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Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment
Erin McMoneagle, Jin Zhou, Shiyao Zhang, Weixue Huang, Sunday Solomon Josiah, Ke Ding, Yun Wang & Jinwei ZhangÂ
doi : 10.1038/s41401-023-01149-9
Volume 45 Issue 1, January 2024
Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery
Si Gao, Xue-ping Liu, Ting-ting Li, Li Chen, Yi-ping Feng, Yu-kun Wang, Yan-jun Yin, Peter J. Little, Xiao-qian Wu, Suo-wen Xu & Xu-dong JiangÂ
Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems
Ze-xian Yang, Yu Zhang, Qing Wang, Lei Zhang, Yi-fei Liu, Ye Zhang, Yu Ren, Chen Zhou, Hui-wen Gao, Nai-xia Zhang & Lin-yin FengÂ
Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
Xi-zhen Ma, Lei-lei Chen, Le Qu, Hui Li, Jun Wang, Ning Song & Jun-xia XieÂ
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model
An Cheng, Wenbin Jia, David I. Finkelstein, Nadia Stefanova, Haoyang Wang, Takuya Sasaki, Ichiro Kawahata & Kohji FukunagaÂ
Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats
Chang-peng Cui, Xue Xiong, Jia-xin Zhao, Dong-hong Fu, Yan Zhang, Peng-bo Ma, Di Wu & Bai-yan LiÂ
SGLT2 inhibitor empagliflozin alleviates cardiac remodeling and contractile anomalies in a FUNDC1-dependent manner in experimental Parkinson’s disease
Wei Yu, Lin Wang, Wei-ying Ren, Hai-xia Xu, Ne N. Wu, Dong-hui Yu, Russel J. Reiter, Wen-liang Zha, Qing-dong Guo & Jun RenÂ
Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling
Shuang Yang, Hou-wei Li, Jia-ying Tian, Zheng-kai Wang, Yi Chen, Ting-ting Zhan, Chun-yue Ma, Min Feng, Shi-feng Cao, Yu Zhao, Xue Li, Jing Ren, Qian Liu, Lu-ying Jin, Zhi-qi Wang, Wen-yu Jiang, Yi-xiu Zhao, Yan Zhang & Xue LiuÂ
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
Yi-min Huang, Yu-sen Wu, Yuan-ye Dang, Yi-ming Xu, Kong-yang Ma & Xiao-yan DaiÂ
PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release
Jing-yao Li, Xi-ang Sun, Xin Wang, Ning-hao Yang, Hong-yan Xie, Heng-jiang Guo, Li Lu, Xin Xie, Li Zhou, Jun Liu, Wei Zhang & Li-min LuÂ
Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway
Hua Miao, Yan-ni Wang, Wei Su, Liang Zou, Shou-gang Zhuang, Xiao-yong Yu, Fei Liu & Ying-yong ZhaoÂ
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
Bo Wang, Li-na Yang, Le-tian Yang, Yan Liang, Fan Guo, Ping Fu & Liang MaÂ
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway
Chun-mei Wu, Jia-wen Mao, Jin-zhi Zhu, Can-can Xie, Jia-ying Yao, Xiao-qian Yang, Mai Xiang, Yi-fan He, Xiao Tong, Dilinaer Litifu, Xiao-yu Xiong, Meng-nan Cheng, Feng-hua Zhu, Shi-jun He, Ze-min Lin & Jian-ping ZuoÂ
Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199
Wen-xiang Ren, Hao Guo, Sheng-yan Lin, Si-yi Chen, Yao-ying Long, Liu-yue Xu, Di Wu, Yu-lin Cao, Jiao Qu, Bian-lei Yang, Hong-pei Xu, He Li, Ya-li Yu, An-yuan Zhang, Shan Wang, Yi-cheng Zhang, Ke-shu Zhou, Zhi-chao Chen & Qiu-bai LiÂ
Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis
Huan Liu, Rui Deng, Cheng-wei Zhu, Hong-kuan Han, Gang-fan Zong, Lang Ren, Peng Cheng, Zhong-hong Wei, Yang Zhao, Su-yun Yu & Yin LuÂ
Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway
Hua Miao, Yan-ni Wang, Wei Su, Liang Zou, Shou-gang Zhuang, Xiao-yong Yu, Fei Liu & Ying-yong ZhaoÂ
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
Bo Wang, Li-na Yang, Le-tian Yang, Yan Liang, Fan Guo, Ping Fu & Liang MaÂ
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway
Chun-mei Wu, Jia-wen Mao, Jin-zhi Zhu, Can-can Xie, Jia-ying Yao, Xiao-qian Yang, Mai Xiang, Yi-fan He, Xiao Tong, Dilinaer Litifu, Xiao-yu Xiong, Meng-nan Cheng, Feng-hua Zhu, Shi-jun He, Ze-min Lin & Jian-ping ZuoÂ
Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199
Wen-xiang Ren, Hao Guo, Sheng-yan Lin, Si-yi Chen, Yao-ying Long, Liu-yue Xu, Di Wu, Yu-lin Cao, Jiao Qu, Bian-lei Yang, Hong-pei Xu, He Li, Ya-li Yu, An-yuan Zhang, Shan Wang, Yi-cheng Zhang, Ke-shu Zhou, Zhi-chao Chen & Qiu-bai LiÂ
Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis
Huan Liu, Rui Deng, Cheng-wei Zhu, Hong-kuan Han, Gang-fan Zong, Lang Ren, Peng Cheng, Zhong-hong Wei, Yang Zhao, Su-yun Yu & Yin LuÂ
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome
Yi-hui Yang, Wan Li, Li-wen Ren, Hong Yang, Yi-zhi Zhang, Sen Zhang, Yue Hao, Dong-ke Yu, Rong-sheng Tong, Guan-hua Du, Jian-you Shi & Jin-hua WangÂ
