Neurology




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Assignment Completed: The Optic Nerve Should Graduate to Be the Fifth Lesion Site for the Diagnosis of Multiple Sclerosis.

Galetta, Steven MD; Brownlee, Wallace MBChB

doi : 10.1212/WNL.0000000000207913

Volume 102(1) pgs. e207913-e208009 January 9, 2024

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Progression Independent of Relapse Activity in Multiple Sclerosis: Closer to Solving the Pathologic Puzzle.

Tur, Carmen MD, PhD; Rocca, Maria A. MD

doi : 10.1212/WNL.0000000000207936

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Distinguishing Transient Cerebral Ischemia From Other Brief Neurologic Events.

Warach, Steven MD, PhD; Schellinger, Peter D. MD, PhD

doi : 10.1212/WNL.0000000000208024

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Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke.

Forman, Rachel MD; Okumu, Rita MD; Mageid, Razaz MD; Baker, Anna MPH; Neu, Dalton MAR; Parker, Ranisha RN, MSN; Peyravi, Reza BS; Schindler, Joseph L. MD; Sansing, Lauren H. MD, MS; Sheth, Kevin N. MD; de Havenon, Adam MD, MSc; Jasne, Adam MD; Narula, Reshma MD; Wira, Charles MD; Warren, Joshua PhD; Sharma, Richa MD, MPH

doi : 10.1212/WNL.0000000000207764

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Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.

Cagol, Alessandro MD; Benkert, Pascal PhD; Melie-Garcia, Lester PhD; Schaedelin, Sabine A. MSc; Leber, Selina MS; Tsagkas, Charidimos MD, PhD; Barakovic, Muhamed PhD; Galbusera, Riccardo MD; Lu, Po-Jui PhD; Weigel, Matthias PhD; Ruberte, Esther PhD; Radue, Ernst-Wilhelm MD; Yaldizli, Ozgur MD; Oechtering, Johanna MD; Lorscheider, Johannes MD; D'Souza, Marcus MD; Fischer-Barnicol, Bettina MD; Mu[Combining Diaeresis]ller, Stefanie MD; Achtnichts, Lutz MD; Vehoff, Jochen MD; Disanto, Giulio MD, PhD; Findling, Oliver MD; Chan, Andrew MD; Salmen, Anke MD; Pot, Caroline MD, PhD; Bridel, Claire MD; Zecca, Chiara MD; Derfuss, Tobias MD; Lieb, Johanna M. MD; Remonda, Luca MD; Wagner, Franca MD; Vargas, Maria Isabel MD; Du Pasquier, Renaud A. MD; Lalive, Patrice H. MD; Pravata, Emanuele MD; Weber, Johannes MD; Cattin, Philippe C. PhD; Absinta, Martina MD, PhD; Gobbi, Claudio MD; Leppert, David MD; Kappos, Ludwig MD; Kuhle, Jens MD, PhD; Granziera, Cristina MD, PhD

doi : 10.1212/WNL.0000000000207768

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Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA: A Pooled Analysis.

Best, Jonathan G. MD; Ambler, Gareth PhD; Wilson, Duncan PhD; Du, Houwei MD; Lee, Keon-Joo MD; Lim, Jae-Sung MD, PhD; Teo, Kay Cheong MBBS, MRCP; Mak, Henry MD; Kim, Young Dae MD, PhD; Song, Tae-Jin MD, PhD; Selcuk Demirelli, Derya MD; Nishihara, Masashi MD; Yoshikawa, Masaaki MD; Kubacka, Marta MD; Zietz, Annaelle MMed; Al-Shahi Salman, Rustam MD, PhD; Jager, Hans Rolf MD; Lip, Gregory Y.H. MD; Panos, Leonidas MD; Goeldlin, Martina B. MD; Slater, Lee-Anne MBBS, FRANZCR, MMed; Karayiannis, Christopher Charles MD; Phan, Thanh G. MBBS, FRACP, PhD; Bellut, Maximilian MD; Abrigo, Jill MD; Cheng, Cyrus MD; Leung, Thomas W. MD; Chu, Winnie MD; Chappell, Francesca PhD; Makin, Stephen D.J. PhD; van Dam-Nolen, Dianne H.K. MD; Kooi, M. Eline PhD; Kohler, Sebastian PhD; Staals, Julie MD, PhD; Kuchcinski, Gregory MD, PhD; Bordet, Regis MD; Dubost, Florian PhD; Wardlaw, Joanna M. MD; Soo, Yannie O.Y. MD; Fluri, Felix MD; Srikanth, Velandai K. MD, PhD; Jung, Simon MD; Peters, Nils MD; Hara, Hideo PhD; Yakushiji, Yusuke PhD; Necioglu Orken, Dilek MD; Heo, Ji-Hoe MD; Lau, Gary Kui Kai DPhil; Bae, Hee-Joon MD; Werring, David J. PhD

doi : 10.1212/WNL.0000000000207795

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Adding the Optic Nerve in Multiple Sclerosis Diagnostic Criteria: A Longitudinal, Prospective, Multicenter Study.

