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Commentary: Atypical melanocytic skin lesions – does the anatomical location have an impact on their clinical and dermoscopic appearance?
T. Deinlein
doi : 10.1111/jdv.17141
Volume 35, Issue 3 p. 566-566
The clinical and dermoscopic differentiation between early melanomas and atypical naevi remains challenging, especially in patients with multiple pigmented lesions and in lesions with worrisome clinical and/or dermoscopic features. Several (site-related) melanoma-specific criteria and standardized algorithms are described and increased early melanoma recognition remarkably. However, none of these approaches considered the lesion’s location and the amount of sun exposure as important factors on their clinical and dermoscopic appearance.1, 2
Commentary on “The risk of anti-osteoporotic agent-induced severe cutaneous adverse drug reactions and their association with HLA” by W-H Chung et al
T. Shiohara
doi : 10.1111/jdv.17138
Volume 35, Issue 3 p. 567-568
Severe adverse drug reactions (ADRs) encompass two distinct clinical entities, the most common being drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS). Another one is Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). The two forms of severe ADRs likely exhibit individually distinctive pathogenic mechanisms, although some of causative drugs are common. DiHS/DRESS is characterized by sequential reactivations of herpesviruses associated with further progression of defects of regulatory T cells (Tregs),1 while SJS/TEN is characterized by aberrant activation of effector T cells.2 Wen-Hung Chung et al.3 have found a striking association between HLA-B*33:03 allele and strontium ranelate (SR)-induced SJS. Previous studies, however, demonstrated that many sensitive carriers with a specific HLA phenotype are unlikely to develop severe ADRs upon drug intake. These findings suggest that multiple factors, other than HLA allele, which modulate immune responses, may determine the disease phenotype. Consistent with this view, the clinical phenotype may vary with time and some patients with a mild form of ADRs have been reported to evolve into SJS/TEN. Indeed, evidence has linked the specific HLA alleles with the subsequent risk of developing ADRs, but not specific to DiHS/DRESS or SJS/TEN. In this regard, we demonstrated that HLA-A*31:01 has been linked to carbamazepine (CBZ)-induced ADRs in Japanese,4 northern Europeans and southern Chinese populations. Thus, the HLA-A*31:01 appears to be a specific marker for CBZ-induced ADRs but not necessarily a specific marker for CBZ-induced SJS or DiHS/DRESS.
Pioneers in Dermatology and Venereology: an Interview with Professor Jouni Uitto
J. Uitto
doi : 10.1111/jdv.17142
Volume 35, Issue 3 p. 569-571
Smallpox scars in a 19th-century portrait at the Turku Art Museum
N. Kluger
doi : 10.1111/jdv.16937
Volume 35, Issue 3 p. 572-573
2020 European guideline on the management of syphilis
M. Janier, M. Unemo, N. Dupin, G.S. Tiplica, M. Poto?nik, R. Patel
doi : 10.1111/jdv.16946
Volume 35, Issue 3 p. 574-588
The 2020 edition of the European guideline on the management of syphilis is an update of the 2014 edition.
‘Occupational dermatoses from Personal Protective Equipment during the COVID-19 pandemic in the tropics – A Review’
H.C. Lee, C.L. Goh
doi : 10.1111/jdv.16925
Volume 35, Issue 3 p. 589-596
The COVID-19 pandemic has enveloped the world and there has been a high incidence of occupational dermatoses related to Personal Protective Equipment (PPE) amongst healthcare workers (HCWs) during this period. Prevention and management of these conditions will not only improve staff morale and quality of life, but will also minimize the risk of breaching PPE protocol due to such symptoms. The tropical climate in Singapore predisposes HCWs to more skin damage and pruritus due to intense heat, high humidity and sun exposure. The effects of friction, occlusion, hyperhidrosis and overheating on the skin in the tropics should not be neglected. Preventive measures can be taken based on our recommendations, and the working environment can be made more conducive for frontline HCWs. We review the literature and discuss various preventive and management strategies for these occupational skin diseases for our frontline HCWs, especially those working in less controlled working environments beyond the hospital in Singapore. Shorter shifts and frequent breaks from PPE are recommended. Duration of continuous PPE-usage should not exceed 6 h, with breaks in non-contaminated areas every 2–3 h to hydrate and mitigate the risk of skin reactions. Other strategies, such as teledermatology, should be considered so that consultations can remain accessible, while ensuring the safety and well-being of our clinical staff.
