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Caring for older people with chronic kidney disease—primum non nocere
Naomi Clyne
doi : 10.1093/ndt/gfaa254
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 953–956
Striking new path(way)s—how a conceptual model of patient outcomes can help us advance outcomes that matter to patients
Krister Cromm, Kathrin I Fischer
doi : 10.1093/ndt/gfaa274
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 956–959
Staging pregnancy-related acute kidney injury according to Kidney Disease: Improving Global Outcomes guidelines: what are the barriers?
Hadrien de Buhren, Alexandre Hertig
doi : 10.1093/ndt/gfaa259
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 959–961
Chronic kidney disease of unknown origin in agricultural communities: beyond tropical mist?
Claire Rigothier, Bertrand Chauveau, Sébastien Rubin, Christian Combe
doi : 10.1093/ndt/gfaa265
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 961–962
Fruit for thought: lifestyle interventions to reduce the risk of future chronic kidney disease
Jennifer S Lees, Patrick B Mark
doi : 10.1093/ndt/gfaa266
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 963–965
The role of activin: the other side of chronic kidney disease–mineral bone disorder?
Giuseppe Cianciolo, Gaetano La Manna, Irene Capelli, Lorenzo Gasperoni, Andrea Galassi, Paola Ciceri, Mario Cozzolino
doi : 10.1093/ndt/gfaa203
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 966–974
Chronic kidney disease–mineral bone disorder (CKD-MBD) plays a pivotal role in the excess of cardiovascular morbidity and mortality associated with CKD. There is now a growing awareness that pathways involved in CKD-MBD, like canonical Wnt signalling, are activated from the earliest stages of CKD, playing a role in the development of adynamic bone disease with unknown consequences on vasculature. These changes occur before the classic changes in mineral metabolism: secondary hyperparathyroidism, calcitriol deficiency and hyperphosphataemia. Furthermore, vascular calcification is frequently associated and evolves with decreased bone mineral density and deranged bone turnover, while bone and arterial mineralization share common pathways. Therefore, results of clinical trials focused on mineral bone disorder, aimed at preserving bone and cardiovascular health, are considered unsatisfactory. In order to identify more effective therapeutic strategies, it is necessary to clarify the pathways modulating the cross-talk between bone and vasculature and identify new mediators involved in the pathogenesis of CKD-MBD. Much attention has been paid recently to the role of the transforming growth factor-beta superfamily members in renal disease, and in particular of activin A (ActA). Preclinical studies demonstrate an upgrade of ActA signalling in kidney, skeleton, vasculature and heart during CKD. This supports the idea that an endocrine factor produced in the kidney during renal disease, in addition to promoting the progression of kidney damage, deranges other organs’ homoeostasis and participates in CKD-MBD. In this review, we analyse the contribution of ActA to kidney fibrosis and inflammation as well as its role in the development of CKD-MBD.
The Prepare for Kidney Care Study: prepare for renal dialysis versus responsive management in advanced chronic kidney disease
Emma Murphy, Aine Burns, Fliss E M Murtagh, Leila Rooshenas, Fergus J Caskey
doi : 10.1093/ndt/gfaa209
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 975–982
Shared decision making in advanced chronic kidney disease (CKD) requires unbiased information on survival and person-centred outcomes known to matter to patients: quality of life, symptom burden and support from family and healthcare professionals. To date, when deciding between dialysis and conservative care, patients have had to rely on evidence from small observational studies. Clinicians recognize that like is not being compared with like in these studies, and interpret the results differently. Furthermore, support differs considerably between renal units. What patients choose therefore depends on which renal unit they attend. To address this, a programme of work has been underway in the UK. After reports on survival and symptoms from a small number of renal units, a national, mixed-methods study—the Conservative Kidney Management Assessment of Practice Patterns Study—mapped out conservative care practices and attitudes in the UK. This led to the Prepare for Kidney Care study, a randomized controlled trial comparing preparation for dialysis versus preparation for conservative care. Although powered to detect a positivist 0.345 difference in quality-adjusted life years between the two treatments, this trial also takes a realist approach with a range of person-centred secondary outcomes and embedded qualitative research. To understand generalizability, it is nested in an observational cohort study, which is nested in a CKD registry. Challenges to recruitment and retention have been rapidly identified and addressed using an established embedded mixed methods approach—the QuinteT recruitment intervention. This review considers the background to and progress with recruitment to the trial.
