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2020 Update in basic kidney research: chronic hypoxia, insulin resistance, sarcopaenia, phosphate binders and peritoneal fibrosis in chronic kidney disease
Chenyu Li, Hans-Joachim Anders
doi : 10.1093/ndt/gfab071
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1145–1147
no abstract
The unsolved challenge of implementing sustained reductions of sodium intake in patients with chronic kidney disease
Michel Burnier, Denis Fouque
doi : 10.1093/ndt/gfaa268
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1148–1151
Prevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine
Hervé Lobbes, Sabine Mainbourg, Jean-Christophe Lega
doi : 10.1093/ndt/gfaa337
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1151–1154
Health literacy problems of kidney patients
Norbert Lameire, Raymond Vanholder
doi : 10.1093/ndt/gfaa340
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1155–1157
Malignant hypertension and thrombotic microangiopathy: complement as a usual suspect
Fadi Fakhouri, Salima Sadallah, Véronique Frémeaux-Bacchi
doi : 10.1093/ndt/gfaa362
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1157–1159
Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases
Andreas Kronbichler, Hans-Joachim Anders, Gema Maria Fernandez-Ju?rez, Jürgen Floege, Dimitrios Goumenos, M?rten Segelmark, Vladimir Tesar, Kultigin Turkmen, Cees van Kooten, Annette Bruchfeld, the Immunonephrology Working Group of the ERA-EDTA (European Renal Association—European Dialysis and Transplant Association)
doi : 10.1093/ndt/gfab064
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1160–1168
Coronavirus disease 2019 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of severe acute respiratory syndrome coronavirus 2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group of the European Renal Association–European Dialysis and Transplant Association discuss 13 frequently asked questions regarding the safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms and disease activity following the administration of COVID-19 vaccines. Some of the candidates induce signalling pathways, which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favour the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies, patients might be protected by a sufficient cellular immune response capable of reducing the severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important, as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.
Benefits and risks of frequent or longer haemodialysis: weighing the evidence
Pantelis Sarafidis, Danai Faitatzidou, Aikaterini Papagianni
doi : 10.1093/ndt/gfaa023
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1168–1176
Although the ability of individuals with end-stage renal disease to maintain body homoeostasis is equally impaired during all weekdays, conventional haemodialysis (HD) treatment is scheduled thrice weekly, containing two short and one long interdialytic interval. This intermittent nature of HD and the consequent fluctuations in volume, metabolic parameters and electrolytes have long been hypothesized to predispose to complications. Large observational studies link the first weekday with an increased risk of cardiovascular morbidity and mortality. Several schemes of frequent and/or longer, home or in-centre HD have been introduced, aiming to alleviate the above risks by both increasing total dialysis duration and reducing the duration of interdialytic intervals. Observational studies in this field have non-uniform results, showing that enhanced frequency in home (but not in-centre) HD is associated with reduced mortality. Evidence from the randomized Daily and Nocturnal Trials of the Frequent HD Network suggest the opposite, showing mortality benefits with in-centre daily but not with home nocturnal dialysis. Secondary analyses of these trials indicate that daily and nocturnal schedules do not have equal effects on intermediate outcomes. Alternative schemes, such as thrice weekly in-centre nocturnal HD or every-other-day HD, seem to also offer improvements in several intermediate endpoints, but need further testing with randomized trials. This review summarizes the effects of frequent and/or longer HD methods on hard and intermediate outcomes, attempting to provide a balanced overview of the field.
Post-transplant lymphoproliferative disorder: risk factors and management
Jolanta Malyszko
doi : 10.1093/ndt/gfz207
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1177–1179
Renal transplant surgery: important things a nephrologist should know
Karen Stevenson
doi : 10.1093/ndt/gfz253
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1180–1182
A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations
Marko Ugrica, Carla Bettoni, Soline Bourgeois, Arezoo Daryadel, Eva-Maria Pastor-Arroyo, Nicole Gehring, Nati Hernando, Carsten A Wagner, Isabel Rubio-Aliaga
doi : 10.1093/ndt/gfab015
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1183–1191
Phosphate intake has increased in the last decades due to a higher consumption of processed foods. This higher intake is detrimental for patients with chronic kidney disease, increasing mortality and cardiovascular disease risk and accelerating kidney dysfunction. Whether a chronic high phosphate diet is also detrimental for the healthy population is still under debate.
