhD
doi : 10.1111/jocd.13483
Volume20, Issue1 January 2021 Pages 181-187
Shampoos remove fat and pus from the skin and hair. The most critical part of these products is their cleansing properties; therefore, the amount of shampoo cleanser plays an essential role in consumer acceptance.
Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow’s feet, and collagen content: A double?blind, randomized, placebo?controlled trial
Ping Lin MS Ruth Audy Alexander MS Chia?Hua Liang PhD Cheng Liu PhD Yung?Hao Lin MS Yung?Hsiang Lin BA Leong?Perng Chan MD Chen?Meng Kuan PhD
doi : 10.1111/jocd.13500
Volume20, Issue1 January 2021 Pages 188-194
The efficacy of Djulis for skin care is currently based on cellular or animal models, and the clinical aspect is not in place.
Skin irritation potential of cosmetic preservatives: An exposure?relevant study
Xue Ma MSc Huan Wang MSc Yanqing Song MSc Yao Pan PhD
doi : 10.1111/jocd.13502
Volume20, Issue1 January 2021 Pages 195-203
Preservatives represent one of the main causes of skin irritation and contact allergies.
A case report on the use of topical cysteamine 5% cream in the management of refractory postinflammatory hyperpigmentation (PIH) resistant to triple combination cream (hydroquinone, topical corticosteroids, and retinoids)
Nomathamsanqa Mathe BMedSci, BMBS, MRCP(UK)(Derm) Mariam Balogun MBBS, BMedSci, PgMedEd, MRCP(UK)(Derm) Jinah Yoo MBChB, MRCP, MSc
doi : 10.1111/jocd.13755
Volume20, Issue1 January 2021 Pages 204-206
Postinflammatory hyperpigmentation (PIH) occurs as a result of different inflammatory dermatoses and exogenous factors in individuals with darker skin types. With current skin lightening treatments, there are concerns about irritation leading to worsening of their underlying inflammatory skin condition or worsening of PIH.
Novel yeast extract is superior to colloidal oatmeal in providing rapid itch relief
Rachita Dhurat MD, PhD Aseem Sharma MD Ravina Surve MD John McCoy PhD Maja Kovacevic MD Andy Goren MD Yimei Tan MD Ying Zou MD Mohamad Goldust MD Mirna Situm MD, PhD Andrija Stanimirovic MD, PhD
doi : 10.1111/jocd.13436
Volume20, Issue1 January 2021 Pages 207-209
Approximately, 13.5% of the population suffers from chronic itch. Many cosmetic and pharmaceutical treatments for itch are available; however, cosmetic treatments are not reliably effective and most pharmaceutical formulations carry the risk of adverse events with chronic use.
Theoretical basis and clinical practice for FUE megasession hair transplantation in the treatment of large area androgenic alopecia
Yu?Yang Gan MD Li?Juan Du MD, PhD Wei?Jin Hong MD Zhi?Qi Hu MD, PhD Yong Miao MD, PhD
doi : 10.1111/jocd.13432
Volume20, Issue1 January 2021 Pages 210-217
Large area androgenic alopecia patients seeking hair transplantation treatment has become common. FUE Megasession has become a choice for more and more people. Long?term in vitro preservation of hair follicles during FUE Megasession has become a new challenge.
A simple modified surgical technique combined with tissue adhesive for steatocystoma multiplex
Long Jiang MD Jianna Yan MD Xiaogang Chen MD Yuchong Chen MD Yichen Tang MD
doi : 10.1111/jocd.13438
Volume20, Issue1 January 2021 Pages 218-221
Steatocystoma multiplex (SM) is a disorder of the pilosebaceous unit characterized by multiple sebum?containing dermal cysts. Psychological distress of patients is always derived from these undesirable lesions. Although various treatments have been attempted to improve cosmetic outcomes, no optimal treatment strategy has been established to date..
Pain perception of a new Ahmad?Humayun solution for local anesthesia in hair transplantation: One step ahead
Mohammad Humayun Mohmand MD, FRCS, ABHRS Muhammad Ahmad MD, ABHRS Mussarat Jabeen PhD, (Chemistry)
doi : 10.1111/jocd.13442
Volume20, Issue1 January 2021 Pages 222-226
Local anesthetic is one of the major ways to obtain satisfactory anesthesia in majority of plastic surgical procedures.