Rituximab in minimal change disease and focal segmental glomerulosclerosis
Andreas Kronbichler, Philipp Gauckler, Annette Bruchfeld
doi : 10.1093/ndt/gfz205
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 983–985
Risk factors, pathogenesis, presentation and management of BK virus infection in kidney transplantation
Erol Demir, Aydin Turkmen, Mehmet Sukru Sever
doi : 10.1093/ndt/gfz214
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 985–987
Targeted deletion of nicotinamide adenine dinucleotide phosphate oxidase 4 from proximal tubules is dispensable for diabetic kidney disease development
Vicki Thallas-Bonke, Sih Min Tan, Runa S Lindblom, Matthew Snelson, Cesare Granata, Jay Chandra Jha, Karly C Sourris, Adrienne Laskowski, Anna Watson, Michel Tauc, Isabelle Rubera, Guoping Zheng, Ajay M Shah, David C H Harris, Mahmoud H Elbatreek, Phillip Kantharidis, Mark E Cooper, Karin Jandeleit-Dahm, Melinda T Coughlan
doi : 10.1093/ndt/gfaa376
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 988–997
The nicotinamide adenine dinucleotide phosphate oxidase isoform 4 (Nox4) mediates reactive oxygen species (ROS) production and renal fibrosis in diabetic kidney disease (DKD) at the level of the podocyte. However, the mitochondrial localization of Nox4 and its role as a mitochondrial bioenergetic sensor has recently been reported. Whether Nox4 drives pathology in DKD within the proximal tubular compartment, which is densely packed with mitochondria, is not yet known.
Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease
Griet Glorieux, Raymond Vanholder, Wim Van Biesen, Anneleen Pletinck, Eva Schepers, Nathalie Neirynck, Marijn Speeckaert, Dirk De Bacquer, Francis Verbeke
doi : 10.1093/ndt/gfab004
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 998–1005
Several protein-bound uraemic toxins (PBUTs) have been associated with cardiovascular (CV) and all-cause mortality in chronic kidney disease (CKD) but the degree to which this is the case per individual PBUT and the pathophysiological mechanism have only partially been unraveled.
Increased dishevelled associated activator of morphogenesis 2, a new podocyte-associated protein, in diabetic nephropathy
Chenyang Qi, Faten Alsomali, Jinyong Zhong, Raymond C Harris, Valentina Kon, Haichun Yang, Agnes B Fogo
doi : 10.1093/ndt/gfab014
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1006–1016
Previously, by using proteomic analysis and RNA sequencing in isolated glomeruli, we identified several novel differentially expressed proteins in human and mouse diabetic nephropathy (DN) versus controls, including dishevelled associated activator of morphogenesis 2 (DAAM2). DAAM2 binds the Wnt effector Dvl. We aimed to study possible contributions of DAAM2 to DN.
Immunoglobulin G/albumin staining in tubular protein reabsorption droplets in minimal change disease and focal segmental glomerulosclerosis
Lihong Bu, James Mirocha, Mark Haas
doi : 10.1093/ndt/gfaa039
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1016–1022
Some renal biopsies cannot distinguish minimal change disease (MCD) from primary focal segmental glomerulosclerosis (FSGS) because of inadequate sampling and/or a lack of sampled glomeruli with segmental sclerosis. As protein excretion in MCD has been described as being albumin-selective, we examined whether the ratio of immunoglobulin G (IgG)/albumin staining in protein reabsorption droplets (tPRD) might help distinguish MCD from FSGS.
Acute kidney injury e-alerts in pregnancy: rates, recognition and recovery
Rouvick M Gama, Katherine Clark, Mahua Bhaduri, Amanda Clery, Kelly Wright, Priscilla Smith, Hayley Martin, Royce P Vincent, Satish Jayawardene, Kate Bramham
doi : 10.1093/ndt/gfaa217
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1023–1030
Acute kidney injury (AKI) in pregnancy (Pr-AKI) is associated with substantial maternal morbidity and mortality. E-alerts are routinely used for detection of AKI in non-pregnant patients but their role in maternity care has not been explored.
Decreased kidney function and agricultural work: a cross-sectional study in middle-aged adults from Tierra Blanca, Mexico
Diego Aguilar-Ramirez, Alejandro Ra?a-Custodio, Antonio Villa, Ximena Rubilar, Nadia Olvera, Alejandro Escobar, Richard J Johnson, Laura Sanchez-Lozada, Gregorio T Obrador, Magdalena Madero
doi : 10.1093/ndt/gfaa041
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1030–1038
We aimed to determine the prevalence of decreased kidney function in a potential chronic kidney disease (KD) of unknown aetiology hotspot in Mexico, assess its distribution across occupations and examine the associated risk factors.