Reducing salt intake by urine chloride self-measurement in non-compliant patients with chronic kidney disease followed in nephrology clinics: a randomized trial
Vincenzo Panuccio, Francesca Mallamaci, Patrizia Pizzini, Rocco Tripepi, Carlo Garofalo, Giovanna Parlongo, Graziella Caridi, Michele Provenzano, Angela Mafrica, Giuseppina Simone, Sebastiano Cutrupi, Graziella D’Arrigo, Gaetana Porto, Giovanni Tripepi, Antonella Nardellotto, Gina Meneghel, Piero Dattolo, Francesco Pizzarelli, Francesco Rapisarda, Anna Ricchiuto, Pasquale Fatuzzo, Simone Verdesca, Maurizio Gallieni, Loreto Gesualdo, Giuseppe Conte, Mario Plebani, Carmine Zoccali
doi : 10.1093/ndt/gfaa262
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1192–1199
Adherence to low salt diets and control of hypertension remain unmet clinical needs in chronic kidney disease (CKD) patients.
Risk factors for venous thromboembolism in patients with nephrotic syndrome: a retrospective cohort study
Kanna Shinkawa, Satomi Yoshida, Tomotsugu Seki, Motoko Yanagita, Koji Kawakami
doi : 10.1093/ndt/gfaa134
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1199–1206
Nephrotic syndrome is associated with an increased risk of venous thromboembolism (VTE). However, the risk factors of VTE in nephrotic syndrome, other than hypoalbuminemia and severe proteinuria, are not well established. Therefore we aimed to investigate the risk factors of VTE in patients with nephrotic syndrome.
How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies
Marco D Boonstra, Sijmen A Reijneveld, Elisabeth M Foitzik, Ralf Westerhuis, Gerjan Navis, Andrea F de Winter
doi : 10.1093/ndt/gfaa273
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1207–1221
Limited health literacy (LHL) is associated with multiple adverse health outcomes in chronic kidney disease (CKD). Interventions are needed to improve this situation, but evidence on intervention targets and strategies is lacking. This systematic review aims to identify potential targets and strategies by summarizing the evidence on: (i) patient- and system-level factors potentially mediating the relation between LHL and health outcomes; and (ii) the effectiveness of health literacy interventions customized to CKD patients.
Association between thrombotic microangiopathy and activated alternative complement pathway in malignant nephrosclerosis
Ying Zhang, Chaona Yang, Xinjin Zhou, Ruimin Hu, Songxia Quan, Yali Zhou, Yuan Li, Guolan Xing
doi : 10.1093/ndt/gfaa280
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1222–1233
Malignant nephrosclerosis, defined as renal microangiopathy in the setting of severe hypertension, remains a critical renal emergency leading to end-stage renal disease despite aggressive anti-hypertensive treatment. Recently, activation of the complement alternative pathway (AP) has been reported to play a prominent role in the pathogenesis of malignant nephrosclerosis. However, subsequent study failed to recapitulate the findings of genetic complement abnormalities in the disease. This study aimed to determine the presence of AP activation and genetic complement defects and establish their correlations to renal microangiopathy lesions, clinical features and prognosis in patients with malignant nephrosclerosis.
Tissue sodium concentrations in chronic kidney disease and dialysis patients by lower leg sodium-23 magnetic resonance imaging
Elena Qirjazi, Fabio R Salerno, Alireza Akbari, Lisa Hur, Jarrin Penny, Timothy Scholl, Christopher W McIntyre
doi : 10.1093/ndt/gfaa036
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1234–1243
Sodium-23 magnetic resonance imaging (23Na MRI) allows direct measurement of tissue sodium concentrations. Current knowledge of skin, muscle and bone sodium concentrations in chronic kidney disease (CKD) and renal replacement therapy patients is limited. In this study we measured the tissue sodium concentrations in CKD, hemodialysis (HD) and peritoneal dialysis (PD) patients with 23Na MRI of the lower leg and explored their correlations with established clinical biomarkers.
Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, for treatment of anemia of chronic kidney disease: two randomized Phase 2 trials in Japanese patients
Masaomi Nangaku, Youssef M K Farag, Emil deGoma, Wenli Luo, Dennis Vargo, Zeeshan Khawaja
doi : 10.1093/ndt/gfaa060
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1244–1252
Vadadustat is an investigational, oral hypoxia-inducible factor prolyl hydroxylase inhibitor in development in Japan for the treatment of chronic kidney disease (CKD)-induced anemia.