Gender?related differences in the facial aging of Caucasian French subjects and their relations with perceived ages and tiredness
Frederic Flament PhD Soraya Belkebla Bsc Anne?Sophie Adam Bsc Aurelie Abric Bsc David Amar PhD
doi : 10.1111/jocd.13446
Volume20, Issue1 January 2021 Pages 227-236
(a) To assess and compare the changes in five facial signs with age between genders of Caucasian subjects and (b) to evaluate their links with perceived ages and tiredness.
Childhood vitiligo in Egypt: Clinico?epidemiologic Profile of 483 patients
Rania El?Husseiny MD Ahmed Abd?Elhaleem M.B.B.Ch Waleed Salah El?Din MD Marwa Abdallah MD
doi : 10.1111/jocd.13451
Volume20, Issue1 January 2021 Pages 237-242
Childhood vitiligo is commonly encountered. Pattern and distribution of childhood vitiligo were not clearly described in past.
Correlation analysis between advanced glycation end products detected noninvasively and skin aging factors
Cong Xin MS Yaochi Wang MS Mengting Liu MS Bo Zhang MD Sen Yang MD
doi : 10.1111/jocd.13452
Volume20, Issue1 January 2021 Pages 243-248
To investigate the correlation between advanced glycation end products (AGEs) and skin elasticity or blood perfusion values in healthy people of different age groups and to evaluate the relationship between noninvasive detection of AGEs and age or skin aging.
Variation of biophysical parameters of the skin with age, gender, and lifestyles
Chaoshuai Zhao MM Xin Wang MD Yaqi Mao MD Ziqian Xu MM Yue Sun MD Xingyu Mei MD Weimin Shi PhD
doi : 10.1111/jocd.13453
Volume20, Issue1 January 2021 Pages 249-255
Sweet, spicy or greasy food, staying up late, and using electronic products for a long time are common bad habits nowadays. Their role in skin diseases has been paid much attention.
A new method for skin aging evaluation of Chinese women
Rui Ye PhD Wenting Chang MSc Jingjing Hu MSc Liyuan Qiao MSc Qianqian Wang MD, PhD
doi : 10.1111/jocd.13461
Volume20, Issue1 January 2021 Pages 256-262
With the development of cosmetic industry in China, an aging evaluation method of Chinese women is in great need.
Vermilionectomy followed by reconstruction of the vermilion mucosa using allograft dermal matrix in patients with actinic cheilitis of the lower lip
Shao?hai Chang DDS, MD Zhuo?shan Huang DDS, PhD Wei?liang Chen DDS, MD, MBA Bin Zhou DDS, PhD Jiang?long Zhong DDS
doi : 10.1111/jocd.13473
Volume20, Issue1 January 2021 Pages 263-266
When treating actinic cheilitis (AC), it is essential to minimize the risk of malignant transformation (MT) and maintain lip functionality and cosmesis.
Intralesional verapamil in the treatment of keloids: A clinical, histopathological, and immunohistochemical study
Doaa A. E. Abou?Taleb MD Dalia M. Badary MD
doi : 10.1111/jocd.13476
Volume20, Issue1 January 2021 Pages 267-273
The histopathological changes and immunohistochemical studies occurring in keloids in vivo after treatment by intralesional (IL) verapamil are not yet assessed. This study aimed to evaluate the efficacy and safety as well as the histological/immunohistochemical effects of intralesional verapamil on keloids.
Reduction of enlarged facial pore using ion?paired amino acid through enhancement in skin permeation and exfoliation: A placebo?controlled in vivo study
Koo Chul Kwon PhD Sung Woo Lee BS Hongmin Kim MA Hyungjoon Jeon PhD Sang?Wook Park MS
doi : 10.1111/jocd.13479
Volume20, Issue1 January 2021 Pages 274-284
Serine is a hypoallergenic but inefficient chemical exfoliant. Serine paired with arginine (ion?paired amino acid, IPA) shows enhanced lipophilicity, skin permeation, and exfoliation efficacy.