Healthy lifestyle reduces incidence of trace/positive proteinuria and rapid kidney function decline after 2 years: from the Japan Ningen Dock study
Rieko Okada, Kazuyo Tsushita, Kenji Wakai, Kiminori Kato, Takashi Wada, Yukito Shinohara
doi : 10.1093/ndt/gfaa224
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1039–1048
Lifestyle modification is recommended for subjects with trace proteinuria during health checkups. However, whether overall healthy lifestyle reduces the incidence of trace/positive proteinuria or rapid decline in estimated glomerular filtration rate (eGFR) is not clarified.
The impact of comorbid chronic kidney disease and diabetes on health-related quality-of-life: a 12-year community cohort study
Melanie L R Wyld, Rachael L Morton, Leyla Aouad, Dianna Magliano, Kevan R Polkinghorne, Steve Chadban
doi : 10.1093/ndt/gfaa031
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1048–1056
Quality-of-life is an essential outcome for clinical care. Both chronic kidney disease (CKD) and diabetes have been associated with poorer quality-of-life. The combined impact of having both diseases is less well understood. As diabetes is the most common cause of CKD, it is imperative that we deepen our understanding of their joint impact.
Effect of hemodiafiltration on measured physical activity: primary results of the HDFIT randomized controlled trial
Roberto Pecoits-Filho, John Larkin, Carlos Eduardo Poli-de-Figueiredo, Américo Lourenço Cuvello-Neto, Ana Beatriz Lesqueves Barra, Priscila Bezerra Gonçalves, Shimul Sheth, Murilo Guedes, Maggie Han, Viviane Calice-Silva, Manuel Carlos Martins de Castro, Peter Kotanko, Thyago Proenca de Moraes, Jochen G Raimann, Maria Eugenia F Canziani, the HDFIT Study Investigators
doi : 10.1093/ndt/gfaa173
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1057–1070
Dialysis patients are typically inactive and their physical activity (PA) decreases over time. Uremic toxicity has been suggested as a potential causal factor of low PA in dialysis patients. Post-dilution high-volume online hemodiafiltration (HDF) provides greater higher molecular weight removal and studies suggest better clinical/patient-reported outcomes compared with hemodialysis (HD).
Home and facility haemodialysis patients: a comparison of outcomes in a matched cohort
Emily K Yeung, Kevan R Polkinghorne, Peter G Kerr
doi : 10.1093/ndt/gfaa358
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1070–1077
Home haemodialysis (HHD) is utilized significantly less often than facility HD globally with few exceptions, despite being associated with improved survival and better quality of life. Previously HHD was exclusively offered to younger patients with a few comorbidities. However, with the increasing burden of end-stage kidney disease (ESKD) alongside an ageing population, increasing numbers of older patients are being treated with HHD. This study aims to re-evaluate survival and related outcomes in the context of this epidemiological shift.
Recovery of kidney function in patients treated with maintenance dialysis—a report from the ERA-EDTA Registry
Lily Jakulj, Anneke Kramer, Anders ?sberg, Johan de Meester, Carmen Santiuste de Pablos, Jaakko Helve, Marc H Hemmelder, Alexandre Hertig, Mustafa Arici, Samira Bell, Lucile Mercadal, Carmen Diaz-Corte, Runolfur Palsson, Manuel Benitez Sanchez, Julia Kerschbaum, Frederic Collart, Ziad A Massy, Kitty J Jager, Marlies Noordzij
doi : 10.1093/ndt/gfaa368
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1078–1087
Literature on recovery of kidney function (RKF) in patients with end-stage kidney disease treated with maintenance dialysis (i.e. >90?days) is limited. We assessed the incidence of RKF and its associated characteristics in a European cohort of dialysis patients.
Efficacy and safety of oral tolvaptan in patients undergoing hemodialysis: a Phase 2, double-blind, randomized, placebo-controlled trial
Hiroaki Ogata, Naoko Shimofurutani, Tadashi Okada, Hisashi Nagamoto, Tadao Akizawa
doi : 10.1093/ndt/gfaa148
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1088–1097
Loop diuretics are used to manage fluid retention in patients with end-stage kidney disease undergoing hemodialysis (HD). This randomized, double-blind, placebo-controlled, Phase 2 trial evaluated the efficacy and safety of tolvaptan, a vasopressin V2 receptor antagonist, in Japanese HD patients.
Utility of serological tumor biomarkers for surveillance of hepatocellular carcinoma in patients undergoing dialysis
Hidenori Toyoda, Kan Kikuchi, Yuki Tsuruta, Atsushi Hiraoka, Kunihiko Tsuji, Junko Tanaka
doi : 10.1093/ndt/gfaa165
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1097–1103
Patients undergoing dialysis are at risk of hepatocellular carcinoma (HCC) and preferably should undergo HCC surveillance. We investigated the utility of HCC tumor markers for HCC surveillance in patients undergoing dialysis.