The importance of skin manifestations, serology and nailfold (video)capillaroscopy in morphea and systemic sclerosis: current understanding and new insights
Y. Mostmans, B. Richert, V. Badot, C. Nagant, V. Smith, O. Michel
doi : 10.1111/jdv.16813
Volume 35, Issue 3 p. 597-606
Since the field around morphea and systemic sclerosis (SSc) is evolving rapidly, this review approaches conventional as well as more recent clinical developments from a dermatological point of view. Skin manifestations are critical in sub-classifying these diseases ensuring a correct prognosis for these patients. They can be discretely present, and therefore, diagnosis can be challenging sometimes, implicating a thorough dermatological examination is mandatory. Furthermore, a growing amount of dermatologists perform nailfold videocapillaroscopy (NVC), a more recent reliable non-invasive imaging technique used for in vivo assessment of the microcirculation at the nailfold. After all, specific NVC-changes are present in a majority of patients with SSc. This way, dermatologists not only take part in the diagnosis process through clinical investigation but also through the use of a modern state of the art imaging technique that is becoming the golden standard in SSc multidisciplinary workup. In this review, current understandings for NVC in morphea and SSc are revised. So far, the role of NVC in the diagnosis/prognosis/classification of morphea patients has not been thoroughly investigated to make proper conclusions. As for SSc, it is well known that NVC contributes to the diagnosis and can make a fundamental difference especially when obvious clinical SSc signs are absent. This review emphasizes the (somewhat underestimated) role of dermatologists in the process of diagnosis and follow-up, and thus, the difference we can make for our patients and fellow colleagues in the multidisciplinary workup of SSc and morphea.
Systematic review of BRAF/MEK inhibitors-induced Severe Cutaneous Adverse Reactions (SCARs)
I. Torres-Navarro, B. de Unamuno-Bustos, R. Botella-Estrada
doi : 10.1111/jdv.16894
Volume 35, Issue 3 p. 607-614
Severe cutaneous adverse reactions (SCARs) [Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed eruption (GBFE)] are severe drug reactions that often require hospitalization and could be fatal. BRAF and MEK inhibitors (BRAF/MEKi) are a standard of care in patients with BRAF-mutated metastatic melanomas. These agents are administered until disease progression or unacceptable toxicity occurs. This review has focus on BRAF/MEKi-induced SCARs. A systematic search of the following terms: ‘vemurafenib’, ‘cobimetinib’, ‘dabrafenib’, ‘trametinib’, ‘encorafenib’, ‘binimetinib’, ‘Acute Generalized Exanthematous Pustulosis’, ‘Stevens Johnson syndrome’, ‘Toxic Epidermal Necrolysis’, ‘Generalized Bullous Fixed Eruption’ ‘Drug Hypersensitivity Syndrome’, and ‘DRESS’ in simple combination (every drug with each disease) and all in combination, was performed on MEDLINE, EMBASE, Web of Knowledge and The Cochrane Library repositories, with no restriction on language, for original studies. One hundred sixty-eight original articles were found, 26 (retrospective series, case reports and conference abstracts) were selected, and 21 were included in the qualitative synthesis. A total of 31 SCAR cases (23 DRESS and 8 SJS/TEN – 1 SJS and 7 TEN –) were identified. Vemurafenib was the culprit drug in all but one case, which was dabrafenib-induced. Mean time to SCAR onset from drug intake was 15.5 and 11.4 days, for SJS/TEN and DRESS, respectively. For the DRESS cases, hepatic involvement occurred in 96% and renal alterations in 87% of patients. Overall, BRAF/MEKi-induced SCARs are rare. Among them, vemurafenib is the drug that requires more close monitoring for SCARs. Prior immunotherapy can favour SCARs. Vemurafenib DRESS is likely to occur within the first fifteen days of treatment accompanied by hepatic and renal involvement. Following vemurafenib-induced SCAR resolution, switching to dabrafenib seems to be a safe alternative for these patients’ treatment.