Treatment of linear scleroderma “En coup de Sabre” with single?stage autologous fat grafting: A case report and review of the literature
Rita Ayoub MSc Salim C. Saba MD, FACS
doi : 10.1111/jocd.13490
Volume20, Issue1 January 2021 Pages 285-289
Linear scleroderma “en coups de sabre” is a disease that causes scar?like lesions in the forehead and the scalp, and atrophy of the underlying structures. The result is an acute facial asymmetry that can be distressing to affected young adults. Several surgical treatments are available such as free tissue transfer and synthetic fillers.
A case of ingrown nail using buckle VHO?Osthold® Perfect as a method of conservative treatment
Faustyna Kuros MSc Dominika Wcis?o?Dziadecka MD, PhD
doi : 10.1111/jocd.13495
Volume20, Issue1 January 2021 Pages 290-294
Ingrowing Nail is an ailment in the toe area. This problem is observed in 20% of the population, in all age groups, but most often occurs in teenagers and young adults. The process of ingrowing nail stimulates natural defense mechanisms of the body in the form of inflammation and severe pain.
Successful treatment of doughnut warts with intralesional Candida antigen immunotherapy
Ahmad Nofal MD Ibrahim Fouda MD Hany Aboelwafa MD Mohamed M. Fawzy MD
doi : 10.1111/jocd.13496
Volume20, Issue1 January 2021 Pages 295-299
Doughnut warts, also called ring or annular warts, are a distinctive type of warts with central clearing and annular recurrence. There are very few studies illustrating this uncommon phenomenon and its treatment.
Bilateral, buccinator myomucosal advancement flaps to reconstruct central upper labial myomucosal defects after ablation of early?stage cancer in minor salivary glands
Juan?Kun Liao DDS, PhD Qiong?Lan Tang PhD Wei?Liang Chen DDS, MD, MBA Bin Zhou DDS, PhD Zuo?Zheng Wen DDS Zi?Xian Huang PhD
doi : 10.1111/jocd.13513
Volume20, Issue1 January 2021 Pages 300-303
Reconstruction of upper labial myomucosal defects is surgically challenging.
N?acetylglucosamine microemulsions: Assessment of skin penetration, cytotoxicity, and anti?melanogenesis
Krisada Wuttikul PhD Prapaporn Boonme PhD Chayanee Thammarat MSc Pasarat Khongkow PhD
doi : 10.1111/jocd.13431
Volume20, Issue1 January 2021 Pages 304-309
N?acetylglucosamine (NAG) is an amino sugar which can reduce melanin production. NAG has previously been formulated for topical use in many nanocarrier systems, excluding microemulsions (MEs). In this study, NAG was prepared in the form of MEs and assessed in terms of skin permeability, cytotoxicity, and effectiveness for cosmetic applications.
Clinical efficacy and reflectance confocal microscopy monitoring in moderate?severe skin aging treated with a polyvinyl gel containing retinoic and glycolic acid: An assessor?blinded 1?month study proof?of?concept trial
Elena Campione MD, PhD Terenzio Cosio MS Caterina Lanna MD Sara Mazzilli MD Emi Dika MD, PhD Luca Bianchi MD
doi : 10.1111/jocd.13463
Volume20, Issue1 January 2021 Pages 310-315
Retinoids and alpha?hydroxy acids are commonly used topically as anti?aging substances. Current medical devices contain retinoic acid (0.02%) and glycolic acid (4%) in a polyvinyl gel vehicle (R?G gel). There are still no clinical data nor objective evaluation of the anti?aging effect this product has in the short term.
The relationship between acne vulgaris and irritable bowel syndrome: A preliminary study
Abdullah Demirba? MD ?mer Faruk Elmas MD
doi : 10.1111/jocd.13481
Volume20, Issue1 January 2021 Pages 316-320
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by chronic abdominal pain and changes in bowel movements without underlying organic pathology. Many skin diseases have been reported to be more common in individuals with functional bowel diseases.
Unsaturated fatty acid?enriched extract from Hippophae rhamnoides seed reduces skin dryness through up?regulating aquaporins 3 and hyaluronan synthetases 2 expressions
Qifeng Yao MS Tinghan Jia MD Wu Qiao MS Hongjian Gu BS Ken Kaku PhD
doi : 10.1111/jocd.13482
Volume20, Issue1 January 2021 Pages 321-329
Seed oil of sea buckthorn (SBT) is well known to contain high amount of polyunsaturated fatty acid (PUFA), and PUFA is generally acknowledged to promote skin hydration by reducing trans?epidermal water loss (TEWL).