Vidal-Jordana, Angela MD, PhD; Rovira, Alex MD; Calderon, Willem MD; Arrambide, Georgina MD, PhD; Castillo, Joaquin MD; Moncho, Dulce MD; Rahnama, Kimia MD; Collorone, Sara MD, PhD; Toosy, Ahmed T. MD; Ciccarelli, Olga MD, PhD; Papadopoulou, Athina MD; Cerda-Fuertes, Nuria MD; Lieb, Johanna M. MD; Ruggieri, Serena MD, PhD; Tortorella, Carla MD, PhD; Gasperini, Claudio MD, PhD; Bisecco, Alvino MD, PhD; Capuano, Rocco MD; Gallo, Antonio MD, PhD; De Barros, Andrea MD; Salerno, Annalaura MD; Auger, Cristina MD; Sastre-Garriga, Jaume MS, PhD; Tintore, Mar MD, PhD; Montalban, Xavier MD, PhD

doi : 10.1212/WNL.0000000000207805

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Association of Glycemic Variability With Imaging Markers of Vascular Burden, [beta]-Amyloid, Brain Atrophy, and Cognitive Impairment.

Jang, Hyemin MD, PhD *; Lee, Sungjoo MS *; An, Sungsik MD; Park, Yuhyun PhD; Kim, Soo-Jong MS; Cheon, Bo Kyoung PhD; Kim, Ji Hyun MS; Kim, Hee Jin MD, PhD; Na, Duk L. MD, PhD; Kim, Jun Pyo MD; Kim, Kyunga PhD +; Seo, Sang Won MD, PhD +

doi : 10.1212/WNL.0000000000207806

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Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology.

Baril, Andree-Ann PhD; Kojis, Daniel J. BA; Himali, Jayandra J. PhD; Decarli, Charles S. MD; Sanchez, Erlan PhD; Johnson, Keith A. MA; El Fakhri, Georges PhD; Thibault, Emma BA; Yiallourou, Stephanie R. PhD; Himali, Dibya MS; Cavuoto, Marina G. MD; Pase, Matthew P. PhD; Beiser, Alexa S. PhD *; Seshadri, Sudha MD *

doi : 10.1212/WNL.0000000000207807

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Combined Impact of Migraine and Pregnancy-Induced Hypertension on Long-term Risk of Premature Myocardial Infarction and Stroke.

Hvitfeldt Fuglsang, Cecilia MD, PhD; Pedersen, Lars MSc, PhD; Schmidt, Morten MD, PhD, DMSc; Vandenbroucke, Jan P. MD, PhD; Botker, Hans Erik MD, PhD, DMSc; Toft Sorensen, Henrik MD, PhD, DMSc

doi : 10.1212/WNL.0000000000207813

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Role of Daytime Continuous Polysomnography in the Diagnosis of Pediatric Narcolepsy Type 1.

Pizza, Fabio MD, PhD; Vignatelli, Luca MD; Vandi, Stefano RPSGT; Zenesini, Corrado MSc; Biscarini, Francesco MD; Franceschini, Christian PsyD, PhD; Antelmi, Elena MD, PhD; Ingravallo, Francesca MD, PhD; Mignot, Emmanuel MD, PhD; Bruni, Oliviero MD; Nobili, Lino MD, PhD; Veggiotti, Pierangelo MD; Ferri, Raffaele MD, PhD; Plazzi, Giuseppe MD, PhD

doi : 10.1212/WNL.0000000000207815

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Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities.

Zammit, Andrea R. PhD, MSc; Klein, Hans-Ulrich PhD; Yu, Lei PhD; Levey, Allan I. MD, PhD; Seyfried, Nicholas T. PhD; Wingo, Aliza P. MD; Wingo, Thomas S. MD; Schneider, Julie A. MD; Bennett, David A. MD; Buchman, Aron S. MD

doi : 10.1212/WNL.0000000000207816

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Trends of Sex Differences and Associated Factors in Stroke Outcomes Among Patients With Acute Ischemic Stroke: 2007 to 2018.

Liu, Huihui MD, PhD *; Jin, Aoming PhD *; Pan, Yuesong PhD; Jing, Jing MD, PhD; Meng, Xia MD, PhD; Li, Hao PhD; Li, Zixiao MD, PhD; Wang, Yongjun MD

doi : 10.1212/WNL.0000000000207818

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Muscle MRI in Patients With Oculopharyngeal Muscular Dystrophy: A Longitudinal Study.