Atopic dermatitis and bone health: a systematic review
I.M. Mukovozov, D.E. Morra, D. Giustini, M. Tadrous, A.M. Cheung, A.M. Drucker
doi : 10.1111/jdv.16895
Volume 35, Issue 3 p. 615-628
Atopic dermatitis (AD) is associated with systemic inflammation and systemic corticosteroid use which can lead to poor bone health. The aim of this systematic review is to investigate the relationship between AD and bone mineral density (BMD), osteoporosis and fractures. We searched Web of Science, Cochrane Database of Systematic Reviews, MEDLINE and Embase. Title, abstract and full-text screening, and data extraction were done in duplicate. Quality appraisal was performed using the Agency for Healthcare Research and Quality Methodology Checklist (cross-sectional studies) and Newcastle-Ottawa Scale (cohort studies). We screened 3800 abstracts and included fifteen studies (twelve cross-sectional, three cohort). In cross-sectional studies, AD was associated with decreased BMD and increased fractures. In cross-sectional studies and a cohort study, AD was associated with a higher prevalence of osteoporosis compared to controls. There was inconsistency across studies, with some finding no association. In a large cohort study, AD was associated with increased risk of fractures of the hip (HR: 1.06, 95% CI: 1.02 to 1.11), spine (HR: 1.14, 95% CI: 1.06 to 1.23) and wrist (HR: 1.06, 95% CI: 1.01 to 1.10), with further increased risk with more severe AD. Differences between studies precluded quantitative synthesis. There is some evidence supporting an association between AD and poor bone health. Research is needed to clarify this association, underlying mechanisms and develop strategies to improve bone health of individuals with AD.
Common causes of hair loss – clinical manifestations, trichoscopy and therapy
A. Alessandrini, F. Bruni, B.M. Piraccini, M. Starace
doi : 10.1111/jdv.17079
Volume 35, Issue 3 p. 629-640
The field of hair disorders is constantly growing. The most important hair diseases are divided in non- cicatricial and cicatricial ones. Non-cicatricial alopecia are more frequent than cicatricial alopecia. The first step is to obtain a good history and physical examination. Laboratory testing is often unnecessary, while trichoscopy is fundamental for all hair diseases. Scalp biopsy is strongly suggested in cicatricial alopecia and in doubtful cases. Androgenetic alopecia, alopecia areata, telogen effluvium, trichotillomania are common causes of non- cicatricial alopecia. Frontal fibrosing alopecia, discoid lupus erythematosus, lichen planopilaris, follicullitis decalvans are some of the most common forms of cicatricial hair loss. Many treatments are available, and a prompt diagnosis is very important for the prognosis.
Chemical peelings for the treatment of actinic keratosis: a systematic review and meta-analysis
T. Steeb, E.A.T. Koch, A. Wessely, L.G. Wiest, L. Schmitz, C. Berking, M.V. Heppt
doi : 10.1111/jdv.16844
Volume 35, Issue 3 p. 641-649
Actinic keratosis (AK) is a common precancerous lesion of the skin that may be treated with chemical peelings. Despite their long-standing usage and clinical experience, no evidence-based recommendation regarding the efficacy and safety of chemical peelings for AK exists.
The impact of anatomical location and sun exposure on the dermoscopic recognition of atypical nevi and early melanomas: usefulness of an integrated clinical-dermoscopic method (iDScore)
L. Tognetti, A. Cartocci, E. Cinotti, E. Moscarella, F. Farnetani, A. Lallas, D. Tiodorovic, C. Carrera, C. Longo, S. Puig, J.L. Perrot, G. Argenziano, G. Pellacani, G. Cataldo, A. Balistreri, G. Cevenini, P. Rubegni
doi : 10.1111/jdv.16847
Volume 35, Issue 3 p. 650-657
The anatomical location of atypical melanocytic skin lesion (aMSL) was never combined into an algorithm for discriminating early melanomas (EM) from atypical nevi (AN).
Primary cutaneous peripheral T-cell lymphoma, not otherwise specified: results of a multicentre European Organization for Research and Treatment of Cancer (EORTC) cutaneous lymphoma taskforce study on the clinico-pathological and prognostic features
W. Kempf, C. Mitteldorf, M. Battistella, R. Willemze, L. Cerroni, M. Santucci, E. Geissinger, P. Jansen, M.H. Vermeer, M. Marschalko, E. Papadavid, M.A. Piris, P.L. Ortiz-Romero, M. Novelli, M. Paulli, P. Quaglino, A. Ranki, J.L. Rodr?guez Peralto, M. Wobser, B. Auschra, A. Robson
doi : 10.1111/jdv.16969
Volume 35, Issue 3 p. 658-668
Cutaneous peripheral T-cell lymphoma, not otherwise specified (PTL NOS) is an aggressive, but poorly characterized neoplasm.