Tissue expression of IL?17A and FOXP3 in acne vulgaris patients
Azza Gaber Antar Farag MD Alaa Hassan Maraee MD Dalia Rifaat Al?Sharaky MD Mustafa Elsayed Elshaib Marwa Samir Mohamed Kohla MSc Wafaa Ahmed Shehata MD
doi : 10.1111/jocd.13485
Volume20, Issue1 January 2021 Pages 330-337
CD4+ T helper (Th) cells through its pro?inflammatory cell type, interleukin?17 (IL?17)?generating cells and its anti?inflammatory category forkhead box P3?positive (FOXP3+) regulatory T (Treg) cells, play a vital role in the immune balance in inflammatory disorders. Therefore, assessment of both IL?17 and FOXP3 in acne vulgaris (AV), a chronic inflammatory disease of the pilosebaceous unit, could be of value in understanding AV pathogenesis. This study aimed to investigate the immunohistochemical expression of IL?17A and FOXP3 in acne vulgaris lesions versus normal skin.
Quantitative evaluation of rejuvenation treatment of nasolabial fold wrinkles by regression model and 3D photography
Rou?Yu Fang MD Han?Chao Zhang MD Yu?Guang Liu MD Qiu?Ning Sun MD
doi : 10.1111/jocd.13486
Volume20, Issue1 January 2021 Pages 338-345
With the application of 3D photography, our study aimed to quantify parameters of static nasolabial fold wrinkles and establish mathematic regression model between parameters of wrinkles and age, further to quantitatively evaluate the effect of rejuvenation treatment in terms of age.
The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris
Ikbal Esen Aydingoz MD Gulsen Tukenmez Demirci MD Deniz Agirbasli MD, PhD Devrim Oz?Arslan PhD Guven Yenmis PhD
doi : 10.1111/jocd.13498
Volume20, Issue1 January 2021 Pages 346-351
Epidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70%?100% of patients in a dose?dependent manner. Acneiform folliculitis is considered to be caused by an inflammatory process due to follicular hyperkeratosis and subsequently a set of changes both in epidermis and hair follicles as a result of epidermal growth factor receptor (EGFR) blockade. Both acne vulgaris and acneiform folliculitis due to EGFRIs show similar changes in the pilosebaceous unit. Furthermore, in both groups of patients, topical application of recombinant human epidermal growth factor (EGF) has been reported to improve the disease.
Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study
Sinu Rose Mathachan MD Pursuing Ananta Khurana MD, DNB, MNAMS Ram Kishan Gautam MD, DNB, MNAMS Anita Kulhari MD Lokesh Sharma MD Kabir Sardana MD, DNB, MNAMS
doi : 10.1111/jocd.13499
Volume20, Issue1 January 2021 Pages 352-359
Oxidative damage to melanocytes, resulting from an imbalance between the damaging oxidative pathways and the protective anti?oxidants likely plays a pathogenic role in vitiligo.
Modulation of skin androgenesis and sebum production by a dermocosmetic formulation
Elisete Isabel Crocco MD, PhD Evellin Barbosa Bonif?cio B.Pharm Gustavo Facchini PhD Gustavo Henrique da Silva BSc Michelle Sabrina da Silva PhD Ana Lucia Tabarini Alves Pinheiro MD Paula Voltarelli Franco Avelar MD Samara Eberlin PhD
doi : 10.1111/jocd.13503
Volume20, Issue1 January 2021 Pages 360-365
Excessive androgenesis in the skin promotes sebaceous hyperproduction which is the onset of acne vulgaris pathogenesis. Free fatty acids and lipid accumulation in the glandular infundibulum culminates in microbiota imbalance, triggering inflammatory response and follicular hyperkeratinization.
Deep fungal infection at the sites of previous insect bites
Ecem Bostan MD Duygu Gulseren MD Ozay Gokoz MD Diclehan Orhan MD Selin Aytac MD Sibel Ersoy?Evans MD
doi : 10.1111/jocd.13433
Volume20, Issue1 January 2021 Pages 366-367