Kroon, Rosemarie H.M.J.M. MA; Kalf, Johanna G. PhD; de Swart, Bert J.M. PhD; Heskamp, Linda PhD; de Rooy, Jacky W.J. MD; van Engelen, Baziel G.M. MD, PhD *; Horlings, Corinne G.C. MD, PhD *

doi : 10.1212/WNL.0000000000207833

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Presenting Symptoms and Diffusion-Weighted MRI Positivity by Time After Transient Neurologic Events: A Pooled Analysis of 3 Cohort Studies.

Tanaka, Koji MD, PhD; Coutts, Shelagh B. MD; Joundi, Raed A. MD, Dphil; Singh, Nishita MD; Uehara, Tohiyuki MD, PhD; Ohara, Tomoyuki MD, PhD; Koga, Masatoshi MD, PhD; Koge, Junpei MD, PhD; Toyoda, Kazunori MD, PhD; Penn, Andrew M. MD; Balshaw, Robert F. PhD; Bibok, Maximilian M.B. PhD; Votova, Kristine PhD; Smith, Eric E. MD, MPH; Minematsu, Kazuo MD, PhD; Demchuk, Andrew M. MD

doi : 10.1212/WNL.0000000000207846

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Clinical, Imaging, Genetic, and Disease Course Characteristics in Patients With GM2 Gangliosidosis: Beyond Age of Onset.

Kern, Jan MD; Bohringer, Judith Dr rer nat; Timmann, Dagmar MD; Trollmann, Regina MD; Stendel, Claudia MD; Kamm, Cristoph MD; Robl, Markus MD; Santhanakumaran, Vidiyaah MSc; Groeschel, Samuel MD; Beck-Wodl, Stefanie Dr rer nat; Goricke, Sophia MD; Krageloh-Mann, Ingeborg MD *; Synofzik, Matthis MD *

doi : 10.1212/WNL.0000000000207898

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Association of Neurofilament Light Chain, [18F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With [beta]-Amyloid-Negative CBS.

Palleis, Carla MD; Franzmeier, Nicolai PhD; Weidinger, Endy MD; Bernhardt, Alexander M. MD; Katzdobler, Sabrina; Wall, Stephan; Ferschmann, Christian; Harris, Stefanie; Schmitt, Julia; Schuster, Sebastian; Gnorich, Johannes MD; Finze, Anika; Biechele, Gloria MD; Lindner, Simon MD; Albert, Nathalie L. MD; Bartenstein, Peter MD; Sabri, Osama MD; Barthel, Henryk MD; Rupprecht, Rainer MD; Nuscher, Brigitte; Stephens, Andrew W.; Rauchmann, Boris-Stephan MD; Perneczky, Robert MD, PhD, MBA; Haass, Christian PhD; Brendel, Matthias MD *; Levin, Johannes MD *; Hoglinger, Gunter U. MD *

doi : 10.1212/WNL.0000000000207901

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Characteristics and Prognosis of Tumor-Related Epilepsy During Tumor Evolution in Patients With IDH Wild-Type Glioblastoma.

Pallud, Johan MD, PhD; Roux, Alexandre MD, PhD *; Moiraghi, Alessandro MD *; Aboubakr, Oumaima MD, MSc; Elia, Angela MD, MSc; Guinard, Eleonore MD, PhD; Oppenheim, Catherine MD, PhD; Tauziede-Espariat, Arnault MD, PhD; Parraga, Eduardo MD; Gavaret, Martine MD, PhD; Chretien, Fabrice MD, PhD; Huberfeld, Gilles MD, PhD; Zanello, Marc MD, PhD

doi : 10.1212/WNL.0000000000207902

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Sensitivity and Specificity of the Boston Criteria Version 2.0 for the Diagnosis of Cerebral Amyloid Angiopathy in a Community-Based Sample.

Zanon Zotin, Maria Clara MD, PhD; Makkinejad, Nazanin PhD; Schneider, Julie A. MD; Arfanakis, Konstantinos PhD; Charidimou, Andreas MD, PhD; Greenberg, Steven M. MD, PhD *; van Veluw, Susanne J. PhD *

doi : 10.1212/WNL.0000000000207940

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Prevalence, Demographic, and Clinical Factors Associated With Cognitive Dysfunction in Patients With Neuromyelitis Optica Spectrum Disorder.