3D wide-field multispectral photoacoustic imaging of human melanomas in vivo: a pilot study
B. Park, C.H. Bang, C. Lee, J.H. Han, W. Choi, J. Kim, G.S. Park, J.W. Rhie, J.H. Lee, C. Kim
doi : 10.1111/jdv.16985
Volume 35, Issue 3 p. 669-676
The Breslow depth is an important parameter to determine the excision margin and prognosis of melanoma. However, it is difficult to accurately determine the actual Breslow depth before surgery using the existing ocular micrometer and biopsy technique.
Secukinumab efficacy in reducing the severity and the psychosocial impact of moderate-to-severe psoriasis as assessed by the Simplified Psoriasis Index: results from the IPSI-PSO study
M.-A. Richard, J.-P. Lacour, M.-P. Konstantinou, M. Ruer-Mulard, P. Joly, S. Aractingi, P. Auquier, B. Pelvet, M.L. Augustin, E. Mahé, R.J.G. Chalmers
doi : 10.1111/jdv.16893
Volume 35, Issue 3 p. 677-684
The utility of the Simplified Psoriasis Index (SPI), a recently developed multidomain tool for assessing psoriasis, was investigated in a study assessing response to secukinumab.
Comparison of the impact of childhood psoriasis on mothers’ and fathers’ quality of life – does gender of a caregiver play a role?
M. ?ychowska, A. Reich, J. Maj, A. Jankowska-Konsur, J. C. Szepietowski
doi : 10.1111/jdv.16930
Volume 35, Issue 3 p. 685-692
Psoriasis is a chronic skin condition that in one third of cases starts in the first two decades of life. The disease might impact the quality of life (QoL) of the affected children and their caregivers. The issue of gender differences in the assessment of psychological burden of dermatological conditions has been the subject of few studies with contradictory results.
Brodalumab for the treatment of moderate-to-severe plaque-type psoriasis: a real-life, retrospective 24-week experience
M.C. Fargnoli, M. Esposito, P. Dapavo, A. Parodi, M. Rossi, R. Tiberio, S. Dastoli, A.M. Offidani, G. Argenziano, P. Gisondi, A. Lo Schiavo, F. Loconsole, P. Pella, F. Bardazzi, F. Cusano, M. Gattoni, M. Nacca, S.P. Cannav?, C. Pellegrini, A. Costanzo, BRILLIANT Working Group
doi : 10.1111/jdv.16931
Volume 35, Issue 3 p. 693-700
Brodalumab was efficacious and safe in moderate-to-severe plaque-type psoriasis in the AMAGINE trials; published reports under real-life conditions are limited.
A phase 4, randomized, head-to-head trial comparing the efficacy of subcutaneous injections of brodalumab to oral administrations of fumaric acid esters in adults with moderate-to-severe plaque psoriasis (CHANGE)
A. Pinter, M. Hoffmann, K. Reich, M. Augustin, K. Kaplan, S.D. Gudj?nsd?ttir, T. Delvin, U. Mrowietz, on behalf of the CHANGE investigator group
doi : 10.1111/jdv.16932
Volume 35, Issue 3 p. 701-711
Brodalumab is a fully human monoclonal immunoglobulin IgG2 antibody that binds to the human IL-17 receptor subunit A and by that inhibits the biologic action of IL-17A, IL-17F, IL-17C and IL-17E. Therapy with fumaric acid esters (FAE) is a well established and widely used first-line systemic treatment for subjects with moderate-to-severe plaque psoriasis.
The risk of anti-osteoporotic agent-induced severe cutaneous adverse drug reactions and their association with HLA
C.-B. Chen, Y.-E. Chen, M.-T. Chu, C.-W. Wang, R. C.-Y. Hui, C.-W. Lu, Y.-P. Hsiao, C.-Y. Chu, M.M. Chang, C. M.-t. Cheung, C.-Y. Cheng, Y.-W. Wang, Y.-J. Lin, C.-J. Chang, S.-I. Hung, W.-H. Chung, the Taiwan Severe Cutaneous Adverse Reaction Consortium
doi : 10.1111/jdv.16924
Volume 35, Issue 3 p. 712-720
There is increasing use of anti-osteoporotic agents (AOA) worldwide for prevention or management of patients with osteoporosis. However, there have been reports of severe cutaneous adverse reactions (SCAR) induced by AOA. A recent study showed weak association between HLA and strontium ranelate (SR)-SCAR.