The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury and/or proteinuria
Sophie Ferlicot, Matthieu Jamme, François Gaillard, Julie Oniszczuk, Aymeric Couturier, Olivia May, Anne Grünenwald, Aurélie Sannier, Anissa Moktefi, Ophélie Le Monnier, Camille Petit-Hoang, Nadine Maroun, Albane Brodin-Sartorius, Arthur Michon, Hélène Dobosziewicz, Fabrizio Andreelli, Matthieu Guillet, Hassane Izzedine, Christian Richard, Manon Dekeyser, Romain Arrestier, Thomas Stehlé, Edouard Lefèvre, Alexis Mathian, Christophe Legendre, Charlotte Mussini, Marie-Christine Verpont, Nicolas Pallet, Zahir Amoura, Marie Essig, Renaud Snanoudj, Isabelle Brocheriou-Spelle, Hélène François, Xavier Belenfant, Guillaume Geri, Eric Daugas, Vincent Audard, David Buob, Ziad A Massy, Mohamad Zaidan, the AP-HP/Universities/Inserm COVID-19 research collaboration
doi : 10.1093/ndt/gfab042
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1253–1262
The coronavirus disease 2019 (COVID-19) may be associated with kidney injury, which may impact patient's prognosis.
Impact of acute kidney injury on anticancer treatment dosage and long-term outcomes: a pooled analysis of European Organisation for Research and Treatment of Cancer trials
Julien Péron, Anouk Neven, Laurence Collette, Vincent Launay-Vacher, Ben Sprangers, Sandrine Marreaud
doi : 10.1093/ndt/gfaa049
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1263–1271
The impact of kidney dysfunction on long-term outcomes of patients with advanced cancer remains unclear.
Association of tubular solute clearances with the glomerular filtration rate and complications of chronic kidney disease: the Chronic Renal Insufficiency Cohort study
Yan Chen, Leila R Zelnick, Ke Wang, Ronit Katz, Andrew N Hoofnagle, Jessica O Becker, Chi-Yuan Hsu, Alan S Go, Harold I Feldman, Rupal C Mehta, James P Lash, Sushrut S Waikar, L Hamm, Jing Chen, Tariq Shafi, Bryan R Kestenbaum, the CRIC Study Investigators
doi : 10.1093/ndt/gfaa057
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1271–1281
The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function. The degree to which secretory solute clearance corresponds with the glomerular filtration rate (GFR) and potential metabolic implications of net secretory clearance are largely unknown.
Effect of increased potassium intake on the renin–angiotensin–aldosterone system and subcutaneous resistance arteries: a randomized crossover study
Rasmus Dreier, Bahareh Abdolalizadeh, Camilla L Asferg, Lisbet R H?lmich, Niels H Buus, Julie L Forman, Ulrik B Andersen, Martin Egfjord, Majid Sheykhzade, J?rgen L Jeppesen
doi : 10.1093/ndt/gfaa114
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1282–1291
Increased potassium intake lowers blood pressure (BP) in hypertensive patients. The underlying mechanism is not fully understood but must be complex because increased potassium intake elevates circulating concentrations of the BP-raising hormone aldosterone.
Persistence of antibody response to SARS-CoV-2 in a cohort of haemodialysis patients with COVID-19
Suzanne Forbes, Maria Davari, Sahana Gnanasampanthan, Noam Roth, Gregor Young, Ravindra Rajakariar, Andrea Cove-Smith, Muhammed Magdi Yaqoob, Teresa Cutino-Moguel, Viyaasan Mahalingasivam, Kieran McCafferty
doi : 10.1093/ndt/gfab066
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1292–1297
Haemodialysis (HD) patients are extremely vulnerable to coronavirus disease 2019 (COVID-19). Their immune response after infection is unclear. We have found high seroconversion rates in this population, with 95% developing antibodies. It is unclear if and how long these antibodies persist. Here we investigate this with serial antibody (Ab) testing.
Association between implementation of novel therapies and improved survival in patients starting haemodialysis: the Swedish Renal Registry 2006–15
Marie Evans, Hong Xu, Helena Rydell, Karl-G?ran Prütz, Bengt Lindholm, Maria Stendahl, M?rten Segelmark, Juan-Jesus Carrero
doi : 10.1093/ndt/gfaa357
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1298–1306
The recent years have witnessed significant therapeutic advances for patients on haemodialysis (HD). We evaluated temporal changes in treatments practices and survival rates among incident HD patients.