Association of subjective global assessment of nutritional status with gut microbiota in hemodialysis patients: a case–control study
Ting-Yun Lin, Szu-Chun Hung
doi : 10.1093/ndt/gfaa019
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1104–1111
Protein-energy wasting (PEW) is prevalent and associated with adverse outcomes in patients with chronic kidney disease (CKD). However, the pathogenesis of PEW in CKD patients has not been fully identified. The gut microbiota has been implicated in the regulation of host metabolism and energy balance. Therefore, we aimed to explore the association between nutritional status and the composition of the gut microbiota in hemodialysis patients.
Early net ultrafiltration rate and mortality in critically ill patients receiving continuous renal replacement therapy
Thummaporn Naorungroj, Ary Serpa Neto, Lara Zwakman-Hessels, Fumitaka Yanase, Glenn Eastwood, Raghavan Murugan, John A Kellum, Rinaldo Bellomo
doi : 10.1093/ndt/gfaa032
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1112–1119
In patients treated with continuous renal replacement therapy (CRRT), early net ultrafiltration (NUF) rates may be associated with differential outcomes. We tested whether higher early NUF rates are associated with increased mortality in CRRT patients.
Influence of a low-dose tacrolimus protocol on the appearance of de novo donor-specific antibodies during 7 years of follow-up after renal transplantation
Kohei Unagami, Hideki Ishida, Miyuki Furusawa, Kumiko Kitajima, Toshihito Hirai, Yoichi Kakuta, Daisuke Toki, Tomokazu Shimizu, Kazuya Omoto, Masayoshi Okumi, Kosaku Nitta, Kazunari Tanabe
doi : 10.1093/ndt/gfaa258
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1120–1129
Tacrolimus (TAC) is a key immunosuppressant drug for kidney transplantation (KTx). However, the optimal serum trough level of TAC for good long-term outcomes remains unclear. This study aimed to investigate the relationship between the maintenance TAC trough level and the appearance of de novo donor-specific anti-human leukocyte antigen (HLA) antibodies (dnDSAs).
Regular RNA screening detects asymptomatic SARS-CoV-2 infection in haemodialysis patients
Ben Storey, Matt Bottomley, Salim Hammad, Allie Thornley, Lucinda Barrett, Oliver O’Sullivan, Katherine Bull
doi : 10.1093/ndt/gfab044
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1130–1132
The humoral immune response to SARS-CoV-2 mounts and is durable in symptomatic haemodialysis patients
Vincenzo La Milia, Silvia Tonolo, Francesco Luzzaro, Claudio Bonato, Andrea Cavalli, Barbara Foglieni, Consuelo Debiase, Monica Limardo, Selena Longhi, Chiara Ravasi, Sara Vigan?
doi : 10.1093/ndt/gfab047
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1132–1134
Prevalence and outcomes of hyponatremia and hypernatremia in patients hospitalized with COVID-19
Jamie S Hirsch, Nupur N Uppal, Purva Sharma, Yuriy Khanin, Hitesh H Shah, Deepa A Malieckal, Alessandro Bellucci, Mala Sachdeva, Helbert Rondon-Berrios, Kenar D Jhaveri, Steven Fishbane, Jia H Ng, the Northwell Nephrology COVID-19 Research Consortium
doi : 10.1093/ndt/gfab067
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1135–1138
Effect of increased potassium intake on the renin–angiotensin–aldosterone system and subcutaneous resistance arteries: a randomized crossover study
Rasmus Dreier, Bahareh Abdolalizadeh, Camilla L Asferg, Lisbet R H?lmich, Niels H Buus, Julie L Forman, Ulrik B Andersen, Martin Egfjord, Majid Sheykhzade, J?rgen L Jeppesen
doi : 10.1093/ndt/gfaa292
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Page 1139
Erratum to: Sodium Zirconium Cyclosilicate Increases Serum Bicarbonate Concentrations Among Patients with Hyperkalaemia: Exploratory Analyses from Three Randomized, Multi-Dose, Placebo-Controlled Trials
Simon D Roger, Bruce S Spinowitz, Edgar V Lerma, Steven Fishbane, Stephen R Ash, Julian G Martins, Carol Moreno Quinn, David K Packham
doi : 10.1093/ndt/gfaa305
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Page 1139
Erratum to: Kidney Disease Pathways, Options and Decisions (KD-POD): An Environmental Scan of International Patient Decision Aids (PtDA)
Anna E Winterbottom, Andrew Mooney, Lynne Russon, Vicki Hipkiss, Lucy Ziegler, Richard Williams, Jeanette Finderup, Hilary L Bekker
doi : 10.1093/ndt/gfaa315
Nephrology Dialysis Transplantation, Volume 36, Issue 6, June 2021, Pages 1140–1143