The Chronic Urticaria Registry: rationale, methods and initial implementation
K. Weller, A. Giménez-Arnau, C. Grattan, R. Asero, P. Mathelier-Fusade, M. Bizjak, M. Hanna, M. Maurer, on behalf of the CURE Investigators
doi : 10.1111/jdv.16947
Volume 35, Issue 3 p. 721-729
Chronic urticaria (CU) is a common disease, characterized by the recurrent appearance of wheals, angioedema or both for more than 6 weeks. Its underlying biology is not well understood, and many patients do not obtain sufficient relief from recommended treatments. Patient registries are rapidly growing as a form of research, because they can provide powerful, data-driven insights about the epidemiology of diseases, real-world effectiveness of treatments, rare patient types, safety monitoring, healthcare costs and opportunities for quality improvement of healthcare delivery.
Continuous glucose monitoring systems give contact dermatitis in children and adults despite efforts of providing less ‘allergy- prone’ devices: investigation and advice hampered by insufficient material for optimized patch test investigations
C. Svedman, M. Bruze, A. Antelmi, N. Hamnerius, I. Hauksson, J. Ulriksdotter, M. Mowitz
doi : 10.1111/jdv.16981
Volume 35, Issue 3 p. 730-737
Medical devices are increasingly being reported to cause contact allergic dermatitis reactions.
The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non-lesional skin: A comparative, retrospective, explorative statistical analysis of 4,484 patients in a real-world cohort
C. Zeidler, M.P. Pereira, M. Dugas, M. Augustin, M. Storck, V. Weyer-Elberich, G. Schneider, S. St?nder
doi : 10.1111/jdv.16929
Volume 35, Issue 3 p. 738-743
Chronic prurigo (CPG) is known as a high burdensome disease characterized by severe pruritus and multiple pruriginous lesions. Interestingly, the disease-specific burden is not well established and there are no data which compare the impact of CPG with chronic pruritus (CP) on non-lesional skin (CP-NL).
Patients’ perspective on current treatments and demand for novel treatments in vitiligo
V.S. Narayan, S.E. Uitentuis, R.M. Luiten, M.W. Bekkenk, A. Wolkerstorfer
doi : 10.1111/jdv.16927
Volume 35, Issue 3 p. 744-748
The treatment of non-segmental vitiligo (NSV) remains a challenge. Current treatments often achieve suboptimal clinical results. To improve these treatment results, several new therapies are being developed and investigated. There is, however, little evidence on the actual need for novel therapies.
Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach
S. Meki?, C. Wigmann, D.A. Gunn, L.C. Jacobs, M. Kayser, T. Schikowski, T. Nijsten, L.M. Pardo
doi : 10.1111/jdv.17014
Volume 35, Issue 3 p. 749-754
The severity of facial telangiectasia or red veins is associated with many lifestyle factors. However, the genetic predisposition remains unclear.
Factors influencing quality of life in children with low-flow vascular malformations: a qualitative study using focus groups
E. Casassa, A. Bergeron, A. Maruani, C. Labreze, S. Barbarot, H. Aubert, J. Malloizel-Delaunay, J. Shourick, A. Croiset, I. Dreyfus, J. Mazereeuw-Hautier
doi : 10.1111/jdv.17037
Volume 35, Issue 3 p. 755-761
Very few studies have evaluated the quality of life (QoL) of children suffering from low-flow vascular malformations. This is the first study investigating the influencing factors.
Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing
A.K. Langton, J. Ayer, T.W. Griffiths, E. Rashdan, K. Naidoo, M.P. Caley, M.A. Birch-Machin, E.A. O'Toole, R.E.B. Watson, C.E.M. Griffiths
doi : 10.1111/jdv.17063
Volume 35, Issue 3 p. 762-768
Photoageing describes complex cutaneous changes which occur following chronic exposure to solar ultraviolet radiation (UVR). Amongst White Northern Europeans, facial photoageing appears as distinct clinical phenotypes: ‘hypertrophic’ photoageing (HP) and ‘atrophic’ photoageing (AP). Deep, coarse wrinkles predominate in individuals with HP, whereas those with AP have relatively smooth, unwrinkled skin with pronounced telangiectasia. AP individuals have an increased propensity for developing keratinocyte cancers.