Tissue sodium stores in peritoneal dialysis and hemodialysis patients determined by sodium-23 magnetic resonance imaging
Melis Sahinoz, Supisara Tintara, Serpil Muge Deger, Aseel Alsouqi, Rachelle L Crescenzi, Cindy Mambungu, Andrew Vincz, Olivia J Mason, Heather L Prigmore, Andrew Guide, Thomas G Stewart, David G Harrison, Friedrich C Luft, Jens Titze, Talat Alp Ikizler
doi : 10.1093/ndt/gfaa350
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1307–1317
Tissue sodium (Na+) content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) was previously explored using 23Na+ magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of Na+ stores in patients on dialysis as well as the factors influencing this Na+ accumulation.
Perspectives on mental health among patients receiving dialysis
Melissa Nataatmadja, Nicole Evangelidis, Karine E Manera, Yeoungjee Cho, David W Johnson, Jonathan C Craig, Amanda Baumgart, Camilla S Hanson, Jenny Shen, Chandana Guha, Nicole Scholes-Robertson, Allison Tong, for SONG-HD and SONG-PD
doi : 10.1093/ndt/gfaa346
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1317–1325
Diminished mental health is associated with increased morbidity and mortality and may contribute to loss of independence and motivation in patients receiving dialysis and their caregivers. Increased understanding of the patient perspective on triggers, impacts and strategies for managing mental health may inform ways to address mental health conditions in this population.
Blood pressure monitoring in kidney transplantation: a systematic review on hypertension and target organ damage
Anna Pisano, Francesca Mallamaci, Graziella D’Arrigo, Davide Bolignano, Gregoire Wuerzner, Alberto Ortiz, Michel Burnier, Nada Kanaan, Pantelis Sarafidis, Alexandre Persu, Charles J Ferro, Charalampos Loutradis, Ioannis N Boletis, Gérard London, Jean-Michel Halimi, Bénédicte Sautenet, Patrick Rossignol, Liffert Vogt, Carmine Zoccali
doi : 10.1093/ndt/gfab076
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1326–1346
Few studies show that ambulatory blood pressure (BP) monitoring (ABPM) is superior to office BP (oBP) measurements to predict target organ damage and cardiovascular (CV) events in kidney transplant recipients (KTRs). We performed a systematic review aimed at determining the potential associations between BP recordings by different methods and renal and CV outcomes in this population.
Antibody response to mRNA SARS-CoV-2 vaccine among dialysis patients—a prospective cohort study
Timna Agur, Naomi Ben-Dor, Shira Goldman, Shelly Lichtenberg, Michal Herman-Edelstein, Dafna Yahav, Benaya Rozen-Zvi, Boris Zingerman
doi : 10.1093/ndt/gfab155
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1347–1349
Younger children treated with rituximab for nephrotic syndrome are at higher risk of adverse events
Camille Laroche, Dominique Lemieux, Philippe Sylvestre, Anne-Laure Lapeyraque, Adrien Flahault
doi : 10.1093/ndt/gfab013
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1349–1351
Rituximab in primary membranous nephropathy: a comparative study of three dosing regimens
Raja Ramachandran, Saurabh Nayak, Vinod Kumar, Jasmine Sethi, Ranjana Minz, Vivek Kumar, Manish Rathi, Harbir Singh Kohli
doi : 10.1093/ndt/gfab037
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Pages 1352–1354
Errata
Francesco G Casino, Carlo Basile, Dimitrios Kirmizis, Mehmet Kanbay, Frank van der Sande, Daniel Schneditz, Sandip Mitra, Andrew Davenport, Loreto Gesualdo, the Eudial Working Group of ERA-EDTA
doi : 10.1093/ndt/gfaa317
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Page 1355
Erratum to: Hematological disorders following kidney transplantation
Jolanta Malyszko, Grzegorz Basak, Krzysztof Batko, Giavambatista Capasso, Anna Capasso, Joanna Drozd-Sokolowska, Katarzyna Krzanowska, Pawel Kulicki, Joanna Matuszkiewicz-Rowinska, Maria Jose Soler, Ben Sprangers, Jacek Malyszko
doi : 10.1093/ndt/gfaa318
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Page 1355
Erratum to: Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy
Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita
doi : 10.1093/ndt/gfaa319
Nephrology Dialysis Transplantation, Volume 36, Issue 7, July 2021, Page 1356