Vlahovic, Luka MD, MSCR *; McDonald, Jamie MD, MS; Hinman, Jessica PhD; Tomczak, Anna MS; Lock, Christopher MD, PhD; Palmer, Chella A. MPH; Cook, Lawrence J. PhD; Yeaman, Michael R. PhD; Burnett, Melinda K. MD; Deutsch, Gayle K. PhD; Nelson, Lorene M. PhD; Han, May H. MD *; for CIRCLES Study Group

doi : 10.1212/WNL.0000000000207965

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CADMUS: A Novel MRI-Based Classification of Spontaneous Intracerebral Hemorrhage Associated With Cerebral Small Vessel Disease.

Goeldlin, Martina B. MD; Mueller, Madlaine MD; Siepen, Bernhard M. MD; Zhang, Wenpeng MSc; Ozkan, Hatice MPhil; Locatelli, Martina MD; Du, Yang; Valenzuela, Waldo PhD; Radojewski, Piotr MD; Hakim, Arsany MD; Kaesmacher, Johannes MD, PhD; Meinel, Thomas R. MD, PhD; Clenin, Leander MMed; Branca, Mattia PhD; Strambo, Davide MD; Fischer, Tim MD; Medlin, Friedrich MD; Peters, Nils MD; Carrera, Emmanuel MD; Lovblad, Karl-Olof MD; Karwacki, Grzegorz M. MD; Cereda, Carlo W. MD; Niederhauser, Julien MD; Mono, Marie-Luise MD; Mueller, Achim MD; Wegener, Susanne MD; Sartoretti, Sabine MD; Polymeris, Alexandros A. MD, PhD; Altersberger, Valerian MD; Katan, Mira MD; Psychogios, Marios MD; Sturzenegger, Rolf MD; Nauer, Claude MD; Schaerer, Michael MD; Buitrago Tellez, Carlos MD; Renaud, Susanne; Minkner Klahre, Katharina; Z'Graggen, Werner J. MD; Bervini, David; Bonati, Leo H. MD; Wiest, Roland MD; Arnold, Marcel MD; Simister, Robert J. PhD; Wilson, Duncan MD, PhD; Jager, Hans Rolf MD; Fischer, Urs MD *; Werring, David J. MD, PhD *; Seiffge, David J. MD *; for Swiss Stroke Registry Investigators and SIGNAL Investigators

doi : 10.1212/WNL.0000000000207977

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FDA Patient-Focused Drug Development Guidances: Considerations for Trial Readiness in Rare Developmental and Epileptic Encephalopathies.

Berg, Anne T. PhD; Ludwig, Natasha N. PhD; Wojnaroski, Mary PhD; Chapman, Chere A.T. MBA, MHSc; Hommer, Rebecca EdD; Conecker, Gabrielle MPH; Hecker, JayEtta Z. MS; Downs, Jenny PhD

doi : 10.1212/WNL.0000000000207958

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Veni, Vidi, Scribivi: I Came, I Saw, I Wrote.

Acosta, Lealani Y. Mae MD; Gutmann, Ludwig MD; Moawad, Heidi MD; Wynn, Michael L. DO

doi : 10.1212/WNL.0000000000208017

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Teaching NeuroImage: Unilateral Primary Angiitis of the CNS.

Alkabie, Samir MD; Gray, Madison T. MD; Lau, Jonathan C. MD; Barra, Lillian MD; Mandzia, Jennifer MD; Zhang, Qi MBBS; Budhram, Adrian MD

doi : 10.1212/WNL.0000000000208018

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Editors' Note: Challenges to Brain Death in Revising the Uniform Determination of Death Act: The UDDA Revision Series.

Siegler, James E. MD; Galetta, Steven MD

doi : 10.1212/WNL.0000000000208046

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Reader Response: Challenges to Brain Death in Revising the Uniform Determination of Death Act: The UDDA Revision Series.

Machado, Calixto

doi : 10.1212/WNL.0000000000208044

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Author Response: Challenges to Brain Death in Revising the Uniform Determination of Death Act: The UDDA Revision Series.

Bernat, James L.

doi : 10.1212/WNL.0000000000208045

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Comparison of the Effectiveness and Side Effects of Intravenous TPA Injection in Acute Stroke Patients Between 0 and 4.5 Hours and the First 4.5 to 6 Hours From the Onset of Symptoms (P7-5.018)

doi : 10.1212/WNL.0000000000207971

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Pearls & Oy-sters: CACNA1A-Related Paroxysmal Tonic Upgaze With Ataxia Responsive to Acetazolamide.

Lazar, Steven M. MD, MEd; Abid, Farida MD

doi : 10.1212/WNL.0000000000207992

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Emerging Subspecialties in Neurology: Women's Neurology.

Thornton, Hayley F. MD, MSc; LaHue, Sara C. MD; Bove, Riley MD, MMSc; Waters, Janet MD, MBA; O'Neal, Mary A. MD; Bui, Esther MD

doi : 10.1212/WNL.0000000000208009

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