Immunological and virological profile of children with chilblain-like lesions and SARS-CoV-2
L. Fertitta, A. Welfringer-Morin, A. Ouedrani, L. Polivka, S. Chhun, L. Chatenoud, J. Fourgeaud, S. Hadj-Rabia, S. Temmam, M. Eloit, I. Sermet-Gaudelus, C. Bodemer
doi : 10.1111/jdv.16972
Volume 35, Issue 3 p. e164-e167
Diagnosis of hair disorders during the COVID-19 pandemic: an introduction to teletrichoscopy
M. Randolph, A. Al-alola, A. Tosti
doi : 10.1111/jdv.16989
Volume 35, Issue 3 p. e167-e168
A multicenter study on effectiveness and safety of risankizumab in psoriasis: an Italian 16-week real-life experience during the COVID-19 pandemic
K. Hansel, A. Zangrilli, L. Bianchi, K. Peris, A. Chiricozzi, A. Offidani, F. Diotallevi, M.C. Fargnoli, M. Esposito, P. Amerio, G. Gualdi, L. Bianchi, L. Stingeni
doi : 10.1111/jdv.17003
Volume 35, Issue 3 p. e169-e170
Increase in sexually transmitted infection during the COVID-19 pandemic in Taiwan
K.-K. Lee, C.-C. Lai, C.-M. Chao, H.-J. Tang
doi : 10.1111/jdv.17005
Volume 35, Issue 3 p. e171-e172
Self-reported cutaneous manifestations in 1429 Brazilian COVID-19-infected patients
H.A. Miot, M. Ianhez, P. Müller Ramos
doi : 10.1111/jdv.17024
Volume 35, Issue 3 p. e172-e173
COVID-19 in patients with cutaneous immune-mediated diseases in The Netherlands: real-world observational data
L.E.M. de Wijs, M.M. Joustra, J.I. Olydam, T. Nijsten, D.J. Hijnen
doi : 10.1111/jdv.17025
Volume 35, Issue 3 p. e173-e176
Adverse skin reactions following different types of mask usage during the COVID-19 pandemic
C. Chaiyabutr, T. Sukakul, C. Pruksaeakanan, J. Thumrongtharadol, W. Boonchai
doi : 10.1111/jdv.17039
Volume 35, Issue 3 p. e176-e178
Impact of the COVID-19 pandemic on inpatient dermatology: a multicentre study from Hubei, China
Y. Zhang, J. Wen, M. Alamgir, J. Xie, H. Jing, M. Fang, J. Wang, M. Zhang, Z. Meng, L. Yang, J. Tao
doi : 10.1111/jdv.17041
Volume 35, Issue 3 p. e179-e181
SARS-CoV-2-induced telogen effluvium: a multicentric study
O.M. Moreno-Arrones, A. Lobato-Berezo, A. Gomez-Zubiaur, S. Arias-Santiago, D. Saceda-Corralo, C. Bernardez-Guerra, R. Grimalt, P. Fernandez-Crehuet, J. Ferrando, R. Gil, A. Hermosa-Gelbard, R. Rodrigues-Barata, D. Fernandez-Nieto, S. Merlos-Navarro, S. Va??-Galv?n
doi : 10.1111/jdv.17045
Volume 35, Issue 3 p. e181-e183
Lack of skin manifestations in COVID-19 hospitalized patients during the second epidemic wave in Spain: a possible association with a novel SARS-CoV-2 variant – a cross-sectional study
D. Fernandez-Nieto, D. Ortega-Quijano, A. Suarez-Valle, J. Jimenez-Cauhe, P. Jaen-Olasolo, M. Fernandez-Guarino
doi : 10.1111/jdv.17051
Volume 35, Issue 3 p. e183-e185
Wearing a mask and skin disease: patients with atopic dermatitis speak it out
S. Merhand, L. Misery, V. Delvigne, C. Le Floch, C. Taïeb
doi : 10.1111/jdv.16917
Volume 35, Issue 3 p. e185-e187
SARS-CoV-2 spike protein is present in both endothelial and eccrine cells of a chilblain-like skin lesion
T. Gambichler, J. Reuther, M. Stücker, R. Stranzenbach, C. Torres-Reyes, R. Schlottmann, W.E. Schmidt, R. Hayajneh, A. Sriram, J.C. Becker
doi : 10.1111/jdv.16970
Volume 35, Issue 3 p. e187-e189
Transferability of suggested molecular classifiers for psoriasis and eczema to the Chinese population
M.-n. Xu, L. Li, W. Pan, S.-q. Dai, Q. Wang, M.-l. Wang, K. Zeng, X.-w. Huang, K. Eyerich
doi : 10.1111/jdv.16898
Volume 35, Issue 3 p. e189-e192
Analysis of non-responders to dupilumab in clinical practice: a cohort study
C. Linder, J. Shourick, A.T Touhouche, F. Giordano-Labadie, M. Severino-Freire, C. Borjesson, C. Richet, M.C. Marguery, M. Tauber, C. Paul
doi : 10.1111/jdv.16900
Volume 35, Issue 3 p. e192-e194
Anonymous automated counselling for aesthetic dermatology using a chatbot – an analysis of age- and gender-specific usage patterns
S. Feuchter, M. Kunz, V. Djamei, A.A. Navarini
doi : 10.1111/jdv.16907
Volume 35, Issue 3 p. e194-e195
Disease severity, patient-reported outcomes and skin hydration improve during balneotherapy with hydrocarbonate- and sulphur-rich water of psoriasis
R. Darlenski, I. Bogdanov, M. Kacheva, D. Zheleva, Z. Demerdjieva, E. Hristakieva, J.W. Fluhr, N. Tsankov
doi : 10.1111/jdv.16908
Volume 35, Issue 3 p. e196-e198
Short- and long-term efficacy of fumaric acid esters or acitretin in combination with a 12-week course of PUVA in the treatment of palmoplantar pustulosis: results from a prospective randomized trial
M.C. Aichelburg, A. Pinkowicz, G. Holzer, S. Radakovic, P.-G. Sator, A. Tanew
doi : 10.1111/jdv.16909
Volume 35, Issue 3 p. e198-e200
New insights into lichen planus pigmentosus associated with cicatricial alopecia
M.F.R.G. Dias, H. Dutra Rezende, J.R. Furtado Cardoso de Moraes, N. Dlova, C.N. Ekelem, E.A.G. Vilar, R.M. Trüeb
doi : 10.1111/jdv.16918
Volume 35, Issue 3 p. e200-e203
Novel blue blotch lesions in folliculitis decalvans – a clinical, histopathological and immunohistochemical study of seven cases
I. Doche, M.M. Rebeis, P. Gerlero, N.Y.S. Valente, M.C. Rivitti-Machado
doi : 10.1111/jdv.16919
Volume 35, Issue 3 p. e203-e205
Trichoscopic features of mild frontal fibrosing alopecia
D. Saceda-Corralo, O.M. Moreno-Arrones, M. Rubio-Lambra?a, R. Gil-Redondo, C. Bern?rdez, ?. Hermosa-Gelbard, P. Jaén-Olasolo, S. Va??-Galv?n
doi : 10.1111/jdv.16920
Volume 35, Issue 3 p. e205-e207
Selection process of measures for core outcome set should utilize the highest methodology level and should be maximally free of bias. Comment on ‘IDQoL, CDLQI and the 45-item CADIS received a sufficient content validity rating during the HOME VII meeting in Japan: a group discussion study’
P.V. Chernyshov, L. Tomas Aragones, C.M. Salavastru, F. Sampogna, M.J. Boffa, F. Poot, V. Bettoli, N. Pusti?ek, A.W.M. Evers, A. Bewley, S.E. Marron, D. Abeni, A. Svensson, J.S. Szepietowski
doi : 10.1111/jdv.16921
Volume 35, Issue 3 p. e208-e209
Talimogene laherparepvec can initiate plasma cell invasion into infiltrated melanoma lesions – a case series
G. Richtig, L. Cerroni, H. Schmidt, C. Beham-Schmid, T. Deinlein, C. Vallant, E. Richtig
doi : 10.1111/jdv.16922
Volume 35, Issue 3 p. e209-e211
Granuloma annulare: report of 13 patients treated with photodynamic therapy
A.J. Garc?a-Malinis, T. Gracia-Caza?a, D. Planas Linares, P.J. Ag?n-Banzo, Y. Gilaberte
doi : 10.1111/jdv.16935
Volume 35, Issue 3 p. e211-e214
Systemic aspects of alopecia areata Comment to the article by Lai and Sinclair
L. Rudnicka, A. Wa?kiel-Burnat
doi : 10.1111/jdv.16936
Volume 35, Issue 3 p. e214-e215
Fluorescence-advanced videodermatoscopy characterization of demodex mites: a comparison with reflectance confocal microscopy
D. Fernandez-Nieto, G. Segurado-Miravalles, A. Gonzalez-Cantero, D. Ortega-Quijano, J. Jimenez-Cauhe, P. Boixeda
doi : 10.1111/jdv.16938
Volume 35, Issue 3 p. e215-e216
Prevalence and indicators of fear of melanoma in patients with familial melanoma during surveillance
C. Hinnen, A. Boonstra, N. Kukutsch, R. van Doorn
doi : 10.1111/jdv.16939
Volume 35, Issue 3 p. e217-e218
Involvement of small-diameter nerve fibres in long-term chronic pain after Stevens–Johnson syndrome or toxic epidermal necrolysis. A neurophysiological assessment
J.-P. Lefaucheur, C. Hajj, L. Valeyrie-Allanore, A. Colin, S. Ng Wing Tin, N. de Prost, P. Wolkenstein, O. Chosidow, S. Ingen-Housz-Oro
doi : 10.1111/jdv.16940
Volume 35, Issue 3 p. e218-e221
An approach for the transition from systemic immunosuppressants to dupilumab
L.E.M. de Wijs, J.P. Thyssen, C. Vestergaard, H.B. Thio, A.C.M. Kunkeler, T. Biedermann, D.J. Hijnen
doi : 10.1111/jdv.16941
Volume 35, Issue 3 p. e221-e223
Primary cutaneous follicle centre lymphoma, spindle cell type, presenting with multicentre figurated erythema and complete remission after intralesional injections of ultra-low-dose Interferon alpha-2a
L. Vlahova, W. Kempf, M.P. Sch?n, C. Mitteldorf
doi : 10.1111/jdv.16942
Volume 35, Issue 3 p. e223-e225
Duck-like lips: a new clinical feature for diagnosis of Mycoplasma-Induced Rash and Mucositis
A. Dondi, A. Di Altobrando, R. Parladori, C. Biagi, C. Balsamo, C. Ghizzi, A. Patrizi, M. Lanari, I. Neri
doi : 10.1111/jdv.16952
Volume 35, Issue 3 p. e225-e227
Group B streptococcal necrotizing soft-tissue infection: role of pharyngeal and perineal carriage
C. Charpentier, F. Kouby, C. Hua, E. Sbidian, M. Darty, R. Bosc, N. De Prost, C. Gomart, P.-L. Woerther, A. Tazi, J.-W. Decousser, O. Chosidow, Henri Mondor Hospital Necrotizing Fasciitis Group
doi : 10.1111/jdv.16943
Volume 35, Issue 3 p. e227-e228
Interferon-beta as an enhancer of paraviral exanthema during influenza virus infection
C. Braegelmann, D. Niebel, J. Wenzel, T. Bieber, A.M. Eis-Hübinger, D. Wilsmann-Theis
doi : 10.1111/jdv.16954
Volume 35, Issue 3 p. e228-e230
Dyskeratosis follicularis cured by superficial radiotherapy: long-term follow-up of 10 patients
H.C. Wulf, S.R. Wiegell
doi : 10.1111/jdv.16957
Volume 35, Issue 3 p. e230-e232
Patients’, family members’ and healthcare practitioners’ experiences of Stevens–Johnson syndrome and toxic epidermal necrolysis: a qualitative descriptive study using emotional touchpoints
P. O’Reilly, B. Whelan, B. Ramsay, C. Kennedy, P. Meskell, A. Coffey, D.M. Wilson, D.G. Fortune, S. Ryan
doi : 10.1111/jdv.16958
Volume 35, Issue 3 p. e232-e234
Extramammary Paget's disease: in vivo dynamic optical coherence tomography imaging
A. Rajabi-Estarabadi, F. Garbarino, N.M. Williams, N. Nami, K. Nouri
doi : 10.1111/jdv.16960
Volume 35, Issue 3 p. e234-e236
Oral tuberculosis in a patient with Crohn's disease on TNF-? blockers
V. Reynaert, M. Grosber, A. Tache, F. Mana, P. Buydens, P. Lacor, J. Gutermuth
doi : 10.1111/jdv.16961
Volume 35, Issue 3 p. e236-e237
Dermoscopic features of face and scalp basal and squamous cell carcinomas according to clinical histopathologic characteristics and anatomical location
S. Fagotti, M.A. Pizzichetta, P. Corneli, F. Toffolutti, D. Serraino, N. di Meo, I. Zalaudek
doi : 10.1111/jdv.16968
Volume 35, Issue 3 p. e237-e239
Chronic Prurigo patients do not report higher impulsiveness or more traumatic life experiences than chronic pruritus patients with non-lesional skin
G. Schneider, R. Steinbach, S. St?nder, A. Stumpf
doi : 10.1111/jdv.16973
Volume 35, Issue 3 p. e239-e241
Catastrophizing thinking towards itch and pain in chronic itch patients
M. Granot, S. Yakov, P. Kuperman, G. Yosipovitch, M. Ramon
doi : 10.1111/jdv.16975
Volume 35, Issue 3 p. e241-e242
